JPH0534670Y2 - - Google Patents
Info
- Publication number
- JPH0534670Y2 JPH0534670Y2 JP16440088U JP16440088U JPH0534670Y2 JP H0534670 Y2 JPH0534670 Y2 JP H0534670Y2 JP 16440088 U JP16440088 U JP 16440088U JP 16440088 U JP16440088 U JP 16440088U JP H0534670 Y2 JPH0534670 Y2 JP H0534670Y2
- Authority
- JP
- Japan
- Prior art keywords
- adapter
- nasal
- spray
- present
- nasal administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007921 spray Substances 0.000 claims description 17
- 230000003139 buffering effect Effects 0.000 claims description 5
- 210000003928 nasal cavity Anatomy 0.000 claims description 4
- 239000006199 nebulizer Substances 0.000 claims description 4
- 229920003002 synthetic resin Polymers 0.000 claims description 2
- 239000000057 synthetic resin Substances 0.000 claims description 2
- 210000002850 nasal mucosa Anatomy 0.000 description 8
- 230000007794 irritation Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 210000001944 turbinate Anatomy 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 229930182556 Polyacetal Natural products 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 229940098165 atrovent Drugs 0.000 description 1
- KEWHKYJURDBRMN-XSAPEOHZSA-M chembl2134724 Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-XSAPEOHZSA-M 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 208000001319 vasomotor rhinitis Diseases 0.000 description 1
Description
本考案は鼻腔内に筒状部を挿入して用いる噴霧
器用経鼻投与用アダプターに関する。
急性鼻炎、鼻過敏症（アレルギー性または血管
運動性鼻炎）等による鼻汁分泌過多の治療の際、
抗コリン薬を主薬とし、鼻腔内に筒状部を挿入し
て噴霧して投与する噴霧器を用いた経鼻投与用噴
霧製剤が知られている。
しかしながら、従来の噴霧器用経鼻投与用アダ
プターは容器内の加圧された噴霧液が噴霧口から
直接鼻粘膜に噴霧されるというものであつた。
そのため、鼻粘膜に強い刺激感を与え、鼻粘膜
が刺激に対し鋭敏な患者にとつては、使用が困難
である、という問題があつた。
本考案の目的は、以上の問題を改善した噴霧器
用経鼻投与用アダプターを提供せんとするもので
ある。
例えば香水用噴霧器等においては、マイルドに
噴霧するため噴射力緩衝手段を有するメカニカル
ブレークアツプを設けることがおこなわれてい
た。しかしながら、本考案のような筒状部を有す
る経鼻投与用噴霧器にこのようなメカニカルブレ
ークアツプを用いた例は、従来全く知られていな
い。
そこで本考案者らは、このようなメカニカルブ
レークアツプを噴霧器用経鼻投与用アダプターに
用いることにより上記した鼻粘膜への刺激の低減
化を図つたところ、刺激の低減下の面では十分な
効果が得られたものの、それだけでは鼻粘膜のう
ちでも鼻汁の分泌腺が存在する下鼻道・下鼻甲介
より深部に噴霧液が付着するようにするのが望ま
しいにも拘らず、その付着状態の点で未だ十分な
ものとは言えなかつた。
そこでさらに、アダプターの筒状部の長さにつ
いても鋭意検討を重ねた結果本考案に到達したも
のである。
すなわち本考案は、鼻腔内に筒状部１を挿入し
て用いる噴霧器用経鼻投与用の合成樹脂製のアダ
プターにおいて、該アダプターの噴出口部分に、
噴射力緩衝手段を有するメカニカルブレークアツ
プ２が設けられており、該メカニカルブレークア
ツプ２の噴霧口２′から該筒状部１の先端部まで
の長さを３mm〜15mmの範囲であるように構成した
ものである。
以下、本考案に係る噴霧器用経鼻投与用アダプ
ターの実施例を第１図を参照して説明する。
第１図は、本考案の噴霧器用経鼻投与用アダプ
ターの実施例を示した断面図である。
この実施例におけるアダプターは、例えばポリ
エチレンを成形したものであつて、その噴出口部
分に、噴射力緩衝手段を有するメカニカルブレー
クアツプ２が固定して設けられている。噴射力緩
衝手段を有するメカニカルブレークアツプとして
２は、例えば香水用噴霧器において噴射力を柔ら
げるのに通常用いられているものを適宜選択して
用いることができる。かかるメカニカルブレーク
アツプは、例えばポリアセタールを成形したもの
である。
そして、本考案においては、前記メカニカルブ
レークアツプ２の中心に設けられている噴霧口
２′から該アダプターの筒状部１の先端部までの
長さが３〜15mmの範囲となるように該筒状部を形
成する。この長さは好ましくは５〜10mmである。
本考案の噴霧器用経鼻投与用アダプターにおい
ては、アダプターのサイズ、噴霧液収納容器のサ
イズに応じて、アダプター内部のバルブと嵌合す
る部分および容器と嵌合する部分の内径等、アダ
プターのサイズを任意に形成することができる。
また、アダプターの筒状部には、保管時におけ
るほこりの付着等を防止するためのキヤツプを装
着させることができる。
考案の効果
本考案のアダプターと、従来の、噴射力緩衝手
段を有するメカニカルブレークアツプが設けられ
ていないアダプターにおいて、筒状部の長さが
各々下記第１表の長さのものを作成し、アトロベ
ント
１回噴霧による鼻粘膜への刺激感と付着部
位を10名のボランテイアを対象に聞き取り調査し
た。付着部位は、外鼻孔、鼻前庭、下鼻道・下鼻
甲介より深部への付着感に基づいて聞き取り調査
した。
併せて、筒状部内面への付着状態を調べ、結果
を第１表に示した。
The present invention relates to a nasal administration adapter for a sprayer, which is used by inserting a cylindrical part into the nasal cavity. When treating excessive nasal secretion due to acute rhinitis, nasal hypersensitivity (allergic or vasomotor rhinitis), etc.
Spray preparations for nasal administration are known, which contain an anticholinergic drug as the main drug and use a sprayer that inserts a cylindrical part into the nasal cavity and sprays the drug for administration. However, in the conventional adapter for nasal administration for a sprayer, the pressurized spray liquid in the container is sprayed directly onto the nasal mucosa from the spray opening. Therefore, there was a problem in that it gave a strong sense of irritation to the nasal mucosa and was difficult to use for patients whose nasal mucosa was sensitive to irritation. The object of the present invention is to provide an adapter for nasal administration for a sprayer that improves the above-mentioned problems. For example, in perfume atomizers and the like, a mechanical break-up having a spray force damping means has been installed in order to mildly spray the perfume. However, there has been no known example of using such a mechanical breakup in a nasal sprayer having a cylindrical portion as in the present invention. Therefore, the inventors of the present invention attempted to reduce the irritation to the nasal mucosa described above by using such a mechanical breakup in a nasal administration adapter for a nebulizer, and found that it was sufficiently effective in terms of reducing irritation. However, even though it is desirable to have the spray liquid adhere to the deeper part of the nasal mucosa than the inferior nasal meatus and inferior nasal turbinate where the glands that secrete nasal secretions exist, In this respect, it could still not be said to be sufficient. Therefore, the present invention was arrived at as a result of intensive study on the length of the cylindrical portion of the adapter. That is, the present invention provides a synthetic resin adapter for nasal administration for a nebulizer, which is used by inserting the cylindrical part 1 into the nasal cavity.
A mechanical breakup 2 having a jetting force buffering means is provided, and the length from the spray port 2' of the mechanical breakup 2 to the tip of the cylindrical portion 1 is in the range of 3 mm to 15 mm. This is what I did. Hereinafter, an embodiment of the adapter for nasal administration for a sprayer according to the present invention will be described with reference to FIG. FIG. 1 is a sectional view showing an embodiment of the nasal administration adapter for a sprayer of the present invention. The adapter in this embodiment is made of polyethylene, for example, and has a mechanical breakup 2 having a jetting force buffering means fixed to its jetting port. As the mechanical break-up having a spray force buffering means 2, a mechanical break-up which is normally used for softening the spray force in a perfume atomizer, for example, can be appropriately selected and used. Such a mechanical breakup is, for example, molded from polyacetal. In the present invention, the cylinder is arranged such that the length from the spray nozzle 2' provided at the center of the mechanical breakup 2 to the tip of the cylinder part 1 of the adapter is in the range of 3 to 15 mm. form a shaped part. This length is preferably between 5 and 10 mm. In the adapter for nasal administration for a nebulizer of the present invention, the size of the adapter, such as the inner diameter of the part that fits with the valve inside the adapter and the part that fits with the container, depends on the size of the adapter and the size of the spray liquid storage container. can be formed arbitrarily. Further, a cap can be attached to the cylindrical portion of the adapter to prevent dust from adhering during storage. Effects of the invention In the adapter of the present invention and the conventional adapter which is not provided with a mechanical break-up having a jetting force buffering means, the lengths of the cylindrical portions are each as shown in Table 1 below, and Atrovent Interviews were conducted with 10 volunteers regarding the irritation caused to the nasal mucosa by a single spray and the site of adhesion. The attachment site was investigated based on the feeling of attachment deeper than the external nostril, nasal vestibule, inferior nasal meatus, and inferior nasal turbinate. In addition, the state of adhesion to the inner surface of the cylindrical portion was investigated, and the results are shown in Table 1.
【表】
第１表から、本考案のアダプターの場合には、
噴霧による鼻粘膜の刺激が大巾に低減化され、筒
状部の長さを調節することによつて、筒状部内面
へ付着せしめることなく鼻粘膜、特に下鼻道・下
鼻甲介より深部への付着を図れたことが判る。[Table] From Table 1, in the case of the adapter of the present invention,
The irritation of the nasal mucosa caused by the spray is greatly reduced, and by adjusting the length of the cylindrical part, it can be applied to the nasal mucosa, especially deeper than the inferior nasal meatus and inferior nasal turbinates, without adhering to the inner surface of the cylindrical part. It can be seen that the adhesion was achieved.
第１図は本考案の噴霧器用経鼻投与用アダプタ
ーを示した断面図である。
１……筒状部、２……メカニカルブレークアツ
プ、２′……噴霧口。
FIG. 1 is a sectional view showing the nasal administration adapter for a sprayer of the present invention. 1... Cylindrical part, 2... Mechanical breakup, 2'... Spray nozzle.
Claims (1)
鼻投与用の合成樹脂製のアダプターにおいて、該
アダプターの噴出口部分に、噴射力緩衝手段を有
するメカニカルブレークアツプ２が設けられてお
り、該メカニカルブレークアツプ２の噴霧口２′
から該筒状部１の先端部までの長さが３mm〜15mm
の範囲であることを特徴とする噴霧器用経鼻投与
用アダプター。 In a synthetic resin adapter for nasal administration for a sprayer used by inserting a cylindrical part 1 into the nasal cavity, a mechanical breakup 2 having a spray force buffering means is provided at the spout portion of the adapter, Spray port 2' of the mechanical breakup 2
The length from to the tip of the cylindrical part 1 is 3 mm to 15 mm.
An adapter for nasal administration for a nebulizer, characterized in that the adapter is in the range of:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16440088U JPH0534670Y2 (en) | 1988-12-21 | 1988-12-21 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16440088U JPH0534670Y2 (en) | 1988-12-21 | 1988-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0284642U JPH0284642U (en) | 1990-07-02 |
| JPH0534670Y2 true JPH0534670Y2 (en) | 1993-09-02 |
Family
ID=31449973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16440088U Expired - Lifetime JPH0534670Y2 (en) | 1988-12-21 | 1988-12-21 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0534670Y2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008297001A (en) * | 2007-06-04 | 2008-12-11 | Toyo Aerosol Ind Co Ltd | Pushbutton for aerosol |
-
1988
- 1988-12-21 JP JP16440088U patent/JPH0534670Y2/ja not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008297001A (en) * | 2007-06-04 | 2008-12-11 | Toyo Aerosol Ind Co Ltd | Pushbutton for aerosol |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0284642U (en) | 1990-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7122206B2 (en) | Aqueous-based pharmaceutical composition | |
| US7980247B2 (en) | Therapeutic aerosol device | |
| US20040010239A1 (en) | Atomizer for applying liquids onto eyes | |
| GB9511514D0 (en) | Electrostatic spraying | |
| US6000580A (en) | Device for dispensing preservative-free nasal sprays and similar preparations | |
| CA2451716A1 (en) | Nebulizer for applying liquids on the surface of the eye or the ocular connective tissue | |
| JPH0534670Y2 (en) | ||
| EP1082157B1 (en) | Nasal spray device with improved spray geometry | |
| CA2348474A1 (en) | Pharmaceutically active composition and dispensing device | |
| EP0250129A3 (en) | Lip medication applicator | |
| JPH0634852Y2 (en) | The head of the acupressure container | |
| US2276878A (en) | Nebulizer | |
| JPH0391364U (en) | ||
| JPH0326923Y2 (en) | ||
| JPS623404U (en) | ||
| JPH0437549U (en) | ||
| JPS63197658U (en) | ||
| JPH0383941U (en) | ||
| JPS58146558U (en) | Vegetation material spray nozzle | |
| JPH02117046U (en) | ||
| JPH02143949U (en) | ||
| JPS63158853U (en) | ||
| JPS63146653U (en) | ||
| JPH04132075U (en) | aerosol button | |
| JPS6235660U (en) |