JPH0471889B2 - - Google Patents

Description

[Detailed description of the invention]

[Field of Industrial Application] The present invention relates to a bactericidal composition, more specifically, a bactericidal composition containing a sulfur agent silver salt and a surfactant to improve the bactericidal effect and thermal stability of the sulfur agent silver salt. relating to things. [Prior Art and its Problems] Many sulfur agents having excellent bactericidal or bacteriostatic effects have been known. However, it has been desired to provide a preparation that further improves the bactericidal, bacteriostatic effects and thermal stability of the sulfur agent. [Means for Solving the Problem] Under such circumstances, the present inventor has conducted intensive research and found that if a specific surfactant is blended with the silver salt of the sulfur agent, the bactericidal effect of the silver salt of the sulfur agent can be improved. The present invention has been completed based on the discovery that the thermal stability is significantly improved. That is, the present invention provides one or more surfactants selected from sulfur agent silver salts, polyoxyethylene fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene alkyl ether phosphate salts, and alkyl sulfate salts. The present invention provides a disinfectant composition containing the following. The sulfur agent silver salt used in the present invention includes:
For example, what is shown by the following formula can be mentioned. These silver salts are prepared according to a conventional method, for example, by dropping silver nitrate onto a sodium salt of a sulfur agent. Moreover, the following can be mentioned as a surfactant. Polyoxyethylene fatty acid ester Polyoxyethylene (6) monolaurate (product name: NIKKOL MYL-6) Polyoxyethylene (10) monolaurate (product name: NIKKOL MYL-6)
NIKKOL MYL10) Polyoxyethylene (30) monolaurate (NIKKOL MYL10)
NIKKOL MYL-30) Polyoxyethylene alkyl ether Polyoxyethylene(2) lauryl ether (NIKKOL MYL-30)
NIKKOL BL-2) Polyoxyethylene (4.2) lauryl ether (NIKKOL BL-4.2) Polyoxyethylene (9) lauryl ether (NIKKOL BL-4.2)
NIKKOL BL-9EX) Polyoxyethylene (21) lauryl ether (NIKKOL BL-9EX)
NIKKOL BL-21) Polyoxyethylene (25) lauryl ether (NIKKOL BL-21)
NIKKOL BL-25) Polyoxyethylene alkyl ether phosphate ester salt Polyoxyethylene (10) sodium lauryl ether phosphate (NIKKOL SLP-N) Polyoxyethylene (4) sodium lauryl ether phosphate (NIKKOL TLP-4) Alkyl sulfate ester salt Sodium lauryl sulfate (NIKKOL SLS)
Potassium lauryl sulfate (NIKKOL KLS) Monoethanolamine lauryl sulfate (NIKKOL KLS)
MEALS) Lauryl sulfate diethanolamine Lauryl sulfate triethanolamine (MEALS)
NIKKOL TEALS) The bactericidal composition of the present invention can be made into a cream, ointment, sterilizing effervescent tablet, etc. by a known method, and the dosage thereof is the same as that of a normal bactericidal agent using a sulfur agent. shall be determined accordingly. To prepare the disinfectant composition of the present invention, 0.001% or more of a surfactant is added to the composition, and 1 % of a sulfur agent silver salt is added to the composition.
It is sufficient if the weight ratio is 0.001 or more. In particular,
A particularly preferred amount of surfactant in the composition is 0.01
~1%, weight ratio 6.5 to 1 sulfur agent silver salt
~20000. [Effect] Next, the results of testing the bactericidal effect of the bactericidal composition of the present invention will be shown. Test Example 1 Polyoxyethylene (9) lauryl ether and sodium lauryl sulfate were dissolved in sterilized water and 100%
mg/ml, 20mg/ml, 2mg/ml, 0.2mg/ml and
Make a 0.02mg/ml solution. Dispense 5 ml of each of these into different test tubes, and add the above compound 1 dissolved or suspended in sterile water to each concentration.
Add 5 ml of the solution to prepare composition sample solutions of various concentrations. After keeping each sample solution in a 37°C constant temperature bath for about 3 hours, it was added to Escherichia coli O-1, which had been previously cultured at 37°C for 20 to 24 hours.
Add 1 ml of culture solution of Pseudomonas aeruginosa IFO13736 or Staphylococcus aureus ATCC6538P, and after 1 hour, inoculate one platinum loopful of this solution into ordinary broth culture medium. The presence or absence was observed. Also to check thermal stability
Similar tests were also conducted on each sample solution that had been autoclaved at 120°C for 20 minutes. The results are shown in Table 1-A and Table 1-B.

【table】

【table】

[Table] Test Example 2 Dissolve the test surfactant in sterile water to make a 20 mg/ml solution. 5 ml of each of these was dispensed into different test tubes, and 5 ml of a sulfur agent silver salt solution dissolved or suspended in sterile water at each concentration was added to prepare composition sample solutions at each concentration. Thereafter, the MLC value for Pseudomonas aeruginosa IFO13736 was measured in the same manner as in Test Example 1. In this test, the results without heating are shown in Table 2-A, and the results with heating are shown in Table 2-B.

【table】

〔Example〕

Next, the present invention will be described with reference to reference examples and examples. Reference example 1 Suspend 2.78g of sulfamethazine in 20ml of water,
Add 0.40 g of sodium hydroxide dissolved in 20 ml of water dropwise. Stir for 5 to 30 minutes and filter out the insoluble portion. A solution of 1.70 g of silver nitrate dissolved in 20 ml of water is added dropwise to the solution, then 40 ml of water is added and stirred for 30 minutes to 1 hour. The precipitated crystals are washed successively with water, ethanol, and ether, and air-dried to obtain 3.27 g of sulfamethazine silver salt (compound 5) (yield: 85%).
Melting point over 300℃. Reference Example 2 Dissolve 2.86 g of sulfamerazine sodium salt in 20 ml of water and filter the insoluble portion. Add silver nitrate to the solution
A solution of 1.70 g dissolved in 20 ml of water is added dropwise, then 40 ml of water is added and stirred for 30 minutes to 1 hour. Wash the precipitated crystals sequentially with water, ethanol, and ether,
When air-dried, sulfamerazine silver salt (compound 4)
3.27 g (yield 88%) is obtained. Melting point 272-275°C (decomposition). Example 1 (Hydrophilic ointment) 100g of hydrophilic ointment with the following ingredients and amounts according to the usual method
was manufactured. Silver sulfabenzamide 0.1g Polyoxyethylene (9) lauryl ether 1.5g White petrolatum 14g Stearyl alcohol 22g Propylene glycol 15g Isopropanol ester 8g Add purified water to bring the total amount to 100g. Example 2 (Macrogol ointment) Macrogol ointment with the following ingredients and amounts according to the usual method
100g was produced. Silver sulfabenzamide 0.1g Polyoxyethylene (9) lauryl ether 2g Propylene glycol 10g Macrogol 4000 44g Macrogol 400 43.9g Example 3 (Sterilized effervescent tablets) One tablet with the following ingredients and quantities was manufactured according to a conventional method. . ^N1 Silver acetylsulfanilamide 100mg Sodium lauryl sulfate 1000mg Citric acid 700mg Sodium hydrogen carbonate 1000mg Hydroxypropylcellulose 10mg Adjust the total amount to 4000mg with mannitrate.

Claims (1)

[Claims] 1. A disinfectant containing a sulfur agent silver salt and one or more surfactants selected from polyoxyethylene fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene alkyl ether phosphate ester salts, and alkyl sulfate ester salts. Composition.