JPH0490756A - Adhesive dressing - Google Patents
Adhesive dressingInfo
- Publication number
- JPH0490756A JPH0490756A JP20499790A JP20499790A JPH0490756A JP H0490756 A JPH0490756 A JP H0490756A JP 20499790 A JP20499790 A JP 20499790A JP 20499790 A JP20499790 A JP 20499790A JP H0490756 A JPH0490756 A JP H0490756A
- Authority
- JP
- Japan
- Prior art keywords
- porous membrane
- adhesive
- acrylate
- porous film
- hydrophobic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000853 adhesive Substances 0.000 title claims abstract description 30
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 30
- 229910052751 metal Inorganic materials 0.000 claims abstract description 23
- 239000002184 metal Substances 0.000 claims abstract description 23
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 21
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 17
- 239000012790 adhesive layer Substances 0.000 claims abstract description 12
- 229920000098 polyolefin Polymers 0.000 claims abstract description 8
- 230000035699 permeability Effects 0.000 claims abstract description 5
- 239000012528 membrane Substances 0.000 claims description 59
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000011148 porous material Substances 0.000 claims description 8
- 125000005396 acrylic acid ester group Chemical group 0.000 claims description 3
- 230000000379 polymerizing effect Effects 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 16
- 208000027418 Wounds and injury Diseases 0.000 abstract description 16
- -1 ester acrylate Chemical class 0.000 abstract description 16
- 241000894006 Bacteria Species 0.000 abstract description 7
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 abstract description 7
- 238000010559 graft polymerization reaction Methods 0.000 abstract description 7
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 abstract description 7
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 239000003522 acrylic cement Substances 0.000 abstract description 4
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 abstract description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract description 2
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 abstract description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract description 2
- 229920001577 copolymer Polymers 0.000 abstract description 2
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 239000012466 permeate Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000004743 Polypropylene Substances 0.000 description 11
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 9
- 229910052709 silver Inorganic materials 0.000 description 9
- 239000004332 silver Substances 0.000 description 9
- 229920001155 polypropylene Polymers 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 239000002033 PVDF binder Substances 0.000 description 4
- 229940057995 liquid paraffin Drugs 0.000 description 4
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 210000000416 exudates and transudate Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000001771 vacuum deposition Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 150000001721 carbon Chemical group 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000000774 hypoallergenic effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 229920006264 polyurethane film Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- AJDIZQLSFPQPEY-UHFFFAOYSA-N 1,1,2-Trichlorotrifluoroethane Chemical compound FC(F)(Cl)C(F)(Cl)Cl AJDIZQLSFPQPEY-UHFFFAOYSA-N 0.000 description 1
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004709 Chlorinated polyethylene Substances 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 229920006370 Kynar Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003484 crystal nucleating agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000002667 nucleating agent Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、疎水性の多孔質膜と低刺激性粘着剤層からな
り、空気や水蒸気は透過するが、水分や細菌の侵入を防
ぐことができる外科用ドレッシングに関する。[Detailed description of the invention] [Industrial application field] The present invention consists of a hydrophobic porous membrane and a hypoallergenic adhesive layer, which allows air and water vapor to pass through, but prevents moisture and bacteria from entering. Regarding surgical dressings that can be used.
手術後の縫合部や傷の手当等に使用する創傷ドレッシン
グ材は、簡単に操作することができ、貼った後も手や足
の関節等の屈伸が容易であり、患者が入浴したりシャワ
ーを浴びたりする場合に交換する必要がなく、傷口への
感染を防止することが必要である。Wound dressings used for sutures and wounds after surgery can be easily manipulated, and even after application, the joints of the hands and feet can be easily flexed and stretched, making it easy for patients to take a bath or shower. There is no need to change it when taking a bath, and it is necessary to prevent infection of the wound.
従来はガーゼ、脱脂綿が用いられていたが、滲出液をす
みやかに吸収するために、創傷面が脱水症状になり乾燥
してしまい、その結果癲皮ができる。この際にガーゼが
創面に固着して離れにくく、剥す際に患者に苦痛を与え
てしまい、出血等を伴うものである。また滲出液がガー
ゼを通して表面に出てくると、細菌が傷に侵入する可能
性が考えられる。Conventionally, gauze and absorbent cotton have been used, but because they absorb exudate quickly, the wound surface becomes dehydrated and dry, resulting in the formation of scabs. At this time, the gauze adheres to the wound surface and is difficult to remove, causing pain to the patient when it is removed and causing bleeding. Additionally, if exudate comes to the surface through the gauze, bacteria may enter the wound.
これに代わるものとして、吸湿性パッドと非粘着性フィ
ルムからなるスポンジ状パッドと防水性絆創膏を組み合
わせたドレッシング（Ａｉｒｓｔｒｉｐ［Ｆ］Ｓｍ１ｔ
ｈ ＆ Ｎｅｐｈｅｗ Ｌｉｍ１ｔｅｄ）や高水蒸気透
過性を有するポリウレタンフィルムと接着剤層からなる
接着性ドレッシング（Ｏｐ−５ｉｔｅ（９，５Ｉｌｉｔ
ｈ ＆ ＮｅｐｈｅｗＬｉＩｌｔｔｅｄ； Ｂｆｏｃｌ
ｕｓｉｖｅｏ、 Ｊｏｈｎｓｏｎ ＆ ｊｏｈｎｓｉｎ
；Ｔｅｇｏｄｅｒｍｏ３Ｍ＞など力（市販されている。As an alternative, a dressing (Airstrip [F] Sm1t
Adhesive dressings consisting of a polyurethane film with high water vapor permeability and an adhesive layer (Op-5ite (9,5Ilit))
h &NephewLiIltted; Bfocl
usiveo, johnson &johnsin
; Tegodermo 3M> etc. (commercially available).
しかしながらこれらのうち吸湿性のパッド等を使用して
いるドレッシングでは多層構造から構成され、かさ高く
なることから脇から水分や細菌等が侵入して（る可能性
が考えられる。また高水蒸気透過性を有するポリウレタ
ンフィルムは原料として医療グレードになると汎用の材
料ではなく、高価である等の問題がある。However, among these dressings that use hygroscopic pads, etc., they have a multilayer structure and are bulky, so there is a possibility that moisture and bacteria can enter from the armpit. When polyurethane film is made into a medical grade raw material, it is not a general-purpose material and has problems such as being expensive.
一方、特開昭５８−１５５８５４号公報に見られるよう
に、多孔質フィルムからなる創傷被覆材があるが、手術
後の縫合部や関節部位等の偏向に適用した場合、粘着部
分が存在しない為、皮膚との密着性に問題かあり、細菌
感染することが予想される。On the other hand, as seen in Japanese Patent Application Laid-Open No. 58-155854, there is a wound dressing made of a porous film, but when applied to the deflection of sutures or joints after surgery, there is no adhesive part. , there may be problems with adhesion to the skin, and bacterial infections are expected.
また創傷面や傷口の縫合部では感染が起こりやすい為、
抗菌剤を含有したクリーム基材を使用して感染防止を行
なっている。しかし抗菌剤をガーゼに練り込んだ場合、
滲出液とともにガーゼ包帯に約５７％が染み込み、創面
には約２１％しか到達しない。またクリーム基剤では毎
日のように創傷面に塗り込むなど操作上面倒である。In addition, infection is likely to occur on the wound surface and the sutured part of the wound.
A cream base containing antibacterial agents is used to prevent infection. However, when antibacterial agents are kneaded into gauze,
Approximately 57% of the exudate soaks into the gauze bandage, and only about 21% reaches the wound surface. In addition, cream-based products are cumbersome to use, as they have to be applied to the wound surface every day.
このような点から、一般に接着性ドレッシングとしては
、１）操作性がよいこと、２）使用時までに滅菌されて
いること、３）全面接着が可能であること、４）創面に
固着しないこと、５）原料が容易に入手でき、製造が容
易でかつ安価であること等の要件を満たすことが望まれ
るが、未だこれらの条件を満たすドレッシングは得られ
ていないのが現状である。From these points of view, adhesive dressings generally require 1) good operability, 2) sterilization before use, 3) ability to adhere to the entire surface, and 4) not sticking to the wound surface. , 5) It is desired that the raw materials be easily available, the production is easy and inexpensive, etc., but at present no dressing that satisfies these conditions has yet been obtained.
上記目的は下記の構成を有する接着ドレッシングによっ
て達成される。The above object is achieved by an adhesive dressing having the following construction.
（１） 疎水性多孔質膜と接着剤層からなる接着性ド
レッシング。(1) Adhesive dressing consisting of a hydrophobic porous membrane and an adhesive layer.
（２）疎水性多孔質膜がポリオレフィンあるいはハロゲ
ン化ポリオレフィンである１項に記載の接着性ドレッシ
ング
（３）疎水性多孔質膜の平均孔径が０．０１〜１．〇−
である１−または２項に記載の接着性ドレッシング。(2) The adhesive dressing according to item 1, wherein the hydrophobic porous membrane is a polyolefin or a halogenated polyolefin. (3) The average pore diameter of the hydrophobic porous membrane is 0.01 to 1. 〇－
The adhesive dressing according to item 1 or 2.
（４）疎水性多孔質膜の水蒸気透過率が２００〜５００
０ ｇ ／ ｒｒｒ ・２４ｈｒである１乃至３項のい
ずれかの項に記載の接着性ドレッシング。(4) Water vapor permeability of hydrophobic porous membrane is 200 to 500
0 g / rrr · 24 hr. The adhesive dressing according to any one of items 1 to 3.
（５）疎水性多孔質膜が多孔質膜にアクリル酸エステル
をグラフト重合させて弾性を付与したものである１乃至
４項のいずれかの項に記載の接着性ドレッシング。(5) The adhesive dressing according to any one of items 1 to 4, wherein the hydrophobic porous membrane is obtained by graft polymerizing an acrylic acid ester to a porous membrane to impart elasticity.
（６） アクリル酸エステルがアクリル酸メチル、エ
チル、ｎ−プロピル、１ｓｏ−プロピル、ｎブチルまた
は１ｓｏ−ブチルである５項に記載の接着性ドレッシン
グ。(6) The adhesive dressing according to item 5, wherein the acrylic ester is methyl, ethyl, n-propyl, 1so-propyl, n-butyl or 1so-butyl acrylate.
（７）疎水性多孔質膜と接着剤層のいずれか一方の層に
抗菌性を有する金属を蒸着させて抗菌性を付与した１乃
至６項のいずれかの項に記載された接着性ドレッシング
。(7) The adhesive dressing according to any one of items 1 to 6, wherein an antibacterial metal is vapor-deposited on either the hydrophobic porous membrane or the adhesive layer to impart antibacterial properties.
本発明の接着性ドレッシングは上記のように疎水性の多
孔質膜と低刺激性粘着剤層からなり、空気や水蒸気は透
過するが、水分や細菌の侵入を防ぐことができる。As described above, the adhesive dressing of the present invention is composed of a hydrophobic porous membrane and a hypoallergenic adhesive layer, and is permeable to air and water vapor, but can prevent moisture and bacteria from entering.
本発明に用いられる膜は多孔質膜であり、多孔質のもの
であれば、特に限定されないが、汎用で低価格な面を考
慮に入れると、好ましくはポリオレフィンあるいは一部
ハロゲン化されたポリオレフィンが望ましい。他に例を
上げると、ポリエチレン、ポリプロピレン、ポリフッ化
ビニリデン、ポリ塩化ビニリデン、塩素化ポリエチレン
などがある。しかし、接着性ドレッシングとして使用す
るには、孔径０．Ｏｆ〜１．０−１水蒸気透過率２００
〜５０００ｇ／ｒｒｒ・２４ｈｒの範囲内にあるものが
よい。The membrane used in the present invention is a porous membrane, and is not particularly limited as long as it is porous, but in consideration of general purpose and low cost, polyolefin or partially halogenated polyolefin is preferably used. desirable. Other examples include polyethylene, polypropylene, polyvinylidene fluoride, polyvinylidene chloride, and chlorinated polyethylene. However, for use as an adhesive dressing, pore size 0. Of~1.0-1 water vapor transmission rate 200
~5000g/rrr・24hr is preferable.
本発明に用いられる膜は、多孔質膜にアクリル酸エステ
ルをグラフト重合させて弾性を付与した多孔質膜である
ことか好ましく、弾性体を有する高分子が高分子化反応
あるいはビニルモノマーをグラフト重合できるものであ
れば、特に限定されないが、好ましくはアクリル酸エチ
ルあるいはアクリル酸ｎ−ブチルをグラフト重合するの
が望ましい。しかし接着性ドレッシングとして使用する
には、グラフト重合した多孔質膜の孔径が０．０１〜１
．０！Ｅｎ、水蒸気透過率２００〜５０００ｇ ／ ｒ
ｒ？ ・２４ｈｒの範囲内にあるものがよい。The membrane used in the present invention is preferably a porous membrane in which elasticity is imparted by graft polymerization of an acrylic acid ester to a porous membrane, in which a polymer having an elastic body undergoes a polymerization reaction or a vinyl monomer is graft polymerized. Although there is no particular limitation as long as it is possible, it is preferable to graft-polymerize ethyl acrylate or n-butyl acrylate. However, for use as an adhesive dressing, the pore size of the grafted porous membrane must be between 0.01 and 1.
．． 0! En, water vapor transmission rate 200-5000g/r
r?・It is better to use within 24 hours.
接着剤を形成するものとしては、アクリル系接着剤、例
えば、２−エチルへキシルアクリレート、ブチルアクリ
レート、アクリル酸等から合成されたアクリレートエス
テルの共重合体が好適に用いられる。本発明においては
、疎水性多孔質膜と接着層のいずれか一方の層に抗菌性
のある金属を蒸着させて抗菌性を付与することができる
。As a material forming the adhesive, an acrylic adhesive such as a copolymer of acrylate ester synthesized from 2-ethylhexyl acrylate, butyl acrylate, acrylic acid, etc. is suitably used. In the present invention, antibacterial properties can be imparted to either the hydrophobic porous membrane or the adhesive layer by vapor-depositing an antibacterial metal.
本発明において抗菌剤として使用される金属は銀、銅又
は亜鉛等であるが、抗菌性の点から銀が好ましい。また
膜表面に存在させる金属は２種類以上であっても良いし
、酸化物、塩の状態であっても良い。そして、多孔質膜
に存在させる金属の量については、特に限定されないが
、コスト面、溶出金属による２次汚染等から、膜表面に
存在させる金属は、膜表面のＸ線光電子スペクトルによ
る金属原子／炭素原子比が０．０２〜５．０の範囲内に
あるものか良い。すなわち、金属原子／炭素原子が５．
０を越えると、膜表面での金属存在比か過剰となり、抗
菌性を有するものの、孔径が付着した金属により縮小化
して膜本来の水蒸気透過性が失われてしまう。又、過剰
に金属が付着してこの金属が薄膜化してしまうと、孔が
閉塞されたり、金属層が衝撃等で剥離するばかりか、非
経済的である。逆に金属原子／炭素原子比が０．０２以
下であると、安定した抗菌性が失われる虞がある。The metal used as the antibacterial agent in the present invention includes silver, copper, zinc, etc., and silver is preferred from the viewpoint of antibacterial properties. Further, two or more types of metals may be present on the film surface, or they may be in the form of oxides or salts. The amount of metal present in the porous membrane is not particularly limited, but due to cost considerations, secondary contamination due to eluted metal, etc., the amount of metal present on the membrane surface is determined by metal atoms/ It is preferable that the carbon atomic ratio is within the range of 0.02 to 5.0. That is, the metal atom/carbon atom is 5.
If it exceeds 0, the metal abundance ratio on the membrane surface will be excessive, and although it has antibacterial properties, the pore size will be reduced by the attached metal and the membrane's inherent water vapor permeability will be lost. Furthermore, if an excessive amount of metal adheres and the metal becomes thin, the pores may become clogged, the metal layer may peel off due to impact, etc., and this is uneconomical. Conversely, if the metal atom/carbon atom ratio is less than 0.02, stable antibacterial properties may be lost.
本発明の接着性ドレッシングは例えば次のようにして製
造される。The adhesive dressing of the present invention is manufactured, for example, as follows.
まずポリプロピレン粉末に所定量の流動パラフィン及び
結晶核形成剤を加えて溶融混練しペレット化する。この
ペレットを１５０〜２００℃で溶融し、Ｔダイ付の押出
機により押出し、冷却固定化液中に導き冷却固定化して
フィルムにし、該フィルム中の流動パラフィンの抽出を
行い、１３５℃程度の空気中で約２分間熱処理を行い、
ポリプロピレン製の多孔質膜を得る。該膜にアクリル酸
エチルをプラズマ開始表面グラフト重合し、弾性を付与
したポリプロピレン製の多孔質膜を得る。First, a predetermined amount of liquid paraffin and a crystal nucleating agent are added to polypropylene powder, and the mixture is melt-kneaded and pelletized. The pellets are melted at 150 to 200°C, extruded using an extruder equipped with a T-die, introduced into a cooling fixation liquid, cooled and fixed, and made into a film. The liquid paraffin in the film is extracted, and the Heat treatment is performed for about 2 minutes in
A porous membrane made of polypropylene is obtained. Plasma-initiated surface graft polymerization of ethyl acrylate is applied to the membrane to obtain a porous polypropylene membrane imparted with elasticity.
この膜は処理前のポリプロピレン製の多孔質膜と比較し
て、強度が１．８倍、伸度１０倍以上であった。This membrane had 1.8 times the strength and more than 10 times the elongation of the polypropylene porous membrane before treatment.
次にこの多孔質膜を真空蒸着用のペルジャー内に収容し
、ペルジャー内を減圧し、所定時間銀を真空蒸着する。Next, this porous membrane is placed in a Pel jar for vacuum deposition, the pressure inside the Pel jar is reduced, and silver is vacuum deposited for a predetermined period of time.
尚、膜表面に金属を存在させる方法は、他にスパッタリ
ング法、イオンビーム法等があり、特に限定されない。Note that the method for making metal present on the film surface is not particularly limited, and there are other methods such as sputtering method and ion beam method.
上記で得られた金属が膜に蒸着した多孔膜上に、アクリ
ル系の接着剤を精密被覆用具（アプリケーター）を用い
て塗布させることにより本発明の接着性ドレッシングが
作製される。The adhesive dressing of the present invention is produced by applying an acrylic adhesive using a precision coating tool (applicator) onto the porous membrane on which the metal obtained above is vapor-deposited.
本発明の接着性ドレッシングは、膜表面に金属を存在さ
せたので、この金属による抗菌作用によって抗菌性多孔
質膜で捕捉された細菌の増殖が制御される。Since the adhesive dressing of the present invention has metal present on the membrane surface, the antibacterial action of this metal controls the growth of bacteria trapped in the antibacterial porous membrane.
抗菌性のｎ１定は、金属（銀）を蒸着させた多孔質膜か
らｌｃｄを切り取り、緑膿菌を塗布した培地上に置き、
評価を行った。To determine the antibacterial n1 level, cut the LCD from a porous membrane coated with metal (silver) and place it on a medium coated with Pseudomonas aeruginosa.
We conducted an evaluation.
表 １
表１から銀を存在させていない多孔質膜は抗菌性が全く
なく、銀を０，０５分しか存在させる処理を行っていな
い多孔質膜ではＡｇ ／Ｃ比が０．０１であり、抗菌性
を示さなかった。Table 1 From Table 1, the porous membrane in which silver is not present has no antibacterial properties, and the porous membrane treated to have silver present for only 0.05 minutes has an Ag/C ratio of 0.01. It showed no antibacterial properties.
以下、実施例を示して本発明をさらに具体的に説明する
。Hereinafter, the present invention will be explained in more detail with reference to Examples.
多孔質膜の作製（１）
メルトフローインデックスが３０及び０，３のポリプロ
ピレン混合物（混合重量比１００ ： ４０）１００重
量部当り、４００重量部の流動パラフィン（平均分子量
３２４）及び０３重量部の結晶核形成剤としての１．３
，２．４−ビス（ｐ−エチルベンジリデン）ソルビトー
ルを二軸型押出機により溶融混練し、ペレット化した。Preparation of porous membrane (1) 400 parts by weight of liquid paraffin (average molecular weight 324) and 0.3 parts by weight of crystals per 100 parts by weight of a polypropylene mixture with a melt flow index of 30 and 0.3 (mixing weight ratio 100:40) 1.3 as a nucleating agent
, 2.4-bis(p-ethylbenzylidene)sorbitol were melt-kneaded using a twin-screw extruder and pelletized.
このベレットを上記二軸型押出機を用いて１５０〜２０
０℃で溶融し、スリット０．６ｍｍのＴダイより空気中
に押出しフィルム状にし、このフィルム状物をＴダイ直
下に置かれたガイドローラーによって冷却固定化液中に
導き冷却固定化した後巻取る。この巻取ったフィルム状
物を一定寸法に切断し、縦横両方向を固定し、１，１．
２−トリクロロ−１，２，２−トリフルオロエタン中に
１０分間計４回浸漬して、フィルム状物中の流動パラフ
ィンの抽出を行う。次いで１３５℃の空気中で２分間熱
処理を行って、孔径０．６ｔｍ、膜厚１４０μのポリプ
ロピレン製多孔質膜を得た。This pellet was heated to 150 to 20 mm using the above twin screw extruder.
The film is melted at 0°C and extruded into the air through a T-die with a slit of 0.6 mm to form a film.This film-like material is introduced into a cooling fixing liquid by a guide roller placed directly below the T-die, and is then cooled and fixed. take. Cut this rolled-up film-like material into a certain size, fix it both vertically and horizontally, and proceed as follows: 1.
The liquid paraffin in the film-like material is extracted by immersion in 2-trichloro-1,2,2-trifluoroethane for 10 minutes four times in total. Next, heat treatment was performed in air at 135° C. for 2 minutes to obtain a polypropylene porous membrane with a pore diameter of 0.6 tm and a film thickness of 140 μm.
多孔質膜の作製（２）
ポリフッ化ビニリデン粉末（三菱油化■）製Ｋｙｎａｒ
Ｋ２Ｏ２１８Ｆｉ量部をアセトン７３．８重量部及び
ジメチルホルムアミド８．２重量部に溶解してなる溶液
を、ポリエチレンテレフタレートフィルム上にキャスト
した後、 １，１．２− トリクロロトリフルオロエタ
ン浴中に５分間浸漬し、乾燥して平均孔径０．４５虜、
膜厚１３５ｕｎのポリフッ化ビニリデン多孔質膜を得た
。Preparation of porous membrane (2) Kynar made of polyvinylidene fluoride powder (Mitsubishi Yuka ■)
A solution prepared by dissolving parts of K2O218Fi in 73.8 parts by weight of acetone and 8.2 parts by weight of dimethylformamide was cast onto a polyethylene terephthalate film, and then placed in a 1,1,2-trichlorotrifluoroethane bath for 5 minutes. Soaked and dried to an average pore size of 0.45,
A polyvinylidene fluoride porous membrane having a thickness of 135 nm was obtained.
弾性多孔質膜の作製（３）
上記（１）で得られた膜にアクリル酸エチルをプラズマ
開始表面グラフト重合し、弾性を付与したポリプロピレ
ン製の多孔質膜を得た。Preparation of Elastic Porous Membrane (3) Plasma-initiated surface graft polymerization of ethyl acrylate was carried out on the membrane obtained in the above (1) to obtain a polypropylene porous membrane imparted with elasticity.
即ち、ＰＰ膜に０．ＩＴｏｒｒ １５秒アルゴンプラズ
マを照射した後、アクリル酸エチル雰囲気中で（２５’
Ｃ，４Ｔｏｒｒ） 、３０分グラフト重合を行なった。That is, the PP film has 0. ITorr After irradiating argon plasma for 15 seconds, in an ethyl acrylate atmosphere (25'
C, 4 Torr), graft polymerization was carried out for 30 minutes.
得られたアクリル酸エチルグラフト化ＰＰ膜は破断伸度
が約２００％であり、手足の関節等の屈伸部で使用して
も破断しないものであった。また、未グラフトのＰＰ膜
の破断伸度は約Ｉｌ１％であり、ひき伸ばすことによっ
て容易に破断され、実用に耐えないものであった。また
、１００％伸長時の弾性回復率も９６％であり、伸ばし
た後の創部への密着性も実用上支障のないフィルムであ
った。The obtained ethyl acrylate grafted PP membrane had a breaking elongation of about 200%, and did not break even when used at bending/stretching parts such as joints of hands and feet. Furthermore, the elongation at break of the ungrafted PP membrane was about Il1%, and it was easily broken by stretching, making it unusable for practical use. Furthermore, the elastic recovery rate at 100% elongation was 96%, and the film had no practical problems in adhesion to the wound after elongation.
弾性多孔質膜の作製（４）
上記（２）で得られた膜にアクリル酸エチルをプラズマ
開始表面にグラフト重合し、弾性を付与したポリフッ化
ビニリデン多孔質膜を得た。Preparation of Elastic Porous Membrane (4) Ethyl acrylate was graft-polymerized onto the plasma initiation surface of the membrane obtained in (2) above to obtain a polyvinylidene fluoride porous membrane imparted with elasticity.
銀蒸着した多孔質膜の作製（５） 上記（１）乃至（４）の多孔質膜に銀を真空蒸着する。Preparation of porous membrane with silver vapor deposition (5) Silver is vacuum-deposited on the porous membranes of (1) to (4) above.
この真空蒸着は、まず多孔質膜を真空蒸着用のペルジャ
ーに設置し、１０’Ｔｏｒｒにまで減圧した後、シャタ
ーを開いて多孔質膜に所定時間銀を真空蒸着した。In this vacuum deposition, the porous membrane was first placed in a Pel jar for vacuum deposition, and after the pressure was reduced to 10'Torr, the shutter was opened and silver was vacuum deposited on the porous membrane for a predetermined period of time.
接着性ドレッシングの作製
上記（１）乃至（５）で得られた多孔質膜に、アクリル
系の接着剤を精密被覆用具（アプリケーター）を用いて
塗布し製膜することにより接着性ドレッシングを得るこ
とかできた。Preparation of adhesive dressing: An adhesive dressing is obtained by applying an acrylic adhesive to the porous membrane obtained in (1) to (5) above using a precision coating tool (applicator) to form a film. I was able to do it.
以上述べたように本発明は、疎水性多孔質膜と接着剤層
からなることを特徴とする接着性ドレッシングであり、
空気や水蒸気は透過するが、水分や細菌の侵入を防ぐこ
とができ、更に患者が入浴したりシャワーを浴びたりす
る場合にドレッシングを交換する必要がなく、傷口への
感染を防止することができる。As described above, the present invention is an adhesive dressing characterized by comprising a hydrophobic porous membrane and an adhesive layer,
It allows air and water vapor to pass through, but prevents moisture and bacteria from entering, and it also eliminates the need to change the dressing when the patient takes a bath or shower, preventing infection of the wound. .
また、疎水性多孔質膜に弾性を付与することにより関節
部への適用が可能となる。さらに、疎水性多孔質膜また
は接着剤層のいずれか一方の層に抗菌性のある金属を蒸
着させることにより、創傷部の細菌感染をより有効に防
止することができる。Furthermore, by imparting elasticity to the hydrophobic porous membrane, it becomes possible to apply it to joints. Furthermore, by depositing an antibacterial metal on either the hydrophobic porous membrane or the adhesive layer, bacterial infection in the wound can be more effectively prevented.
特許出願人 テ ル モ 株 式 会 社”Ｊ （外１名）Patent Applicant: Telmo Co., Ltd. “J” (1 other person)
Claims (6)
シング。(1) Adhesive dressing consisting of a hydrophobic porous membrane and an adhesive layer.
ン化ポリオレフィンである請求項１に記載の接着性ドレ
ッシング。(2) The adhesive dressing according to claim 1, wherein the hydrophobic porous membrane is a polyolefin or a halogenated polyolefin.
ｍである請求項１または２に記載の接着性ドレッシング
。(3) The average pore diameter of the hydrophobic porous membrane is 0.01 to 1.0μ
The adhesive dressing according to claim 1 or 2, which is m.
０ｇ／ｍ＾２・２４ｈｒである請求項１乃至３のいずれ
かの項に記載の接着性ドレッシング。(4) Water vapor permeability of hydrophobic porous membrane is 200 to 500
The adhesive dressing according to any one of claims 1 to 3, which has a dosage of 0 g/m^2.24 hr.
をグラフト重合させて弾性を付与したものである請求項
１乃至４のいずれかの項に記載の接着性ドレッシング。(5) The adhesive dressing according to any one of claims 1 to 4, wherein the hydrophobic porous membrane is made by graft polymerizing an acrylic acid ester to a porous membrane to impart elasticity.
抗菌性を有する金属を蒸着させて抗菌性を付与した請求
項１乃至５のいずれかの項に記載された接着性ドレッシ
ング。(6) The adhesive dressing according to any one of claims 1 to 5, wherein an antibacterial metal is deposited on one of the hydrophobic porous membrane and the adhesive layer to impart antibacterial properties. .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20499790A JPH0490756A (en) | 1990-08-03 | 1990-08-03 | Adhesive dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20499790A JPH0490756A (en) | 1990-08-03 | 1990-08-03 | Adhesive dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0490756A true JPH0490756A (en) | 1992-03-24 |
Family
ID=16499751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20499790A Pending JPH0490756A (en) | 1990-08-03 | 1990-08-03 | Adhesive dressing |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0490756A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995030410A3 (en) * | 1994-05-10 | 1995-12-07 | Svedman Paul | Transdermal device for administration through de-epithelialized skin |
| EP1053728A1 (en) * | 1998-12-02 | 2000-11-22 | Nichiban Company Limited | Pressure-sensitive adhesive tape for pasting on skin and base material for use therein |
| AU731508B2 (en) * | 1994-05-10 | 2001-03-29 | Pal Svedman | Transdermal device for administration through de-epithelialized skin |
-
1990
- 1990-08-03 JP JP20499790A patent/JPH0490756A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995030410A3 (en) * | 1994-05-10 | 1995-12-07 | Svedman Paul | Transdermal device for administration through de-epithelialized skin |
| AU731508B2 (en) * | 1994-05-10 | 2001-03-29 | Pal Svedman | Transdermal device for administration through de-epithelialized skin |
| EP1053728A1 (en) * | 1998-12-02 | 2000-11-22 | Nichiban Company Limited | Pressure-sensitive adhesive tape for pasting on skin and base material for use therein |
| EP1053728A4 (en) * | 1998-12-02 | 2002-07-24 | Nichiban Kk | Pressure-sensitive adhesive tape for pasting on skin and base material for use therein |
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