JPH0495021A - Cosmetic for preventing sunburn - Google Patents
Cosmetic for preventing sunburnInfo
- Publication number
- JPH0495021A JPH0495021A JP20800690A JP20800690A JPH0495021A JP H0495021 A JPH0495021 A JP H0495021A JP 20800690 A JP20800690 A JP 20800690A JP 20800690 A JP20800690 A JP 20800690A JP H0495021 A JPH0495021 A JP H0495021A
- Authority
- JP
- Japan
- Prior art keywords
- cholesteryl
- cosmetic
- hydroxystearate
- sunburn
- liquid crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 16
- 206010042496 Sunburn Diseases 0.000 title abstract description 11
- 230000003405 preventing effect Effects 0.000 title abstract description 6
- 239000004973 liquid crystal related substance Substances 0.000 claims abstract description 19
- XKMYWNHZAQUEPY-YZGJEOKZSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] 12-hydroxyoctadecanoate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCCCCCC(O)CCCCCC)C1 XKMYWNHZAQUEPY-YZGJEOKZSA-N 0.000 claims abstract description 11
- WCLNGBQPTVENHV-MKQVXYPISA-N cholesteryl nonanoate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCCC)C1 WCLNGBQPTVENHV-MKQVXYPISA-N 0.000 claims abstract description 8
- 150000001840 cholesterol esters Chemical class 0.000 claims description 7
- 230000000475 sunscreen effect Effects 0.000 claims description 2
- 239000000516 sunscreening agent Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 5
- 239000002904 solvent Substances 0.000 abstract description 3
- 238000013329 compounding Methods 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 description 10
- 239000006096 absorbing agent Substances 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 239000004986 Cholesteric liquid crystals (ChLC) Substances 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
- 229940114069 12-hydroxystearate Drugs 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000003098 cholesteric effect Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-hydroxyoctadecanoic acid Chemical compound CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 description 1
- RJECHNNFRHZQKU-UHFFFAOYSA-N Oelsaeurecholesterylester Natural products C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C2C1(C)CCC(OC(=O)CCCCCCCC=CCCCCCCCC)C2 RJECHNNFRHZQKU-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- RJECHNNFRHZQKU-RMUVNZEASA-N cholesteryl oleate Chemical group C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)C1 RJECHNNFRHZQKU-RMUVNZEASA-N 0.000 description 1
- 108010006161 conchiolin Proteins 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 231100000434 photosensitization Toxicity 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は日焼は防止用化粧料に関する。[Detailed description of the invention] [Industrial application field] The present invention relates to cosmetics for preventing sunburn.
更に−詳しくは、液晶を利用した日焼は防止用化粧料に
関する。More specifically, the present invention relates to a sunscreen cosmetic using liquid crystals.
コ＼レステリツク液晶を化粧料に含有させることは、特
開昭５７−３２２１１号公報、
特開平１−２４６２０９号公報などにより広く知られて
いる。しかし紫外線吸収能については記載されていない
。The inclusion of cholesterol liquid crystals in cosmetics is widely known from JP-A-57-32211 and JP-A-1-246209. However, there is no mention of ultraviolet absorption ability.
他方、日焼は防止のために、各種の紫外線吸収剤が化粧
品原料として利用されている。On the other hand, various ultraviolet absorbers are used as cosmetic raw materials to prevent sunburn.
紫外線吸収剤は光感作性などの点て皮膚の安全性に問題
がある。化粧品原料の中ではもっとも問題のある薬剤で
ある。また、吸収波長が２７０ｎｏ＋以下の短波長の紫
外線吸収を有するものは数多くあるが、それ以上の波長
を吸収するものは余りない。Ultraviolet absorbers have problems with skin safety in terms of photosensitization and other issues. It is the most problematic drug among cosmetic raw materials. Furthermore, although there are many materials that absorb ultraviolet light at short wavelengths of 270 no+ or less, there are few materials that absorb wavelengths longer than that.
本発明の目的は、皮膚に温和な作用を示し、安全であり
、なおかつ紫外線を吸収して日焼は防止に有効な化粧料
を提供することである。An object of the present invention is to provide a cosmetic that has a gentle effect on the skin, is safe, and is effective in preventing sunburn by absorbing ultraviolet rays.
本発明者らは、各種紫外線吸収能を有する物質を探し出
し、安全性など、いろいろな角度から利用可能性を検討
したが、現状の紫外線吸収剤を越えるものは見い出すこ
とができなかった。The present inventors have searched for various types of substances with ultraviolet absorbing ability and examined their potential use from various angles such as safety, but have not been able to find anything that exceeds the current ultraviolet absorbers.
そこで、物質の分子構造で紫外線を吸収するものの検討
から離れて、製剤全体から検討した。Therefore, instead of considering the molecular structure of the substance that absorbs ultraviolet rays, we considered the formulation as a whole.
中でも、結晶の構造で光を反射、吸収する液晶を検討し
た。In particular, we investigated liquid crystals, which reflect and absorb light through their crystal structure.
その結果、コレステリル１２−ヒドロキシステアレート
を液晶中、４０重量％以上とコレステリルノナノエート
よりなる液晶は溶媒に溶かした状態では、他のコレステ
ロールエステルと同様、２５０ｎＩ１１以下の短波長し
か紫外線吸収能はないが、Ｍ晶状ｆｉになると、他のコ
レステロールエステルと異なり、４００ ｎｍを中心に
した吸収が出現することを見い出して本発明を完成した
。As a result, when a liquid crystal containing cholesteryl 12-hydroxystearate (40% by weight or more) and cholesteryl nonanoate is dissolved in a solvent, it has the ability to absorb ultraviolet rays only at short wavelengths of 250nI11 or less, just like other cholesterol esters. However, when it becomes M-crystalline fi, unlike other cholesterol esters, it was discovered that absorption centered on 400 nm appears, and the present invention was completed.
即ち本発明はコレステリック１２−ヒドロキシステアレ
ートを４０重量％以上とコレステリック１２−ヒドロキ
システアレート以外のコレステロールエステルがコレス
テリルノナノエートである液晶を含む日焼は防止用化粧
料である。That is, the present invention is a sunburn prevention cosmetic containing liquid crystal containing 40% by weight or more of cholesteric 12-hydroxystearate and cholesteryl nonanoate as a cholesterol ester other than cholesteric 12-hydroxystearate.
一般的なコレステリック液晶は、可視部に光を反射、吸
収を持つことは当然であるが、本発明者らは可視部から
紫外部にわたり反射、吸収を調べたところ、一般的なコ
レステリック液晶には２５０ｎＩ１１以下と可視部に反
射、吸収かあるのるであったが、コレステリル１２−ヒ
ドロキンステアレートを４０重量％以上含み、他のコレ
ステロールエステルがコレステリルノナノエートである
液晶のみ４００ ｎｍを中心にした吸収が見い出された
。It goes without saying that common cholesteric liquid crystals reflect and absorb light in the visible region, but the inventors investigated reflection and absorption from the visible region to the ultraviolet region, and found that common cholesteric liquid crystals reflect and absorb light in the visible region. It was 250nI11 or less, and there was some reflection and absorption in the visible region, but only the liquid crystal containing 40% by weight or more of cholesteryl 12-hydroquine stearate and the other cholesterol ester being cholesteryl nonanoate was centered at 400 nm. Absorption was found.
この物質は、溶媒に溶かして紫外線吸収を測定すると、
他のコレステロールと同様に、２５０ｎｍ以下にしか吸
収はないが、液晶状態になると、他のコレステロールエ
ステルと異なり、４００ｎＩ１１ヲ中心とした吸収か出
現する。When this substance is dissolved in a solvent and its ultraviolet absorption is measured,
Like other cholesterols, it has absorption only below 250 nm, but when it becomes a liquid crystal, unlike other cholesterol esters, absorption centered on 400nI11 appears.
このことは、他の紫外線吸収剤とは、根本的に原理を異
にし、新しい紫外線吸収の考え方を導入しなければなら
ない。This fundamentally differs in principle from other ultraviolet absorbers, and a new way of thinking about ultraviolet absorption must be introduced.
また、粉体等、光を反射するものは当然あるか、それ自
体、皮膚に何等かの有用性があるわけてはない。Furthermore, it is natural that there are substances such as powders that reflect light, but they themselves do not have any usefulness for the skin.
ところが、コレステリック液晶は、特にコレステリル１
２−ヒドロキシステアレートを含むコレステリック液晶
は、本出願人による特開平］−２４６２０９号公報、特
願平］−４３２５５号などにより、安全性は勿論、各種
の有効性があることかすでに確認されている。However, cholesteric liquid crystals, especially cholesteryl 1
Cholesteric liquid crystals containing 2-hydroxystearate have been confirmed not only to be safe but also to have various efficacies, such as in Japanese Patent Application Laid-Open No. 246209 and Japanese Patent Application No. 43255 filed by the present applicant. There is.
また、実際の製剤を作成する場合、他の紫外線吸収剤と
併用することは同等問題はないか、十分に安全性を考慮
しなければ、本発明の主旨から外れることになる。In addition, when creating an actual preparation, if the use of the UV absorber in combination with other ultraviolet absorbers does not pose the same problem or sufficiently considers safety, it will deviate from the spirit of the present invention.
剤形としては、特に他の液晶人化粧料とがゎるところは
ない。In terms of dosage form, it is not particularly different from other liquid crystal cosmetics.
また、コンキオリンとの相乗作用もあり、日焼は防止用
化粧品にしても、その効果を発揮することは勿論である
。It also has a synergistic effect with conchiolin, so it goes without saying that it can also be used as a sunburn prevention cosmetic.
配合に関しては、本出願人による特開平１−２４６２０
９号公報、特願平１−４３２５５号と異なり、コレステ
リル１２−ヒドロキシステアレートの配合量は、４０％
以上として、コレステリル１２−ヒドロキシステアレー
ト以外のコレステロールエステルは、コレステリルノナ
ノエートがもっとも良いことか分った。Regarding the formulation, please refer to Japanese Patent Application Laid-Open No. 1-24620 by the present applicant.
Unlike Publication No. 9 and Japanese Patent Application No. 1-43255, the amount of cholesteryl 12-hydroxystearate is 40%.
As described above, it was found that cholesteryl nonanoate is the best cholesterol ester other than cholesteryl 12-hydroxystearate.
以下に実施例により、本発明を具体的に説明するか、本
発明はこの実施例によって同等限定されるものではない
。The present invention will be specifically explained below with reference to Examples, but the present invention is not limited to the same extent by these Examples.
コレステリル１２−ヒドロキシステアレート １０．
０コレステリルノナノエート １
０，０カルボキシビニルポリマー
１，０グリセリン ５，０１．３
ブチレングリコール ５０酸化防
止剤（トコフェノール）０，１
精製水 ６８．９
（比較例１）
実施例１においてコレステリル１２−ヒドロキシステア
レートをコレステリルオレエートに置き換えたもの
官能評価
女性１０名、男性５名に対して、１ケ月間使用し、アン
ケートを取った。Cholesteryl 12-hydroxystearate 10.
0 cholesteryl nonanoate 1
0,0 carboxyvinyl polymer
1,0 Glycerin 5,01.3
Butylene glycol 50 Antioxidant (tocophenol) 0.1 Purified water 68.9 (Comparative example 1) Example 1 except that cholesteryl 12-hydroxystearate was replaced with cholesteryl oleate Sensory evaluation 10 women, 5 men After using the product for one month, we conducted a questionnaire survey.
評価は５段階で、以下のように記載してもらった。The evaluation was on a five-point scale and was written as follows.
＋５ 実施例の方が非常によい。+5 The example is much better.
＋４ 実施例の方かかなりよい。+4 The example is considerably better.
＋３ 実施例の方がよい。+3 Example is better.
＋２ 実施例の方がややよい。+2 Example is slightly better.
＋１ 実施例の方が若干よい。+1 The example is slightly better.
０ 差がない。0 There is no difference.
−１比較例の方が若干よい。-1 Comparative example is slightly better.
−２比較例の方がややよい。-2 Comparative example is slightly better.
３ 比較例の方がよい。3. Comparative example is better.
４ 比較例の方がかなりよい。4. Comparative example is much better.
−５比較例の方が非常によい。-5 Comparative example is much better.
この合計を表に示すと、
これの液晶部分を０．１ｇ取り２枚の石英ガラス板で挾
み直径２０ｍｍになるように押し潰した。This total is shown in the table below. 0.1 g of the liquid crystal part was taken between two quartz glass plates and crushed to a diameter of 20 mm.
これを分光光度計で２００〜７００ｎ＋＋の間の吸光度
を測定した。The absorbance of this was measured using a spectrophotometer between 200 and 700 n++.
その結果を第１図に示す。The results are shown in FIG.
このようにコレステリル１２−ヒドロキシステアレート
を４０重量％以上とコレステリルナノエートよりなる液
晶は、４００ ｎｉ付近の波長において、吸収があり、
日焼は防止の効果があることか判った。更にこの日焼は
防止化粧料には保湿性の効果もあることが明らかである
。In this way, a liquid crystal made of cholesteryl nanoate and 40% by weight or more of cholesteryl 12-hydroxystearate has absorption at a wavelength around 400 ni,
It turns out that it is effective in preventing sunburn. Furthermore, it is clear that this sunburn prevention cosmetic also has a moisturizing effect.
従来の液晶を含む化粧料では、外観上の優位性であり、
コレステリル１２−ヒドロキシステアレートを含む液晶
では、これに保湿性が優れるという有効性が付加される
ことが知られていた。本発明は、コレステリル１２−ヒ
ドロキシステアレートを４０重量％以上とコレステリル
ノナノエートよりなる液晶を含む化粧料が今までの液晶
にはない日焼予防すなわち、紫外線防止作用があること
を見い出したことにあり、これまでの紫外線吸収剤にな
い、新しい紫外線防止機能を提供することで、極めて大
きな意義がある。Conventional cosmetics containing liquid crystals have an advantage in appearance,
It has been known that liquid crystals containing cholesteryl 12-hydroxystearate have the added benefit of excellent moisturizing properties. The present invention is based on the discovery that a cosmetic containing a liquid crystal containing 40% by weight or more of cholesteryl 12-hydroxystearate and cholesteryl nonanoate has a sunburn prevention effect, that is, an ultraviolet ray prevention effect that conventional liquid crystals do not have. This is extremely significant as it provides a new UV protection function not found in conventional UV absorbers.
第１図は実施例１の液晶部分を２枚の石英ガラス板に挟
み、直径２０關になるように押し潰したものを分光光度
計により、２００〜７００ ｒ＋＋＊の波長の吸光度を
測定したグラフである。
吸光度（ＡＢＳ）Figure 1 is a graph obtained by measuring the absorbance at wavelengths of 200 to 700 r++* using a spectrophotometer after the liquid crystal part of Example 1 was sandwiched between two quartz glass plates and crushed to a diameter of 20 mm. It is. Absorbance (ABS)
Claims (1)
０重量％以上とコレステリル１２−ヒドロキシステアレ
ート以外のコレステロールエステルがコレステリルノナ
ノエートである液晶を含む日焼け防止用化粧料。(1) Cholesteryl 12-hydroxystearate 4
A sunscreen cosmetic comprising a liquid crystal in which the cholesterol ester other than cholesteryl 12-hydroxystearate is cholesteryl nonanoate in an amount of 0% by weight or more.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20800690A JP2825627B2 (en) | 1990-08-08 | 1990-08-08 | Sunburn prevention cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20800690A JP2825627B2 (en) | 1990-08-08 | 1990-08-08 | Sunburn prevention cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0495021A true JPH0495021A (en) | 1992-03-27 |
| JP2825627B2 JP2825627B2 (en) | 1998-11-18 |
Family
ID=16549111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20800690A Expired - Lifetime JP2825627B2 (en) | 1990-08-08 | 1990-08-08 | Sunburn prevention cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2825627B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9855162B2 (en) | 2012-10-01 | 2018-01-02 | Kawamura Gishi Co., Ltd. | Spinal orthosis |
-
1990
- 1990-08-08 JP JP20800690A patent/JP2825627B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9855162B2 (en) | 2012-10-01 | 2018-01-02 | Kawamura Gishi Co., Ltd. | Spinal orthosis |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2825627B2 (en) | 1998-11-18 |
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| Date | Code | Title | Description |
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