JPH0478640B2 - - Google Patents
Info
- Publication number
- JPH0478640B2 JPH0478640B2 JP58125153A JP12515383A JPH0478640B2 JP H0478640 B2 JPH0478640 B2 JP H0478640B2 JP 58125153 A JP58125153 A JP 58125153A JP 12515383 A JP12515383 A JP 12515383A JP H0478640 B2 JPH0478640 B2 JP H0478640B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- interferon
- virus
- per
- produced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004369 blood Anatomy 0.000 claims description 54
- 239000008280 blood Substances 0.000 claims description 54
- 102000014150 Interferons Human genes 0.000 claims description 32
- 108010050904 Interferons Proteins 0.000 claims description 32
- 229940079322 interferon Drugs 0.000 claims description 32
- 241000700605 Viruses Species 0.000 claims description 24
- 239000003146 anticoagulant agent Substances 0.000 claims description 8
- 229940127219 anticoagulant drug Drugs 0.000 claims description 8
- 230000035931 haemagglutination Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 description 11
- 210000000265 leukocyte Anatomy 0.000 description 10
- 239000000725 suspension Substances 0.000 description 10
- 241000711408 Murine respirovirus Species 0.000 description 9
- 230000016396 cytokine production Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000002504 physiological saline solution Substances 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 235000019270 ammonium chloride Nutrition 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000012980 RPMI-1640 medium Substances 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 2
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58125153A JPS6029000A (ja) | 1983-07-08 | 1983-07-08 | ヒトインタ−フェロンの産生方法 |
| US06/624,752 US4745053A (en) | 1983-07-08 | 1984-06-26 | Process for producing human interferon and method for assaying the interferon productivity of blood |
| DE19843424640 DE3424640A1 (de) | 1983-07-08 | 1984-07-04 | Verfahren zur gewinnung und/oder bestimmung von humanspezifischem interferon im blut |
| GB08417350A GB2146027B (en) | 1983-07-08 | 1984-07-06 | Process for producing human interferon and method for assaying the interferon productivity of blood |
| FR8410752A FR2548538B1 (fr) | 1983-07-08 | 1984-07-06 | Production d'interferon humain et procede pour le dosage de l'aptitude du sang a produire de l'interferon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58125153A JPS6029000A (ja) | 1983-07-08 | 1983-07-08 | ヒトインタ−フェロンの産生方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6029000A JPS6029000A (ja) | 1985-02-14 |
| JPH0478640B2 true JPH0478640B2 (enrdf_load_html_response) | 1992-12-11 |
Family
ID=14903181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58125153A Granted JPS6029000A (ja) | 1983-07-08 | 1983-07-08 | ヒトインタ−フェロンの産生方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6029000A (enrdf_load_html_response) |
-
1983
- 1983-07-08 JP JP58125153A patent/JPS6029000A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6029000A (ja) | 1985-02-14 |
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