JPH05345711A - Skin protection agent - Google Patents

Abstract

PURPOSE:To provide a skin-protection agent capable of forming a tack-free water-insoluble film of chitosan on the skin to effectively protect the skin from chapping without lowering the operability in work. CONSTITUTION:A water-insoluble chitosan film is formed on the skin by combining (A) an aqueous solution of an acid salt of chitosan or a water-soluble chitosan derivative selected from carboxylated compound, sulfonated compound, glycolated compound or quaternized compound of chitosan with (B) a dilute alkaline aqueous solution or an aqueous solution of a polymeric compound having charge opposite to the charge of the chitosan derivative. The agent may be incorporated with a humectant component such as sodium hyaluronate. The film gives moist feeling to the skin without causing tackiness and the lowering of the operability in work. The chitosan film can easily be removed by washing with an weakly acidic aqueous solution or an aqueous solution of an anionic substance or a cationic substance.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is convenient for water work and the like, which comprises an aqueous solution of an acid salt or a water-soluble derivative of chitosan and a dilute alkaline aqueous solution or an aqueous solution of a polymer compound having an opposite charge to the chitosan derivative. The present invention relates to a skin protective agent that can effectively protect the skin by various operations.

[0002]

2. Description of the Related Art A skin protectant is conventionally used for the purpose of protecting the skin when doing water work or handling chemicals that are irritating to the skin for housework or work, or the skin becomes rough after work. Cosmetics and external preparations for skin were used to prevent and treat the above. Also, in the case of hands, gloves were used during work.

The above-mentioned skin protectant is mainly oil or an oil or emulsion obtained by adding powder to the oil, and is coated with oil in its constituents or powder particles used in combination. Most of them were aimed at the effect of the above.

Further, the cosmetics / skin external preparations to be used after the work include those containing creams and emulsions for the purpose of supplying water and oil to the skin and anti-inflammatory agents for the purpose of improving rough skin. There were many.

[0005]

However, the conventional skin protectants have a stickiness due to the oil component which is a constituent component, and have an adverse effect on the work of oil components, powders, etc. It did not show strong tolerance.

On the other hand, cosmetics and skin external preparations for improving rough skin are also used as symptomatic treatments, and it takes time to treat rough skin that has occurred once, and it is not possible to completely prevent rough skin from occurring. There wasn't.

Further, even if gloves are used, there is a problem that the delicate feeling of the fingertips is lost by the gloves, and fine work cannot be performed.

[0008]

[Means for Solving the Problems] In order to effectively protect the skin from the irritation caused by water and chemicals during the work, it is necessary to develop an effective skin protectant with the above-mentioned drawbacks improved. .. We focused on the usefulness of chitosan in developing such a skin protectant.

[0009] Chitosan is a polymer compound obtained by deacetylating chitin, which is often contained in the shells of crustaceans such as crabs and shrimps, and the exoskeleton of insects, and D-glucosamine is β
It has been reported that it is a -1,4 bond, and has thin film / film forming properties, moisturizing properties, and the like. A lot of cosmetics, dermatological agents, and the like containing chitosan have been disclosed so far.

Regarding the application of chitosan to a skin protectant, there is an example in which a stickiness is improved by blending a chitosan salt (JP-A-61-254517). But,
We succeeded in effectively protecting the skin by forming a chitosan film on the skin by using the film forming property of chitosan and coating the skin with the thin film. That is, chitosan is used as a water-soluble salt or derivative, and this aqueous solution is applied onto the skin, dried to form a film, and then a dilute alkaline aqueous solution is applied to render the chitosan film water-insoluble, or An aqueous solution of a polymer compound having an opposite charge to the chitosan derivative is applied to form an ionic complex and render the chitosan film water-insoluble. This film is resistant not only to water but also to chemicals such as organic solvents. As a result, the skin can be coated with a water-insoluble chitosan film, and it becomes possible to protect the skin from irritation due to water, chemicals, etc. when performing various operations.

Further, at the end of the work, the chitosan film can be easily removed by washing with a cleaning solution composed of a weakly acidic aqueous solution or a cleaning solution composed of an aqueous solution containing anions or cations.

[0012]

In other words, the skin protectant according to the present invention is the first liquid consisting of an aqueous solution of an acid salt of chitosan, the second liquid consisting of a dilute alkaline aqueous solution, or one selected from a carboxylated product, a sulfonated product and a glycolated product. A first liquid consisting of an aqueous solution of one or more anionic derivatives, a second liquid consisting of an aqueous solution of a polymer compound having a positive charge, or a first liquid consisting of a cationic aqueous solution of a quaternized chitosan, and a negative liquid It is composed of a combination of a second liquid composed of an aqueous solution of a polymer compound having an electric charge. When a first liquid consisting of an acid salt of chitosan or an aqueous solution of a water-soluble chitosan derivative is applied on the skin, a chitosan film is formed on the skin after drying. Further, by applying the second liquid and treating the chitosan film with an alkaline aqueous solution, the chitosan salt is made into water-insoluble chitosan, or the chitosan derivative is brought into contact with an aqueous solution of a polymer compound having an opposite charge. It is possible to strengthen the film by forming an ionic complex between the chitosan derivative and the polymer compound to insolubilize the chitosan film.

As the acid salt of chitosan, inorganic salts such as hydrochloric acid and nitric acid, formic acid, acetic acid, oxalic acid, citric acid, succinic acid,
Examples thereof include organic acids such as tartaric acid, lactic acid, adipic acid, ascorbic acid, and pyrrolidonecarboxylic acid, and acidic amino acids such as glutamic acid and aspartic acid. As the alkaline aqueous solution, sodium hydroxide, potassium hydroxide, triethanolamine, N-tris (hydroxymethyl) methylglycine, N-tris (hydroxymethyl) -2-aminopropanesulfonic acid, boric acid, arginine, lysine, histidine Aqueous solutions of basic amino acids and the like. Examples of the polymer compound having a positive charge include cation-modified cellulose ether derivative, polyvinylpyrrolidone derivative quaternary ammonium, and polyacrylic acid derivative quaternary ammonium. On the other hand, examples of the polymer compound having a negative charge include sodium alginate, sodium carboxymethyl cellulose, hydroxypropyl cellulose, sodium polyacrylate and the like.

In the present invention, a substance having a moisturizing property such as sodium pyrrolidonecarboxylate, sodium hyaluronate, glycerin, propylene glycol and the like and perfume and the like can be added.

In order to remove the skin protectant from the skin after the work is completed, when an insoluble film of chitosan is formed, a weakly acidic aqueous solution is used to form a high molecular compound having an anionic derivative of chitosan and a positive charge. When forming an ionic complex, wash with an aqueous solution containing an anionic substance, and when forming an ionic complex from a cationic derivative and a polymer compound having a negative charge, wash with an aqueous solution containing a cationic substance. Just do it. In the former case, chitosan forms an acid salt to become water-soluble, and in the latter two cases, the chitosan derivative and the polymer are formed by competition between the polymer compound and the chitosan derivative and the ionic complex formation reaction between each ionic substance. The ionic complex with the compound dissociates, and the chitosan derivative becomes water-soluble and can be easily washed with water.

[0016]

EXAMPLES The present invention will be described in more detail with reference to examples. The formulations for Example 1 and Example 2 are shown in Table 1.
And shown in Table 2. Both Example 1 and Example 2 are prepared by mixing and dissolving the respective components of the first liquid and the second liquid in the table.

[Table 1]

[Table 2]

In use, in each of the examples, the first liquid is first applied onto the skin, dried and then the second liquid is applied. The following use tests were performed on these examples by comparison with comparative examples prepared according to the formulations shown in Table 3. Comparative Examples were prepared by heating and dissolving the water phase component in column A and the oil phase component in column B in Table 3 at 75 ° C., adding the oil phase to the water phase to emulsify, and then cooling. It has a creamy appearance.

[Table 3]

Each of Example 1, Example 2, and Comparative Example was used by 10 housewives and 10 perm operators in blinds for one month, and then the skin condition was evaluated. In addition, sensory evaluation was performed on the feel during and after use. The skin condition was evaluated by visual observation according to the criteria shown in Table 4. The sensory evaluation was evaluated according to the criteria shown in Table 5 for each evaluation item. As a result, each evaluation is an average value of 10 people,
The results are shown in Table 6.

[Table 4]

[Table 5]

[Table 6]

[0019]

As is clear from Table 6, regarding the skin condition after 1 month of use, the users of the examples were housewives,
Both the perm-applied persons showed almost good skin condition, and there was a clear difference from the fact that the users of the comparative examples evaluated that there was no change or slight lumpiness.
In particular, a significant improvement was observed even in perm practitioners who often deal with perm solution that is more irritating than ordinary housewives.

Regarding the stickiness at the time of use, most users felt the stickiness in the creamy skin protectant of the comparative example, but the users of the respective examples seemed to be hardly concerned. Regarding operability during work,
The users of each Example were judged to be almost good, which contrasts with the users of Comparative Example being judged to be considerably poor. Even for a perm operator who needs to perform more detailed work than a general housewife, the users of each example were judged to be almost good.

With respect to the moist feeling or rough skin after use, the users of the respective examples also gave good evaluations, and there was a clear difference that the evaluations of the users of the comparative examples were not bad but good. ..

As described above, according to the present invention, it is possible to provide a skin protective agent capable of effectively protecting the skin from being roughened by a simple application operation without being sticky and without impairing the operability during work. It was This skin protectant can be removed by simple washing and gives a refreshing and excellent moist feeling even after use.

Claims (3)

[Claims] 1. An aqueous solution of a salt of chitosan is used as a first liquid,
A skin protectant containing a dilute alkaline aqueous solution as the second liquid. 2. A skin comprising an aqueous solution of at least one chitosan derivative selected from a carboxylated product, a sulfonated product and a glycolized product of chitosan as a first liquid and an aqueous solution of a polymer compound having a positive charge as a second liquid. Protectant. 3. A skin protectant comprising an aqueous solution of a quaternized product of chitosan as a first liquid and an aqueous solution of a polymer compound having a negative charge as a second liquid.