JPH058018B2 - - Google Patents
Info
- Publication number
- JPH058018B2 JPH058018B2 JP59272326A JP27232684A JPH058018B2 JP H058018 B2 JPH058018 B2 JP H058018B2 JP 59272326 A JP59272326 A JP 59272326A JP 27232684 A JP27232684 A JP 27232684A JP H058018 B2 JPH058018 B2 JP H058018B2
- Authority
- JP
- Japan
- Prior art keywords
- nozzle
- tank
- capsule
- composite
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000463 material Substances 0.000 claims description 43
- 239000002775 capsule Substances 0.000 claims description 39
- 239000011248 coating agent Substances 0.000 claims description 35
- 238000000576 coating method Methods 0.000 claims description 35
- 239000002131 composite material Substances 0.000 claims description 31
- 238000001125 extrusion Methods 0.000 claims description 14
- 239000000110 cooling liquid Substances 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 description 17
- 239000002826 coolant Substances 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 239000012530 fluid Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Description
【発明の詳細な説明】
「産業上の利用分野」
本発明はシームレス（継目無し）カプセルを製
造する装置に関するものである。DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to an apparatus for manufacturing seamless capsules.
「従来の技術」
従来のシームレスカプセルの製造装置は、例え
ば実開昭59−46540号公報に開示されている。"Prior Art" A conventional seamless capsule manufacturing apparatus is disclosed in, for example, Japanese Utility Model Application Publication No. 59-46540.
この装置は、大径なノズルの中に小径なノズル
を設けた同心二重円筒状の複合ノズルをカプセル
形成槽内の冷却液中に下向状態で臨ませ、前記大
径なノズルには加熱して流動化した外皮膜化物質
を、前記小径なノズルには流動化した充填物質
を、それぞれの恒温タンクよりそれぞれの給送パ
イプを経て圧送し、前記複合ノズルから前記外皮
膜化物質と充填物質とを複合ジエツト流として前
記カプセル形成槽内の冷却液中に連続的に押出
し、前記複合ジエツト流として押出されたものを
順次先端より所定の大きさに切断し、これを内部
の冷却液が一定方向へ流れるように構成したカプ
セル回収パイプに導いて回収しつつ冷却する構造
のものである。 This device has a concentric double cylindrical compound nozzle with a small diameter nozzle installed inside a large diameter nozzle facing downward into the cooling liquid in the capsule forming tank, and the large diameter nozzle is heated. The fluidized coating substance is fed to the small diameter nozzle, and the fluidized filling substance is fed from each constant temperature tank through each feeding pipe, and the coating substance and the coating substance are filled from the composite nozzle. The substance is continuously extruded as a composite jet stream into the cooling liquid in the capsule forming tank, and the extruded composite jet stream is sequentially cut into a predetermined size from the tip, and the internal cooling liquid is It has a structure in which the capsules are cooled while being collected by being led to a capsule collection pipe configured to flow in a fixed direction.
切断された各片は、外皮膜化物質がその表面張
力により充填物質を包んだ状態になつており、外
皮膜化物質が流動状態を保つている間に冷却液の
液流中で丸みをおびた形状に成形され、この外皮
膜化物質が冷却液で冷却されて皮膜化することに
よりカプセルに成形される。 Each cut piece is in a state where the outer coating material wraps around the filling material due to its surface tension, and while the outer coating material remains in a fluid state, it becomes rounded in the flow of coolant. The capsule is formed into a capsule by cooling the coated material with a cooling liquid and forming a film.
前記装置において、ゼラチンその他の高分子物
質からなる外皮膜化物質を加熱するため、前記複
合ノズルの周囲に加熱ジヤケツトを設けるととも
に、外皮膜化物質の給送パイプの周囲へ当該給送
パイプのほぼ全長にわたつて加熱ジヤケツトを設
けている。 In the apparatus, in order to heat the coating material made of gelatin or other polymeric material, a heating jacket is provided around the composite nozzle, and a heating jacket is provided around the coating material feeding pipe. A heating jacket is provided along the entire length.
「発明が解決しようとする問題点」
この種の製造装置において、ゼラチン等の高分
子物質の溶液からなる外皮膜化物質は、押出し時
の適切な流動性を得るため70℃〜80℃に加熱する
のであるが、高温に保たれている時間がながいと
分子が小さくなつて劣化し、カプセル化後に壊れ
易くなる。したがつて、タンクでは流動できる状
態でなるべく低温に保ち、複合ノズルから押出さ
れる時に前記程度の温度に調節するのがより好ま
しい。``Problem to be solved by the invention'' In this type of manufacturing equipment, the coating material, which is a solution of a polymeric substance such as gelatin, is heated to 70°C to 80°C in order to obtain appropriate fluidity during extrusion. However, the longer it is kept at high temperatures, the smaller the molecules become and deteriorate, making them more likely to break after encapsulation. Therefore, it is more preferable to keep the temperature as low as possible in the tank so that it can flow, and to adjust the temperature to the above range when extruded from the composite nozzle.
また、押出し時の温度が変化すると粒径が揃わ
なくなるので、押出し時の温度は設定温度の±２
℃の範囲内に制御するのが好ましい。 Also, if the temperature during extrusion changes, the particle size will not be uniform, so the temperature during extrusion should be ±2 of the set temperature.
It is preferable to control the temperature within the range of °C.
ところで、前述の従来のシームレスカプセル製
造装置は、外皮膜化物質の給送パイプのほぼ全長
にわたつて加熱ジヤケツトを設けており、外皮膜
化物質は恒温タンクを出た直後からパイプで送ら
れながら加熱されるので、押出し時における温度
を設定温度の±２℃以内に制御することは非常に
難しく、カプセルの大きさ及び形状が不揃いにな
り易い。この傾向は、設計上外皮膜化物質の給送
パイプが短いほど、また造粒が高速（外皮膜化物
質の流速が高速）になるほど顕著になる。 By the way, in the conventional seamless capsule manufacturing equipment described above, a heating jacket is provided over almost the entire length of the feeding pipe for the coating material, and the coating material is fed through the pipe immediately after leaving the constant temperature tank. Since it is heated, it is very difficult to control the temperature during extrusion to within ±2° C. of the set temperature, and the size and shape of the capsules tend to be irregular. This tendency becomes more pronounced as the supply pipe for the coating material becomes shorter in design and as the granulation speed increases (the flow rate of the coating material increases).
本発明の目的は、前述のような問題を解決し、
外皮膜化物質の給送パイプの長さや、造粒速度に
ほとんど関係なく、外皮膜化物質の押出し時の温
度をより厳密に制御することができるシームレス
カプセル製造装置を提供することにある。 The purpose of the present invention is to solve the above-mentioned problems,
It is an object of the present invention to provide a seamless capsule manufacturing apparatus that can more strictly control the temperature during extrusion of a coating material, almost regardless of the length of a feeding pipe for the coating material or the granulation speed.
「問題点を解決するための手段」
本発明は前述の目的を達成するために、複合ノ
ズルの押出し部直前に前記外皮膜化物質の温度を
調節する温度調節タンクを設けるとともに、前記
外皮膜化物質の給送パイプの途中の一箇所に前記
温度調節タンクとは独立した中間加熱器を設けた
ものである。"Means for Solving the Problems" In order to achieve the above-mentioned object, the present invention provides a temperature control tank for adjusting the temperature of the outer coating material immediately before the extrusion section of the composite nozzle, and An intermediate heater independent of the temperature control tank is provided at one point in the material supply pipe.
「作用」
本発明に係る製造装置によれば、外皮膜化物質
は、給送パイプによつて温度調節タンクに送られ
る途中で中間加熱器内に達すると、給送パイプ内
での流速より遅くなり、中間加熱器内で一担留め
られたような状態になる。この状態で加熱された
後、温度調節タンクに送られ、押出し適温に加熱
調節される。"Operation" According to the manufacturing apparatus according to the present invention, when the outer coating material reaches the intermediate heater while being sent to the temperature control tank by the feeding pipe, the flow rate is slower than that in the feeding pipe. It becomes like being stuck in the intermediate heater. After being heated in this state, it is sent to a temperature control tank where it is heated to an appropriate temperature for extrusion.
このように一担留まつた状態で加熱されること
により、給送パイプが短い場合でも、また高速造
粒の場合でも押出し時の設定温度近くまで十分に
加熱することができるので、後方の温度調節タン
クによる押出し温度の制御がより正確になる。 By being heated in this way, even when the feeding pipe is short or when granulating at high speed, it is possible to sufficiently heat it to close to the set temperature during extrusion, so that the temperature at the rear can be reduced. Control of extrusion temperature by regulating tank becomes more precise.
「実施例」
図面は本発明装置の好適な一実施例を示すもの
である。"Embodiment" The drawings show a preferred embodiment of the device of the present invention.
１はゼラチン水溶液よりなる外皮膜化物質ａの
タンク、２はカプセル充填物質ｂのタンクで、各
タンク１，２はそれぞれ図示しない加熱用ジヤケ
ツトを備えて内部の外皮膜化物質ａ、充填物質ｂ
を加熱するように構成され、タンク１，２内部の
外皮膜化物質ａ、充填物質ｂは常にほぼ定量を保
つべく随時他より補給されるようになつている。 Reference numeral 1 denotes a tank containing a coating substance a made of an aqueous gelatin solution, and 2 a tank containing a capsule filling substance b.Each tank 1 and 2 is equipped with a heating jacket (not shown) to hold the coating substance a and the filling substance b inside.
The outer coating material a and the filling material b inside the tanks 1 and 2 are replenished from other sources as needed to maintain a substantially fixed amount at all times.
タンク１内の外皮膜化物質ａは、流動性を保つ
のに必要最低限の45℃〜50℃程度に加熱され、加
圧管１１からの圧力により給送パイプ３１を経て
押出し部直前の温度調節タンク４に供給される。 The coated substance a in the tank 1 is heated to about 45°C to 50°C, which is the minimum necessary to maintain fluidity, and the temperature is adjusted by the pressure from the pressurizing pipe 11 via the feeding pipe 31 just before the extrusion section. It is supplied to tank 4.
給送パイプ３１の途中には温度計を備えた独立
した中間加熱器３が設置されており、前記外皮膜
化物質ａは、この中間加熱器３内に達して流速が
低下し、一担留められたような状態で70〜80℃の
間の適当な設定温度近くまで加熱された後、温度
調節タンク４で設定温度に温度調節され、後述の
複合ノズル５における大径なノズル５１から押出
される。 An independent intermediate heater 3 equipped with a thermometer is installed in the middle of the feed pipe 31, and the outer coating material a reaches the inside of this intermediate heater 3, the flow rate is reduced, and it is held at once. After being heated to near a suitable set temperature between 70 and 80°C, the temperature is adjusted to the set temperature in the temperature adjustment tank 4, and extruded from the large diameter nozzle 51 of the composite nozzle 5, which will be described later. Ru.
また、加圧管１１を使用しない場合は、給送パ
イプ３１におけるバイパスパイプ３２の定量ポン
プ３３によつて外皮膜化物質ａを前述の経路で給
送する。 Furthermore, when the pressurizing pipe 11 is not used, the coating substance a is fed through the above-mentioned route by the metering pump 33 of the bypass pipe 32 in the feeding pipe 31.
第２図で示すように、温度調節タンク４は、図
示しないヒーターを内蔵した加熱用ジヤケツト４
１及び給送パイプ３１の連結用ソケツト４３を備
え、タンク４内に挿入された温度検出器４２で給
送パイプ３１から供給された外皮膜化物質ａの温
度を常時検出し、この検出値に基いて前記ヒータ
ーを制御することにより、外皮膜化物質ａの温度
を押出適温（後述の複合ノズル５における大径な
ノズル５１から押出す時の適温）に調節されるよ
うに構成している。 As shown in FIG. 2, the temperature control tank 4 is a heating jacket 4 with a built-in heater (not shown).
1 and a socket 43 for connecting the feeding pipe 31, the temperature detector 42 inserted into the tank 4 constantly detects the temperature of the coating material a supplied from the feeding pipe 31, and the detected value is By controlling the heater based on this, the temperature of the outer coating substance a is adjusted to an appropriate extrusion temperature (an appropriate temperature when extruding from a large-diameter nozzle 51 in a composite nozzle 5, which will be described later).
この温度調節タンク４の下端の開口部４４に
は、後述の小径なノズル５２とともに複合ノズル
５を構成する大径なノズル５１が取付けられ、こ
の複合ノズル５は下方のカプセル形成槽６内に臨
ませてある。４５はタンク４に取付けられたエヤ
ーセパレーターである。 A large-diameter nozzle 51 that constitutes a composite nozzle 5 together with a small-diameter nozzle 52 (described later) is attached to the opening 44 at the lower end of the temperature control tank 4, and the composite nozzle 5 faces into the capsule forming tank 6 below. I have it. 45 is an air separator attached to the tank 4.
なお、前述の温度調節タンク４においては、ヒ
ーターに代えて熱湯で加熱するように構成しても
よい。 Note that the temperature adjustment tank 4 described above may be configured to be heated with hot water instead of the heater.
第１図に示すタンク２内のカプセル充填物質ｂ
は、充填物質の給送パイプ２１の途中に設けられ
た定量ポンプ２２により、前記給送パイプ２１、
複合ノズル５の小径なノズル５２（第２図）に連
結され温度調節タンク４を貫通している昇降自在
な可動給送パイプ２３を経て前記ノズル５２へ供
給される。 Capsule filling material b in tank 2 shown in FIG.
is, by a metering pump 22 provided in the middle of the feeding pipe 21 of the filling material, the feeding pipe 21,
The liquid is supplied to the nozzle 52 through a movable feed pipe 23 which is connected to a small diameter nozzle 52 (FIG. 2) of the composite nozzle 5 and which passes through the temperature control tank 4 and is movable up and down.
第１図において、２４は定量ポンプ２２による
充填物質ｂの微小な脈流を防止して前記小径なノ
ズル５２における内圧を一定に保つアキユムレー
ター、２５は充填物質ｂのレリーフ量調整バイブ
である。 In FIG. 1, 24 is an accumulator that prevents minute pulsating flow of the filling material b caused by the metering pump 22 and keeps the internal pressure constant in the small diameter nozzle 52, and 25 is a vibration amount adjustment vibrator for adjusting the relief amount of the filling material b.
複合ノズル５は、第２図のように外皮膜化物質
ａを押出すための大径なノズル５１と、このノズ
ル５１の中にあつてカプセル充填物質ｂを押出す
ための小径なノズル５２から構成されており、両
物質ａ，ｂはこの複合ノズル５からカプセル形成
槽６内の流動パラフインよりなる冷却液ｃ内に複
合ジエツト流として連続的に押出される。 As shown in FIG. 2, the composite nozzle 5 includes a large-diameter nozzle 51 for extruding the outer coating substance a, and a small-diameter nozzle 52 located inside this nozzle 51 for extruding the capsule-filling substance b. Both substances a and b are continuously extruded from this composite nozzle 5 into a cooling liquid c made of liquid paraffin in a capsule forming tank 6 as a composite jet stream.
また複合ノズル５は、前記可動給送パイプ２３
に取付けられているねじ２６を回し、可能給送パ
イプ２３とともに小径なノズル５２を少し昇降さ
せることによつて、大径なノズル５１と小径なノ
ズル５２との間〓の広狭を調節することができる
ように構成されており、これによつて大径なノズ
ル５１から押出される外皮膜化物質ａの量、即ち
カプセルｄ形成後の外皮膜a′の厚みを調節し得る
ようになつている。 Further, the composite nozzle 5 has the movable feed pipe 23
By turning the screw 26 attached to the feed pipe 23 and slightly raising and lowering the small diameter nozzle 52, the width between the large diameter nozzle 51 and the small diameter nozzle 52 can be adjusted. This makes it possible to adjust the amount of the outer coating material a extruded from the large-diameter nozzle 51, that is, the thickness of the outer coating a' after the capsule d is formed. .
前記複合ノズル５において、充填物質ｂを押出
す小径なノズル５２は大径なノズル５１の中に離
した状態で複数設けてもよい。この場合に形成さ
れるカプセルは複数の核を持つカプセルとなる。 In the composite nozzle 5, a plurality of small-diameter nozzles 52 for extruding the filler material b may be provided within the large-diameter nozzle 51 and spaced apart from each other. The capsule formed in this case has multiple nuclei.
複合ノズル５から連続的に押出される充填物質
ｂと外皮膜化物質ａとの複合ジエツト流には、カ
プセル形成槽６内において該ジエツト流を側周か
ら囲む状態の断続流ノズル６０より冷却液の断続
流が規則的に加えられ、この断続流の衝撃によつ
て複合ジエツト流には先端より所定の間隔毎に凹
みが形成される。 The composite jet flow of the filling material b and the coating material a that is continuously extruded from the composite nozzle 5 is supplied with a cooling liquid from an intermittent flow nozzle 60 that surrounds the jet flow from the side in the capsule forming tank 6. An intermittent flow of is applied regularly, and the impact of this intermittent flow causes depressions to be formed at predetermined intervals from the tip of the composite jet flow.
なお前記断続流ノズル６０は、下方の調整ねじ
６２によつて開口の程度を調整し得るように構成
されている。 Note that the intermittent flow nozzle 60 is configured so that the degree of opening can be adjusted by a lower adjustment screw 62.
冷却液ｃは冷却液タンク７からポンプ７０によ
り熱交換器７１、給送パイプ７２を経てカプセル
形成槽６、形成槽６内において複合ノズル５の下
方に垂設された上下可動な漏斗管８、カプセル回
収管８１、回収用ホツパー９、冷却液タンク７へ
と循環しているから、前記複合ジエツト流は下の
漏斗管８の方向へ引かれて前記凹みの部分から順
次切断される。切断された各片は、その外皮膜化
物質が流動状態を保つている間に、漏斗管８内の
冷却液ｃの流れによつて順次丸みをおびつつ冷却
凝固してカプセルｄに成形され、カプセル回収管
８１を経て回収用ホツパー９に達し、メツシユ９
１によつて側方の図示しないコンベアー等へ供給
される。 The coolant c is supplied from the coolant tank 7 by a pump 70 to a heat exchanger 71, a feeding pipe 72, a capsule forming tank 6, a vertically movable funnel tube 8 vertically installed below the composite nozzle 5 in the forming tank 6, Since the composite jet flow is circulated to the capsule collection pipe 81, the collection hopper 9, and the coolant tank 7, it is drawn toward the funnel pipe 8 below and is sequentially cut from the recessed portion. Each cut piece is cooled and solidified while being sequentially rounded by the flow of the cooling liquid c in the funnel tube 8 while the outer coating material remains in a fluid state, and is formed into a capsule d. It reaches the collection hopper 9 through the capsule collection pipe 81, and the mesh 9
1 to a conveyor (not shown) on the side.
複合ジエツト流に断続流を加える冷却液は、冷
却液タンク７からポンプ７３により給送パイプ７
４を経て断続流発生器７５に達し、この断続流発
生器７５により規則的な断続流として給送パイプ
７６を経て断続流ノズル６０へ供給され、カプセ
ル形成槽６内の冷却液ｃとともに前記経路を循環
する。 The coolant that adds an intermittent flow to the composite jet flow is transferred from the coolant tank 7 to the feed pipe 7 by a pump 73.
The intermittent flow generator 75 supplies the intermittent flow through the feed pipe 76 to the intermittent flow nozzle 60 as a regular intermittent flow, and flows along with the cooling liquid c in the capsule forming tank 6 into the above-mentioned path. cycle.
この実施例において、複合ジエツト流を先端よ
り所定の大きさに順次切断するには、前記のよう
に複合ジエツト流に側方より断続流を加えること
に代えて、カプセル形成槽６内における冷却液ｃ
の流速を断続的に速めてもよい。 In this embodiment, in order to sequentially cut the composite jet stream into predetermined sizes from the tip, instead of adding an intermittent flow to the composite jet stream from the side as described above, a cooling liquid in the capsule forming tank 6 is used. c.
The flow rate may be increased intermittently.
第１図において、７７は断続流発生器７５に対
する冷却液の圧力を一定に保つためのアキユムレ
ーター、６１はカプセル形成槽６から冷却液タン
ク７に通じたオーバーフローパイプである。 In FIG. 1, 77 is an accumulator for keeping the pressure of the coolant constant for the intermittent flow generator 75, and 61 is an overflow pipe leading from the capsule forming tank 6 to the coolant tank 7.
この実施例のカプセル製造装置は、前述のよう
に給送パイプ３１の途中に温度調節タンク４とは
独立した中間加熱器３が設置されており、外皮膜
化物質ａは、この中間加熱器３内に達して流速が
低下し、加熱器３内に一担留められた状態で設定
温度近くまで加熱することができる。 In the capsule manufacturing apparatus of this embodiment, as described above, an intermediate heater 3 independent of the temperature control tank 4 is installed in the middle of the feeding pipe 31, and the outer coating substance a is transferred to the intermediate heater 3. When the temperature reaches the inside of the heater 3, the flow rate decreases, and it is possible to heat the heater 3 to a temperature close to the set temperature while it is held in the heater 3.
したがつて、従来のように給送パイプ３１で給
送しつつ加熱するのに比べ、温度調節タンク４に
よる温度制御がより正確におこなわれ、ノズル５
による押出し設定温度の±２℃以内に容易に制御
することができる。この効果は、外皮膜化物質の
給送パイプが短い場合や、高速造粒の場合特に顕
著である、
「発明の効果」
本発明は、外皮膜化物質の給送パイプの途中一
箇所に、複合ノズルの周囲の温度調節タンクとは
独立した中間加熱器を設置したので、外皮膜化物
質はこの中間加熱器で一担留められたような状態
で加熱され、後方の温度調節タンクによる押出し
時の温度制御を正確にすることが容易になる。 Therefore, compared to the conventional method of heating while feeding through the feed pipe 31, the temperature control by the temperature control tank 4 is performed more accurately, and the nozzle 5
The extrusion temperature can be easily controlled within ±2°C of the set extrusion temperature. This effect is particularly noticeable when the feeding pipe for the coated material is short or when high-speed granulation is performed. Since we installed an intermediate heater independent of the temperature control tank surrounding the composite nozzle, the material to be coated is heated as if it were held in place by this intermediate heater, and when extruded by the rear temperature control tank. It becomes easy to accurately control the temperature of
したがつて、給送パイプの長さや造粒速度にあ
まり左右されないで、形状や大きさはばらつきの
ないより均一な粒のシームレスカプセルを製造す
ることができる。 Therefore, it is possible to produce seamless capsules with more uniform grains without variations in shape and size, without being greatly influenced by the length of the feeding pipe or the granulation speed.
図面は本発明に係るシームレスカプセル製造装
置の一実施例を示すもので、第１図は一部を断面
とした全体系統図、第２図はその要部の拡大断面
図である。
図中主要符号の説明、１は外皮膜化物質のタン
ク、２はカプセル充填物質のタンク、２１，２３
はカプセル充填物質の給送パイプ、３１は外皮膜
化物質の給送パイプ、４は温度調節タンク、４１
は加熱用ジヤケツト、４２は温度検出器、５は複
合ノズル、５１は大径なノズル、５２は小径なノ
ズル、６はカプセル形成槽、ａは外皮膜化物質、
ｂはカプセル充填物質、ｃは冷却液、ｄはカプセ
ルを示す。
The drawings show an embodiment of the seamless capsule manufacturing apparatus according to the present invention, in which FIG. 1 is an overall system diagram with a partially sectional view, and FIG. 2 is an enlarged sectional view of the main parts thereof. Explanation of main symbols in the figure: 1 is a tank for the outer coating material, 2 is a tank for the capsule filling material, 21, 23
3 is a supply pipe for capsule filling material, 31 is a supply pipe for outer coating material, 4 is a temperature control tank, 41
is a heating jacket, 42 is a temperature detector, 5 is a composite nozzle, 51 is a large diameter nozzle, 52 is a small diameter nozzle, 6 is a capsule forming tank, a is an outer coating material,
b indicates capsule filling material, c indicates cooling liquid, and d indicates capsule.
Claims (1)
した数個のノズルを設けた複合ノズルをカプセル
形成槽内の冷却液中に臨ませ、前記大径なノズル
には流動化した外皮膜化物質を、前記小径なノズ
ルには流動化したカプセル充填物質を、それぞれ
のタンクよりそれぞれの給送パイプを経て圧送
し、前記複合ノズルから前記外皮膜化物質とカプ
セル充填物質とを複合ジエツト流として前記カプ
セル形成槽内の冷却液中に連続的に押出し、前記
複合ジエツト流として押出されたものを先端より
順次所定の大きさに切断しつつ造粒するように構
成されたカプセルの製造装置において、前記複合
ノズルの押出し部直前に前記外皮膜化物質の温度
調節タンクを設けるとともに、前記外皮膜化物質
の給送パイプの途中一箇所に前記温度調節タンク
とは独立した中間加熱器を設けたことを特徴とす
る、シームレスカプセルの製造装置。1. A composite nozzle consisting of a large-diameter nozzle and one small-diameter nozzle or several nozzles spaced apart from each other is placed facing into the cooling liquid in the capsule forming tank, and the large-diameter nozzle is coated with a fluidized outer coating. The fluidized capsule filling material is pumped from each tank through each feed pipe to the small diameter nozzle, and the coated material and capsule filling material are fed as a composite jet stream from the composite nozzle. A capsule manufacturing apparatus configured to continuously extrude into a cooling liquid in the capsule forming tank and granulate the extruded composite jet stream while sequentially cutting it into a predetermined size from the tip, A temperature regulating tank for the outer coating material is provided immediately before the extrusion part of the composite nozzle, and an intermediate heater independent of the temperature regulating tank is provided at one point in the middle of the outer coating material feeding pipe. Seamless capsule manufacturing equipment featuring:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59272326A JPS61149151A (en) | 1984-12-24 | 1984-12-24 | Apparatus for producing seamless capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59272326A JPS61149151A (en) | 1984-12-24 | 1984-12-24 | Apparatus for producing seamless capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61149151A JPS61149151A (en) | 1986-07-07 |
| JPH058018B2 true JPH058018B2 (en) | 1993-02-01 |
Family
ID=17512324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59272326A Granted JPS61149151A (en) | 1984-12-24 | 1984-12-24 | Apparatus for producing seamless capsule |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61149151A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001238934A (en) * | 1999-12-20 | 2001-09-04 | Chugai Pharmaceut Co Ltd | Method for manufacturing seamless capsule |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2963291T3 (en) * | 2007-04-26 | 2024-03-26 | Sublimity Therapeutics Ltd | Manufacturing of multiple mini capsules |
| CN106140008A (en) * | 2016-07-26 | 2016-11-23 | 天津长荣印刷设备股份有限公司 | The cutter sweep of a kind of pulse cutting soft gelatin capsule machine and method of work thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5946540B2 (en) * | 1978-10-27 | 1984-11-13 | ダイキン工業株式会社 | Fluoro rubber composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5946540U (en) * | 1982-09-21 | 1984-03-28 | 湧永製薬株式会社 | Seamless encapsulation device |
-
1984
- 1984-12-24 JP JP59272326A patent/JPS61149151A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5946540B2 (en) * | 1978-10-27 | 1984-11-13 | ダイキン工業株式会社 | Fluoro rubber composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001238934A (en) * | 1999-12-20 | 2001-09-04 | Chugai Pharmaceut Co Ltd | Method for manufacturing seamless capsule |
| JP4610727B2 (en) * | 1999-12-20 | 2011-01-12 | 中外製薬株式会社 | Seamless capsule manufacturing method |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61149151A (en) | 1986-07-07 |
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