JPH0495006A - Paste - Google Patents

Abstract

PURPOSE:To obtain a paste capable of improving bonding and fitting of a denture to the gingiva and stabilizing mounting of the denture base by blending polyacrylate powder which is a stringy polymer, polymer organic acid powder and an oily ointment base with nonstringy water-soluble powder for foods, etc. CONSTITUTION:A paste is obtained by blending polyacrylate powder which is a stringy polymer such as sodium polyacrylate, polymer organic acid powder of a carboxyvinyl polymer such as 'Carbopol(R)' capable of exhibiting effects on enhancement of affinity between the polyacrylate powder and an oily oint ment base such as 'Plastibase(R)' and remarkable enhancement of tackiness of the paste and the oily ointment base with nonstringy water-soluble polymer powder, capable of increasing hardness or strength of a water absorbing gel of the polyacrylate such as sodium carboxymethyl cellulose, controlling diffusivity and solubility in water, moderating the cushioning properties in fitting, further softening stickiness in the mouth and prolonging duration of viscosity and useful for foods or pharmaceutically acceptable.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a paste that has the effect of improving the adhesion between dentures and gums, for example, and stabilizing the attachment of dentures.

(Prior Art) A denture stabilizer using polyacrylate powder is already known (Japanese Unexamined Patent Publication No. 55-38143) (Problem to be Solved by the Invention) However, it is difficult to use known polyacrylate powder. The denture adhesive used had good performance such as adhesiveness and spreadability (ease of use),
In addition, the water-absorbing gel formed by polyacrylate, which has high water-absorbing and swelling properties, is soft and flows easily, and also exhibits rubber elasticity, so its long-lasting adhesion cannot be said to be sufficient. Improvement is desired.

(Means for Solving the Problems) Therefore, as a result of various studies, the present inventors have improved the hardness and strength of the polyacrylate water-absorbing gel, controlled its diffusion solubility in water, and improved the cushioning properties when worn. It has been found that it is effective to incorporate food-grade or pharmaceutically acceptable non-spinnable water-soluble polymers to moderate the stickiness, reduce stickiness during the day, and prolong the duration of adhesion. It was done. It has also been found that the polymeric organic acid has the effect of increasing the affinity between the polyacrylate and the oily ointment base, thereby significantly increasing the stickiness of the paste.

The present invention has been completed based on the above findings. That is, the present invention consists of three types of powders each of a polyacrylate of a spinnable polymer, a polymeric organic acid, a food-grade or pharmaceutically acceptable non-stringinable water-soluble polymer, and an oily ointment base. Regarding paste.

The polyacrylates used in the present invention include alkali metal salts such as sodium salts and potassium salts of polyacrylic acid;
Examples include salts such as ammonium salts, calcium salts, aluminum salts, iron salts, etc., which have stringing properties (those that have the property of stringing when made into a 0.5% aqueous solution), and sodium salts. preferable. In the case of salts with polyvalent metals such as calcium salts, aluminum salts, iron salts, the degree of substitution is 100.
% salt is not preferable because the stringiness will be lost.
Preferably, the degree of substitution is about 50% or less. Also, the intrinsic viscosity of polyacrylate powder is 0.30g/100-
The particle size is preferably 0.45 g/100 or more, and the particle size is 60 mesh (Tyler) or less, more preferably 100 mesh or less.

Preferably, the high-molecular organic acid is one whose aqueous solution has a pH lower than 4.5 and is food-grade or pharmaceutically acceptable, such as carboxyvinyl polymer, acrylic acid polymer such as polyacrylic acid, chondroitin sulfate, hyaluronic acid, etc. Examples include acidic mucopolysaccharides such as alginic acid, and carboxyvinyl polymers such as carbopol are preferred.

In addition, the average molecular weight thereof is preferably about 10,000 or more,
In addition, the particle size of the powder is 60 mesh (tie ÷ -) or less,
Preferably it is 100 meshes or less.

In addition, as a food-use or pharmaceutically acceptable non-stringinable water-soluble polymer, the pH of its 0.5% aqueous solution is pH 4, 5.
- Approximately 8.5 and does not exhibit stringy properties,
Examples include cellulose ether derivatives such as sodium carboxydimethylcellulose, methylcellulose, and hydroxypropylmethylcellulose, casein, sodium deoxyliponucleic acid, soluble starch, water-soluble vegetable gums such as acacia, gum tragacanth, guar gum, and xanthan gum, and polyethylene oxide. , cellulose ethyl derivatives such as sodium carboxymethyl cellulose are preferred. The average molecular weight is preferably about 10,000 or more, and the particle size of the powder is preferably 60 meshes (Tyler) or less, more preferably 100 meshes or less, and one or more of these may be used alone or in combination. Selectively used in conjunction with polyacrylate powder. Oily ointment bases include, for example, petrolatum and Plastibase.
(manufactured by ibaseSquibb), liquid paraffin, etc. are preferred, and mixtures of vegetable oil and beeswax are also used. Furthermore, medicinal ingredients such as anti-inflammatory agents and antibiotics and various surfactants may be added as appropriate.

The ratio of each component in the paste-like denture stabilizer of the present invention is such that polyacrylate powder is about 20 to 65 W/W%, more preferably about 30 to 55 W/W%, and polymeric organic acid is about 1 to 65 W/W%.
25 W/W%, more preferably about 2 to 20 W/W%, and about 2 to 40 W/W%, more preferably about 5 to 30W
/W%, more preferably about 60 to 20 IOW/W% of the oily ointment base.

(Effects of the Invention) Adhesive strength, wet adhesive strength, adhesive persistence, and spreadability were observed for the paste-like denture stabilizers according to the present invention described in Examples and comparative examples (PANA single formulation products and commercially available products).

1. Experimental method i. Measurement of adhesion force.Paste denture stabilizer 0.5- is placed on the lower movable methacrylic plate of a rheometer (manufactured by Fudo Kogyo ■), and this is applied to the tip of a stainless steel spindle fixed to the machine. Glue the denture resin plate by hand onto the supporting disk (1.5 cm in diameter).
Press firmly for 5 seconds and let stand for 2 minutes. Next, the lower movable methacrylic plate is moved downward at a speed of 2 cm/min, and the value of the resistance force (g: ie, adhesive force) displayed on the meter is read at this time.

i. Measurement of wet adhesion force Place 0.5 - of the paste denture stabilizer on the lower movable methacrylic plate of a rheometer (manufactured by Fudo Kogyo ■), add 1 - of water to this using a microsyringe, and mix thoroughly. Let it absorb water. After standing for 5 minutes, measure according to the method for measuring adhesive strength.

Observation of persistence of adhesion in silkworms Three people wearing complete dentures alternately used paste-like denture stabilizers of the present invention and a commercially available product.
That is, we compared the sustainability of denture stabilization. The evaluation is +2 if you feel the product is very good compared to the inventive product or commercially available products.
Good +1, same 0, not good -11, very bad -
There were 5 levels: 2.

iv. Measurement of spreadability: Place 0.5 mtl' of paste denture stabilizer on the scale plate of a spread meter (manufactured by Rigosha) (< 1 ai x 0.50)
A 263 g glass plate was gently placed on top of the paste, and the diameter (cm 2 ) of the spread paste was measured.

2. Experimental results are shown in Table 1. In addition, each component in the table was described with the following abbreviation.

PANA: Sodium polyacrylate, AI=alginic acid, CP: Carbopol 940, CNC: Sodium carboxymethylcellulose, SS: Soluble starch, Z
G: xanthan gum, GG: guar gum, HPM hydroxypropyl methylcellulose, PB: Plastibase 5
0W, PA: liquid paraffin, as is clear from this table, the paste-like denture stabilizer of the present invention is a paste-like denture stabilizer containing only polyacrylate powder as the tackifying component (JP-A-55-38143 No. , 13 samples) or commercially available products, both the adhesive force and the wet adhesive force were strong, and the effect was long-lasting, so it was confirmed that the denture could be stably fixed locally. In addition, it is desirable that the paste has a hardness that is easy to push out from the ointment tube, easy to apply to the denture, and difficult to protrude from between the denture and the attachment site in the oral cavity.In this case, the spreadability value is 260~
It is almost satisfied within the range of 2.5. 2. of the product of the present invention.
1 to 2.3, Comparative Example 1 had a value of 1.6, showing an unsatisfactory tendency. Furthermore, the product of the present invention was easy to wash off.

Example 1 Using a grinder, 45 parts of Plastibase 50W and 4 parts of Carbokidivir polymer (Carbopol 940) were thoroughly and uniformly kneaded, and then 10 parts of sodium carboxymethylcellulose (Seroken IP-3HS) was added. Knead with the intrinsic viscosity of 0.86g/100ml
-NaOH) and 41 parts of sodium polyacrylate powder with a viscosity of 200 mesh are added and mixed thoroughly and uniformly, and then filled into an ointment tube.

Example 2 Using a grinder, 40 parts of Plastibase 50W, 5 parts of liquid paraffin, and 4 parts of carboxybyl polymer (force/L Bopol 940) were thoroughly and uniformly kneaded, and then sodium carboxymethyl cellulose (Seroken HP- 3H3
) Add 20 parts and knead, and further reduce the intrinsic viscosity to 0.86.
g/100 mA (2N-NaOH), 31 parts of sodium polyacrylate powder with a particle size of 200 mesh is added, and after sufficiently uniformly kneading, the mixture is filled into a plaster tube.

Example 3 Plastibase 50W 4 using a screw kneader
7 parts and carboxypyr polymer (Carbopol 940)
4 parts were sufficiently uniformly kneaded, then 19 parts of sodium carboxyl methylcellulose (Seloken HP-3H3) was added and kneaded, and further the intrinsic viscosity was 0.86 g.
+ 100ml (2N-NaOH), particle size 200
Add 30 parts of sodium polyacrylate powder to the entire mesh, mix thoroughly, and then fill into an ointment tube.

Example 4 Using a grinder, 45 parts of Plastibase 50W and 4 parts of carboxyvir polymer (Carbopol 940) were thoroughly and uniformly kneaded, and then 1 part of carboxymethyl cellulose sodium (Seroken HP-3H3) was added and kneaded. If,
Furthermore, the intrinsic viscosity value is 0.86g/1007ILl (2N-
After adding 50 parts of sodium polyacrylate powder with a particle size of 200 mesh and kneading it thoroughly,
Fill the ointment tube.

Example 5 45 parts of Plastibase 50W, 10 parts of alginic acid, and an intrinsic viscosity of 0.86 g/1007 rLl (2N-Na
A composition consisting of 45 parts of powder of sodium polyacrylate having a viscosity of 200 mesh was processed in the same manner as in Example 1 to obtain a product.

Example 6 45 parts of Plastibase 50W, 5 parts of alginic acid, and intrinsic viscosity value of 0.86 g/100 mj (2N-NaOH)
, Carbopol 940) and 46 parts of powder of sodium polyacrylate having a particle size of 200 mesh was processed in the same manner as in Example 1 to obtain a product.

Example 7 Plastibase 50W 45 parts, soluble starch 1o part, Carbopol 9404 parts, intrinsic viscosity value 0.86 g/10
A composition consisting of 41 parts of powder of sodium polyacrylate having a particle size of 200 mesh was treated in the same manner as in Example 1 to obtain a product.

Example 8 45 parts of Plastibase 50W and 10 parts of suncan gum,
Carbopol 9404 parts, intrinsic viscosity value 0.86g/1
A composition consisting of 41 parts of powder of sodium polyacrylate having a viscosity of 0.00 ml (2N-NaOH) and a viscosity of 200 mesh was processed in the same manner as in Example 1 to obtain a product.

Example 9 45 parts of Plastibase 50W, 10 parts of hydroxypropyl cellulose, 9404 parts of Carbopol, intrinsic viscosity 0.86 g/100 mj (2N-NaOH),
A composition consisting of powdered sodium polyacrylate with a particle size of 200 mesh was processed in the same manner as in the example to obtain a product.

Claims (1)

[Claims] 1. A paste consisting of a spinnable polymer polyacrylate powder, a polymeric organic acid powder, a food-grade or pharmaceutically acceptable non-stringinable water-soluble polymer powder, and an oily ointment base.