JPH04344462A - Method and device for coating - Google Patents
Method and device for coatingInfo
- Publication number
- JPH04344462A JPH04344462A JP11621091A JP11621091A JPH04344462A JP H04344462 A JPH04344462 A JP H04344462A JP 11621091 A JP11621091 A JP 11621091A JP 11621091 A JP11621091 A JP 11621091A JP H04344462 A JPH04344462 A JP H04344462A
- Authority
- JP
- Japan
- Prior art keywords
- coating
- liquid
- coater
- ultrasonic
- coating liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 69
- 239000011248 coating agent Substances 0.000 title claims abstract description 66
- 238000000034 method Methods 0.000 title description 9
- 239000007788 liquid Substances 0.000 claims abstract description 42
- 238000004159 blood analysis Methods 0.000 claims description 15
- 239000006185 dispersion Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000007787 solid Substances 0.000 abstract description 13
- 239000000843 powder Substances 0.000 abstract description 4
- 238000005345 coagulation Methods 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 230000002776 aggregation Effects 0.000 description 6
- 238000004062 sedimentation Methods 0.000 description 6
- 238000005054 agglomeration Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 238000001132 ultrasonic dispersion Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000007765 extrusion coating Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Coating Apparatus (AREA)
Abstract
Description
【０００１】0001
【産業上の利用分野】本発明は、血液分析素子の製造に
係る固液分散系の塗布液の塗布に際して、液中の固形分
の凝集・沈降等を防止する塗布方法およびその装置に関
する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a coating method and apparatus for preventing agglomeration, sedimentation, etc. of solids in a solid-liquid dispersion coating solution used in the manufacture of blood analysis elements.
【０００２】0002
【従来の技術】近年、血液分析方法に関して、ポリエチ
レンテレフタレートなどの透光性支持体上に試薬を積層
塗布した血液分析素子に少量の血液を滴下し、前記試薬
との接触による呈色反応をドライケミストリーなどの分
析装置により光学的に分析する方法が知られている。前
記血液分析素子を構成する試薬は、溶剤中にＩｇＧ ，
ＩｇＭ 抗体粉末等の固形分が含有されており、押出し
コーター、アプリケーターコーター、スライドホッパー
等の塗布コーターにより支持体上へ塗布するに際し、固
形分の凝集・沈降等が問題となる。従来、前記問題を解
決するために、たとえば塗布コーターの内空部分に攪拌
翼を設け、攪拌流により固形分の凝集・沈降を防止し、
スリット詰まり、塗布故障を防止する方法が一般的に知
られている。[Prior Art] In recent years, blood analysis methods have been developed in which a small amount of blood is dropped onto a blood analysis element in which a reagent is layered and coated on a transparent support such as polyethylene terephthalate, and a color reaction caused by contact with the reagent is dried. A method of optical analysis using an analytical device such as a chemistry analyzer is known. The reagent constituting the blood analysis element contains IgG,
Contains solid components such as IgM antibody powder, and when coating onto a support using a coater such as an extrusion coater, applicator coater, or slide hopper, problems such as aggregation and sedimentation of the solid components arise. Conventionally, in order to solve the above problem, for example, stirring blades were provided in the inner space of the coating coater, and the stirring flow prevented solids from coagulating and settling.
Methods for preventing slit clogging and coating failure are generally known.
【０００３】一方、塗工液の顔料分散などの分野におい
て、分散方式の一つとして超音波分散などが知られてい
る。この超音波分散は、塗工液に超音波を与え、超音波
の空洞現象による瞬間的な高圧によって分散を行わしめ
るものである。On the other hand, in the field of dispersing pigments in coating liquids, etc., ultrasonic dispersion is known as one of the dispersion methods. In this ultrasonic dispersion, ultrasonic waves are applied to the coating liquid, and dispersion is performed by instantaneous high pressure caused by the cavitation phenomenon of the ultrasonic waves.
【０００４】0004
【発明が解決しようとする課題】しかしながら、前記攪
拌方式による分散の場合には、局部的な分散は図れても
全体に効率良く分散させることは種々の条件の制約を受
け困難である。また、攪拌翼による渦流により塗布液に
動圧が生じ、塗布液を均一に塗布できないなどの問題も
発生する。また、前記攪拌方式による分散では、塗布液
中に存在する気泡については、効果的に無くすことはで
きない。また、固形分を含有する塗布液の混合槽などに
おいて、超音波分散により固形分の分散を行うことは知
られているが、供給路を通じて送給された塗布液が塗布
コーター内で凝集・沈降を起こす場合がある。[Problems to be Solved by the Invention] However, in the case of dispersion using the above-mentioned stirring method, even if local dispersion can be achieved, it is difficult to achieve efficient dispersion over the entire area due to constraints of various conditions. In addition, dynamic pressure is generated in the coating liquid due to the vortex flow caused by the stirring blade, causing problems such as the inability to uniformly apply the coating liquid. Further, the dispersion using the stirring method cannot effectively eliminate air bubbles present in the coating liquid. In addition, it is known that solids are dispersed by ultrasonic dispersion in a mixing tank for a coating solution containing solids, but the coating solution fed through the supply channel coagulates and settles in the coater. may occur.
【０００５】そこで、本発明の主たる目的は、血液分析
素子の製造における試薬の塗布に際し、塗布液中の固形
分の凝集・沈降等を防止するとともに、塗布液の動圧を
無くし、均一塗布を可能にした塗布方法およびその装置
を提供するものである。Therefore, the main object of the present invention is to prevent solid content from agglomerating and settling in the coating solution when applying reagents in the production of blood analysis elements, and to eliminate dynamic pressure of the coating solution to ensure uniform coating. The present invention provides a coating method and apparatus that make it possible.
【０００６】[0006]
【課題を解決するための手段】前記課題は、血液分析素
子の製造に当り、固液分散系の塗布液を塗布コーターに
より支持体上に塗布する際に、前記支持体上に塗布され
る直前の塗布液に超音波振動を与えながら塗布を行うこ
とで解決できる。[Means for Solving the Problems] The above-mentioned problem is solved when a solid-liquid dispersion coating liquid is applied onto a support by a coating coater in the production of a blood analysis element. This problem can be solved by applying ultrasonic vibration to the coating solution.
【０００７】また、その装置は、血液分析素子の製造に
当り、固液分散系の塗布液を塗布コーターにより支持体
上に塗布する塗布装置において、前記塗布コーターに超
音波発信器を取り付けるものである。[0007] In addition, the apparatus is a coating apparatus for coating a solid-liquid dispersion coating liquid onto a support using a coating coater in manufacturing a blood analysis element, and an ultrasonic transmitter is attached to the coater. be.
【０００８】[0008]
【作用】本発明においては、支持体上に塗布される直前
の塗布液、すなわち塗布コーター内の塗布液に対して超
音波を与えながら塗布を行う。したがって、塗布液が塗
布される最終段階において固形分の凝集・沈降が防止さ
れるため、塗布コーターのスリット詰まり、塗膜の不均
一および塗布故障を無くすことができる。また、超音波
振動による分散であるため、塗布に際しての動圧が無く
なり、塗布膜厚が均一となるとともに、超音波により液
中に存在する気泡が溶解されるため、最良の状態で塗布
を行うことができ、得られる血液分析素子としての品質
・性能も安定化する。[Operation] In the present invention, coating is carried out while applying ultrasonic waves to the coating liquid immediately before being coated on the support, that is, the coating liquid in the coating coater. Therefore, agglomeration and sedimentation of solids are prevented in the final stage of coating the coating solution, thereby eliminating clogging of the slit of the coating coater, non-uniformity of the coating film, and coating failures. In addition, since the dispersion is performed by ultrasonic vibration, there is no dynamic pressure during coating, resulting in a uniform coating thickness, and the ultrasonic waves dissolve air bubbles present in the liquid, ensuring coating in the best conditions. This also stabilizes the quality and performance of the resulting blood analysis element.
【０００９】[0009]
【実施例】以下、本発明を図面に示す具体例に基づき詳
説する。図１において、押出し塗布コーター１（以下、
単に塗布コーターという）は、その内部に液供給路１ｂ
を有し、この液供給路１ｂから外部に連通するスリット
口１ａが形成されている。塗布液は前記液供給路１ｂ内
に図示されないポンプ等により圧送され、前記スリット
口１ａを通して支持体５に塗布される。DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be explained in detail below based on specific examples shown in the drawings. In FIG. 1, an extrusion coating coater 1 (hereinafter referred to as
(simply referred to as an application coater) has a liquid supply path 1b inside it.
A slit opening 1a communicating with the outside from this liquid supply path 1b is formed. The coating liquid is fed under pressure into the liquid supply path 1b by a pump or the like (not shown), and is applied to the support 5 through the slit opening 1a.
【００１０】一方、支持体５は図示されない搬送機構に
よりガイドロールまたはサポートロールなどの支持ロー
ルにより支持されながら移動しており、この移動過程に
おいて前記塗布コーター１と所定のギャップ（隙間）を
有する状態で塗布コーター１から押し出される塗布液が
その表面に成層され、その後の乾燥工程等の次工程に導
かれる。On the other hand, the support body 5 is moved by a transport mechanism (not shown) while being supported by support rolls such as guide rolls or support rolls, and during this movement process, the support body 5 is in a state where it has a predetermined gap with the coating coater 1. The coating liquid extruded from the coating coater 1 is formed in a layer on the surface thereof, and is led to the next process such as the subsequent drying process.
【００１１】前記塗布コーター１の側面には、適宜の間
隔で超音波振動子３、３…が取り付けられており、前記
超音波振動子３、３…からのリード線は、外部に備えら
れた超音波発生器４に接続されている。固液分散系の塗
布液に対して超音波振動を与えることは、超音波エネル
ギーの大部分が液体に空洞を作るのに費やされ、この空
洞現象により、溶液中の固体粉体を分散させることがで
き、凝集・沈降のない均一で細かい分散液を得ることが
できる。また、同時に溶液中に存在していた気体が泡と
なり表面に出てくるため、泡故障などが無くなる。Ultrasonic transducers 3, 3... are attached to the side surface of the coating coater 1 at appropriate intervals, and the lead wires from the ultrasonic transducers 3, 3... are provided externally. It is connected to an ultrasonic generator 4. When applying ultrasonic vibration to a solid-liquid dispersion coating liquid, most of the ultrasonic energy is spent creating cavities in the liquid, and this cavity phenomenon causes the solid powder in the solution to be dispersed. It is possible to obtain a uniform and fine dispersion without agglomeration or sedimentation. Furthermore, since the gas present in the solution forms bubbles and comes out to the surface, bubble failures and the like are eliminated.
【００１２】血液分析素子に係る塗布液は、塗布コータ
ー１に供給される前に、各種の固形粉が調合され、凝集
・沈降のない状態で前記液供給路１ｂまで送給される。
そして、ここで超音波振動が与えられることにより、塗
布コーター１内での凝集・沈降が防止されるとともに、
気泡を無くし、最も良好な状態で塗布される。[0012] Before the coating liquid for the blood analysis element is supplied to the coating coater 1, various solid powders are prepared and fed to the liquid supply path 1b in a state without agglomeration or sedimentation. By applying ultrasonic vibration here, agglomeration and sedimentation within the coating coater 1 are prevented, and
Eliminate air bubbles and apply in the best condition.
【００１３】本発明等によって得られる血液分析素子は
、たとえば図２に示されるように、ポリエチレンテレフ
タレート１０上に試薬層１１、バッファ層１２、展開層
１３を順次積層したものであり、前記展開層１３は滴下
された血液、血清等の試料を拡散・分配するための層と
して機能し、前記バッファ層１２は滴下された試料と試
薬層１１における呈色反応を最適に調整するための層と
して機能し、試薬層１１は試料と接触して呈色反応を示
す層として機能する。[0013] The blood analysis element obtained by the present invention etc. is, for example, as shown in FIG. Reference numeral 13 functions as a layer for diffusing and distributing the dropped sample such as blood or serum, and the buffer layer 12 functions as a layer for optimally adjusting the color reaction between the dropped sample and the reagent layer 11. However, the reagent layer 11 functions as a layer that exhibits a color reaction upon contact with a sample.
【００１４】[0014]
【発明の効果】以上詳説のとおり、本発明によれば、血
液分析素子の製造における試薬の塗布に際し、塗布液中
の固形分の凝集・沈降を防止し、塗布液の動圧を無くし
、さらには液中の気泡を溶解した状態で塗布を行うため
、高品質の血液分析素子の製造が実現される。[Effects of the Invention] As described in detail above, according to the present invention, when applying reagents in the production of blood analysis elements, solid content in the coating solution is prevented from agglomerating and settling, dynamic pressure of the coating solution is eliminated, and Since the coating is performed with the bubbles in the liquid dissolved, it is possible to manufacture high-quality blood analysis elements.
【図１】本発明に係る押出しコーターの斜視図である。FIG. 1 is a perspective view of an extrusion coater according to the present invention.
【図２】血液分析素子の層構成を示す斜視図である。FIG. 2 is a perspective view showing the layer structure of a blood analysis element.
１…塗布コーター、２…サイドプレート、３…超音波振
動子、４…超音波発生器、１１…試薬層、１２…バッフ
ァ層、１３…展開層1...Coater, 2...Side plate, 3...Ultrasonic transducer, 4...Ultrasonic generator, 11...Reagent layer, 12...Buffer layer, 13...Development layer
Claims (2)
塗布液を塗布コーターにより支持体上に塗布する際に、
前記支持体上に塗布される直前の塗布液に超音波振動を
与えながら塗布を行うことを特徴とする塗布方法。[Claim 1] In manufacturing a blood analysis element, when coating a solid-liquid dispersion coating liquid onto a support using a coating coater,
A coating method characterized in that coating is performed while applying ultrasonic vibration to the coating liquid immediately before being coated on the support.
塗布液を塗布コーターにより支持体上に塗布する塗布装
置において、前記塗布コーターに超音波発信器を取り付
けたことを特徴とする塗布装置。2. A coating device for coating a solid-liquid dispersion coating liquid onto a support using a coating coater for manufacturing a blood analysis device, characterized in that an ultrasonic transmitter is attached to the coating coater. Coating device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11621091A JPH04344462A (en) | 1991-05-21 | 1991-05-21 | Method and device for coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11621091A JPH04344462A (en) | 1991-05-21 | 1991-05-21 | Method and device for coating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04344462A true JPH04344462A (en) | 1992-12-01 |
Family
ID=14681568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11621091A Pending JPH04344462A (en) | 1991-05-21 | 1991-05-21 | Method and device for coating |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH04344462A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512335A (en) * | 1994-06-27 | 1996-04-30 | International Business Machines Corporation | Fluid treatment device with vibrational energy means |
-
1991
- 1991-05-21 JP JP11621091A patent/JPH04344462A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512335A (en) * | 1994-06-27 | 1996-04-30 | International Business Machines Corporation | Fluid treatment device with vibrational energy means |
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