JPH0613716Y2 - Closure in a flexible tube - Google Patents

Description

[Detailed description of the device]

[0001]

FIELD OF THE INVENTION The present invention relates to a closure within a flexible tube. More specifically, it is a closure provided inside a flexible tube that connects a number of blood bags without impairing the sterility of the system, and improves the flow state of the fluid in the tube to improve workability. A closure for a flexible tube that can be enhanced.

[0002]

When collecting blood from a donor, the cellular components of whole blood are usually separated from the plasma portion prior to storage and use. Separation is usually performed by centrifugation, which results in an upper plasma layer, an intermediate layer containing white blood cells and platelets, and a lower red blood cell layer.

A synthetic resin bag is generally used for separating the cell component and plasma portion of whole blood. FIG. 8 is a plan view showing a quadrapple blood bag.

The blood collection bag 11 is a blood preservation solution such as CP.
Of the three bags containing D solution and connected to it, two are empty bags 16 and 18, and the other one is a red blood cell preservation solution,
For example, the second liquid bag 17 containing the SAGM liquid,
The blood collection bag 11 and the second liquid bag 17 are provided with a closure device 14.

After the blood is collected in the blood collecting bag via the blood collecting tube 15, the blood collecting tube 15 is sealed in the vicinity of the blood collecting bag and the blood collecting needle portion (not shown) is cut. The blood collection bag 11 is a bag 1 connected via a flexible tube 12 and a connecting tube 13.
Centrifuge with 6, 17, and 18.

Flexible tube of blood collection bag after centrifugation
By grasping 12 by hand and breaking and opening the thin portion of the closure, the upper layer plasma, white blood cells and platelets in the blood collection bag are transferred to the empty bag 18, and the latter bag is separated.

Next, the closure of the second liquid bag 17 is folded by hand to open the passage and return the second liquid to the blood collection bag. In this case, the blood collection bag closure 14 allows liquid to flow in the opposite direction.

When the so-called buffy coat method is used in which the above-mentioned intermediate layer consisting of white blood cells and platelets is independently taken out, this intermediate layer is subjected to secondary centrifugation, and the upper layer component (platelet) is supplied to the second liquid bag 17 ( The second liquid is emptied because it has been transferred to the blood collection bag after the first centrifugation. Therefore, the closure 14 of the second liquid bag, like the closure of the blood collection bag 11, allows the liquid to pass once each for forward and reverse.

However, the conventional closure has a problem that the tip of the closure often breaks through the flexible tube during the centrifugal separation.

Therefore, in order to solve such a problem, the applicant of the present invention has previously proposed a closure having a pair of opposing rounded blades formed along the inner surface of the flexible tube at the tip of the closure. Proposed (Practical application No. 2-65600).

The closure previously proposed by the applicant is shown in FIG.
As shown in FIGS. 10 to 10, two connecting cylinders 21, a columnar portion 22, and a thin portion 23 are provided, each of which has a rounded portion 26 corresponding to the inner surface of the flexible tube at the tip of the columnar portion 22. The blade 25 is formed. The total cross-sectional area of the two blades 25 is set to 25 to 50% of the hollow cross-sectional area of the flexible tube.

When the closure is used, the force with which the tip of the closure hits the inside of the flexible tube during centrifugation can be halved, so the problem of tube breakage as described above is solved. . Further, by setting the cross-sectional area of the blade within the above range, the plasma flow to the child bag can be kept in a good state.

[0013]

As described above, in the operation of separating whole blood components, the drug solution or the component solution flows in the forward and reverse directions.

In order to speed up the component separation operation, it is necessary to increase the passage speed of the opened closing device. In this case, the conventional closing device has a problem that the liquid flow is slow and the workability is poor. It was

In view of the above circumstances, an object of the present invention is to provide a closure in a flexible tube which can improve fluid flow and improve workability.

[0016]

The closure in a flexible tube of the present invention is a closure used in a flexible tube through which a fluid passes, and (a) is smaller than the inner diameter of the flexible tube. A communicating cylinder having a slightly larger outer diameter, (b) a columnar portion integrally formed with the communicating cylinder and having an outer diameter smaller than the outer diameter of the communicating cylinder, and (c) the communicating cylinder and the columnar portion. Is formed between
It is composed of a thin-walled portion having a thickness smaller than that of the communicating tube, and the columnar portion is provided at the end opposite to the thin-walled portion.
A plurality of opposing vanes, the vanes being provided with a roundness on the flexible tube side corresponding to the inner surface of the flexible tube, and between the two vanes going toward the tip. It is characterized in that deep grooves are formed.

[0017]

[Operation] With the closure of the present invention, between the pair of blades,
A groove is formed that becomes deeper toward the tip. Therefore, the resistance of the fluid during the backward flow from the child bag to the blood collection bag is reduced, and the fluid smoothly moves to the blood collection bag. Further, when the cross-sectional shape of the thin portion in the axial direction is made into an approximately ¼ arc shape, there are many irregularities in the fracture surface when the columnar portion is broken, and the flow path is formed between the columnar portion and the communication tube. It is ensured and the flow condition is better.

[0018]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A closure device (hereinafter simply referred to as a closure device) in a flexible tube of the present invention will be described in detail below with reference to the accompanying drawings.

FIG. 1 is a front view including a partial cross section of an embodiment of the closure of the present invention, FIG. 2 is a side view of the closure shown in FIG. 1, and FIG. 3 is an enlarged view of part A of FIG. 4 is an explanatory view showing a state in which the thin portion is broken.

1 and 2, C is a closing tool according to an embodiment of the present invention, and the closing tool C is composed of a communicating tube 1 and a columnar portion 2.

The closure C is made of a rigid material such as hard synthetic resin. Specific examples of synthetic resins that can be used include polycarbonate, polyvinyl chloride, polystyrene and polyethylene terephthalate.

The size of the communication tube 1 is determined in consideration of the size of the flexible tube. That is, the outer diameter of the communication tube 1 is selected to be slightly larger than the inner diameter of the flexible tube. Usually, the outer diameter is about 5 mm, the inner diameter is about 4 mm, and the length is 10 to 17 mm, but it is not limited to these.

A columnar portion 2 is integrally formed with the communication cylinder 1 at one end of the communication cylinder 1. The outer diameter of the columnar portion 2 is smaller than the outer diameter of the communication cylinder 1, and the length is usually about 10 to 12 mm.

Between the columnar portion 2 and the communication cylinder 1, a thin portion 3 thinner than the communication cylinder 1 is formed. The thin portion 3 facilitates breakage of the closure C after the centrifugal separation operation.

As shown in FIG. 3, it is preferable that the thin-walled portion 3 has an axial cross-sectional shape that is a substantially quarter arc shape. When the cross-sectional shape is made into a substantially quarter arc shape, the height h of the unevenness 4 (see FIG. 7) at the fractured portion when the thin portion 3 is fractured becomes large. Therefore, when a reverse flow is generated in the flexible tube, the fracture surfaces do not come into close contact with each other as shown in FIG. 5, and a fluid flow path is secured between the communication tube and the columnar portion. It is possible to obtain a high flow rate.

On the other hand, as shown in FIG. 11, in the case of the conventional thin-walled portion having a V-shaped cross section, the degree of unevenness when broken is small. Therefore, when a flow in the opposite direction is generated in the flexible tube, the fracture surfaces come into close contact with each other as shown in FIG. 6, and a large flow velocity cannot be obtained.

Table 1 shows closures A and B having a substantially quarter arc-shaped cross section and a closure a having a V-shaped cross section.
The measurement results of the uneven height (mm) of are shown. The unit of wall thickness is mm.

[0028]

[Table 1]

As is apparent from Table 1, it is understood that the closure having the substantially quarter arc-shaped cross-section has a larger unevenness than the closure having the V-shaped cross-section.

The columnar portion 2 has a pair of blades 5 at the end opposite to the thin portion 3. The vanes 5 face each other as shown in FIG. 1 and have a roundness 6 on the inner surface side of the flexible tube. Each roundness 6 has a shape corresponding to the inner peripheral surface of the flexible tube, so that the force applied by the blades 5 to the inner surface of the flexible tube during centrifugation can be reduced.

In order for the plasma separated from the blood to be quickly transferred to the child bag through the communication tube and the connecting tube, the cross-sectional area of the vane 5 is preferably less than 50% of the hollow cross-sectional area of the flexible tube. On the other hand, it is preferable that the cross-sectional area of the blade is larger than 25%, and if it is less than 25%, the tip 7 of the blade is too sharp, which may damage the flexible tube during centrifugation.

A groove 8 is formed between the pair of blades 5 so as to become deeper toward the tip 7.
As shown in FIGS. 1 and 2, only one groove 8 may be formed on one side, or a pair of grooves 8 may be formed so as to be back-to-back.

By forming the groove 8 as described above, there is an effect that the flow condition when a reverse flow is generated in the flexible tube is improved and the flow velocity is increased.

[0034]

As described above, in the closure of the present invention, since the groove that becomes deeper toward the tip is formed between the pair of blades, a reverse flow is generated in the flexible tube. In this case, the flow velocity can be increased. Also, if the cross-sectional shape of the thin-walled portion between the communication cylinder and the columnar portion is made into a substantially quarter-arc shape, the fracture surface when the thin-walled portion is broken becomes messy (unevenness increases). The flow path of the fluid at the time of the reverse flow is secured, and a large flow velocity can be obtained.

[Brief description of drawings]

FIG. 1 is a front view including a partial cross section of an embodiment of a closure of the present invention.

2 is a side view of the closure shown in FIG. 1. FIG.

FIG. 3 is a partially enlarged view of a portion A in FIG.

FIG. 4 is an explanatory diagram of a fracture surface when the closure shown in FIG. 1 is fractured at a thin portion.

FIG. 5 is an explanatory view showing the state of the closing tool shown in FIG. 1 when it flows in the reverse direction.

FIG. 6 is an illustration showing a state of a conventional closing device at the time of reverse flow.

FIG. 7 is an explanatory diagram of unevenness of a fractured portion in a thin portion.

FIG. 8 is an explanatory plan view of a quadruple blood bag.

FIG. 9 is a front view including a partial cross section of a conventional closure.

FIG. 10 is a side view of the closure shown in FIG.

11 is a partially enlarged view of a B part in FIG.

[Explanation of symbols]

 C Closing tool 1 Communication cylinder 2 Columnar section 3 Thin section 4 Concavo-convex 5 Blade 12 Flexible tube

Claims (4)

[Scope of utility model registration request] 1. A closure used in a flexible tube through which a fluid passes, comprising: (a) a communication tube having an outer diameter slightly larger than the inner diameter of the flexible tube; and (b) the communication tube. And a columnar portion having an outer diameter smaller than the outer diameter of the communication tube, and (c) formed between the communication tube and the columnar portion,
It is composed of a thin-walled portion having a thickness smaller than that of the communication tube, the columnar portion has two opposing vanes at the end opposite to the thin-walled portion, and the vane has an inner surface of the flexible tube. Is provided on the flexible tube side, and a groove is formed between the two blades, the groove being deeper toward the tip. Closure. 2. The closure according to claim 1, wherein a pair of the grooves are formed so as to be back-to-back between two blades. 3. The closure according to claim 1, wherein the thin-walled portion has a cross-sectional shape in the axial direction which is a substantially quarter arc shape. 4. The closure according to claim 1, wherein the total cross-sectional area of the two blades is 25-50% of the hollow cross-sectional area of the flexible tube.