JPH043927B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to improvements in insect-proof collars for animals. Traditionally, devices designed to gradually release contact insecticides have been used to protect animals from parasites, especially ectoparasites. Most of these devices contain the insecticide within a plastic matrix. Ectoparasitic insecticides act by evaporation or by adhering to the animal's hair and are effective in controlling parasites for several months due to their slow release. Various insect repellent devices have been devised and patented (for example, applicant's French Patent No. 2447679;
No. 2268859, No. 2307466, No. 2436563, No. 2370572, No. 2213014, No. 2374853,
Same No. 2386253, Same No. 2386254, Same No. 2392606
issue). These are basically composed of the following three elements. ● Pesticide (or mixture of pesticides) ● Support (substrate is usually a thermoplastic resin) ● Auxiliary agents (plasticizers, diffusion control agents, etc.) The selection of these basic components is extremely important. In practice, it is difficult to create a device that is effective against parasites, releases slowly and regularly, and is completely harmless both to the animal and the environment, especially children. Even if most and all of these shortcomings of insect collars are resolved, very significant drawbacks remain. That is, either rapidly or after some time after use, animals develop allergic reactions due to local abnormalities such as reddening of the skin, eczema, blotchy fur, and decreased skin flexibility, and/or systemic abnormalities such as vomiting and weight loss. Accordingly, one of the objects of the present invention is to provide a device for controlling ectoparasites, namely a collar, which has a higher practical value than previously known devices for controlling ectoparasites, in particular, which maintains high effectiveness over a long period of time and which is suitable for use in animals. To provide a device for preventing external parasites, that is, a collar, which does not cause any skin damage. According to the present invention, there is provided an insect-proof collar for animals having an insecticidal means that uses at least one insecticidal ingredient in combination with at least one compound selected from unsaturated essential fatty acids having 18 to 22 carbon atoms. . The inventors' extensive experience in the field of animal insect control has shown that insect collars can only be used for a short period of time (and lack durability) due to the lack of certain necessary fatty acids in the animal's skin tissue. Something was observed. According to the present invention, the insecticidal means further includes the following two elements. ● Thermoplastic solid polymer support ● Auxiliary agents (plasticizers and/or inert fillers, and/or dyes and/or deodorizing agents, and/or stabilizers, and/or diffusion regulators) A preferred embodiment of the present invention In embodiments, the insecticidal component is selected from organochlorine compounds and/or organophosphorus compounds and/or carbamate compounds and/or pyrethroid compounds and/or formamidine. In another embodiment, the organochlorine compound is: O,O-dimethyl O-(2,2-dichlorovinyl) phosphate (DDVP); Dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate (NALED). ) ●2-chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phophosphate (STIROFOS). In yet another embodiment, the organophosphorus compound is O,O-diethyl O-2-isopropyl-
4-Methyl-6-pyrimidyl thiophosphate (DIMPYLATE) and O,O-diethyl O-
2-isopropyl-4-methyl-6-pyrimidinyl phosphate (DIAZOXON). In yet another embodiment, the carbamate compound is 2,2-dimethyl-1,3-benzodioxol-4-ol-N-methylcarbamate (BENDIOCARB), 2-isopropoxyphenyl-N-methylcarbamate. (PROPOXUR)
and 1-naphthyl-N-methylcarbamate (CARBARYL). In yet another example, the pyrethroid compound is (±)-α-cyano-3-phenoxybenzyl-(±)-cis, trans-3-(2,2-dichlorovinyl)-2,2- Dimethylcyclopropanecarboxylate (CYPERMETHRIN), α-cyano-3-phenoxybenzyl-2-(4-chlorophenyl)-3-methylbutyrate (FENVALERATE), 5-benzyl-3-furylmethyl-2,2- Dimethyl-3-(2-oxo-2,3,4,5-tetrahydro-3-thienylidenemethyl)-cyclopropanecarboxylate (KADETHRIN), 3-phenoxybenzyl-
2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate (PERMETHRIN) and N-(3,4,5,6-
(tetrahydrophthalimido) methyl-cis, trans-chrysanthemate (NEOPYNAMIN). In yet another embodiment, the formamidine is
N'-(4-chloro-O-tolyl)-N,N-dimethylformamidine (CHLORDIMEFORM) and N-methyl-N'-2,4-xylyl-N-(N
-2,4-xylylformimidoyl)formamidine (AMITRAZ). According to the present invention, the free or esterified unsaturated essential fatty acids include oleic acid, linoleic acid, linolenic acid, arachidonic acid, 11,14-eicosadienoic acid, docosahexaenoic acid, and those having 1 to 4 carbon atoms. selected from the group consisting of linear or branched esters. In another preferred embodiment, vitamin F is used as the fatty acid. Thermoplastic solid polymer supports vary depending on the insecticidal component or unsaturated essential fatty acid used, and include, for example, polyethylene, polypropylene, copolymers of ethylene and propylene, polyacrylates, vinyl polymers, polyvinyl halides, polyvinyl acetals, and polyvinyl halides. Vinylidene compounds, polyurethane,
Polyaldehyde and the like can be used, and a homopolymer of polyvinyl chloride or a copolymer of this with another polymer is particularly preferred. Plasticizers necessary to impart flexibility, mechanical strength and desired surface properties include, for example, phosphoric acid esters such as tricresyl phosphate; methyl, butyl, octyl esters of phthalic acid;
Phthalate esters such as ethyl-2-hexyl ester; adipate esters, azelaic esters, sebacic esters, maleic esters, and the like. The most commonly used adjuvants are dyes,
Deodorants such as ethyl vanilla, vanillin, and limonene,
There are stabilizers, etc. Other adjuvants include diffusion control agents which serve to alter the porosity of the plastic strip by evaporation or decomposition during manufacture.
As the diffusion control agent, nitrogen derivatives such as benzenesulfonylhydrazine and trihydrazinotriazine, and azo derivatives such as azodiisobutyronitrile, diazoaminobenzene and azodicarbonamide are used. In the present invention, pigments, lubricants, complexes of metals such as cadmium, barium, lead, etc. can be added. Additionally, inert fillers such as talc, silica, etc. can be added to reduce the amount of resin and facilitate the use of thermoplastic strips. The composition of the insecticidal device of the present invention includes 5 to 25% insecticidal ingredients, 1 to 10% unsaturated essential fatty acids, 10 to 50%
% polymeric support and 1 to 15% of various adjuvants. In a particularly preferred embodiment of the invention, the insecticidal ingredient used in combination with the fatty acid is DIMPYLATE, used in combination with vitamin F. In the course of subsequent research, the physical appearance (solid or liquid), melting point, boiling point, vapor pressure, thermal or chemical stability, etc., may be determined due to the physicochemical properties of the active ingredients, such that the two active ingredients can be used simultaneously and in an orderly manner. It has been observed that there are cases where diffusion is not possible as well. This rate of diffusion can vary widely in some cases. To select appropriate polymeric supports, plasticizers, additives, fillers and diffusion modifiers,
In some cases, taking into account the physicochemical properties of these two active ingredients (insecticidal ingredients and fatty acids), it is necessary to ensure that their release rates are as similar as possible, if not substantially the same. . One of the objects of the present invention is to produce an insect-proof collar that is not limited by the incompatibility between one of the active ingredients and an unsaturated essential fatty acid. Another object of the present invention is to provide an insect-proof collar for animals having an insecticidal means containing at least one type selected from unsaturated essential fatty acids having 18 to 22 carbon atoms and at least one type of insecticidal component. mixed double strap
one strip contains the insecticidal ingredient, the other contains the fatty acid, and each of the two strips has a thermoplastic polymeric support. An object of the present invention is to provide an insect-proof collar for animals, characterized in that it contains an auxiliary agent selected from a plasticizer, an inert filler, a dye, a deodorizer, a stabilizer, and a diffusion control agent. By joining two plastic strips laterally, each containing one of the active ingredients, the requirements for diffusion and release can be met to the highest degree. In a particularly preferred embodiment of the invention, this mixed string is obtained by hot co-extrusion. In another embodiment of the invention, the mixed string is obtained by molding. However, by whatever technical means (coextrusion or molding) the strips are produced, the properties of the excipients and supports must be adapted to the respective physicochemical properties of the two active ingredients. Therefore, it is extremely easy to keep the operating conditions constant. As a result, the effectiveness of the insecticidal device is greatly improved, and manufacturing limitations and manufacturing costs are significantly reduced, while maintaining the above-mentioned durability performance. Although various methods can be considered for manufacturing the device of the present invention, the so-called hot coextrusion method is industrially most suitable. Hot coextrusion is now widely used in the rubber and plastic materials industry and is a process in which extrudates from two different mixtures are simultaneously extruded through the passages of a single mixing extrusion head. It is manufactured. In this way, by separately preparing two mixtures of ingredients that are compatible with the properties of the active ingredients,
The end result is a more effective insecticidal device. Such a manufacturing method is particularly useful when the two active ingredients have significantly different physicochemical properties. Therefore, even if unsaturated essential fatty acids having 18 to 22 carbon atoms or their esterified derivatives are viscous liquids, the insecticidal component of the present invention is an organochlorine, organophosphorus, or pyrethroid liquid compound or carbamate. , can be a solid compound of formamidine. Furthermore, each group of compounds has different boiling or melting points, a wide range of vapor pressures, and different thermal or chemical stability criteria. It is well known to those skilled in the art that the properties of the polymeric support, adjuvants, etc. have a significant influence on the rate of diffusion and therefore the rate of release and activity. It is clear that the combination of carbamate and/or formamidine with fatty acid ester gives the best results, even if the composition of each component is different. A result is considered "best" if the diffusion rate of each compound is the same. Therefore, depending on the respective compound used, the auxiliary and/or support may, on the basis of one compound,
One must choose one that will speed up or slow down the release of the other compound. The appearance of the device of the invention is in the form of a mixed string, the dimensions of each part being determined by the proportion of active ingredient and its insecticidal or repellent activity, but usually for domestic animals (dogs or cats). It must be compatible with the needs of a cord that can be used as an insect-proof collar. As for the final string dimensions, the width should be approximately 15 to 30
mm, the thickness is approximately 2 to 5 mm, and the length is usually such that it can accommodate the neck of a large livestock.
Preferably, the device is sized to suit each type of domestic animal, such as cats, puppies, dogs, canines, etc. The proportion of insecticidal components ranges from 5 to 25%, and the proportion of fatty acids ranges from 1 to 10%, which is a relatively wide range, so the width of each part varies depending on the proportion of the compound. Usually, the width of the insecticidal part is 10 to 20 mm, and the width of the fatty acid part is 5 mm.
It is from 10mm to 10mm. Since the two mixtures are manufactured separately, each part can contain dyes, pigments, or different light-reflecting or fluorescent materials. In addition to the features described above, the invention also has other features described below. The present invention relates to an insect-proof collar for animals and a method for manufacturing the same. Hereinafter, embodiments of the device of the present invention, composition examples of the device, and animal clinical experiment examples will be given to explain the present invention in more detail. It is not limited. Examples of compositions Examples 1 Parts by weight Active ingredients DIMPYLATE 15 Methyl linoleate 2 Methyl linolenate 3 Additives 2-ethylhexyl adipate 20 Epoxidized soybean oil 5 Calcium stearate 2 Black iron oxide 0.5 Ultrafine silica 1.5 Azodicarbonamide 2 Vinyl chloride homopolymer 49 Example 2 Parts by weight Active ingredient DIMPYLATE 18 Neutral vitamin F 6 Additive isooctyl adipate 23 Epoxidized soybean oil 3 Calcium stearate 2 Red iron oxide 0.5 Ultrafine silica 2 Azodicarbonamide 2 PVC alone Polymer 43.5 Example 3 Parts by weight Active ingredients BENDIOCARB 10 Methyl linoleate 1.5 Methyl linoleate 1.5 Methyl oleate 2 Additives Butyl phthalate 15 Methyl phthalate 10 Epoxidized soybean oil 5 Calcium stearate 2 Red iron oxide 0.25 Black iron oxide 0.25 Azodicarbonamide 2 PVC homopolymer 50.5 Example 4 Parts by weight Active ingredients BENDIOCARB 8 Neutral vitamin F 6 Additives Isooctyl adipate 10 Methyl adipate 15 Epoxidized soybean oil 5 Calcium stearate 2 Azodicarbonamide 2 PVC homopolymer 52 Example 5 Parts by weight Active ingredient CYPERMETHRIN 5 Methyl docosahexanoate 6 Additives Butyl adipate 10 Methyl adipate 10 Calcium stearate 2 Barium/cadmium complex 1 Ultrafine silica 2 Black iron oxide 0.5 PVC homopolymer 63.5 Example 6 Weight Part active ingredient FENVALERATE 6 Methyl linolenate 3 Additive Isooctyl adipate 10 Methyl adipate 15 Epoxidized soybean oil 3 Calcium stearate 2 PVC homopolymer 61 Example 7 Part by weight Active ingredient AMITRAZ 10 Neutral vitamin F 5 Additive 2 -Ethyl-hexyl phthalate 12.5 Butyl phthalate 12.5 Epoxidized soybean oil 5 Calcium stearate 1.5 Black iron oxide 0.5 Red iron oxide 0.5 Azodicarbonamide 2.5 PVC homopolymer 50 Collar production example The composition of Example 2 was used. In a suitable container, 36 kg of DIMPYLATE, 12 kg of neutral vitamin F, 46 kg of isooctyl adipate and 6 kg of epoxidized soybean oil were mixed, and the mixture was then colored with about 1 kg of red iron oxide. 87 kg of PVC homopolymer, 4 kg of calcium stearate, 4 kg of ultrafine silica, and 4 kg of azodicarbonamide were placed in a heating mixer. The former mixture was poured into this mixer with stirring. The resulting dough was kneaded until it became a uniform red color. The mixture was heated to approximately 70°C and stirred for 30 minutes. The resulting powder was placed in the hopper of a screw extruder. The extrusion parameters, namely extrusion head or die temperature, die head pressure, extrusion speed, and cooling rate, were such that the resulting cord was uniform in appearance and size. The string was cut to length and a closure was stapled to one end. Place the obtained insect-proof collar in a triple-layered (PVC-aluminum-paper) packet.
Heat sealed. The manufacturing process was the same as above for all examples, with modifications based on differences in the physical properties of the ingredients. Example of manufacturing mixed double string Two types of mixtures A and B are prepared. Mixture A
contains insecticidal ingredients and mixture B contains fatty acids. The two mixtures (of which several different compositions are discussed below) are homogenized and placed separately into two hoppers of a dual extruder. The two sized strips are passed through a common die head at the exit to effect a lateral bond. This production process can also be carried out using two different extruders connected at the outlet to a single die head, whereby the transverse joining of the first two strands takes place, Final adjustments are made to the shape of the single string. This method has the advantage that extrusion parameters such as die temperature, pressure, and extrusion speed can be adjusted separately. Composition Examples Example 8 Mixture A Part by weight Active ingredient DIMPYLATE (O,O-diethyl O-2-
Isopropyl-4-methyl-6-pyrimidyl
Thiophosphate) 15 Additive Epoxidized soybean oil 3 Calcium stearate 2 2-ethylhexyl phthalate 20 Azodicarbonamide 2 Red iron oxide 0.25 Black iron oxide 0.25 PVC homopolymer 57.5 Mixture B Part by weight Active ingredient Neutral vitamin F 12 Additive Epoxy Chemicalized soybean oil 3 Butyl phthalate 25 Yellow pigment 0.50 Calcium carbonate 5 Calcium stearate 2 PVC homopolymer 57.5 Preparation of mixture A 95% DIMPYLATE 32Kg, epoxidized soybean oil 6Kg, 2-ethylhexyl phthalate 40Kg and calcium stearate 4 kg were mixed in a container and colored with a mixture of two iron oxides. 50 kg of PVC homopolymer and 4 kg of azodicarbonamide were placed in a heating mixer. The above-mentioned mixture was placed in this heating mixer with stirring and heated at 70° C. for 30 minutes. Then PVC
Add the remaining amount of homopolymer, stir while cooling,
A dry, homogeneous powder of uniform brown color was obtained. Preparation of Mixture B A powder of Mixture B was obtained in the same manner as in the case of Mixture A, except that the temperature was lower than 40°C. The powder of Mixture A was placed in the hopper of an extruder and the powder of Mixture B was placed in the hopper of another extruder. The temperature of the extrusion head was adjusted to 100°C for mixture A, 90°C for mixture B, and 90°C for the coextrusion head. At the exit of the die, the resulting mixed string was cooled by passing it through cold water. Cut the string to the desired length and attach a buckle to one end. The standard dimensions obtained from the shape of the die are as follows. Total width 15 mm Width of insecticidal part (brown) 10 mm Width of fatty acid part (yellow) 5 mm Thickness 3 mm Example 9 Mixture A Part by weight Active ingredient AMITRAZ (N-methyl-N'-2,4-xylyl-N-(N) -2,4-xylylformimidoyl)formamidine) 8 Additives Octyl adipate 25 Calcium stearate 2 Epoxidized soybean oil 5 Talc 12.5 White pigment 1 PVC homopolymer 46.5 Mixture B Part by weight Active ingredient Methyl linoleate 1.5 Methyl Linolenate 1.5 Methyl oleate 2 Additives Butyl phthalate 20 Epoxidized soybean oil 5 Calcium stearate 2 Calcium carbonate 15 Black iron oxide 0.5 PVC homopolymer 52.5 Preparation and extrusion were carried out in the same manner as in Example 8. Depending on the specifications of the coextrusion die, the dimensions of the resulting mixed string were as follows. Total width 20mm Width of insecticidal part (white) 15mm Width of fatty acid part (black) 5mm Thickness 2.5mm Example 10 Mixture A Active ingredient by weight PROPOXUR (2-isopropoxyphenyl-
N-Methyl carbamate) 10 Additives Diethyl phthalate 20 Dibutyl phthalate 5 Calcium stearate 5 Epoxidized soybean oil 5 Azodicarbonamide 1 Black iron oxide 0.5 PVC homopolymer 53.5 Mixture B Active ingredient by weight Methyl linoleate 15 Additive Dibutyl phthalate 20 Calcium stearate 5 Calcium carbonate 15 Yellow pigment 1 PVC homopolymer 44 The dimensions of the mixed string obtained by coextrusion were as follows. Overall width 15 mm Width of insecticidal part (black) 10 mm Width of fatty acid part (yellow) 5 mm Thickness 3 mm Clinical examples Numerous clinical observations on animal populations of different ages and species, including dogs and cats, have led to the use of insect-proof collars. It has been found that various skin disorders appear due to this. Insect collars contain free or esterified unsaturated essential fatty acids with 18 to 22 carbon atoms, especially vitamin F.
By including an acid with 18 carbon atoms that constitutes
It was found that these skin reactions were drastically reduced. Test Example 1 A test was conducted on two groups of dogs (P ₁ and P ₂ ) of different sexes, ages, and breeds. Each group is
It is made up of 500 animals. The study was conducted over a period of 10 weeks, and after wearing the collar, 2
Conditions were inspected weekly. In this test, the following disorders were determined to be skin disorders. ●Peeling ●Erythema ●Itching ●Neck hair removal Tests were conducted on collars C ₁ (invention) and C ₂ having the following compositions (% by weight).

[Table] Collar C ₁ was attached to group P ₁ , and collar C ₂ was attached to group P ₂ . The results are shown in Table 1 below. Numbers in the table indicate the number of dogs with local lesions.

[Table] Test Example 2 A test was conducted in the same manner as in Test Example 1 using cat populations P ₁ and P ₂ wearing the collars C ₁ and C ₂ , respectively. The results are shown in Table 2.

[Table] In Test Examples 1 and 2, the compositions of collars C ₁ and C ₂ were free from parasites (fleas and ticks) on the animals.
It was 95% effective in eradicating. Parasite-free animals were kept for 10 weeks during the study.
100% protected. In this case, the local damage was caused only by wearing the collar, and was caused by excessive scratching,
The problem was not caused by a flea problem. Test Example 3 Six dogs wearing collars C ₂ (see Test Example 1) and seven cats wearing collars C ₂ (see Test Example 2) were selected. All of these animals had skin lesions. Remove collar C ₂ and replace collar C ₁
was worn and observed for 5 weeks. The results are shown in Table 3, and it can be seen that the composition containing neutral vitamin F of the present invention can eliminate skin disorders in a very short period of time.

【table】

Claims (1)

[Scope of Claims] 1. A product for animals characterized by having an insecticidal means containing at least one compound selected from unsaturated essential fatty acids having 18 to 22 carbon atoms and at least one insecticidal component. Insect collar. 2. The insect-proof collar according to claim 1, wherein the insecticidal component is selected from an organic chlorine compound, an organic phosphorus compound, a carbamate compound, a pyrethroid compound, and formamidine. 3 The organic chlorine compound is O,O-dimethyl O-
(2,2-dichlorovinyl) phosphate, dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate, 2-chloro-1- (2,
The insect-proof collar according to claim 2, characterized in that the insect-proof collar is selected from 4,5-trichlorophenyl)vinyl dimethyl phosphate. 4 The organic phosphorus compound is O,O-diethyl O-2
-isopropyl-4-methyl-6-pyrimidyl
Thiophosphate and O,O-diethyl O-2
The insect-proof collar according to claim 2, characterized in that the insect-proof collar is selected from -isopropyl-4-methyl-6-pyrimidinyl phosphate. 5 The carbamate compound is 2,2-dimethyl-
1,3-Benzodioxol-4-ol-N-methylcarbamate, 2-isopropoxyphenyl-N-methylcarbamate and 1-naphthyl-N
- Insect-proof collar according to claim 2, characterized in that it is selected from methyl carbamates. 6 The pyrethroid compound is (±)-α-cyano-3-phenoxybenzyl-(±)-cis, trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, α-Cyano-3-phenoxybenzyl-2-(4-chlorophenyl)-3-methylbutyrate, 5-benzyl-3-furylmethyl-2,2-dimethyl-3
-(2-oxo-2,3,4,5-tetrahydro-3-thienylidenemethyl)-cyclopropanecarboxylate, 3-phenoxybenzyl-2,
2-dimethyl-3-(2,2-dichlorovinyl)
Cyclopropane carboxylate and N-(3,
4,5,6-tetrahydrophthalimido)methyl-
The insect-proof collar according to claim 2, characterized in that the collar is selected from cis and trans-chrysanthemate. 7 Formamidine is N′-(4-chloro-O-
tolyl)-N,N-dimethylformamidine and N-methyl-N'-2,4-xylyl-N-(N-
The insect-proof collar according to claim 2, characterized in that the insect-proof collar is selected from 2,4-xylylformimidoyl)formamidine. 8. The unsaturated essential fatty acids are selected from oleic acid, linoleic acid, linolenic acid, arachidonic acid, 11,14-eicosadienoic acid, docosahexaenoic acid, and linear or branched esters thereof having 1 to 4 carbon atoms. An insect-proof collar according to any one of claims 1 to 7. 9. The insect-proof collar according to claim 8, wherein the unsaturated essential fatty acid is vitamin F. 10 The insecticidal component is O,O-diethyl O-2-
10. The insect-proof collar according to claim 1, wherein the collar is isopropyl-4-methyl-6-pyrimidyl thiophosphate, and the unsaturated essential fatty acid is vitamin F. 11. An insect-proof collar for animals having an insecticidal means comprising at least one compound selected from unsaturated essential fatty acids having 18 to 22 carbon atoms and at least one insecticidal component, the insecticidal means further comprising: , thermoplastic solid polymer supports as well as plasticizers, inert fillers, dyes,
An insect-proof collar for animals, characterized in that it contains an auxiliary agent selected from a deodorizer, a stabilizer, and a diffusion regulator. 12. The insect-proof collar according to claim 11, wherein the insecticidal component is selected from an organic chlorine compound, an organic phosphorus compound, a carbamate compound, a pyrethroid compound, and formamidine. 13 The organic chlorine compound is O,O-dimethyl O
-(2,2-dichlorovinyl) phosphate,
Dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate, 2-chloro-1-
The insect-proof collar according to claim 12, characterized in that it is selected from (2,4,5-trichlorophenyl)vinyl dimethyl phosphate. 14 The organophosphorus compound is O,O-diethyl O-
2-isopropyl-4-methyl-6-pyrimidyl thiophosphate and O,O-diethyl O-
The insect-proof collar according to claim 12, characterized in that it is selected from 2-isopropyl-4-methyl-6-pyrimidinyl phosphate. 15 The carbamate compound is 2,2-dimethyl-1,3-benzodioxol-4-ol-N-
Methyl carbamate, 2-isopropoxyphenyl-N-methyl carbamate and 1-naphthyl-
The insect-proof collar according to claim 12, characterized in that it is selected from N-methyl carbamates. 16 The pyrethroid compound is (±)-α-cyano-3-phenoxybenzyl-(±)-cis, trans-3-(2,2-dichlorovinyl)-2,2-
Dimethyl cyclopropane carboxylate, α-
Cyano-3-phenoxybenzyl-2-(4-chlorophenyl)-3-methylbutyrate, 5-benzyl-3-furylmethyl-2,2-dimethyl-
3-(2-oxo-2,3,4,5-tetrahydro-3-thienylidenemethyl)-cyclopropanecarboxylate, 3-phenoxybenzyl-
2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate and N-
The insect-proof collar according to claim 12, characterized in that it is selected from (3,4,5,6-tetrahydrophthalimido)methyl-cis, trans-chrysanthemate. 17 Formamidine is N′-(4-chloro-O
-tolyl)-N,N-dimethylformamidine and N-methyl-N'-2,4-xylyl-N-(N
13. The insect-proof collar according to claim 12, characterized in that the insect-proof collar is selected from -2,4-xylylformimidoyl)formamidine. 18. The unsaturated essential fatty acids are selected from oleic acid, linoleic acid, linolenic acid, arachidonic acid, 11,14-eicosadienoic acid, docosahexaenoic acid, and linear or branched esters thereof having 1 to 4 carbon atoms. An insect-proof collar according to any one of claims 11 to 17. 19. The insect-proof collar according to claim 18, wherein the unsaturated essential fatty acid is vitamin F. 20 Insecticidal ingredients 5-25%, unsaturated essential fatty acids 1-1
10%, thermoplastic polymeric support 10-50% and auxiliary agents selected from plasticizers, inert fillers, dyes, deodorizers, stabilizers and diffusion modifiers 1-15%. An insect-proof collar according to any one of claims 11 to 19. 21 The insecticidal component is O,O-diethyl O-2-
21. The insect-proof collar according to claim 11, wherein the collar is isopropyl-4-methyl-6-pyrimidyl thiophosphate, and the unsaturated essential fatty acid is vitamin F. 22 Insect-proof collar for animals having an insecticidal means containing at least one unsaturated essential fatty acid having 18 to 22 carbon atoms and at least one insecticidal component, the collar having a mixed double layer laterally interconnected. It is in the form of two strips forming a cord, one of the strips containing the insecticidal ingredient, the other containing the fatty acid, and each of the two strips having a thermoplastic solid polymer support. An insect-proof collar for animals, characterized in that it contains body and adjuvants selected from plasticizers, inert fillers, dyes, deodorizers, stabilizers and diffusion control agents. 23. The insect-proof collar according to claim 22, wherein the mixed double string is manufactured by hot co-extrusion. 24. The insect-proof collar according to claim 22, wherein the mixed double string is manufactured by molding. 25. The insect-proof collar according to any one of claims 22 to 24, which contains 5 to 25% of insecticidal ingredients and 1 to 10% of fatty acids. 26 Insect-proof collar for animals having an insecticidal means containing at least one unsaturated essential fatty acid having 18 to 22 carbon atoms and at least one insecticidal component, the collar comprising a mixed double layer laterally interconnected. It is in the form of two strips forming a cord, one of the strips containing the insecticidal ingredient, the other containing the fatty acid, and each of the two strips having a thermoplastic solid polymer support. and auxiliary agents selected from plasticizers, inert fillers, dyes, deodorizers, stabilizers and diffusion modifiers, and further contain dyes, pigments, light-reflecting substances and/or fluorescent substances. An insect-proof collar for animals featuring: 27 At least one unsaturated fatty acid having 18 to 22 carbon atoms
Insect collar for animals having insecticidal means containing seeds and at least one insecticide component, in the form of two strips forming a mixed double strand laterally interconnected, One of the strips contains an insecticidal ingredient, and each of the two strips contains a thermoplastic solid polymeric support and a selected from plasticizers, inert fillers, dyes, deodorizers, stabilizers and diffusion modifiers. A method of manufacturing an insect-proof collar for animals containing an adjuvant such as
Prepare two different homogeneous mixtures, one containing ~25% fatty acids and the other containing 1-10% fatty acids, put these mixtures separately into two hoppers of a double extruder, perform extrusion, and carry out extrusion. A method for producing an insect-proof collar for animals, characterized in that the strips obtained are laterally joined when passing through an extrusion head. 28. Claim No. 2, characterized in that the two mixtures are extruded separately by two different extruders and are joined at their outlet by passing through a single extrusion head. The manufacturing method according to item 27.