JPH05156297A - Detergent composition - Google Patents

Abstract

PURPOSE:To provide the subject composition containing a secondary amide-type N-acylamino acid salt and an antiphlogistic, excellent in detergency, low in irritation, showing an excellent anti-inflammatory effect and excellent in its durability. CONSTITUTION:The objective composition contains (A) a compound of the formula (R<1>CO is a 10-16C straight chain acyl; n is 1 or 2; M is sodium, potassium or alkanolammonium in the case of n=1 and potassium or an alkanolammonium in the case of n=2), (B) an antiphlogistic such as allantoin, ichthammol or quaiazulene and (C) a higher fatty acid salt, e.g. in the case of a liquid detergent in an amount of 5 to 50wt.% component (A) and 0.01 to 5.0 wt.% (preferably 0.05 to 2 wt.%) component (B) and preferably in a weight ratio of [the component (C)/the component (A)]=[(1/20) to (1/2)] [preferably (1/10) to (1/3)].

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a detergent composition, and more specifically, it has low irritation to the skin and hair, a high detergency, a good feeling of use, and an excellent anti-inflammatory action and its durability. Detergent composition.

[0002]

2. Description of the Related Art Conventionally, as a flame-retardant detergent, a medicinal detergent containing various surfactants mixed with a detergent has been used. However, when an anti-inflammatory agent is added to the cleaning agent,
There is a problem that the anti-inflammatory agent itself is washed away from the skin or hair by washing and does not remain sufficiently, and it is hardly possible to exert its effect on the inflammation generated on the skin after washing. Therefore, it is possible to temporarily increase the amount of the anti-inflammatory agent to increase the effect, but it is quite difficult to add an amount sufficient to exhibit the effect, and even if a large amount is added. , The effect was temporarily increased, but the sustainability was poor and it was insufficient.

[0003]

SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide a detergent composition which is less irritating to the skin and hair, has an excellent bactericidal effect, and has excellent durability.

[0004]

Under the circumstances, as a result of intensive investigations by the present inventors, as a result of adding a combination of an anti-inflammatory agent and a secondary amide type N-acyl amino acid salt having a specific structure, a cleaning effect is obtained. The present invention has been completed by finding that it is possible to obtain a cleansing composition which is excellent in anti-inflammatory properties, has no irritation to the skin, has a good feeling in use, and has an excellent anti-inflammatory effect and its durability.

That is, the present invention provides the following components (A) and (B) (A) a secondary amide type N- represented by the following general formula (1).
Acyl amino acid salt R ¹ CONH (CH ₂ ) _n COOM ¹ (1) (In the formula, R ¹ CO represents a linear acyl group having 10 to 16 carbon atoms, n represents a number of 1 or 2, and M ¹ represents When n is 1, sodium, potassium or alkanolammonium is shown, and when n is 2, potassium or alkanolammonium is shown. (B) An anti-inflammatory agent is contained in the detergent composition. ..

The secondary amide type N-acyl amino acid salt of the component (A) used in the present invention has the property of reacting with calcium contained in tap water or the like to form a plate crystal with high lubricity. It exhibits the effect of imparting a good feeling of use such as slippage after washing to a detergent composition containing this. Here, the lubricity of the plate-like crystals produced by the reaction of the secondary amide type N-acyl amino acid salt and calcium is, for example, the plate on which dried pork skin (Aloask, manufactured by Antibody Chemical Industries) is regenerated with physiological saline. It is determined by measuring the coefficient of static friction of crystal-like crystals, and those having a coefficient lower than that of the blank from the time of containing water to the time of drying are evaluated as good. Further, in the present invention, the secondary amide type N-acyl amino acid salt incorporates an anti-inflammatory agent during the production of plate crystals to be crystallized, which adheres to the skin or the like and does not easily flow off. It has an anti-inflammatory effect even with a small amount, and its durability is also good.

In the above-mentioned secondary amide type N-acyl amino acid salt, in the general formula (1), the linear acyl group represented by R ¹ CO has 10 to 16 carbon atoms, particularly 12 to 14 carbon atoms.
Is preferable, and specifically, a caprinoyl group, a lauroyl group, or a myristoyl group is preferable. When the number of carbon atoms exceeds 16, it is not preferable because the lubricity of the plate-like crystals to be formed is lowered, and when the number of carbon atoms is less than 10, foaming is lowered, which is not preferable. In addition, it is very important that the secondary amide type N-acyl amino acid salt has a secondary amide type structure in which the N-acyl group is composed of the linear acyl. That is, when the acyl group constituting the N-acyl group is branched or the amide structure is a tertiary amide type, the production of plate crystals is suppressed, and the physical properties of the produced crystals are poor in lubricity. However, it is difficult to obtain a desirable feeling because it is sticky. Further, in the general formula (1), the one in which n is 2 and M ¹ is a sodium salt has a high Kraft point and is inferior in water solubility, so that it is not preferable when used in a liquid detergent.

As the anti-inflammatory agent (B) used in the present invention, any anti-inflammatory agent having an anti-inflammatory effect and applicable to the body can be used. For example, allantoin, ictamol, guaiazulene, glycyrrhizic acid or a salt thereof, Glycyrrhetinic acid, stearyl glycyrrhetinate,
Glycyrrhetinyl stearate, epsilon aminocaproic acid, butyl flufenamic acid, azulene, camphor, zinc chloride, zinc white, menthol, indomethacin,
Examples thereof include ibuprofen piconol, mefenamic acid, and aloe powder. Of these, allantoin, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, and glycyrrhetinic acid are particularly preferred. These anti-inflammatory agents are used by blending with water or a solvent such as water-lower alcohol.

Component (A) in the cleaning composition of the present invention
The compounding amount depends on the formulation of the detergent composition, but is 5 to 50% by weight in the composition for liquid detergent, 15 to 70% by weight for paste detergent, and 40 to 95 for solid detergent.
It is preferably in the weight%. The compounding amount of the component (B) is 0.01 to 5% by weight, especially 0.05 in any dosage form.
~ 2 wt% is preferred.

By adding a higher fatty acid salt (C) to the detergent composition of the present invention, a detergent having a good foaming property and a good feeling of foam in addition to the above characteristics can be obtained. .. Here, examples of the higher fatty acid salt (C) include basic salts of fatty acids having 8 to 22 carbon atoms. Specific examples include single fatty acids such as lauric acid, myristic acid, palmitic acid, isostearic acid and oleic acid, as well as basic salts of mixed fatty acids such as coconut oil fatty acid and tallow fatty acid. Here, as the salt, inorganic basic salts such as sodium and potassium, ammonium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt, 2-amino-2-methylpropanol, 2-amino-2-methylpropanediol. And basic amino acids such as lysine and arginine. These higher fatty acid salts (C) do not necessarily have to be blended as fatty acid salts, and fatty acids and bases may be blended independently to form fatty acid salts in the formulation system. These higher fatty acid salts may be used alone or in combination of two or more. The blending amount of the higher fatty acid salt (C) in the detergent composition of the present invention depends on the blending amount of the component (A), and the weight ratio is (C) / (A) = 1/20.
It is preferably ½, particularly 1/10 to ⅓.

The detergent composition of the present invention includes other surfactants such as alkyl sulfates, alkyl sulfonates, polyoxyethylene alkyl sulfates, alkylbenzene sulfonates, N-acyl sarcosine salts, and N-acyl. -N-methyl taurine salt, alpha olefin sulfonate, higher fatty acid ester sulfonate, anionic surfactant such as alkyl ether acetate, polyoxyethylene alkyl ether acetate, fatty acid amide, polyoxyethylene alkyl ether, etc. Amphoteric surfactants such as nonionic surfactants, imidazoline-based compounds, betaine-based surfactants and the like can be optionally used in combination as long as the effects of the present invention are not impaired.

Further, as other additives, components usually used in detergents can be optionally used in combination within a range that does not impair the effects of the present invention. For example, propylene glycol, sorbitol, humectants such as glycerin, carboxyvinyl polymer, methyl cellulose, ethanol,
Viscosity modifiers such as polyoxyethylene glycol distearate, pearlizing agents, fragrances, dyes, ultraviolet absorbers, antioxidants, bactericides and preservatives can be added.

The detergent composition of the present invention is manufactured by a conventional method and can be made into a paste form, a gel form, a liquid form, a solid form or the like, and is suitable as a detergent for the body such as skin or hair. In particular, it is preferably used for cleaning the skin.

[0014]

EXAMPLES Next, the present invention will be described in detail based on examples. However, the present invention is not limited to the examples shown below.

Example 1 A detergent composition having the blending composition shown in Table 1 below was prepared, and the anti-inflammatory effect of these detergent compositions was measured by the following method, and the feeling of use was determined by the following method and criteria. It was evaluated based on. The results are shown in Table 1 below. In addition,
No. The detergent compositions of 6 to 11 are comparative products.

(Test method for anti-inflammatory effect) A human forearm is washed with 1 g of the detergent composition and thoroughly rinsed with tap water. After drying, 3 cm
The glass cup of 3 is brought into close contact with the forearm, and the anti-inflammatory agent adsorbed on the skin is extracted with 2 ml of an aqueous ethanol solution (25%). The amount of the anti-inflammatory agent in the solution was quantified by liquid chromatography, and the comparative product No. The value of 6 was shown as a relative ratio with the value of 1.0. The same operation was performed 8 hours later.

(Evaluation of Feel of Use) With respect to each detergent composition, the body was washed by 10 panelists of 10 men and women, and sensory evaluation was performed. For evaluation, an average value was calculated according to the following criteria. When the average value was 4.5 or more, it was very good (⊚), when 3.5 to 4.4, it was good (∘), and 2.5 to
The case of 3.4 was judged to be normal (Δ), and the case of 2.4 or less was judged to be defective (x). (1) Defoaming during rinsing 5; Good defoaming 4; Good defoaming 3; Normal 2; Bad defoaming 1; Bad defoaming (2) Sliding during rinsing, (3) After rinsing And (4) slippage after drying 5; good slippage 4; good slippage 3; normal 2; poor slippage 1; bad slippage

[0018]

[Table 1]

Example 2 (Compounding composition) (% by weight) (1) Lauroyl-β-alanine triethanolamine 25 (2) Dipotassium glycyrrhizinate 0.3 (3) Triethanolamine laurate 4 (4) Trimyristate Ethanolamine 2 (5) Fragrance 0.5 (6) Dibutylhydroxytoluene 0.2 (7) Ethanol 3 (8) Purified water balance According to the above composition, the above components (1) to (4) are dissolved in heated water. After cooling, the above components (5) to (7) are added,
A liquid detergent composition was prepared. When the body was washed with the obtained detergent composition, it was excellent in the effect of preventing skin roughening due to its high anti-inflammatory power, and also had good foaming and defoaming, and had good slipperiness from the time of rinsing to the time of drying, and was excellent in usability. It was

Example 3 (Composition) (% by weight) (1) Lauroyl-β-alanine K 20 (2) Allantoin 0.5 (3) Lauric acid K 2 (4) Myristic acid K 2 (5) Perfume 0 .5 (6) Dibutylhydroxytoluene 0.3 (7) Ethanol 4 (8) Purified water balance According to the above composition, the above components (1) to (4) are dissolved in heated water, and after cooling, the above (5) ~ (7) component is added,
A liquid detergent composition was prepared. When the body was washed with the obtained detergent composition, it was excellent in the effect of preventing skin roughening due to its high anti-inflammatory power, and also had good foaming and defoaming, and had good slipperiness from the time of rinsing to the time of drying, and was excellent in usability. It was

[0021]

EFFECTS OF THE INVENTION The detergent composition of the present invention has high detergency, good feeling in use, low irritation to skin and hair, and good anti-inflammatory effect and its durability. It is particularly suitable for cleaning the skin.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI technical display location C11D 3:32) (C11D 10/02 1:10 3:22) (C11D 10/02 1:10 3:32 1:04) (C11D 10/02 1:10 3:22 1:04)

Claims (2)

[Claims] 1. The following components (A) and (B) (A) A secondary amide type N- represented by the following general formula (1):
Acyl amino acid salt R ¹ CONH (CH ₂ ) _n COOM ¹ (1) (In the formula, R ¹ CO represents a linear acyl group having 10 to 16 carbon atoms, n represents a number of 1 or 2, and M ¹ represents When n is 1, it represents sodium, potassium or alkanolammonium, and when n is 2, it represents potassium or alkanolammonium.) (B) An anti-inflammatory agent is contained in the detergent composition. 2. The cleaning composition according to claim 1, further comprising (C) a higher fatty acid salt.