JPH0520411B2 - - Google Patents

Description

[Detailed description of the invention]

INDUSTRIAL APPLICATION FIELD The present invention relates to cosmetics containing phosphatidylinositol or containing phospholipids rich in this substance. BACKGROUND OF THE INVENTION Phospholipids are widely distributed in living organisms, animals and plants, and are contained in particularly large amounts in tissues that play an important role in living things, such as the brain, nerves, liver, and blood, and perform various physiological functions. For this reason, phospholipids are used as therapeutic agents for arteriosclerosis, hyperlipidemia, liver disease, heart disease, etc., and as emulsifiers for foods, cosmetics, pharmaceuticals, and the like. Normally, phospholipids are produced by separating and refining oils and fats from plant seeds as a gum, but the composition of the phospholipids differs depending on the type of seed material. The phospholipid composition in normal plant seeds is mainly composed of phosphatidylcholine (hereinafter referred to as PC), phosphatidylethanolamine (hereinafter referred to as PE), and phosphatidylinositol (hereinafter referred to as PI).
For example, soybean phospholipids, which are representative of vegetable phospholipids, usually have a PC of 20-25%, a PE of 15-20%, and a PI of 12-17.
% composition, and these mixtures are often used as is. Fractionated lecithin may also be used; in this case, fractionated lecithin is an extract extracted with alcohol such as ethanol, i.e.
PC is the main component (50-60%), and other substances such as PE and phosphatidylserine are also contained. As an example of this, a detergent composition containing the fractionated lecithin and N-acylglutamate is known (Japanese Patent Publication No. 10457/1983). In this case, the fractionated lecithin is mainly composed of highly hydrophilic PC, and O/W
Suitable for mold emulsification. In addition to the above-mentioned phospholipids derived from plant seeds, there are vegetable phospholipids represented by egg yolk lecithin, but commercially available egg yolk lecithin has a phospholipid composition of PC65-75.
%, PE13 to 18, and P11 to 2%, and in this case as well, it is a phospholipid mainly composed of PC as in the case of the fractionated lecithin, and the method of use is also the same. Conventional phospholipids are as described above, but mixed phospholipids have a single property, so they are not necessarily suitable for cosmetics that require a variety of performances. In addition, lecithin with a high PC content obtained by alcohol fractionation from these mixed phospholipids has high hydrophilicity and has problems with O/W type emulsification; Cannot be used in type O cosmetics. Furthermore, animal phospholipids are expensive and difficult to obtain in quantity, making them unsuitable as general-purpose cosmetic raw materials. Problems to be Solved by the Invention An object of the present invention is to eliminate the above-mentioned drawbacks of phospholipids and to obtain a cosmetic that has excellent properties that cannot be obtained with conventional phospholipids. Conventionally, studies have focused on PC as a phospholipid, and the main focus has been on improving the emulsifying and solubilizing properties of PC-concentrated and fractionated types. The present inventors focused on phospholipids other than PC,
The present invention was accomplished by discovering that phospholipids obtained by concentrating and fractionating PI are particularly suitable for W/O emulsification, and are excellent in pigment, dye dispersibility, and as a hair treatment agent. Means for Solving the Problems The present invention relates to a cosmetic containing a phospholipid containing 25% by weight or more of PI. The phospholipid used in the present invention may be one obtained by concentrating and separating PI from any animal or plant phospholipid, but
From the viewpoint of raw materials, cost, etc., those made from vegetable phospholipids are preferred. Plant-based phospholipids include soybeans, rapeseed, sunflowers, safflower, cottonseed, corn, flaxseed, sesame, olives, rice, thorns,
Phospholipids obtained from one or more plant materials selected from grape, avocado, coconut, and palm are suitable, and in the present invention, phospholipids obtained from these
Preferably, PI is concentrated and separated. Generally, phospholipids obtained from plant materials contain a considerable amount of neutral fat as an impurity.
In recent years, phospholipids from which neutral fats have been removed (called high-purity lecithin) have become commercially available.
This material is a solid, highly hygroscopic powder,
In the present invention, any of the above phospholipids can be used as a raw material. Soybean phospholipid is a commercially available general-purpose lecithin, and this is more preferable as a raw material for the concentrated and fractionated PI concentrate used in the present invention in terms of quantity, price, quality, etc. The method for concentrating and fractionating PI involves extracting and removing highly hydrophilic phospholipids such as PC and PE using lower alcohols such as methanol, ethanol, and propanol and their hydrous alcohols, and then concentrating and fractionating PI.
It is also possible to further concentrate and fractionate PI by mainly acetylating PE with acetic anhydride and removing acetylated phospholipids with acetone. When the content of PI concentrated and fractionated from phospholipids in phospholipids is low, there is not much difference in performance from mixed phospholipids, and a concentration of 25% by weight or more is required. PI is 25
If it is less than % by weight, it will not be suitable for W/O type emulsification, and its suitability as a cosmetic will be limited. The concentrated fractionated lecithin of PI thus obtained can be used in whole or in part as a surfactant used as an emulsifier, humectant, emollient, etc. in cosmetics. The amount to be distributed is generally 0.05 to 10% by weight based on the total amount of the cosmetic. There are no particular restrictions on the type of cosmetics, and the application may be applied to creams such as cold cream, vanishing cream, emulsion, lotion, face pack, shampoo, conditioner, hair treatment, lipstick, blusher, pound cake, eye shadow, etc. I can do it. Effects The concentrated and fractionated lecithin of PI in the present invention is
Lecithin has a unique function as an amphoteric surfactant, that is, it has excellent emulsifying properties, moisturizing properties, and emollient properties, and is a highly safe substance, especially as a W/O type emulsifier, pigment, dispersant for pigments, and hair treatment. Excellent as an agent. Example 1 Concentration of phosphatidylinositol,
Fraction (1) Pasty soybean phospholipid (acetone insoluble fraction 63
%, iodine value 78) 500g 93% methanol 3
The mixture was stirred and extracted at 40°C. Subsequently, the methanol layer and the oil layer were separated, and the oil layer was removed from the solvent to obtain 305 g of a pasty brown substance. The obtained brown substance had an acetone insoluble content of 71%, an iodine value of 75, and a phospholipid composition of 10.5% PC, 20.3% PE, and 25.5% PI (hereinafter referred to as the sample). (2) High purity soybean lecithin (acetone insoluble content 97.5
%, iodine value 84) 500g of 95% mixed alcohol of ethanol/methanol = 86/14 (weight ratio)
Stirring and extraction were performed at 45°C under 2.5°C. Continued
The same treatment as in (1) was performed to obtain 330 g of yellow powder. The acetone insoluble content was 96.3%, the iodine value was 82, and the phospholipid composition was 8.5% PC, 22.4% PE, and 27.5% PI. (hereinafter referred to as the sample). (3) 100 g of the sample was dissolved in 200 ml of hexane, 20 ml of acetic anhydride was added, and the mixture was stirred at 70°C for 2 hours. Subsequently, after distilling off the solvent, 1 part of acetone was added and the mixture was thoroughly stirred. The resulting yellow powder substance was filtered off and further dried to obtain 65 g of a yellowish white powder substance. Acetone insoluble content 98.2%, iodine value 83, phospholipid composition:
The contents were 9.0% PC, 1.2% PE, and 51.7% PI (hereinafter referred to as the sample). (4) 40 g of the sample was extracted with 95% ethanol at 30° C. with stirring, and then subjected to the same treatment as in (1) to obtain 32 g of yellow powder. The acetone insoluble content was 97.6%, the iodine value was 80, and the phospholipid composition was 1.5% PC, 2.2% PE, and 62.5% PI (hereinafter referred to as the sample). (5) High purity rapeseed lecithin (acetone insoluble content 96.8
%, iodine value 75) was extracted with stirring at 30°C with 1.2% of a 98% isopropanol solution. Continued
The same treatment as in (1) was performed to obtain 185 g of yellowish brown powder. The acetone insoluble content was 95.2%, the iodine value was 76, and the phospholipid composition was 12.0% PC, 20.2% PE, and 39.5% PI (hereinafter referred to as the sample). Example 2 Formulation example 2-1 Emollient cream (W/O type) Microcrystalline wax
9.0% (weight) Paraffin 2.0 Beeswax 3.0 Vaseline 5.0 Reduced lanolin 8.0 Squalane 32.0 Isooctylic acid glyceride 10.0 Propylene glycol 2.0 Sample 5.5 Polyoxyethylene sorbitan monooleate (20E.0) 1.0 Fragrance, preservative, antioxidant Appropriate amount Purified water Total amount 100% 2-2 Emollient lotion (W/O type) Microcrystalline wax 1.0% Beeswax 2.0 Lanolin 2.0 Liquid paraffin 30.0 Glycerin 7.5 Sample 4.5 Polyoxyethylene sorbitan monooleate (20E.0) 1.0 Stearin Aluminum acid 0.2 Fragrance, preservative, antioxidant Appropriate amount Purified water Total amount 100% 2-3 Eyeliner talc 40.0% Titanium oxide 5.0 Precipitated calcium carbonate 10.0 Pigment 30.0 Glycerin 2.0 Liquid paraffin 10.0 Sample 3.0 Preservative, Antioxidant Appropriate amount 2-3 4 Conditioning shampoo Sodium alkyl ether sulfate (AES-
Na) 18.0% Coconut fatty acid diethanolamide 2.0 Cation modified cellulose ether 1.5 Sample 1.0 Preservatives, pigments, fragrances Appropriate amount Purified water Total amount 100% 2-5 Conditioning rinse Modified starch 2.0% Polyoxyethylene cholesterol 1.0 Sample 2.0 Silicone 0.2 Perfumes, pigments, preservatives Appropriate amounts Purified water Total amount 100% Effects of the invention All of the various cosmetics shown in Example 2 had a good texture and good emulsifying properties, and were recognized to be excellent as cosmetics. Creams and lotions shown in Formulation Examples 2-1 and 2-2, commercial product A (emollient cream), and commercial product B
(emollient lotion) to show the sensual superiority and inferiority of women
Results obtained after 30 people used it continuously for 2 weeks (response rate 90
%) are shown in Table 1.

[Table] From Table 1, it can be seen that the cream according to the present invention had an excellent sensory evaluation. Also, blending example 2-
4. Shampoo, rinse and commercial product C shown in 2-5
(Conditioning Shampoo) and Commercial Product D (Conditioning Rinse) for men and women.
Table 2 shows the results obtained from human use (recovery rate 80%).

Table 2 shows that the shampoo and rinse according to the present invention had excellent sensory evaluations.

Claims (1)

[Scope of Claims] 1. A cosmetic containing a phospholipid containing 25% by weight or more of phosphatidylinositol. 2. The phospholipid is obtained from one or more plant materials selected from soybean, rapeseed, sunflower, safflower, cottonseed, corn, flaxseed, sesame, olive, rice, thorn, grape, avocado, coconut, and palm. The cosmetic according to claim 1, which is obtained by concentrating and fractionating phosphatidylinositol from vegetable lecithin. 3. The cosmetic according to claim 1, wherein the cosmetic is a W/O emulsion.