JPH0534025B2 - - Google Patents

Description

[Detailed Description of the Invention] [Industrial Application Field] This invention relates to a device for automatic alternate injection of drugs or contrast media, and is mainly used to inject drugs or contrast media into two related affected areas for the purpose of diagnosis and treatment. Used for alternating injections.

[Conventional technology]

Conventionally, when making a diagnosis and collecting data by injecting drugs or contrast agents into the affected area, in most cases a catheter was inserted using a puncture needle and a guide wire from near the anterior wall of the right femoral artery, 1 to 2 cm caudal to the inguinal ligament. Insert the tip of the catheter (or sheath) into the affected area, connect the proximal end of the catheter to the outflow side of the drug syringe, and inject the drug and/or contrast agent supplied into the syringe into the affected area. was being carried out.

In addition, when testing two related affected areas or lymph vessels, one drug syringe can be used to inject drugs, contrast media, etc. into the two affected areas or lymph vessels.
Alternatively, both of these have been injected sequentially, or almost simultaneously using two drug injectors.

[Problem to be solved by the invention]

In the conventional method of injecting drugs, contrast media, etc. into two related affected areas or lymph vessels using one drug injector, there is a large time lag when injecting the drug, so It has become impossible to perform angiography and other X-ray imaging of two affected areas under the same conditions, which has hindered correct diagnosis and treatment.

However, when using two drug injectors, it costs almost twice as much to purchase the drug injectors and the consumables that are discarded after use, compared to using one injector. will require extra space.

This invention was made in view of the above circumstances, and its purpose is to inject drugs, contrast media, etc. into two related affected areas, lymph vessels, etc. almost simultaneously using a single drug injector. It is an object of the present invention to provide a device for automatic alternate injection of drugs or contrast agents.

[Means to solve the problem]

In order to achieve the above object, in this invention, a conduit main body made of a material that does not dissolve in the drug used, etc. is connected to a catheter or a sheath at the distal end side of an inflow passage connected to a syringe. Two outflow passages are formed, and an on-off valve operated by a magnetic coil is provided on the side of the two outflow passages, and the on-off valve opens one outflow passage by energizing the magnetic coil. The other outflow passage is closed and the outflow passage is moved in a direction in which the opening and closing of each outflow passage are reversed by switching the energization, thereby forming an instrument for automatic alternate injection of drugs or contrast media.

When it is desired to inject drugs or contrast media at high speed, the on-off valve in the above-mentioned injection device is made of rod-shaped polycarbonate, with an iron piece enclosed in the upper end and a tapered lower end, and the conduit main body has two parts. In the middle of the outflow passage, vertical valve storage chambers are formed, each of which has an upper end protruding from the upper surface of the pipe main body by a set length and a smaller inner diameter at the lower end, and iron pieces are placed inside these valve storage chambers upward. The on-off valve is housed in the pipe body, and two protrusions protruding from the upper surface of the pipe main body are surrounded by two magnet coils, each of which is removably attached in the vertical direction. Preferably, each coil is connected to an adjacent lower magnet coil.

When a drug or a contrast medium can be slowly injected and the configuration is desired to be simplified, the inflow and outflow passages of the conduit main body are formed by flexible plastic tubes, and the on-off valve is formed by two The on-off valve is located between the outflow passages and is movable to a position where the two outflow passages can be pressed by a magnetic coil. A configuration may be provided in which a pressure receiving member is provided which presses the distal end side of the plastic tube and the plastic tube to close one outflow passage when the plastic tube is moved by the plastic tube.

[Effect]

When the proximal end of a catheter or sheath inserted into two affected areas is connected to the two outflow passages formed in the conduit main body, the open/close valve operated by the magnetic coil is activated by one side. Since one outflow passage is opened and the other outflow passage is closed, by switching the direction of movement of the opening/closing valve, the drug, contrast agent, etc. supplied into the syringe can be injected alternately into two related affected areas. .

〔Example〕

Embodiments of the present invention will be described below based on the drawings.

Figures 1 to 4 show an embodiment of this invention,
The device for alternate injection of drugs is mainly composed of a conduit main body 1 which is a disposable member, and a valve opening/closing means 2 which is used repeatedly.

The pipe main body 1 is formed with one horizontal inflow passage 3 and two outflow passages 4 and 5 that are branched at the tip thereof. After branching, the direction is once changed vertically downward, and at the lower end, the direction is changed again to the horizontal direction opposite to the inflow passage 3.

The vertical pipes of each of the outflow passages 4 and 5 extend upward from the horizontal pipes 4a and 5a that branch at the tip of the inflow passage 3, and are located within protrusions 1b and 1b that protrude from the upper surface 1a of the pipe main body 1. has been extended by the length set. In addition, the lower end of the vertical pipe is narrowed to a slightly smaller inner diameter on the front side where the direction can be changed in the horizontal direction, and the valve storage chamber 4b,
5b is formed.

Inside these valve storage chambers 4b, 5b, iron pieces 6a, 7a are enclosed at the upper ends, and rod-shaped open/close valves 6, 7 whose lower ends are tapered.
However, the iron pieces 6a and 7a are connected to the protrusion 1b of the pipe main body 1,
1b. The on-off valves 6 and 7 are formed to be slightly smaller in diameter than the valve storage chambers 4b and 5b.
When moved upward inside b, the valve storage chamber 4
The chemical liquid that has passed through the annular gap between the on-off valves 6 and 7 is sent out from the outflow passages 4 and 5 through the small diameter portions at the lower ends of the valve storage chambers 4 b and 5 b. ,7 are moved downward,
When the lower end portion closes the small diameter portion of the valve storage chambers 4b, 5b, the chemical liquid is not sent out from the outflow passages 4, 5.

The conduit main body 1 is provided with a connecting portion 8 protruding from a vertical surface and connected in an airtight manner to the distal end side of a chemical liquid syringe (not shown) on the inlet side of the inflow passage 3, as well as connecting portions 8 to each of the outflow passages 4, 5. Connecting portions 9 and 10 are provided on the outlet side of the conduit main body 1 so as to protrude from the vertical plane, respectively. It is an engagement holding part provided on the surface.

The conduit main body 1 and the on-off valves 6 and 7 are made of a material that is not dissolved by the drug or contrast medium to be injected.
For example, they are made of polycarbonate, and care is taken to prevent substances other than drugs or contrast agents from getting into the blood in the body when a drug solution is injected into an affected area.

The valve opening/closing means 2 has respective protrusions 1b, 1b at positions corresponding to the two protrusions 1b, 1b of the pipe main body 1.
Through-holes 12, 12 through which the magnets b can be inserted are provided, and two magnetic coils A ₁ , A ₂ and B ₁ , are installed at a set distance in the vertical direction of these through-holes 12 , 12 . _B2 is provided so as to surround the protrusions 1b, 1b.

Magnet coil above each through hole 12, 12
A ₁ and B ₁ are connected to the magnetic coils B ₂ and A ₂ on the lower side of the adjacent through holes 12 and 12, respectively, and one pair of magnetic coils A ₁ and B ₂ can be connected at any selected time. The structure is such that while electricity is being supplied to the other pair of magnet coils B ₁ and A ₂ , electricity is not supplied to the other pair of magnet coils B 1 and A 2 .

Reference numeral 13 denotes a mounting plate fixed to one end of the valve opening/closing means 2, and the engagement holding portion 11 of the pipe main body 1 is attached to a portion of the mounting plate 13 below the valve opening/closing means 2.
A fitting body 14 is provided which fits into the valve opening/closing means 2, and the valve opening/closing means 2 can be attached to and detached from the pipe main body 1. On the back side of the mounting plate 13, after electricity is supplied to one set of magnet coils, for example, A ₁ and B ₂ for a set time, electricity is supplied to the other magnet coils B ₁ and A ₂ . An electric circuit 15 is provided to switch between the two. Switching the energization to each set of magnet coils A ₁ , B ₂ , B ₁ , A ₂ is as follows:
In addition to using automatic switching means, this may be done manually.

Next, the operation of the above embodiment will be explained.

Connecting the proximal ends of catheters or sheaths inserted into two related affected areas at their distal ends to the outflow side connecting parts 9 and 10 of the conduit main body 1,
A drug solution injector equipped with a three-way socket is connected to the inflow side connection part 8, and a drug, a contrast agent, or a drug solution containing both of these is supplied while preventing air from entering the injector.

In this state, the protruding portion 1b of the pipe main body 1,
When one set of magnetic coils A ₁ and B ₂ of the valve opening/closing means 2 attached to valve opening/closing means 1 b is energized for a set time, the iron piece 6 a of one opening/closing valve 6 is quickly turned off by the magnetic coil A ₁ . It is moved upward to open the outflow passage 4, but the other on-off valve 7
Since the iron piece 7a is quickly moved downward by the magnetic coil _B2 to close the outflow passage 5 (see Fig. 4), the medicinal liquid in the pressed syringe is transferred to the outflow passage 4 with the passage opened. It is then injected into one affected area through a catheter or sheath.

After the set time has passed, the electrical circuit 15
When energization is switched to the other set of magnetic coils B ₁ and A ₂ , the opening/closing valve 7, which had previously closed the outflow passage 5, causes the iron piece 7a to quickly move upward due to the attraction force of the magnetic coil B _1. The opening/closing valve 6, which opened the outflow passage 5 when
Because it is quickly moved downward by the suction force of A ₂ and closes the outflow passage 4, the drug solution in the syringe is efficiently injected from the outflow passage 5 to another related affected area through another catheter or sheath. Ru.

Therefore, when using the injection device of this example,
Contrast media can be injected alternately into two related affected areas using a single drug injector, so by combining X-ray equipment, it is possible to perform angiography at two related locations under almost the same conditions, all at once. The photographing process enables efficient photographing. Therefore, it is possible to comprehensively judge the two related affected areas and make a correct diagnosis.

Furthermore, based on this diagnosis, by alternately injecting a drug suitable for treatment into two related affected areas, the drug can be evenly distributed to the two related affected areas and effective treatment can be performed.

The injection device of this example can be used for contrast medium imaging and drug therapy in the abdomen (liver, kidney, pancreas, etc.), urinary organs, obstetrics and gynecology, and lower extremity areas, as well as in neurosurgery and cardiovascular systems. department,
It can also be used in X-ray contrast medium imaging for lymphatic vessels and animal experimental research.

Next, drug treatments for bladder cancer and uterine cancer will be explained in some detail.

In the case of bladder cancer, one catheter is introduced from the right external iliac artery, reaches the left internal iliac artery, and is placed.
Another catheter is introduced from the left external iliac artery, reaches the right internal iliac artery, and is left indwelling, and anticancer drugs are alternately injected via an automatic alternate injection device. The arteries of the bladder enter from the left and right and intersect with each other at peripheral blood vessels, so injecting anticancer drugs from only one side had the disadvantage that the drugs were not evenly distributed to the entire bladder cancer, but from both sides. When an anticancer drug is injected, this adverse effect can be eliminated, and the anticancer drug can be distributed evenly throughout the bladder cancer, thereby increasing the therapeutic effect of bladder cancer.

In the case of uterine cancer, one catheter is introduced from the right external iliac artery and placed in the left uterine artery via the left internal iliac artery, and the other catheter is inserted from the left external iliac artery. It is introduced and placed in the right uterine artery via the right internal iliac artery, and anticancer drugs are alternately injected via an automatic alternate injection device. The arteries of the uterus enter from the left and right and intersect with each other at the peripheral blood vessels, so injecting anticancer drugs from only one side had the disadvantage that the drugs were not evenly distributed throughout the uterine cancer, but from both sides. When anticancer drugs are injected,
This harmful effect can be removed and the therapeutic effect for uterine cancer can be improved.

In addition, in the case of treatment of ovarian cancer, the anticancer agent may be alternately injected from the left and right ovarian arteries instead of the uterine artery, as an application to the treatment of uterine cancer.

FIGS. 5 and 6 show other embodiments of the invention.

Inflow passage 3 and outflow passages 4, 5 of pipe main body 1
is made of a flexible plastic tube, for example a tube made of vinyl chloride resin, and is moved between the two outflow channels 4, 5 by a magnetic coil C towards the two outflow channels 4, 5. An on-off valve 17 is provided, and this on-off valve 1
Pressure receiving members 18 and 19 are respectively provided on opposite sides of the outflow passages 4 and 5 facing both ends of the pipe body 1, the magnetic coil C, and the pressure receiving members 18 and 19. This is the case where they are each held by the attachment member 16.

When the opening/closing valve 17 is moved toward one of the outflow passages 4 by energizing the magnetic coil C, its tip side and the pressure receiving member 18 on the one outflow passage 4 side close the outflow passage in the direction of movement. 4 is compressed to prevent the drug or contrast medium from passing through, and the drug or contrast medium is injected from the other outflow passage 5. Switching the injection of the drug or contrast medium is done by pressing the magnetic coil C. This is done by reversing the direction of energization to move the on-off valve 17 in the opposite direction.

In the case of the configuration of this embodiment, each outflow passage 4, 5
are alternately pressed by the opening/closing valve 17 moved by the magnetic coil C and the pressure receiving members 18, 19, so the structure is extremely simple and production costs can be reduced.

〔Effect of the invention〕

Since this invention is configured as described above, it produces the effects described below.

In the device for automatic alternate injection of drugs or contrast agents according to claim 1, two outflow passages are formed on the distal end side of the inflow passage connected to the injector and connected to the catheter or sheath, and the two outflow passages are connected to the catheter or sheath. for,
A magnetic coil is provided with an on-off valve that opens one outflow passage and closes the other outflow passage, and then drugs or contrast agents are alternately injected into two related affected areas using one syringe. This makes it possible to reduce the burden on patients and increase the effectiveness of diagnosis and treatment more than ever before.

In particular, in various cancer treatments, the peripheral arterial vessels cross each other in the affected area, so injecting anticancer drugs from only one side is not able to distribute the drug evenly throughout the affected area. By alternately injecting the anticancer drug from both sides of the affected area, the drug can be evenly distributed throughout the area, resulting in excellent effects.

In the device for automatic alternate injection of drugs or contrast media according to claim 2, vertical valve storage chambers are provided in the middle of each of the two outflow passages, and opening/closing valves each having an iron piece sealed in the upper end thereof are stored in these storage chambers. death,
Two on-off valves are removably installed on the outside of the upper surface of the pipe main body, and are moved in opposite directions to open one of the two outflow passages and close the other. In addition to being able to perform alternate injections of drugs or contrast media at high speed, the valve opening/closing means, which is equipped with a plurality of magnetic coils that are configured to be removably attached to the tube body, can be used repeatedly. This allows you to save money on purchasing consumables.

In the device for automatic alternate injection of drugs or contrast agents according to claim 3, the inflow and outflow passages are formed by flexible plastic tubes, and the opening and closing of the two outflow passages are moved by magnetic coils. This is done alternately by one on-off valve and two pressure receiving members provided on the opposite side of each outflow passage facing both ends of this on-off valve, making the configuration extremely simple and easy to manufacture. Costs can be reduced.

[Brief explanation of the drawing]

Fig. 1 is an exploded perspective view of an embodiment of the present invention, Fig. 2 is a partially sectional side view of the pipe main body, Fig. 3 is a plan view of the pipe main body, and Fig. 4 shows the state in use. FIG. 5 is a sectional front view, FIG. 5 is a perspective view of another embodiment, and FIG. 6 is a sectional plan view showing the state in use. DESCRIPTION OF SYMBOLS 1...Pipe main body, 1a...Top surface, 1b...Protrusion part, 3...Inflow passage, 4, 5...Outflow passage, 4
b, 5b... Valve storage chamber, 6, 7, 17... Open/close valve, 6a, 7a... Iron piece, 18, 19...
Pressure receiving member, A ₁ , A ₂ , B ₁ , B ₂ , C...magnetic coil.

Claims (1)

[Claims] 1. The main body of the conduit is made of a material that does not dissolve in the drug used, and has two outflow channels connected to the catheter or sheath at the distal end side of the inflow channel connected to the syringe. A passage is formed, and an on-off valve operated by a magnetic coil is provided on the side of the two outflow passages, and the on-off valve opens one outflow passage and opens the other outflow passage by energizing the magnetic coil. 1. A device for automatic alternate injection of a drug or a contrast agent, characterized in that the device is moved in a direction in which the opening and closing of each outflow passage are reversed by closing and switching energization. 2 The on-off valve is made of rod-shaped polycarbonate,
An iron piece is enclosed in the upper end, and the lower end is tapered, and the upper end protrudes from the upper surface of the pipe body by a set length in the middle of the two outflow passages, and the lower end protrudes from the inner diameter. Smaller vertical valve storage chambers are formed, and opening/closing valves with iron pieces on the upper side are housed in these valve storage chambers, and two protrusions projecting from the top surface of the conduit main body are provided with two protrusions surrounding them, respectively. The drug according to claim 1, wherein two magnetic coils are provided so as to be attachable and detachable in the vertical direction, and each of these upper magnetic coils is connected to an adjacent lower magnetic coil. or an instrument for automatic alternating injection of contrast media. 3 The inflow and outflow passages of the pipe main body are formed by flexible plastic tubes, and the on-off valve is located between the two outflow passages and moved to a position where the two outflow passages can be pressed by the magnetic coil. When the on-off valve is moved by a magnetic coil, one of the outflow passages is closed by pressing the tip side and the plastic tube. The device for automatic alternate injection of drugs or contrast agents according to claim 1, which is provided with a pressure receiving member.