JPH0472070B2 - - Google Patents
Info
- Publication number
- JPH0472070B2 JPH0472070B2 JP58174996A JP17499683A JPH0472070B2 JP H0472070 B2 JPH0472070 B2 JP H0472070B2 JP 58174996 A JP58174996 A JP 58174996A JP 17499683 A JP17499683 A JP 17499683A JP H0472070 B2 JPH0472070 B2 JP H0472070B2
- Authority
- JP
- Japan
- Prior art keywords
- plunger
- pressure
- metering pump
- type metering
- discharge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002904 solvent Substances 0.000 claims description 35
- 230000010349 pulsation Effects 0.000 claims description 12
- 238000004811 liquid chromatography Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Reciprocating Pumps (AREA)
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は液体クロマトグラフイー等で使用さ
れ、液体を一定量計量してカラム等へ吐出する高
圧定量ポンプ装置に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a high-pressure metering pump device used in liquid chromatography and the like, which measures a fixed amount of liquid and discharges it to a column or the like.
従来液体クロマトグラフイーにおいて、溶媒等
の液体を一定量計量してカラム等へ吐出する際に
は、例えば第１図に示す如きプランジヤ式定量ポ
ンプ１が用いられている。
In conventional liquid chromatography, a plunger-type metering pump 1 as shown in FIG. 1, for example, is used to measure a fixed amount of liquid such as a solvent and discharge it to a column or the like.
このプランジヤ式定量ポンプ１は、駆動モータ
２の回転を偏心カム３に伝え、該偏心カム３とこ
れに当接するベアリング４の回転及びリターンス
プリング５により、環状シール部材７の内側を液
密に摺動可能なプランジヤ６を往復動させるもの
であり、リターンスプリング５がプランジヤ６を
引き戻してプランジヤ式定量ポンプ１内を負圧に
して、溶媒槽から溶媒をプランジヤ式定量ポンプ
１内に吸引し（矢印Ａ）、次いで偏心カム３の回
転によりプランジヤ６を押し出してプランジヤ式
定量ポンプ１内の溶媒等をカラム側に加圧吐出す
る（矢印Ｂ）。 This plunger type metering pump 1 transmits the rotation of a drive motor 2 to an eccentric cam 3, and slides on the inside of an annular seal member 7 in a liquid-tight manner by the rotation of the eccentric cam 3 and a bearing 4 that contacts the eccentric cam 3, and by the return spring 5. The movable plunger 6 is reciprocated, and the return spring 5 pulls back the plunger 6 to create a negative pressure inside the plunger-type metering pump 1, and sucks the solvent from the solvent tank into the plunger-type metering pump 1 (as indicated by the arrow). A) Next, the plunger 6 is pushed out by the rotation of the eccentric cam 3, and the solvent etc. in the plunger type metering pump 1 is discharged under pressure to the column side (arrow B).
吸入ボール弁８及び吐出ボール弁９は、この時
溶媒の逆流を防止するもので、プランジヤ６の引
き戻しによりポンプ内圧が低くなると吐出ボール
弁９が閉じ、大気圧より低くなると吸入ボール弁
８が開いてプランジヤ式定量ポンプ１内に溶媒が
吸入され、プランジヤ式定量ポンプ１内に溶媒が
満たされる。 The suction ball valve 8 and the discharge ball valve 9 prevent backflow of the solvent at this time. When the pump internal pressure becomes low due to the withdrawal of the plunger 6, the discharge ball valve 9 closes, and when the pressure drops below atmospheric pressure, the suction ball valve 8 opens. The solvent is sucked into the plunger type metering pump 1, and the plunger type metering pump 1 is filled with the solvent.
次いでプランジヤ６の押し出しに伴う圧力の上
昇により、吸入ボール弁８が閉じ、ポンプ内圧が
負荷側より高くなると吐出ボール弁９が開いて溶
媒を吐出する。そして、吐出流量、吐出圧力の制
御は、プランジヤ６のストローク調節、駆動モー
タ２の回転調整等によつて行なう。 Next, the suction ball valve 8 closes due to an increase in pressure as the plunger 6 is pushed out, and when the pump internal pressure becomes higher than the load side, the discharge ball valve 9 opens to discharge the solvent. The discharge flow rate and discharge pressure are controlled by adjusting the stroke of the plunger 6, adjusting the rotation of the drive motor 2, and the like.
〔発明が解決しようとする課題〕
ところが、上述の如きプランジヤ式定量ポンプ
１においては、溶媒の吐出の際プランジヤ６の押
し出しによつてプランジヤ式定量ポンプ１内を加
圧するため、その時溶媒が圧縮されたり、またプ
ランジヤ式定量ポンプ１の内壁やシール部材７等
が変形し、負荷圧力の変化における吐出流量に誤
差が生じて正確な分析結果を得ることができなか
つた。[Problems to be Solved by the Invention] However, in the plunger type metering pump 1 as described above, the inside of the plunger type metering pump 1 is pressurized by pushing out the plunger 6 when discharging the solvent, so the solvent is compressed at that time. Furthermore, the inner wall, seal member 7, etc. of the plunger type metering pump 1 were deformed, and errors occurred in the discharge flow rate due to changes in load pressure, making it impossible to obtain accurate analysis results.
即ち、プランジヤ式定量ポンプ１の１ストロー
ク当りの吐出量は、プランジヤ６の断面積とスト
ロークの積で与えられるが、実際の吐出量は、溶
媒の圧縮あるいはプランジヤ式定量ポンプ１の内
壁やシール部材７等の変化により、負荷圧が変つ
て計算値を下回る。 That is, the discharge amount per stroke of the plunger-type metering pump 1 is given by the product of the cross-sectional area of the plunger 6 and the stroke, but the actual discharge amount depends on the compression of the solvent, the inner wall of the plunger-type metering pump 1, and the sealing member. Due to changes such as 7, the load pressure changes and falls below the calculated value.
この理由は、例えば、プランジヤ６のストロー
クを10mmに設定し、吐出側に負荷をかけた状態で
駆動モータ２を始動すると、偏心カム３の下死点
に当接しているプランジヤ６が前進を開始する
が、この時点では、ポンプ内圧が負荷圧より低い
ので、吐出ボール弁９は開かず、プランジヤ６が
引続いて例えば３mm前進して、溶媒の圧縮あるい
はプランジヤ式定量ポンプ１の内壁やシール部材
７等の変形が終了し、ポンプ内圧が負荷圧と等し
くなつたところで、吐出ボール弁９が開き、残り
のストローク７mm分が吐出される。 The reason for this is, for example, when the stroke of the plunger 6 is set to 10 mm and the drive motor 2 is started with a load applied to the discharge side, the plunger 6, which is in contact with the bottom dead center of the eccentric cam 3, starts moving forward. However, at this point, the pump internal pressure is lower than the load pressure, so the discharge ball valve 9 does not open, and the plunger 6 continues to move forward, for example, by 3 mm, compressing the solvent or compressing the inner wall or sealing member of the plunger metering pump 1. When the deformation 7 and the like is completed and the pump internal pressure becomes equal to the load pressure, the discharge ball valve 9 opens and the remaining stroke of 7 mm is discharged.
つまり、計算値通りに設定したストロークが、
実際には負荷圧がかかるために、吐出しない与圧
ストロークと吐出量を支配する実効ストロークの
二つに分かれるので、計算値通りの吐出量が得ら
れなかつた。 In other words, the stroke set according to the calculated value is
In reality, due to load pressure being applied, the stroke is divided into two: a pressurized stroke that does not discharge, and an effective stroke that controls the discharge amount, so the discharge amount as calculated cannot be obtained.
しかも、微少な流量を得たい場合に、設定した
ストロークが与圧ストローク以下だとすると、プ
ランジヤ６は往復運動しているにもかかわらず、
吐出ボール弁９が開かないため、高圧下で正確な
微少流量を得ることは非常に困難であつた。 Moreover, if you want to obtain a minute flow rate and the set stroke is less than the pressurization stroke, even though the plunger 6 is reciprocating,
Since the discharge ball valve 9 did not open, it was extremely difficult to obtain an accurate minute flow rate under high pressure.
このため、与圧ストロークが存在する状況で所
望の流量を得るには、駆動モータ２の回転数を一
定にしておいて、プランジヤ６のストローク調整
目盛あるいは吸入ボール弁８の開閉時期調整目盛
を調整して、プランジヤ６の全ストロークを13mm
に設定すると、与圧ストローク３mmを除いた実効
ストロークが10mmとなり、所望の流量を得ること
ができる。 Therefore, in order to obtain a desired flow rate in a situation where a pressurization stroke exists, the rotation speed of the drive motor 2 is kept constant, and the stroke adjustment scale of the plunger 6 or the opening/closing timing adjustment scale of the suction ball valve 8 is adjusted. and the full stroke of plunger 6 is 13mm.
When set to , the effective stroke excluding the pressurization stroke of 3 mm becomes 10 mm, and the desired flow rate can be obtained.
しかし、この調整手段は、負荷圧や溶媒等の送
液条件が変わると、与圧ストロークが増減して実
効ストロークがそれに伴い変化するので、新たな
条件下での実効ストロークを得る必要上、再調整
せねばならず、甚だ面倒であつた。 However, with this adjustment means, when the load pressure, solvent, and other liquid delivery conditions change, the pressurization stroke increases or decreases, and the effective stroke changes accordingly. I had to make adjustments, which was extremely troublesome.
本発明は、上記の点に鑑み発明されたもので、
溶媒交換等による装置の安定が、短時間で、かつ
グラジエント送液が良好で、優れた定流量性を有
し、正確な分析結果を得ることができるととも
に、負荷圧の増減に影響されず、高圧下でも微少
な吐出流量を正確に得ることができる液体クロマ
トグラフイー等の高圧定量ポンプ装置を提供する
ことを目的とするものである。 The present invention was invented in view of the above points, and
The device can be stabilized by solvent exchange in a short time, has good gradient liquid transfer, has excellent constant flow performance, and can obtain accurate analysis results, and is not affected by increases or decreases in load pressure. The object of the present invention is to provide a high-pressure metering pump device for liquid chromatography or the like that can accurately obtain a minute discharge flow rate even under high pressure.
本発明は上記目的を達成するためなされたもの
で、溶媒槽とカラムとを連結する流路に、加圧ポ
ンプと、吸入ボール弁及び吐出ボール弁を有する
プランジヤ式定量ポンプとを直列に配設し、該加
圧ポンプの吐出側とプランジヤ式定量ポンプの吸
入ボール弁側とを連結する連結チユーブに、脈動
吸収用チヤンバと前記プランジヤ式定量ポンプの
吸入圧力を測定する圧力センサとを夫々連結し、
前記プランジヤ式定量ポンプの吐出ボール弁側と
カラムとを連結する連結チユーブに、プランジヤ
式定量ポンプの吐出圧力を測定する圧力センサを
連結すると共に、前記両圧力センサからの信号に
より加圧ポンプの加圧力を演算制御して、前記両
連結チユーブ内の圧力差を一定に保持する制御回
路を設けたことを特徴とするものである。
The present invention has been made to achieve the above object, and includes a pressure pump and a plunger-type metering pump having a suction ball valve and a discharge ball valve arranged in series in a flow path connecting a solvent tank and a column. A pulsation absorbing chamber and a pressure sensor for measuring the suction pressure of the plunger type metering pump are respectively connected to a connecting tube connecting the discharge side of the pressure pump and the suction ball valve side of the plunger type metering pump. ,
A pressure sensor for measuring the discharge pressure of the plunger-type metering pump is connected to a connecting tube that connects the discharge ball valve side of the plunger-type metering pump and the column, and a pressure sensor for measuring the discharge pressure of the plunger-type metering pump is connected to the connection tube that connects the discharge ball valve side of the plunger-type metering pump to the column. The present invention is characterized in that a control circuit is provided which calculates and controls the pressure to maintain a constant pressure difference between the two connecting tubes.
したがつて、制御回路により加圧ポンプの加圧
力を、プランジヤ式定量ポンプの吐出圧力に応じ
て制御するので、プランジヤ式定量ポンプ内が負
荷圧に応じた加圧状態になり、プランジヤ式定量
ポンプによる溶媒の圧縮、プランジヤ式定量ポン
プ内壁やシール部剤等の変形がほとんど生せず、
プランジヤ式定量ポンプの押し出しストロークが
直接吐出流量を支配することになり、溶媒の種類
の変化、負荷圧の変動等に無関係に定流量性が得
られる。
Therefore, since the control circuit controls the pressurizing force of the pressurizing pump according to the discharge pressure of the plunger type metering pump, the inside of the plunger type metering pump is pressurized according to the load pressure, and the plunger type metering pump There is almost no compression of the solvent or deformation of the inner wall of the plunger type metering pump or the sealing material.
The extrusion stroke of the plunger-type metering pump directly controls the discharge flow rate, and a constant flow rate can be obtained regardless of changes in the type of solvent, fluctuations in load pressure, etc.
以下に本発明を第２図に示す一実施例に基づい
て詳細に説明する。尚、本実施例におけるプラン
ジヤ式定量ポンプは、前述の第１図に示した従来
のプランジヤ式定量ポンプと同一構造のものを用
いており、説明に際し該プランジヤ式定量ポンプ
については同一符号を用いた。
The present invention will be explained in detail below based on an embodiment shown in FIG. The plunger type metering pump in this example has the same structure as the conventional plunger type metering pump shown in FIG. .
本実施例は、液体クロマトグラフイーに用いる
高圧定量ポンプ装置の一実施例であり、該高圧定
量ポンプ装置Ａは、溶媒槽１０とカラム１１とを
連結する流路に、加圧ポンプ１２及び吸入ボール
弁８と吐出ボール弁９とを有するプランジヤ式定
量ポンプ１を直列に配設している。該加圧ポンプ
１２の吐出側とプランジヤ式定量ポンプ１の吸入
ボール弁８側とを連結する連結チユーブ１３に
は、該連結チユーブ１３内の圧力、即ちプランジ
ヤ式定量ポンプ１の吸入圧力を測定する圧力セン
サ１４及び加圧ポンプ１２からの脈動を吸収する
ための脈動吸収用チヤンバ１５が夫々連結されて
いる。前記プランジヤ式定量ポンプ１の吐出ボー
ル弁９側とカラム１１とを連結する連結チユーブ
１６には、該連結チユーブ１６内の圧力、即ちプ
ランジヤ式定量ポンプ１の吐出圧力を測定する圧
力センサ１７が連結されている。さらに、両圧力
センサ１４，１７からの信号により加圧ポンプ１
２の加圧力を演算制御して、連結チユーブ１６内
と連結チユーブ１３内との圧力差を一定に保持す
るための制御回路１８が設けられている。 This embodiment is an example of a high-pressure metering pump device used for liquid chromatography, and the high-pressure metering pump device A includes a pressure pump 12 and a suction A plunger type metering pump 1 having a ball valve 8 and a discharge ball valve 9 is arranged in series. A connecting tube 13 connecting the discharge side of the pressurizing pump 12 and the suction ball valve 8 side of the plunger type metering pump 1 is provided with a connecting tube 13 that measures the pressure inside the connecting tube 13, that is, the suction pressure of the plunger type metering pump 1. A pressure sensor 14 and a pulsation absorbing chamber 15 for absorbing pulsations from the pressure pump 12 are connected to each other. A pressure sensor 17 is connected to the connecting tube 16 that connects the discharge ball valve 9 side of the plunger type metering pump 1 and the column 11 to measure the pressure inside the connecting tube 16, that is, the discharge pressure of the plunger type metering pump 1. has been done. Furthermore, the pressure pump 1
A control circuit 18 is provided to maintain a constant pressure difference between the inside of the connecting tube 16 and the inside of the connecting tube 13 by calculating and controlling the pressurizing force of 2.
尚１９は試料のカラムへの導入を制御するサン
プリングバルブであり、２０は検出器である。 Note that 19 is a sampling valve that controls the introduction of a sample into the column, and 20 is a detector.
次に本実施例の作用について説明する。 Next, the operation of this embodiment will be explained.
溶媒槽１０中の溶媒は、加圧ポンプ１２により
加圧され、脈動吸収用チヤンバ１５を介して、プ
ランジヤ６が後退しているプランジヤ式定量ポン
プ１内へ吸入ボール弁８を開放し、該プランジヤ
式定量ポンプ１内に流入して、プランジヤ式定量
ポンプ１内に充満する。 The solvent in the solvent tank 10 is pressurized by the pressure pump 12, and the suction ball valve 8 is opened through the pulsation absorbing chamber 15 into the plunger-type metering pump 1 in which the plunger 6 is retracted. It flows into the plunger type metering pump 1 and fills the plunger type metering pump 1.
プランジヤ式定量ポンプ１内に充満された溶媒
は、加圧ポンプ１２によつて圧縮状態にあり、プ
ランジヤ式定量ポンプ１内の内壁やシール部材７
等も既に変形した状態となつている。この状態で
プランジヤ式定量ポンプ１のプランジヤ６が前進
すると、プランジヤ式定量ポンプ１内の溶媒は、
若干加圧されて吐出ボール弁９を開放し、カラム
１１へと吐出される。 The solvent filled in the plunger type metering pump 1 is in a compressed state by the pressurizing pump 12, and the inner wall and seal member 7 inside the plunger type metering pump 1 are compressed.
etc. are already in a transformed state. When the plunger 6 of the plunger type metering pump 1 moves forward in this state, the solvent inside the plunger type metering pump 1 is
It is slightly pressurized, opens the discharge ball valve 9, and is discharged into the column 11.
このとき、プランジヤ６が前進する以前にプラ
ンジヤ式定量ポンプ１内は、前述の如く既に加圧
状態であつたため、プランジヤ６の前進による溶
媒の圧縮、プランジヤ式定量ポンプ１内の変形等
がほとんど生ずることが無く、プランジヤ６の前
進ストロークが直接吐出流量を支配する。 At this time, since the interior of the plunger type metering pump 1 was already pressurized as described above before the plunger 6 moved forward, compression of the solvent and deformation of the interior of the plunger type metering pump 1 occur due to the advancement of the plunger 6. The forward stroke of the plunger 6 directly controls the discharge flow rate.
ここでプランジヤ式定量ポンプ１の吐出圧力と
吸入圧力との差が著しく大きい場合は、従来と同
様に吐出流量に誤差が生ずるので、この差を小さ
く、例えば20Kg／cm2に保持すべく制御回路１８は
設定されている。従つて分析条件等に応じてプラ
ンジヤ式定量ポンプ１の吐出圧力を、例えば200
Kg／cm2に設定すると、この吐出圧力を圧力センサ
１７が検出して制御回路１８に入力し、制御回路
１８は、圧力センサ１４により検出される加圧ポ
ンプ１２の吐出圧力が180Kg／cm2となるように加
圧ポンプ１２モータ（図示せず）の回転数を演算
して出力し、加圧ポンプ１２を制御する。 If the difference between the discharge pressure and the suction pressure of the plunger metering pump 1 is extremely large, an error will occur in the discharge flow rate as in the past, so the control circuit is designed to keep this difference small, for example, 20 kg/cm 2 . 18 is set. Therefore, depending on the analysis conditions, etc., the discharge pressure of the plunger type metering pump 1 can be adjusted to, for example, 200
When set to Kg/cm 2 , the pressure sensor 17 detects this discharge pressure and inputs it to the control circuit 18 , and the control circuit 18 determines that the discharge pressure of the pressurizing pump 12 detected by the pressure sensor 14 is 180 Kg/cm 2 . The rotation speed of the pressure pump 12 motor (not shown) is calculated and output so that the pressure pump 12 is controlled.
即ち、加圧ポンプ１２は、プランジヤ式定量ポ
ンプ１の吸入圧力をプランジヤ式定量ポンプ１の
吐出圧力に応じて高めておくために用いられるも
ので、その加圧力は、両圧力センサ１４，１７か
らの信号を演算する制御回路１８により、プラン
ジヤ式定量ポンプ１の吐出圧力に対し、若干低い
圧力に自動的に制御される。加圧された溶媒は、
脈動吸収用チヤンバ１５に蓄えられ、脈動が吸収
される。 That is, the pressurizing pump 12 is used to increase the suction pressure of the plunger type metering pump 1 according to the discharge pressure of the plunger type metering pump 1, and the pressurizing force is obtained from both pressure sensors 14 and 17. The pressure is automatically controlled to be slightly lower than the discharge pressure of the plunger type metering pump 1 by the control circuit 18 that calculates the signal. The pressurized solvent is
The pulse is stored in the pulsation absorbing chamber 15 and the pulsation is absorbed.
プランジヤ式定量ポンプ１は、脈動吸収用チヤ
ンバ１５内に加圧されて蓄えられた溶媒を、所定
量吸入して吐出するものである。プランジヤ式定
量ポンプ１に吸入される溶媒は、既に加圧されて
いるので、プランジヤ６の前進時に新たに溶媒を
圧縮したり、プランジヤ式定量ポンプ１の内壁や
シール部材等を変形させる与圧ストロークがなく
なり、プランジヤ６のストロークが全て実効スト
ロークとなるため、設定通りの正確な流量が得ら
れる。 The plunger type metering pump 1 sucks in and discharges a predetermined amount of a pressurized solvent stored in a pulsation absorbing chamber 15. Since the solvent sucked into the plunger-type metering pump 1 is already pressurized, the solvent is newly compressed when the plunger 6 moves forward, and the pressurization stroke deforms the inner wall, sealing member, etc. of the plunger-type metering pump 1. Since the stroke of the plunger 6 becomes all the effective stroke, the accurate flow rate as set can be obtained.
したがつて、溶媒の種類、溶媒の送液条件、負
荷圧等に変動があつても、これらに無関係に定流
量性が得られる。 Therefore, even if there are variations in the type of solvent, the conditions for feeding the solvent, the load pressure, etc., constant flow performance can be obtained regardless of these.
本発明は、上述の如く、溶媒槽とカラムとを連
結する流路に、加圧ポンプと、脈動吸収用チヤン
バと、吸入ボール弁及び吐出ボール弁を有するプ
ランジヤ式定量ポンプとを直列に配設し、加圧ポ
ンプの吐出側とプランジヤ式定量ポンプの吸入ボ
ール弁側とを連結する連結チユーブに連結したプ
ランジヤ式定量ポンプの吸入圧力を測定する圧力
センサと、プランジヤ式定量ポンプの吐出ボール
弁側とカラムとを連結する連結チユーブに連結し
たプランジヤ式定量ポンプの吐出圧力を測定する
圧力センサからの信号を演算し、加圧ポンプの加
圧力を制御して、両連結チユーブ内の圧力差を一
定に保持する制御回路を設けたので、プランジヤ
式定量ポンプに吸入される溶媒は、加圧ポンプで
既に加圧されているから、プランジヤの前進時に
新たに溶媒を圧縮したり、プランジヤ式定量ポン
プの内壁やシール部材等を変形させる与圧ストロ
ークがなくなり、プランジヤのストロークが全て
実効ストロークとなるため、設定通りの正確な流
量が得られる。
As described above, the present invention includes a pressurizing pump, a pulsation absorbing chamber, and a plunger-type metering pump having a suction ball valve and a discharge ball valve arranged in series in a flow path connecting a solvent tank and a column. and a pressure sensor that measures the suction pressure of the plunger metering pump connected to a connecting tube that connects the discharge side of the pressure pump and the suction ball valve side of the plunger metering pump, and a pressure sensor that measures the suction pressure of the plunger metering pump, and a pressure sensor that measures the suction pressure of the plunger metering pump. The signal from the pressure sensor that measures the discharge pressure of the plunger-type metering pump connected to the connecting tube that connects the and column is calculated, and the pressurizing force of the pressurizing pump is controlled to maintain a constant pressure difference in both connecting tubes. Since the solvent sucked into the plunger-type metering pump is already pressurized by the pressurizing pump, the solvent can be newly compressed when the plunger advances, and the plunger-type metering pump can be There is no pressurizing stroke that deforms the inner wall, sealing member, etc., and the entire stroke of the plunger becomes an effective stroke, so an accurate flow rate as set can be obtained.
したがつて、溶媒の種類、溶媒の送液条件、負
荷圧等に変動があつても、加圧ポンプの加圧力が
制御回路により自動的に制御されるので、これら
に無関係に定流量性が得られる。 Therefore, even if there are fluctuations in the type of solvent, solvent delivery conditions, load pressure, etc., the pressurizing force of the pressurizing pump is automatically controlled by the control circuit, so constant flow performance is maintained regardless of these changes. can get.
また、加圧ポンプで加圧された溶媒は、脈動吸
収用チヤンバに蓄えられるので、脈動が吸収さ
れ、安定した状態となる。 Further, since the solvent pressurized by the pressure pump is stored in the pulsation absorbing chamber, pulsations are absorbed and a stable state is achieved.
しかも、定量ポンプとして、従来の吸入ボール
弁及び吐出ボール弁を有するプランジヤ式ポンプ
をそのまま利用できるため、特に複雑な弁機構等
を必要としない。 Furthermore, since a conventional plunger type pump having a suction ball valve and a discharge ball valve can be used as is as a metering pump, a particularly complicated valve mechanism or the like is not required.
第１図は従来のプランジヤ式定量ポンプを示す
縦断面図、第２図は本発明の一実施例を示す概略
図である。
１……プランジヤ式定量ポンプ、１１……カラ
ム、１２……加圧ポンプ、１３，１６……連結チ
ユーブ、１４，１７……圧力センサ、１５……脈
動吸収用チヤンバ、１８……制御回路、Ａ……高
圧定量ポンプ。
FIG. 1 is a longitudinal sectional view showing a conventional plunger type metering pump, and FIG. 2 is a schematic diagram showing an embodiment of the present invention. DESCRIPTION OF SYMBOLS 1... Plunger type metering pump, 11... Column, 12... Pressure pump, 13, 16... Connection tube, 14, 17... Pressure sensor, 15... Pulsation absorption chamber, 18... Control circuit, A...High pressure metering pump.
Claims (1)
ンプと、吸入ボール弁及び吐出ボール弁を有する
プランジヤ式定量ポンプとを直列に配設し、該加
圧ポンプの吐出側とプランジヤ式定量ポンプの吸
入ボール弁側とを連結する連結チユーブに、脈動
吸収用チヤンバと前記プランジヤ式定量ポンプの
吸入圧力を測定する圧力センサとを夫々連結し、
前記プランジヤ式定量ポンプの吐出ボール弁側と
カラムとを連結する連結チユーブに、プランジヤ
式定量ポンプの吐出圧力を測定する圧力センサを
連結すると共に、前記両圧力センサからの信号に
より加圧ポンプの加圧力を演算制御して、前記両
連結チユーブ内の圧力差を一定に保持する制御回
路を設けたことを特徴とする液体クロマトグラフ
イー等の高圧定量ポンプ装置。1. A pressure pump and a plunger-type metering pump having a suction ball valve and a discharge ball valve are arranged in series in the flow path connecting the solvent tank and the column, and the discharge side of the pressure pump and the plunger-type metering pump are connected in series. A pulsation absorbing chamber and a pressure sensor for measuring the suction pressure of the plunger metering pump are respectively connected to a connecting tube connecting the suction ball valve side of the pump,
A pressure sensor for measuring the discharge pressure of the plunger-type metering pump is connected to a connecting tube that connects the discharge ball valve side of the plunger-type metering pump and the column, and a pressure sensor for measuring the discharge pressure of the plunger-type metering pump is connected to the connection tube that connects the discharge ball valve side of the plunger-type metering pump to the column. A high-pressure metering pump device for liquid chromatography or the like, characterized in that a control circuit is provided for calculating and controlling the pressure to maintain a constant pressure difference between the two connecting tubes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17499683A JPS6067790A (en) | 1983-09-21 | 1983-09-21 | High pressure constant volume pump for liquid chromatography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17499683A JPS6067790A (en) | 1983-09-21 | 1983-09-21 | High pressure constant volume pump for liquid chromatography |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6067790A JPS6067790A (en) | 1985-04-18 |
| JPH0472070B2 true JPH0472070B2 (en) | 1992-11-17 |
Family
ID=15988392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17499683A Granted JPS6067790A (en) | 1983-09-21 | 1983-09-21 | High pressure constant volume pump for liquid chromatography |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6067790A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11486374B2 (en) | 2018-03-28 | 2022-11-01 | Nikkiso Co., Ltd. | Non-pulsating pump and method of controlling the same |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8292598B2 (en) | 2004-11-23 | 2012-10-23 | Entegris, Inc. | System and method for a variable home position dispense system |
| WO2007067358A2 (en) | 2005-12-02 | 2007-06-14 | Entegris, Inc. | System and method for pressure compensation in a pump |
| US7878765B2 (en) * | 2005-12-02 | 2011-02-01 | Entegris, Inc. | System and method for monitoring operation of a pump |
| JP6115014B2 (en) * | 2012-03-13 | 2017-04-19 | セイコーエプソン株式会社 | Fluid circulation device and medical device using fluid circulation device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5011066A (en) * | 1973-05-30 | 1975-02-04 | ||
| JPS5442446A (en) * | 1977-09-12 | 1979-04-04 | Yamauchi Rubber Ind Co Ltd | Corrosion resistant wire for high tension cable and producing apparatus thereof |
-
1983
- 1983-09-21 JP JP17499683A patent/JPS6067790A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5011066A (en) * | 1973-05-30 | 1975-02-04 | ||
| JPS5442446A (en) * | 1977-09-12 | 1979-04-04 | Yamauchi Rubber Ind Co Ltd | Corrosion resistant wire for high tension cable and producing apparatus thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11486374B2 (en) | 2018-03-28 | 2022-11-01 | Nikkiso Co., Ltd. | Non-pulsating pump and method of controlling the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6067790A (en) | 1985-04-18 |
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