JPH05246863A - Pesticide adsorbent - Google Patents

Abstract

PURPOSE:To provide the subject adsorbent great in adsorbing power, eliminating no pesticide adsorbed even under coexistence of other adsorbent(s), causing no vomiting even if taken, also excellent in molding processability. CONSTITUTION:The objective adsorbent or antidote for pesticides, containing, as active ingredient, a hydrophobic polyamino acid (pref. polyleucine). Use of this hydrophobic polyamino acid as antidote finds application to detoxication of a wide range of pesticides; thus being advantageous for first aid even in case the type of pesticides in question cannot be identified. Also, the hydrophobic amino acid is a material inert to the human body; therefore, having such advantages that, even after orally administered, this compound does not irritate the mucous membrane of the esophagus and stomach, resulting in being seldom vomitted. Besides, the adsorbent of the present invention is easy in molding processing, and can be used in the suction protective masks or clothing in pesticide application.

Description

Detailed Description of the Invention

[0001]

[Industrial application] The present invention relates to agricultural chemical adsorbents and antidotes.

[0002]

[Prior Art]

Phosphoric acid-based pesticides were introduced in 1936 by West Germany S.
Since it was synthesized by chrader et al., the same kind has been developed and has reached the present time, but it is known to be highly toxic. When sprayed as a pesticide, there are many cases where it is inhaled accidentally or penetrated through the skin and absorbed into the body. Gastric lavage as an initial treatment when inhaled into the body due to accidental ingestion,
Intestinal lavage is performed and adsorbent is administered at the same time. When it is adsorbed in the body, blood is purified by dialysis or adsorption,
The currently used adsorbents include powdered activated carbon and adsorbin (Japanese Pharmacopoeia, natural aluminum silicate), but they are not sufficient.

[0004] Activated carbon has an excellent adsorptive power, but also has a large desorption amount (Naohiro Yoshida et al., The 5th Japan Poisoning Research Society East Japan Chapter Preliminary Proceedings, 8, 1991). , There is a problem such as vomiting even when taken. Developed as a paracoat adsorbent, the keixarate does not adsorb organophosphorus pesticides. On the other hand, inorganic adsorbin is associated with a large dose and also has a large desorption amount. In addition, activated carbon has a drawback that once adsorbed pesticide is replaced by heparin or fusan and desorbed when other coexisting drugs such as heparin, fusan, and caixarate, which are blood coagulation inhibitors, coexist and are used in blood purification systems. However, it is inefficient. Further, these are difficult to process into fibers or are extremely expensive even when they become fibers, and are not used, for example, as protective masks or clothing when spraying pesticides.

[0005]

The object of the present invention is to adsorb an agricultural chemical which has a large adsorption power, does not desorb even in the coexistence of other adsorbents, does not vomit even when taken, and is also excellent in molding processability. To provide a drug and an antidote.

[0006]

[Means for Solving the Problems] The inventors have found that a hydrophobic polyamino acid has a large adsorptive power for pesticides such as phosphate-based pesticides, dinitroaniline-based pesticides, aniline-based pesticides, and the coexistence of other adsorbents. The present invention has been completed by discovering that they cannot be detached even underneath. That is, the present invention relates to a pesticide adsorbent and antidote containing polyamino acid as an active ingredient.

The pesticides referred to in the present invention are phosphoric acid type pesticides, aniline type herbicides and the like. Phosphoric acid-based pesticides include 4-nitro-m-tolyldimethylthioate (fenitrothion,
Trade name: Sumithion), Carphos (trade name), etc., Aniline herbicide is xanone (trade name), dinitroaniline herbicide is trefanosite (trade name)
Etc.

The term "hydrophobic polyamino acid" as used in the present invention means a polymer of amino acids alanine, leucine, isoleucine, phenylalanine and valine. Amino acid is L
Any of the body, the D body, and the racemic body may be used.

The hydrophobic polyamino acid of the present invention may be a homopolymer or a copolymer with other amino acids. As other amino acids, most amino acids such as glutamic acid ester, aspartic acid ester, methionine and carbobenzoxylidine are included. Is used, other amino acids are L-form, D-form
Either the body or the racemate may be used. The content of other amino acids is preferably 70 mol% or less of the total.

As the method for producing the hydrophobic polyamino acid, a general method for producing an amino acid polymer is used, and for example, the N-carboxyamino acid anhydride method, the amino acid chloride method and the amino acid active esterification method are used. Edited by The Chemical Society of Japan, Masahisa Ohya et al., "New Experimental Chemistry Lecture" -Polypeptide-244 (Maruzen) Takeshi Endo, "Amino Acid Polymer" -Synthesis of Polyamino Acids-Page 36 (Chemiec)

The molecular weight of the hydrophobic polyamino acid used in the present invention is 1,000 to 500,000, and usually 1
It is preferably at least 2,000.

The shape of the hydrophobic polyamino acid used in the adsorbent of the present invention is appropriately selected according to the usage form such as powder, fiber and film. The molding and processing method is performed by a conventional method.

By orally administering the adsorbent of the present invention to humans, it can be used as an antidote for agricultural chemicals. Administration is usually by powder, with a preferred powder particle size of 0.01
mm to 0.1 mm, with a preferred dose of 0.5-
It is about 5 g, but is not limited to these. When using the hydrophobic polyamino acid of the present invention as an antidote,
Other drugs, such as adsorbin, can be used together without any problem, and are rather effective. That is, by using the hydrophobic polyamino acid of the present invention as an antidote, it can be applied to the detoxification of a wide range of pesticides, which is advantageous for emergency treatment such as pesticide poisoning patients in which the type of pesticide cannot be specified. Hydrophobic polyamino acid is a material that is inactive to the living body (polyleucine has been put into practical use as a wound dressing material), and it has the advantage that even if it is taken orally, it will not vomit without irritating the esophagus or stomach mucosa. There is.

The adsorbent containing the hydrophobic polyamino acid of the present invention as an active ingredient is a mask for suction protection when spraying agricultural chemicals,
It can also be used for clothing, and may be used in the form of powder, and if necessary, it may be used after being molded into a fiber or film. It can also be used as a sheet or fence for preventing pesticide runoff in soil. Other adsorbents, additives, polymer compounds and the like may be mixed and used depending on the application. Examples include activated carbon, ethylcellulose-based fibrin derivatives, synthetic polymer compounds such as nylon, and activated alumina-based inorganic adsorbents.

[0015]

【Example】

Example 1 Synthesis of hydrophobic polyamino acid Both polyleucine and polyphenylalanine were N-
It was synthesized by the carboxylic acid anhydride method. Edited by The Chemical Society of Japan,
Masahisa Ohya et al., "New Experimental Chemistry Course" -Polypeptide-24
Page 4 (Maruzen), edited by Takeshi Endo, "Amino Acid Polymers" -Synthesis of Polyamino Acids-Page 36 (CMS)

Example 2 Absorption and desorption experiments of pesticides 1. Sample Fenitrothion standard product (purity 98%) is a product of Wako Pure Chemical Industries, Sumithion is a product of Yashu Chemical Co., Ltd. Trefanosite is a product of Shionogi Pharmaceutical, Calfos is a product of Sankyo Co., Ltd., and Xanon is Takeda. The products of Yakuhin Kogyo Co., Ltd., Adsorbin and 95% ethyl alcohol were those of the Japanese Pharmacopoeia, and all other reagents were of special grade. Commercially available heparin, fusan and keixarate were used. As the artificial gastric juice and the artificial intestinal fluid, the Japanese Pharmacopoeia disintegration test method first liquid and second liquid were prepared and used.

2. Measurement of Adsorption Rate A drug standard was dissolved in artificial gastric juice or physiological saline, and a calibration curve was prepared from the absorbance of each ultraviolet absorption band. Based on this, the drug is diluted with a solution of 95% ethyl alcohol, artificial gastric juice, artificial intestinal fluid, physiological saline, etc. to 0.5-1.
It was adjusted to mmol / 10 ml and used as a standard solution. 1 g, 50 mg, and 10 mg of the adsorbent were added to 10 ml of this standard solution, respectively.
The mixture was shaken at 37 ° C., and after a certain period of time, the supernatant was filtered to remove the adsorbent and the absorbance was measured to determine the adsorption rate.

3. Measurement of desorption rate Polyleucine, polyphenylalanine, adsorbin,
About 120 mg of activated carbon was saturated and adsorbed in 10 mmol / 10 ml, 100 mg was accurately weighed after drying, 10 ml of artificial gastric juice or 95% ethanol solution or physiological saline solution was added, and the mixture was shaken at 37 ° C. for 60 minutes, The adsorbent was filtered off, and the absorbance of the filtrate was measured as the desorption amount.

[0019]

[Table 1]

[0020]

[Table 2]

[0021]

The adsorbent for agricultural chemicals containing the hydrophobic polyamino acid of the present invention as an active ingredient has an adsorbing power equivalent to that of adsorbin, and has excellent performance not desorbing even in the presence of other adsorbents. Is.

Claims (4)

[Claims] 1. A pesticide adsorbent containing a hydrophobic polyamino acid as an active ingredient. 2. The adsorbent according to claim 1, wherein the hydrophobic polyamino acid is polyleucine. 3. A pesticide antidote containing a hydrophobic polyamino acid as an active ingredient. 4. The antidote according to claim 3, wherein the hydrophobic polyamino acid is polyleucine.