JPH0428360A - Artificial blood vessel and anastomosis for artificial blood vessel - Google Patents
Artificial blood vessel and anastomosis for artificial blood vesselInfo
- Publication number
- JPH0428360A JPH0428360A JP2134608A JP13460890A JPH0428360A JP H0428360 A JPH0428360 A JP H0428360A JP 2134608 A JP2134608 A JP 2134608A JP 13460890 A JP13460890 A JP 13460890A JP H0428360 A JPH0428360 A JP H0428360A
- Authority
- JP
- Japan
- Prior art keywords
- blood vessel
- artificial blood
- tube
- adhesive
- adhesive member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 99
- 239000002473 artificial blood Substances 0.000 title claims abstract description 66
- 230000003872 anastomosis Effects 0.000 title claims abstract description 17
- 230000001070 adhesive effect Effects 0.000 claims abstract description 37
- 239000000853 adhesive Substances 0.000 claims abstract description 33
- 239000002131 composite material Substances 0.000 claims abstract description 22
- 239000000835 fiber Substances 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 14
- 239000002759 woven fabric Substances 0.000 claims abstract description 9
- 239000004744 fabric Substances 0.000 claims description 9
- 229920001184 polypeptide Polymers 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 229920001400 block copolymer Polymers 0.000 claims description 3
- 229920001059 synthetic polymer Polymers 0.000 claims description 3
- 229920000578 graft copolymer Polymers 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 abstract description 11
- 108010035532 Collagen Proteins 0.000 abstract description 11
- 229920001436 collagen Polymers 0.000 abstract description 11
- 229920000728 polyester Polymers 0.000 abstract description 9
- 239000000126 substance Substances 0.000 abstract description 4
- 239000004677 Nylon Substances 0.000 abstract description 2
- 229920001778 nylon Polymers 0.000 abstract description 2
- 229920002994 synthetic fiber Polymers 0.000 abstract description 2
- 239000012209 synthetic fiber Substances 0.000 abstract description 2
- 229920003002 synthetic resin Polymers 0.000 abstract description 2
- 239000000057 synthetic resin Substances 0.000 abstract description 2
- 238000010030 laminating Methods 0.000 abstract 1
- 229920001225 polyester resin Polymers 0.000 abstract 1
- 239000004645 polyester resin Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000000155 melt Substances 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000002356 single layer Substances 0.000 description 3
- 239000010410 layer Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は、人工血管に関するものであり、さらに詳しく
は、レーザーなどによって生体血管と吻合可能でかつ永
続的に代用できる人工血管に関するものである。[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to an artificial blood vessel, and more specifically, to an artificial blood vessel that can be anastomosed with a biological blood vessel using a laser or the like and can be used as a permanent substitute. .
［従来の技術］
従来より、高分子材料製人工血管は使用されているが、
これらの人工血管は、生体血管と糸で縫い合わせて吻合
するものである。[Conventional technology] Artificial blood vessels made of polymeric materials have been used in the past, but
These artificial blood vessels are sewn together and anastomosed with biological blood vessels using threads.
この糸線吻合の場合は、血液が接続部から漏れないよう
にするため縫糸の間隔を密にしなければならないため非
常に手間かかかり、特に迅速な処置を要する血管の吻合
における処置時間は、種々の外科治療現場において深刻
な関心事となっている。In the case of this thread line anastomosis, the sutures must be closely spaced to prevent blood from leaking from the connection, which is very time-consuming, and the procedure time varies, especially for blood vessel anastomoses that require quick treatment. This is a serious concern in the field of surgical treatment.
方、従来より生体血管と生体血管の接続には、１／−ザ
ー光線による吻合か行われている。On the other hand, anastomosis using a 1/- laser beam has conventionally been used to connect living blood vessels.
これは血管の接続部の一部を糸で仮止めするたけで、迅
速かつ緻密な吻合ができるので極めて好都合であるか、
従来の人工血管では生体血管との吻合をレーザー光線で
行うことはできなかった。This is extremely convenient because it allows a quick and precise anastomosis by simply temporarily fixing a part of the blood vessel connection with a thread.
With conventional artificial blood vessels, it was not possible to perform anastomosis with biological blood vessels using a laser beam.
［発明か解決しようとする課題］
本発明は、レーザー光線などで迅速に生体血管と吻合で
きる人工血管を提供することを目的とするものである。[Problems to be Solved by the Invention] An object of the present invention is to provide an artificial blood vessel that can be quickly anastomosed with a biological blood vessel using a laser beam or the like.
［課題を解決するだめの手段］
本発明者らは、生体分解性のない高分子材料を人工血管
の管構造部材として使用して、これに生体血管との接着
性を有する接着部材を複合させて、該接着部材によって
、人工血管の端部を生体血管に接続する方法を見い出し
、この知見により本発明を完成した。[Means for Solving the Problem] The present inventors used a non-biodegradable polymer material as a tubular structural member of an artificial blood vessel, and composited it with an adhesive member that has adhesive properties with biological blood vessels. Then, they discovered a method of connecting the end of an artificial blood vessel to a living blood vessel using the adhesive member, and based on this knowledge, they completed the present invention.
すなわち、本発明は次の各項の発明よりなる。That is, the present invention consists of the following inventions.
１ 高分子材料からなる人工血管であって、該人工血管
の少なくとも端部が、管構造部材及び生体血管との接着
性を有する接着部材とが複合して形成されていることを
特徴とする人工血管。1. An artificial blood vessel made of a polymeric material, characterized in that at least an end portion of the artificial blood vessel is formed by a composite of a tubular structural member and an adhesive member that has adhesive properties with a biological blood vessel. Blood vessels.
２ 接着部材がポリペプタイド又はポリペプタイド連鎖
と合成高分子連鎖とからなるグラフト共重合体若しくは
ブロック共重合体である１項記載の人工血管。2. The artificial blood vessel according to item 1, wherein the adhesive member is a polypeptide or a graft copolymer or block copolymer comprising a polypeptide chain and a synthetic polymer chain.
３ 管構造部材に接着部４１を管全体に均一に複合させ
た複合構造である１又は２項記載の人工血管。3. The artificial blood vessel according to item 1 or 2, which has a composite structure in which the adhesive portion 41 is uniformly combined with the tube structural member over the entire tube.
４ 高分子材料からなるシート又は織布で形成された管
構造部材と接着部材とが積層された２重積一
層管である３項記載の人工血管。4. The artificial blood vessel according to item 3, which is a double-stacked single-layer tube in which a tube structure member made of a sheet or woven fabric made of a polymeric material and an adhesive member are laminated.
５ 管構造部材の繊維織物の一部に接着部材を混入させ
た複合構造である３項記載の人工血管。5. The artificial blood vessel according to item 3, which has a composite structure in which an adhesive member is mixed into a part of the fiber fabric of the tube structural member.
６ 繊維織物製管の全部又は一部の繊維に、管構造部材
と接着部拐を共紡糸させた複合繊維を用いた複合構造で
ある３項記載の人工血管。6. The artificial blood vessel according to item 3, which has a composite structure using a composite fiber in which a tube structural member and an adhesive part are co-spun into all or part of the fibers of the fiber fabric tube.
７１１２．４．５又は６項記載の定尺の寸法及び形状を
有する人工血管であって、端部にのみ接着部利が管構造
部材の中に複合されている人工血管。7112. An artificial blood vessel having the regular dimensions and shape according to paragraph 7112.4.5 or 6, wherein an adhesive joint is integrated into the tubular structural member only at the end.
８ カニユーレの先端に１〜７項記載の人工血管を装着
してなる人工血管。8. An artificial blood vessel comprising the artificial blood vessel described in items 1 to 7 attached to the tip of a cannula.
９１〜８項記載の人工血管の端部にレーザーを当てて、
接着部材を分解熔融して、該分解熔融生成物を接着材と
して使用する人工血管の吻合方法。Applying a laser to the end of the artificial blood vessel described in items 91 to 8,
A method for anastomosis of an artificial blood vessel, in which an adhesive member is decomposed and melted, and the decomposed and melted product is used as an adhesive material.
本発明人工血管の管構造部材は、生体内で分解しなＱ・
ものであって、永続的に管構造を維持できる高分子物質
、例えば、ポリエステル、ナイロン、ポリプロピレン、
ポリカーボイ、−トな七の合成樹脂、合成繊維を使用す
ることかできる。The tubular structure member of the artificial blood vessel of the present invention is characterized by Q.
Polymeric materials that can permanently maintain a tubular structure, such as polyester, nylon, polypropylene,
Polycarbonate, other synthetic resins, and synthetic fibers can be used.
該部材は管構造を永続的に維持するものであり、管状の
形状全宵している。The member permanently maintains the tubular structure and retains its tubular shape.
本発明人工血管の生体血管との接着部材は、物理的又は
化学的処理によって生体血管との接着性を発現する高分
子物質であれば、特に制限なく使用することができる。The member for adhering the artificial blood vessel of the present invention to a living blood vessel can be used without any particular restriction as long as it is a polymeric material that exhibits adhesiveness to a living blood vessel through physical or chemical treatment.
特に、レーザーなどからのエネルギーを吸収して融解し
て、該融解生成物によって管構造部材と生体血管とを接
着するものであれば、レーザーは非常に微細な点にエネ
ルギーを集中することができるので精密な接着作業を行
うことができて便利である。かかるレーザー照射によっ
て接着性を発現する物質としては、例えは、生体血管と
の適合性の点からは、生体に由来するコラーゲン、フィ
ブリルなどのポリペプタイド又はポリペプタイド連鎖と
合成高分子連鎖とのグラフト共重合体又はブロック共重
合体を好適に使用することができる。In particular, if the device absorbs energy from a laser or the like, melts it, and uses the melted product to bond the tubular structure member and the biological blood vessel, the laser can focus the energy on a very fine point. This makes it convenient to perform precise gluing work. From the viewpoint of compatibility with living blood vessels, examples of substances that exhibit adhesive properties upon laser irradiation include polypeptides such as collagen and fibrils derived from living organisms, or grafts of polypeptide chains and synthetic polymer chains. Copolymers or block copolymers can be suitably used.
本発明に用いる上記ポリペプタイド類は、レーザーなど
からのエネルギーによって、融解して融解物か接着機能
を発揮して、生体血管と本発明人工血管全接続すること
かできる。The above-mentioned polypeptides used in the present invention can be melted by energy from a laser or the like, and the melt can exert an adhesive function to completely connect the living blood vessel and the artificial blood vessel of the present invention.
本発明人工血管を生体血管に接続する場合は、まず、両
皿管の端を合わせて、その周囲を３〜４箇所の仮止めを
行い、その合わせ目にレーザー光線を当てて、該合わせ
目を融着して完全に接続することができる。When connecting the artificial blood vessel of the present invention to a biological blood vessel, first align the ends of both dish tubes, temporarily secure the surrounding area in 3 to 4 places, and shine a laser beam on the joint. Can be fused to make a complete connection.
また、本発明人工血管は、人工血管同士を同様に接続す
ることができる。このことにより、−旦接続した血管を
一時切断して再度吻合したり、人工臓器回路に接続した
人工血管を、生体にあらかじめ取り付けた人工血管に付
は変えたりすることができる。Further, in the artificial blood vessel of the present invention, artificial blood vessels can be connected to each other in the same manner. This makes it possible to temporarily disconnect a previously connected blood vessel and reanastomose it, or to change the attachment of an artificial blood vessel connected to an artificial organ circuit to an artificial blood vessel previously attached to a living body.
本発明人工血管を吻合した後には、その接続境界部には
、次第に生体組織か蓄積して、該接続部を密に覆うので
、生体分解性のある本発明人工血管の接着部材が、たと
え分解して消失しても血液が漏れることはない。After the artificial blood vessel of the present invention is anastomosed, biological tissue gradually accumulates at the connection boundary and tightly covers the joint. Even if it disappears, blood will not leak.
本発明人工血管は、管構造部材と接着部材との複合に関
して種々の態様を採用することができる。The artificial blood vessel of the present invention can adopt various embodiments regarding the combination of the tube structure member and the adhesive member.
まず、両部材の複合の態様は、管の端部だけに複合させ
るものと管の材質全体に複合させるものどに分類できる
。First, the manner in which the two members are combined can be classified into two types: one in which the two members are combined only at the end of the tube, and the other in which the entire material of the tube is combined.
管の端部たけに本発明の複合構造を設けるものは、使用
寸法形状が定尺のものをそのまま生体血管に接続する場
合に用いるものである。The composite structure of the present invention provided only at the end of the tube is used when a tube with a fixed size and shape is connected to a biological blood vessel as is.
その形状は、特に、症状の多い患部の寸法と形状に合わ
せて分岐したもの、屈曲したものを使用することかでき
る。The shape may be branched or curved depending on the size and shape of the affected area with many symptoms.
複合の形態は、下記の管全体に均一に複合するものと同
様に行うことができる。The composite configuration can be similar to the uniform composite over the entire tube described below.
本発明人工血管において管全体に均一に複合構造を有す
るものは、患部に応じて必要とされる長さを適宜切断し
て使用することができる。The artificial blood vessel of the present invention, which has a composite structure uniformly throughout the tube, can be used by cutting the length as required depending on the affected area.
この複合の形態は、■管構造部材の繊維織物の一部に接
着部材を混入させた複合構造、■管構造部材の繊維織物
の全部又は一部の繊維に、管構造部材と接着部材を共紡
糸させた複合繊維を用いた複合構造、■織布又はシート
からなる管構造部材層と接着部材層からなる２重管型複
合構造、■管構造部材の７トリツクス中に接着部材が分
散したものなとを使用することができる。This composite structure includes: (1) a composite structure in which an adhesive member is mixed into a part of the fiber fabric of the pipe structural member, and (2) a composite structure in which the pipe structural member and the adhesive member are mixed into all or part of the fiber fabric of the pipe structural member. Composite structure using spun composite fibers; ■Double-pipe composite structure consisting of a tubular structural member layer made of woven fabric or sheet and an adhesive member layer; ■Adhesive member dispersed in the 7 trixes of the tubular structural member. You can use nato.
次に、本発明人工血管を実施例の図面によってさらに詳
細に説明する。Next, the artificial blood vessel of the present invention will be explained in more detail with reference to drawings of examples.
これらの実施例では、管構造部材としてポリエステル繊
維又はシートを用い、接着部材としてコラーゲンを用い
た場合について、上記各複合態様を説明する。In these Examples, each of the above composite embodiments will be described in the case where polyester fibers or sheets are used as the tubular structural member and collagen is used as the adhesive member.
第１図は、ポリエステル繊維の織布によって構成された
外管を管構成部材１として、その内面にコラーゲン織布
が接着部材２として積層されている人工血管である。FIG. 1 shows an artificial blood vessel in which an outer tube made of a woven polyester fiber is used as a tube component 1, and a collagen woven fabric is laminated as an adhesive member 2 on the inner surface of the outer tube.
これを生体血管と吻合する場合は、第２図に示すように
、本発明人工血管５と生体血管６の端を外側に垂直に立
てて、両管の内面を合わせて接続して、２〜４箇所を止
め糸７で仮止めを行う。かかる仮止め操作は数が少ない
ので迅速に実施することができる。When anastomosing this with a biological blood vessel, as shown in FIG. Temporarily fasten the four locations with the thread 7. Since the number of such temporary fixing operations is small, they can be performed quickly.
ついで、管の仮接合部の周りにレーザーを当てると、コ
ラーゲン織布は融解してフィブリンとなって、生体血管
と人工血管の管構造部材であるポリエステル織布とを接
着する。Next, when a laser is applied around the temporary joint of the tube, the collagen fabric melts and becomes fibrin, which bonds the biological blood vessel and the polyester fabric that is the tube structural member of the artificial blood vessel.
この接着は、融着により完全に密着しているので、血液
が漏れることはない。Since this adhesion is completely adhered by fusion, blood will not leak.
そして、吻合の後に人工血管と生体血管の接合部に血液
が流れると、この吻合部分の内面に生体組織が付着して
、これが接合境界を覆うようになる。When blood flows to the junction between the artificial blood vessel and the biological blood vessel after the anastomosis, biological tissue adheres to the inner surface of the anastomotic portion and covers the junction boundary.
この付着組織が接合部の密着性及び接合強度を内面から
強化するので、吻合後接続部から血液が漏れたり、血管
が破裂する恐れは全くなくなる。Since this adherent tissue strengthens the adhesion and joint strength of the joint from the inside, there is no risk of blood leaking from the connection after anastomosis or rupture of the blood vessel.
第３図は、本発明人工血管を単層の管で形成した例であ
り、この態様としては、例えば、ポリエステル繊維とコ
ラーゲン繊維を交織すした織布、ポリエステルとコラー
ゲンとの混紡糸よりなる織布、コラーゲンとポリエステ
ルとのパイラテラル糸からなる織布などがある。FIG. 3 shows an example in which the artificial blood vessel of the present invention is formed of a single-layer tube. Examples of this embodiment include, for example, a woven fabric made of a mixture of polyester fibers and collagen fibers, and a woven fabric made of a blended yarn of polyester and collagen. There are fabrics, woven fabrics made of pilateral yarns of collagen and polyester, etc.
第４図は、コラーゲン粒子を均一に分散させたポリエス
テルシートよりなる単層の人工血管である。FIG. 4 shows a single-layer artificial blood vessel made of a polyester sheet in which collagen particles are uniformly dispersed.
第３図及び第４図の人工血管は、コラーゲンか管全体に
均一に分布しているので、表裏どちらの面にも接着する
ことができる。In the artificial blood vessels shown in FIGS. 3 and 4, collagen is uniformly distributed throughout the tube, so that it can be adhered to either the front or back surface.
第５図は、カニユーレ４の先端に接続した人工血管５で
あり、これは、人工心臓などの人工臓器と生体血管を接
続する場合に使用することができる。カニユーレ４と人
工血管５とは通常の接着剤などで接着されている。FIG. 5 shows an artificial blood vessel 5 connected to the tip of the cannula 4, which can be used when connecting an artificial organ such as an artificial heart to a living blood vessel. The cannula 4 and the artificial blood vessel 5 are bonded together using a normal adhesive or the like.
第５図の人工血管によって、人工臓器側に接続されてい
る本カニユーレの先端と生体血管との吻合を容易に可能
にすることができる。The artificial blood vessel shown in FIG. 5 allows easy anastomosis between the tip of the cannula connected to the artificial organ and the biological blood vessel.
［発明の効果］
本発明の人工血管は、レーザーなどにより生体血管との
迅速な吻合ができる利点があり、しかも、永続的に強固
な吻合が維持できるので、多くの外科手術に広く使用で
きて有用である。[Effects of the Invention] The artificial blood vessel of the present invention has the advantage of being able to quickly anastomose with a biological blood vessel using a laser or the like, and furthermore, can maintain a strong anastomosis permanently, so it can be widely used in many surgical procedures. Useful.
また、本発明人工血管を切断してから再結合するのも簡
単に行える利点がある。Another advantage is that the artificial blood vessel of the present invention can be easily cut and then reattached.
第１図は、本発明の一実施例の人工血管の斜視図であり
、第２図はその吻合工程を示す説明図であり、第３図、
第４図及び第５図は人工血管の他の実施例の斜視図であ
る。
図中の符号は、１；管構造部材、２：接着部材、４；カ
ニユーレ、５：人工血管、６；生体血管、７；仮止め糸
である。
特許出願人 日本ゼオン株式会社FIG. 1 is a perspective view of an artificial blood vessel according to an embodiment of the present invention, FIG. 2 is an explanatory diagram showing the anastomosis process, and FIG.
4 and 5 are perspective views of other embodiments of the artificial blood vessel. The symbols in the figure are 1: tube structure member, 2: adhesive member, 4: cannula, 5: artificial blood vessel, 6: biological blood vessel, 7: temporary fixing thread. Patent applicant Zeon Corporation
Claims (1)
の少なくとも端部が、管構造部材及び生体血管との接着
性を有する接着部材とが複合して形成されていることを
特徴とする人工血管。 ２ 接着部材がポリペプタイド又はポリペプタイド連鎖
と合成高分子連鎖とからなるグラフト共重合体若しくは
ブロック共重合体である請求項１記載の人工血管。 ３ 管構造部材に接着部材を管全体に均一に複合させた
複合構造である請求項１又は２記載の人工血管。 ４ 高分子材料からなるシート又は織布で形成された管
構造部材と接着部材とが積層された２重積層管である請
求項３記載の人工血管。 ５ 管構造部材の繊維織物の一部に接着部材を混入させ
た複合構造である請求項３記載の人工血管。 ６ 繊維織物製管の全部又は一部の繊維に、管構造部材
と接着部材を共紡糸させた複合繊維を用いた複合構造で
ある請求項３記載の人工血管。 ７ 請求項１、２、４、５又は６記載の定尺の寸法及び
形状を有する人工血管であって、端部にのみ接着部材が
管構造部材の中に複合されている人工血管。 ８ カニューレの先端に請求項１〜７記載の人工血管を
装着してなる人工血管。 ９ 請求項１〜８記載の人工血管の端部にレーザーを当
てて、接着部材を分解熔融して、該分解熔融生成物を接
着材として使用する人工血管の吻合方法。[Scope of Claims] 1. An artificial blood vessel made of a polymeric material, in which at least an end portion of the artificial blood vessel is formed by a composite of a tubular structural member and an adhesive member having adhesive properties with a living blood vessel. An artificial blood vessel characterized by: 2. The artificial blood vessel according to claim 1, wherein the adhesive member is a polypeptide or a graft copolymer or a block copolymer comprising a polypeptide chain and a synthetic polymer chain. 3. The artificial blood vessel according to claim 1 or 2, which has a composite structure in which the adhesive member is composited uniformly over the entire tube with the tube structural member. 4. The artificial blood vessel according to claim 3, which is a double laminated tube in which a tube structure member made of a sheet or woven fabric made of a polymeric material and an adhesive member are laminated. 5. The artificial blood vessel according to claim 3, which has a composite structure in which an adhesive member is mixed into a part of the fiber fabric of the tube structural member. 6. The artificial blood vessel according to claim 3, which has a composite structure using composite fibers in which a tube structural member and an adhesive member are co-spun into all or part of the fibers of the fiber fabric tube. 7. An artificial blood vessel having a regular size and shape according to claim 1, 2, 4, 5, or 6, wherein an adhesive member is integrated into the tubular structure member only at the end portion. 8. An artificial blood vessel comprising the artificial blood vessel according to claims 1 to 7 attached to the tip of a cannula. 9. A method for anastomosis of an artificial blood vessel, which comprises applying a laser to the end of the artificial blood vessel according to claims 1 to 8, decomposing and melting the adhesive member, and using the decomposed and melted product as an adhesive material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2134608A JPH0428360A (en) | 1990-05-24 | 1990-05-24 | Artificial blood vessel and anastomosis for artificial blood vessel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2134608A JPH0428360A (en) | 1990-05-24 | 1990-05-24 | Artificial blood vessel and anastomosis for artificial blood vessel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0428360A true JPH0428360A (en) | 1992-01-30 |
Family
ID=15132381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2134608A Pending JPH0428360A (en) | 1990-05-24 | 1990-05-24 | Artificial blood vessel and anastomosis for artificial blood vessel |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0428360A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006122578A (en) * | 2004-11-01 | 2006-05-18 | Terumo Corp | Artificial blood vessel joint body and joining method |
| WO2007030892A1 (en) * | 2005-09-15 | 2007-03-22 | Avastra Ltd | Method of tissue repair iii |
| JP2008301954A (en) * | 2007-06-06 | 2008-12-18 | Olympus Corp | Member for anastomosis |
| CN102641161A (en) * | 2012-04-23 | 2012-08-22 | 东华大学 | Composite structure artificial blood vessel and dynamic preparation method thereof |
-
1990
- 1990-05-24 JP JP2134608A patent/JPH0428360A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006122578A (en) * | 2004-11-01 | 2006-05-18 | Terumo Corp | Artificial blood vessel joint body and joining method |
| WO2007030892A1 (en) * | 2005-09-15 | 2007-03-22 | Avastra Ltd | Method of tissue repair iii |
| JP2008301954A (en) * | 2007-06-06 | 2008-12-18 | Olympus Corp | Member for anastomosis |
| CN102641161A (en) * | 2012-04-23 | 2012-08-22 | 东华大学 | Composite structure artificial blood vessel and dynamic preparation method thereof |
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