JPH056598B2 - - Google Patents
Info
- Publication number
- JPH056598B2 JPH056598B2 JP59002365A JP236584A JPH056598B2 JP H056598 B2 JPH056598 B2 JP H056598B2 JP 59002365 A JP59002365 A JP 59002365A JP 236584 A JP236584 A JP 236584A JP H056598 B2 JPH056598 B2 JP H056598B2
- Authority
- JP
- Japan
- Prior art keywords
- adhesive
- weight
- wetting agent
- collagen hydrolyzate
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001070 adhesive effect Effects 0.000 claims description 34
- 239000000853 adhesive Substances 0.000 claims description 33
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 16
- 238000001879 gelation Methods 0.000 claims description 16
- 239000003112 inhibitor Substances 0.000 claims description 16
- 102000008186 Collagen Human genes 0.000 claims description 15
- 108010035532 Collagen Proteins 0.000 claims description 15
- 229920001436 collagen Polymers 0.000 claims description 15
- 239000000080 wetting agent Substances 0.000 claims description 15
- 108010010803 Gelatin Proteins 0.000 claims description 8
- 239000008273 gelatin Substances 0.000 claims description 8
- 229920000159 gelatin Polymers 0.000 claims description 8
- 235000019322 gelatine Nutrition 0.000 claims description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims description 8
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 8
- 239000004202 carbamide Substances 0.000 claims description 6
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 claims description 6
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 claims description 6
- 150000005846 sugar alcohols Polymers 0.000 claims description 5
- NJYFRQQXXXRJHK-UHFFFAOYSA-N (4-aminophenyl) thiocyanate Chemical class NC1=CC=C(SC#N)C=C1 NJYFRQQXXXRJHK-UHFFFAOYSA-N 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- -1 rhodankali Chemical compound 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241001674044 Blattodea Species 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000005667 attractant Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
Description
〔技術分野〕
この発明は、絆創膏等に用いられる水溶性粘着
剤に関する。
〔背景技術〕
従来、絆創膏等に用いられている粘着剤として
は、ゴム系やアクリル系のものがある。しかし、
このような粘着剤は、水溶性でないので、付着し
たもの（糊残りしたもの等）を水洗により除去す
ることができず取り扱いがわずらわしいという問
題があつた。
他方、従来一般に用いられているゼラチンを主
成分とする湿布剤や貼付剤は水溶性であり、粘着
性も多少はある。そのため、このような湿布剤や
貼付剤を粘着剤として用いることも考えられる。
しかし、粘着力が弱いので、湿布や貼付以外の用
途に用いても良い結果が得られない。
〔発明の目的〕
の発明は、このような事情に鑑みてなされたも
ので、水溶性で粘着力の強い粘着剤を提供するこ
とを目的としている。
〔発明の開示〕
前記のような目的を達成するため、この発明
は、コラーゲン加水分解物と、尿素、チオ尿素、
ロダン塩類および２価金属塩類からなる群の中か
ら選ばれる少なくとも１種のゲル化阻害剤と、多
価アルコール類およびピロリドンカルボン酸ソー
ダから選ばれる少なくとも１種の湿潤剤とを含む
粘着剤をその要旨としている。以下、この発明を
詳しく説明する。
ここで、主成分となるコラーゲン加水分解物
は、コラーゲン加水分解することにより誘導され
る物質であつて、たとえば、ゼラチン等が好まし
い例としてあげられる。湿潤剤は、水を保持する
ことによりコラーゲン加水分解物に対して可塑性
を与える物質であつて、グリセリン、エチレング
リコール、プロピレングリコールなどの多価アル
コール類およびピロリドンカルボン酸ソーダから
選ばれる少なくとも１種があげられる。ゲル化阻
害剤は、コラーゲン加水分解物が常温または低温
において水溶液中で水素結合しゲル化するのを妨
げる物質（Hydrogen Bond Breaker）であつ
て、たとえば、尿素、チオ尿素、ロダンカリなど
のロダン塩類、塩化カルシウムなどの２価金属塩
類があげられる。湿潤剤とゲル化阻害剤とは、ゲ
ル化阻害剤として塩化カルシウムを用いかつ湿潤
剤としてピロリドンカルボン酸ソーダを用いる場
合のように両者を混ぜ合わせた場合に反応する等
して不安定にならないような組み合わせを選ぶ必
要がある。
この粘着剤は、たとえば、前記のようなコラー
ゲン加水分解物、湿潤剤およびゲル化阻害剤を水
に溶かし、塗布乾燥することにより調製すること
ができる。上記３者を水溶液としておいて、使用
時にこの水溶液をスプレー等により塗布して乾燥
させることにより調製するようにしてもよい。３
社の割合は、粘着剤の用途によつて要求される粘
着性等が異なるので、所望とする粘着剤の性能に
応じて決める必要があるが、一般的には、３成分
系でみてコラーゲン加水分解物を10〜60重量部、
湿潤剤を10〜60重量部、ゲル化阻害剤を５〜40重
量部の割合でそれぞれ用いるようにするのが好ま
しい。この理由は、次のとおりである。すなわ
ち、湿潤剤が10重量部未満か、またはゲル化阻害
剤が５重量部未満の場合は、一般的に、粘着力が
不足する傾向にあり、湿潤剤が60重量部を超える
か、またはゲル化阻害剤が40重量部を超えると、
一般的に、粘着剤がベタベタし過ぎるものになる
傾向にあつて、用途によつては問題になることが
あるからであり、コラーゲン加水分解物が10重量
部未満の場合は、一般的に、凝集力が低下し、粘
着剤がベタベタし過ぎるものになる傾向にあり、
60重量部を超えると凝集力は上昇するが粘着剤
（タツク）が低下するからである。しかし、使用
する湿潤剤やゲル化阻害剤の種類、コラーゲン加
水分解物の分子量により、それぞれの、可塑効
果、ゲル化阻害効果、凝集力が異なるので、３者
の使用量は必要に応じて適宜決める必要がある。
したがつて、上記の割合は絶対的なものではな
い。粘着剤の粘着性は調製の際の条件を変えるこ
とにより調節することが可能である。なお、この
発明の粘着剤には、粘着剤の性能を向上させた
り、原材料全体の価格を低下させるなどといつた
目的で上記３者以外の原材料、たとえば、芳香
剤、増量剤等を添加することができる。
この発明にかかる粘着剤は、コラーゲン加水分
解物を主成分としているので水溶性であり、他に
湿潤剤およびゲル化阻害剤を含むので、粘着力も
強い。
湿潤剤およびゲル化阻害剤として、火傷面、創
傷面、粘膜、皮膚などに対して刺激が少なく安全
性が高いもの、たとえば、湿潤剤として多価アル
コール類および／またはピロリドンカルボン酸ソ
ーダを用い、ゲル化阻害剤として、尿素、塩化カ
ルシウム等を用いるようにするとよい。そうすれ
ば、火傷面等に対して刺激が少なく、皮膚にかぶ
れが生じたりすることのない生体親和性に優れた
粘着剤を得ることができるからである。
従来、一般に用いられているゴム系やアクリル
系粘着剤は、皮膚にかぶれを生じさせるため、生
体組織に直接接触させるようにして使用すること
ができなかつたが、前記のような生体親和性に優
れた粘着剤は、生体組織に直接接触させるよう
な、絆創膏、茎皮薬剤、火傷および創傷被覆、生
体起電力誘導用皮膚電極などの用途の粘着剤とし
て使用することができる。この場合等、必要に応
じて紫外線等を照射したり、その他の方法によつ
たりして滅菌および架橋処理を行うことがある。
なお、この発明にかかる水溶性粘着剤は、ゴキ
ブリ、ハエ、ネズミ等を引き寄せる特性を有する
コラーゲン加水分解物（蛋白質）を含むので、こ
れらを捕獲するための粘着剤として用いることも
できる。この場合、誘引剤が添加されることがあ
る。
つぎに、実施例および比較例について説明す
る。
実施例１〜６および比較例１〜９の粘着剤を、
第１表〜第３表に示されている配合成分を用いて
つくつた。ただし、第１表の水溶性ゼラチンは、
平均分子量約１万で、20重量％濃度の水溶液にし
たときに５℃でもゲル化しないものである。第２
表のゼラチンは、粘度44mP、ゼリー強度
270Bloom（JIS6503法による）のアルカリ処理ゼ
ラチンである。第３表の重合ゼラチンは、第２表
のアルカリ処理ゼラチンを空気中で加熱すること
により不溶化しない程度に重合させたもので、粘
度72mP、ゼリー強度285Bloom（JIS6503法によ
る）のものである。グリセリン、ピロリドンカル
ボン酸ソーダは湿潤剤であり、尿素、塩化カルシ
ウムはゲル化阻害剤である。
[Technical Field] The present invention relates to a water-soluble adhesive used for bandages and the like. [Background Art] Conventionally, there are rubber-based and acrylic-based adhesives used in bandages and the like. but,
Since such adhesives are not water-soluble, there is a problem in that they are cumbersome to handle because they cannot be removed by washing with water (such as adhesive residue). On the other hand, poultices and patches that have gelatin as a main component that have been commonly used in the past are water-soluble and have some degree of tackiness. Therefore, it is also possible to use such poultices and patches as adhesives.
However, since the adhesive strength is weak, good results cannot be obtained even when used for purposes other than applying as a poultice or pasting. [Object of the Invention] The invention was made in view of the above circumstances, and its purpose is to provide a water-soluble adhesive with strong adhesive force. [Disclosure of the Invention] In order to achieve the above-mentioned objects, the present invention provides collagen hydrolyzate, urea, thiourea,
The adhesive comprises at least one gelation inhibitor selected from the group consisting of Rodan salts and divalent metal salts, and at least one wetting agent selected from polyhydric alcohols and sodium pyrrolidone carboxylate. This is the summary. This invention will be explained in detail below. Here, the collagen hydrolyzate serving as the main component is a substance derived by hydrolyzing collagen, and preferable examples thereof include gelatin. The wetting agent is a substance that imparts plasticity to the collagen hydrolyzate by retaining water, and includes at least one member selected from polyhydric alcohols such as glycerin, ethylene glycol, and propylene glycol, and sodium pyrrolidone carboxylate. can give. A gelation inhibitor is a substance (Hydrogen Bond Breaker) that prevents a collagen hydrolyzate from forming a gel through hydrogen bonding in an aqueous solution at room temperature or low temperature, and includes, for example, urea, thiourea, rhodan salts such as rhodankali, Examples include divalent metal salts such as calcium chloride. Wetting agents and gelation inhibitors should be used in such a way that they do not react or become unstable when they are mixed together, such as when calcium chloride is used as a gelation inhibitor and sodium pyrrolidone carboxylate is used as a wetting agent. It is necessary to choose a suitable combination. This adhesive can be prepared, for example, by dissolving a collagen hydrolyzate, a wetting agent, and a gelation inhibitor as described above in water, and applying and drying the solution. The above three materials may be prepared as an aqueous solution, and the aqueous solution may be applied by spraying or the like and dried at the time of use. 3
Since the required adhesive properties differ depending on the application of the adhesive, the ratio of collagen needs to be determined depending on the desired performance of the adhesive, but in general, collagen hydrated in a three-component system is 10 to 60 parts by weight of decomposition product,
Preferably, the wetting agent is used in an amount of 10 to 60 parts by weight, and the gelation inhibitor is used in an amount of 5 to 40 parts by weight. The reason for this is as follows. In other words, if the wetting agent is less than 10 parts by weight or the gelation inhibitor is less than 5 parts by weight, the adhesive strength tends to be insufficient, and if the wetting agent is more than 60 parts by weight or the gelation inhibitor is less than 5 parts by weight, the gelling If the inhibitor exceeds 40 parts by weight,
Generally, adhesives tend to be too sticky, which can be a problem depending on the application.If the collagen hydrolyzate is less than 10 parts by weight, Cohesive strength decreases and the adhesive tends to become too sticky,
This is because if it exceeds 60 parts by weight, the cohesive force will increase but the adhesive (tack) will decrease. However, the plasticizing effect, gelation inhibiting effect, and cohesive force of each of them differ depending on the type of wetting agent and gelation inhibitor used and the molecular weight of the collagen hydrolyzate, so the amounts used of the three should be adjusted as necessary. I need to decide.
Therefore, the above percentages are not absolute. The tackiness of the adhesive can be adjusted by changing the conditions during preparation. In addition, raw materials other than the above three, such as aromatics, fillers, etc., may be added to the adhesive of this invention for the purpose of improving the performance of the adhesive or reducing the price of the raw materials as a whole. be able to. The adhesive according to the present invention is water-soluble because it has a collagen hydrolyzate as its main component, and has strong adhesive strength because it also contains a wetting agent and a gelation inhibitor. As wetting agents and gelation inhibitors, we use substances that are less irritating to burnt surfaces, wound surfaces, mucous membranes, skin, etc. and are highly safe; for example, polyhydric alcohols and/or sodium pyrrolidone carboxylate are used as wetting agents; It is preferable to use urea, calcium chloride, etc. as the gelation inhibitor. This is because it is possible to obtain an adhesive with excellent biocompatibility that is less irritating to burnt surfaces and does not cause skin irritation. In the past, commonly used rubber-based and acrylic-based adhesives caused skin irritation and could not be used in direct contact with living tissue. Good adhesives can be used as adhesives for applications such as adhesive plasters, skin preparations, burn and wound dressings, and skin electrodes for inducing bioelectromotive forces, which are in direct contact with living tissue. In this case, etc., sterilization and crosslinking treatment may be performed by irradiating with ultraviolet rays or using other methods as necessary. Furthermore, since the water-soluble adhesive according to the present invention contains collagen hydrolyzate (protein) that has the property of attracting cockroaches, flies, rats, etc., it can also be used as an adhesive for capturing these. In this case, attractants may be added. Next, Examples and Comparative Examples will be described. The adhesives of Examples 1 to 6 and Comparative Examples 1 to 9,
It was made using the ingredients shown in Tables 1 to 3. However, the water-soluble gelatin in Table 1 is
It has an average molecular weight of about 10,000, and does not gel even at 5°C when made into an aqueous solution with a concentration of 20% by weight. Second
The gelatin in the table has a viscosity of 44mP and a jelly strength.
270Bloom (according to JIS6503 method) alkali-treated gelatin. The polymerized gelatin shown in Table 3 is obtained by heating the alkali-treated gelatin shown in Table 2 in air to polymerize it to the extent that it does not become insolubilized, and has a viscosity of 72 mP and a jelly strength of 285 Bloom (according to JIS6503 method). Glycerin and sodium pyrrolidone carboxylate are wetting agents, and urea and calcium chloride are gelation inhibitors.
【表】【table】
【表】【table】
この発明にかかる粘着剤は、コラーゲン加水分
解物と、尿素、チオ尿素、ロダン塩類および２価
金属塩類からなる群の中から選ばれる少なくとも
１種のゲル化阻害剤と、多価アルコール類および
ピロリドンカルボン酸ソーダから選ばれる少なく
とも１種の湿潤剤とを含むので、水溶性であり、
しかも粘着力が強い。
The adhesive according to the present invention comprises a collagen hydrolyzate, at least one gelation inhibitor selected from the group consisting of urea, thiourea, rhodan salts, and divalent metal salts, a polyhydric alcohol, and pyrrolidone. It is water-soluble because it contains at least one wetting agent selected from sodium carboxylate,
Moreover, the adhesive strength is strong.
Claims (1)
ロダン塩類および２価金属塩類からなる群の中か
ら選ばれる少なくとも１種のゲル化阻害剤と、多
価アルコール類およびピロリドンカルボン酸ソー
ダから選ばれる少なくとも１種の湿潤剤とを含む
粘着剤。 ２ コラーゲン加水分解物がゼラチンである特許
請求の範囲第１項記載の粘着剤。[Claims] 1 Collagen hydrolyzate, urea, thiourea,
An adhesive comprising at least one gelation inhibitor selected from the group consisting of rhodan salts and divalent metal salts, and at least one wetting agent selected from polyhydric alcohols and sodium pyrrolidone carboxylate. 2. The adhesive according to claim 1, wherein the collagen hydrolyzate is gelatin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59002365A JPS60147487A (en) | 1984-01-09 | 1984-01-09 | Pressure-sensitive adhesive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59002365A JPS60147487A (en) | 1984-01-09 | 1984-01-09 | Pressure-sensitive adhesive |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60147487A JPS60147487A (en) | 1985-08-03 |
| JPH056598B2 true JPH056598B2 (en) | 1993-01-26 |
Family
ID=11527228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59002365A Granted JPS60147487A (en) | 1984-01-09 | 1984-01-09 | Pressure-sensitive adhesive |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60147487A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9919075B2 (en) * | 2014-03-20 | 2018-03-20 | Anexis, Llc | Cohesive materials including derivatized collagens and methods of making and using them |
| CN110205090B (en) * | 2019-06-17 | 2020-09-04 | 厦门大学 | Preparation method of bio-based soybean protein adhesive based on ultrahigh pressure modification |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51139699A (en) * | 1975-05-05 | 1976-12-02 | Seruhisu Dekusupurowatashion A | Method of producing adhesive for industrial tobacco article |
-
1984
- 1984-01-09 JP JP59002365A patent/JPS60147487A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51139699A (en) * | 1975-05-05 | 1976-12-02 | Seruhisu Dekusupurowatashion A | Method of producing adhesive for industrial tobacco article |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60147487A (en) | 1985-08-03 |
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