JPH04202122A - Diketone deodorizing composition and deodorizing method - Google Patents

Abstract

PURPOSE: To obtain a diketone-deodorizing composition that contains a specific 1, 3-diketone and a topical carrier, is suitable for application to skin, clothes which are put on near skin and enables treatment or inhibition of the not- microbial, unpleasant smell accompanied by perspiration. CONSTITUTION: This deodorant composition comprises (A) a diketone [W is O, S, (CH2 )n (n is 1-3); X=H, a halogen, a 1-5C (substituted) alkyl, or the two X parts have covalent bonds, form alkyl, heteroalkyl, aryl or heteroaryl ring that has 3-12 cyclic atoms including 0-3 heteroatoms and may be substituted], preferably 2,2-dimethyl-1,3-dioxane-4,6-dione and (B) a topical carrier in the form of liquid, solid, cream, or gel. The content of the component A is 0.01-20wt.%, particularly 0.5-20wt.%. The effective dose of the component A is 0.002-40mg, particularly 0.01-1.0mg/cm<2> of skin, clothes or fabrics.

Description

DETAILED DESCRIPTION OF THE INVENTION TECHNICAL FIELD The present invention relates to compositions and methods for treating or preventing malodors associated with human perspiration.

BACKGROUND OF THE INVENTION A vast amount of chemical, medical and cosmetic literature has been published regarding the causes, effects and prevention of human sweating.

"Sweating" or "sweat" is commonly defined to include the excretion of sweat glands located in the dermis or subcutaneous tissue, known as ephrine sweat glands, which are distributed over most of the body's surface.

Although sweat serves an important function in cooling the body through its evaporation, the by-products resulting from its bacterial breakdown are malodorous and aesthetically unpleasant.

Malodor is particularly associated with sweat secreted in areas of the body where apocrine sweat glands are also found in addition to ephrine sweat glands.

The two main areas with apocrine sweat glands are the axillae and crotch. For example, J,I,abows,at al,.

-Perspectives 011 Axillar
y 0dor” (perspectives on axillary odor), 34.J,S
oc, CosmeLic Chemists, 193-
202 (+982) and P. Jackman, “Bod
y 0dor-TI+e Role O "5kin B
Acteria” (body odor – role of skin bacteria), 1°5e
IIlinars in Dchromatology, 1
See 43-148 (1982).

A variety of bacteria have been implicated in the development of axillary malodor, with the main bacteria responsible for such malodor being Gram-positive bacteria naturally found in the axilla, such as Corynebacterium (Corynebacillus).
eria) and Propionium cutilia (Propio
diphtheriae such as NibacLeria and SLaphylococcus
and Gram-positive cocci such as Microcoeus.

Various compositions have been developed and described in the literature for controlling or eliminating aesthetic problems associated with sweating.

For example, S. PIcchner, “Antipersp.
irants and Deodorants”, 2. Co5n+etics.

5science and technology, 37
3-41 [i (M, Ba1san+ and E, Saga
Rin CD, 1972). Such compositions are commonly classified as antiperspirants that help stop or reduce sweat flow, fragrances that mask unpleasant odors caused by sweat, and deodorants that stop or reduce the production of malodorants in sweat. I can do it. Deodorizing compositions are preferred by many consumers for a variety of reasons.

For example, some individuals are unable to use commercial antiperspirant products due to sensitivity to the astringents typically used in these products.

Deodorizing compositions have been primarily conceived in the art for their role in halting or reducing the formation of bacterial byproducts in perspiration. This has been accomplished through the use of antifungal agents that attack the bacteria responsible for producing malodorous byproducts.

Although these antimicrobial deodorizers were effective in reducing malodors, they did not completely eliminate the formation of malodor conditions. Therefore, it is desirable to provide a deodorizing composition that can further reduce malodors.

In addition, it is desirable to reduce malodor as soon as it forms. In some cases, malodors remain even after washing, for example in the armpit and crotch areas or in the armpit and crotch areas of clothing. Classically, already formed malodors have been masked by fragrances.

It would be desirable to provide improved methods and compositions for reducing malodors that remain after washing people or clothing. 198
In one approach, described in PCT International Patent Application No. WO 37/4341, published July 30, 2007, 4-j, axillary malodor is treated with cupric sulfate, silver sulfate,
Neutralization is disclosed through the use of potassium permanganate, ferric chloride, sodium hydroxide, silver protein, sodium hypochlorite, zinc sulfate or copper gluconate. However, it would be desirable to provide alternative techniques for neutralizing malodors.

It is an object of the present invention to provide a composition effective in suppressing non-microbial malodor of human sweat. Another object of the present invention is to provide an effective method for suppressing non-microbial malodor of human sweat.

SUMMARY OF THE INVENTION The present invention provides a deodorizing composition for suppressing bad odors caused by perspiration, which comprises a 1,3-diketone compound having the following general formula: [In the above formula, each W is each independently selected from the group consisting of OlS and (CH2)n(n-1 to 3); each X is independently hydrogen, hydrogen, substituted or unsubstituted having about 1 to about 5 carbon atoms; or the two X moieties are covalently bonded to form a substituted or unsubstituted alkyl or aryl ring having from about 3 to about 12 carbon atoms in the ring.
and clothing applications used on or near the skin include topical carriers.

Also provided is a method of suppressing sweat malodor by topically applying a safe and effective amount of a 1,3-diketone compound or composition of the invention to the skin of the axilla or crotch area. Laundry products, fabric treatments, diapers and sanitary compositions containing such 1<3>-diketone compounds are also included in the invention.

DETAILED DESCRIPTION OF THE INVENTION It has been suggested that malodor formation and neutralization involve more than one mechanism, but such mechanisms are not completely understood. The present inventors believe that even if sweat from a person's axillary or crotch area is sterilized and no viable bacteria remain on the hostage to produce malodorous bacterial by-products,
It has been determined that sweating can still produce an aesthetically unpleasant odor. Such malodors are hereinafter referred to as "non-microbial malodors."

The inventors have determined that certain vitamin B6 compounds, normally secreted by the human eccrine sweat glands, react to form non-microbial malodors when mixed with apocrine sweat gland secretions. The inventors have further determined that deodorizing compositions containing certain 1<3>-diketone compounds are highly effective in reducing such non-microbial malodors in human sweat. These compositions are particularly useful in controlling the malodor associated with perspiration associated with the avocrine and ephrin combinations. Additionally, such compositions are effective in preventing the formation of non-microbial malodors.

It has been discovered that 1,3-diketone compositions of the type described above are very effective in inhibiting the development of malodorous conditions of perspiration and further deodorizing malodorous perspiration or preventing the formation of malodor in perspiration. Non-microbial malodor increases over time, especially when sweat rates are high and times between washes are long. The concentration of non-microbial malodor precursors on the skin is thought to increase as more perspiration is secreted and the aqueous component of the already secreted perspiration evaporates, thus increasing the formation of recognizable non-microbial malodors. . Without being bound by any theory, it is believed that 1,3-diketone compounds are strong nucleophiles at the 2-carbon plane between the quinone groups.

The aldehyde form of vitamin B6 (P L
It is thought that it reacts with P) and changes the PLP molecule, preventing its mixing with other compounds in sweat that normally cause malodor formation. The occurrence of such malodor conditions from non-microbial sources is
can be substantially reduced by the 1,3-diketone compounds and compositions of the present invention.

The compositions of the present invention include as essential ingredients a 1,3-diketone compound that suppresses non-microbial malodor and a compatible carrier. As used herein, "suppressing non-microbial malodors" means reducing already formed non-microbial malodors to a level that is not appreciably perceived by the human sense of smell and/or inhibiting the development of non-microbial malodors. do.

As used herein, "compatible" means that none of the components of the carrier react with the 1,3-diketone compound so as to substantially impair the ability of the composition to control non-microbial malodors. means.

The term "alkyl" as used herein means straight chain, branched or cyclic, substituted or unsubstituted, saturated, -
unsaturated (i.e., one double or triple bond in the chain) or polyunsaturated (e.g., two or more double bonds in the chain; two or more triple bonds in the chain; one or more double bonds in the chain; and one triple bond). As used herein, a saturated alkyl group is referred to as an "alkanyl," an unsaturated alkyl group with a double bond in the chain is referred to as an "alkenyl," and an unsaturated alkyl group with a triple bond in the chain is referred to as an "alkenyl." is called "alkynyl". As used herein “
The term "short chain alkyl" refers to 1 to about 6 carbon atoms in the chain.
H means alkyl.

The term "aryl" as used herein refers to a substituted or unsubstituted aryl group.

"Substituted aryl" means an aryl group having a substituent on the aryl ring. Examples of aryl are phenyl,
Naphthyl and substituted phenyl or naphthyl.

The term "substituted" as used herein means - or polysubstitution, especially -, di- or tri-substitution.

Examples of substituents include halogen (in particular fluorine, chlorine or bromine), alkyl, hydroxy, amino, aryl (
In particular, phenyl or naphthyl), carboxylate, nitro, -CF3 and -O(0)R or =OR [R is about 1 to about 3 carbon atoms]
(particularly methoxy and ethoxy). The alkyl substituent is preferably C
1-C6 alkyl, more preferably C1-06 alkanyl, even more preferably methyl or ethyl.

The deodorizer of the present invention is a cyclic diketone compound having the following general formula: In the above formula, each W is independently OSS and (CH2),
1 (n = 1-3); each X is independently hydrogen, halogen, about 1 to about 5 carbon atoms;
or the two X moieties are covalently bonded to contain about 3 atoms in the ring, including from 0 to about 3 (preferably O or 1) Peter atoms. to about 12 to form a substituted or unsubstituted alkyl, heteroalkyl, aryl or heteroaryl ring. As used herein, "heteroatom" refers to an atom that covalently bonds with two other atoms to form a stable ring. Preferred heteroatoms include N, 0 and S.

Preferred W's are each independently O and (CH2).

(n-1 to 3). Both Ws are O, or one W is 0 and the other W is (CH2)
The case where n (n -1 to 3) is preferable, and the case where both Ws are (CH2) n (n=1 to B) is also more preferable, and both Ws are O or one of the Ws is It is even more preferable that W is O and the other W is CH2, and both W
It is even more preferable that is CH. Both W is 0
Most preferably.

X is preferably each independently selected from the group consisting of hydrogen, halogen (particularly chloro or fluoro) and substituted or unsubstituted alkyl having from about 1 to about 5 carbon atoms, or the two X moieties are covalently about 5 to about 6 carbon atoms attached
to form a substituted or unsubstituted alkyl or aryl ring. Preferably such rings are alkanyl, alkenyl or phenyl, preferably unsubstituted. Even more preferred X's are each independently selected from the group consisting of hydrogen and substituted or unsubstituted alkanyl or alkenyl having from about 1 to about 5 carbon atoms; even more preferred X's are each independently hydrogen and unsubstituted or substituted alkanyl ( In particular, selected from the group consisting of (hydroxymethyl). Even more preferably, one X is hydrogen and the other X is unsubstituted or substituted alkanyl having about 1 to about 5 carbon atoms. It is even more preferred that each X is independently selected from the group consisting of hydrogen, methyl and ethyl. Most preferably both X's are methyl.

The composition of the present invention comprises 5,5-dimethyl-1,3-cyclohexanedione (dimedone), 2,2-dimethyl-1,3
-dioxane-4,6-dione (Meldrum's acid), spiro[4,5)-6,1,0-dioxa-7,9-dioxodecane, spiro[5,5)-1,5-dioxa-2,
4-dioxoundecane, 2,2-hydroxymethyl-
It is preferable to include a 1°3-diketone compound selected from the group consisting of 1°3-dioxane-4,6-dione and 1,3-cyclohexanedione. Spiro [4,5)
-6,10-dioxa-7,9-dioxodecane, spiro(5,53-1,5-dioxa-2,4-dioxoundecane and 2,2-hydroxymethyl-1,3-dioxane-4,6-dione) is more preferred. 2,2-dimethyl-1°3-dioxane-4,6-dione is most preferred.

Substituted moieties are limited to those that do not render the compound substantially malodorous or ineffective in controlling malodour. Furthermore, 1
．． The W, It is preferable to limit the amount so as not to react with the vitamin B6 aldehyde compound in the product. However, fragrances may also be added to the composition as an optional ingredient to mask the slight malodor of the 1,3-diketone compound and its reaction products.

The compositions of the present invention contain a safe amount of 1,3-diketone compound when used as intended.

As used herein, a "safe and effective amount" is an amount that is effective in eliminating or substantially reducing non-microbial malodor and is safe for the intended use with a reasonable benefit/risk ratio.

1,3-diketone compounds useful in the compositions of the present invention are manufactured by Sigma Chemical Co.
a+pany) (St. Louis, Missouri), Aldrich Chemical Company (Aldrich C11cm1
cal Company) [K & K Lab, Milwaukee, Wisconsin 3
oratories) [Plainview, New York] and P&B Research Chemicals (P&B R
e5earch C1+emicals) [Waterbury, CT].

A0 Topical Compositions One aspect of the present invention is a deodorizing composition comprising a 1,3-diketone compound and a topical carrier. The deodorizing compositions of the present invention comprising 1,3-diketone compounds may be a variety of products that are applied topically to the skin or applied to clothing worn close to the skin in normal use. Compositions formulated for topical application to the skin or manufactured for deposition on clothing and designed to remain deposited at least initially as the clothing is worn contain a safe and effective amount of 1,3-diketone. Includes a topical carrier for depositing or releasing the compound and deodorant. As used herein, "applied to the skin" and "application to the skin" refer to compositions in which the deodorant is not typically deposited, such as skin cleaning compositions that are typically washed off after use. (described in more detail below) and its deposition on the skin such that the deodorant remains on the skin even after treatment of the skin with the composition.

The topical carrier for the deodorizing compositions of the present invention is in the form of a liquid, solid, cream, gel, lotion or other form, preferably formulated to be capable of depositing the deodorant on the skin or clothing. Ru. As used herein, "deposited" and "deposition" of a deodorizing agent on the skin refers to deodorizing after typical use of the deodorizing composition, including any conventional post-deodorizing composition application steps. refers to the application of a deodorizing composition to the skin such that the agent remains on the skin. Such topical carriers include, but are not limited to, conventional deodorizing compositions such as creams, sticks, roll-on liquids, and spray liquids (including aerosols); skin lotions, skin conditioners, skin creams, and windscreens. There are carriers that are formulated as skin cleansing products such as body lotions, creams and oils; bar soaps, liquid soaps and cleaning gels.

Typically, the topical deodorizing compositions of the present invention will contain from about 0.01 to
about 20%, preferably about 0.05 to about 5%, more preferably about 0.05%. Contains 5 to about 2% 1°3-diketone deodorizer.

Preferred deodorizing compositions of the present invention are conventional deodorizing compositions, including antiperspirant/deodorizing compositions formulated for topical application to the axillary region of the body or for application to the crotch region. The specific ingredients contained in the deodorizing compositions of the present invention will depend on the specific mode of application desired. These methods of application and the ingredients used in such compositions are well known in the art. A number of such compositions are described by S. Plcchncr, “Antip
crspirants and DeodoranLs”
(Antiperspirant and deodorant), 2. Co5IIletic
s.

5science and Technology, 37
3-416 (M, Balsam and R, Sagari
ed, 1972), which is incorporated herein by reference.

1,3-di'r on the skin in the axillary area for odor control
The topical carrier for deodorizing compositions primarily formulated for the deposition of I.n. deodorants preferably contains no more than about 510% water, more preferably no more than about 226% water, and most preferably essentially 0% water. It is hydrophobic to the extent that it exists. Other compositions may contain large amounts of water, and due to the presence of water, 1
．． It is unlikely that the effectiveness of the 3-diketone deodorizer would be affected or increased.

Topical carriers useful for depositing 1,3-diketone deodorants on the skin in the form of creams, ointments, lotions, oil-in-water and water-in-oil emulsions are known in the art and are known in the art, e.g. Water-in-oil emulsions disclosed in U.S. Pat. and two-phase emulsion carrier systems, such as the silicone oil-in-liquid-in-water emulsions disclosed in European Patent Application Box 281,394 to Pigueroa et al., incorporated herein by reference.

1. Liquid compositions useful in the present invention, such as liquid roll-ons, sprays, and aerosols, preferably contain a liquid emollient as all or a substantial portion of the topical carrier. Such compositions are suitable for delivery from conventional roll-on, spray and aerosol containers (respectively) known in the art. Such emollients include fatty acid and fatty alcohol esters, water-insoluble ethers and alcohols, polyorganosilicones, and mixtures thereof. Polyorganosilicone is one of the preferred emollients used herein. Liquid topical carriers are disclosed in U.S. Patent No. 4,053,85 issued to Pader et al.
Issue 1, December 27, 1977 Miles, Jr.
U.S. Patent Section 4,065,564, 19, issued to et al.
U.S. Patent Section 4'07'3,880 issued to Padcr et al. on February 14, 1981;
No. 55; E published in Lee J on October 24, 1979
I+ni et al. UK Patent Application Section 2,018. ．． No. 590;
and Bcck+n published on July 11, 1984.
European Patent Application No. 28.853 to Cycr et al.

The liquid deodorizing compositions of the present invention may also contain alcohols and/or polyols as a substantial component of the topical carrier. Alcohols that can be used here include ethanol, propatool, isopropateol, and mixtures thereof. Examples of polyols used here include glycols such as propylene glycol.

The liquid composition may also contain fillers to modify the physical and/or cosmetic characteristics of the composition. Such fillers are typically present at about 1 to about 8% 1 novel. Bulking agents useful herein include talc, colloidal silica, clays, and mixtures thereof.

2. Aerosols The aerosol compositions of the present invention contain one or more volatile substances, i.e. herein "
The aerosol propellants useful herein typically have a boiling point in the range of about -45 to about 5°C. It is liquefied when filled into a container. The rapid boiling of the aerosol propellant upon exiting the aerosol container serves to atomize the other components of the aerosol composition.

Aerosol propellants useful herein include those well known in the art. Such aerosol propellants include chemically inert hydrocarbons, such as propane, n-butane, isobutane, cyclopropane and mixtures thereof, as well as halogenated hydrocarbons, such as dichlorodifluoromethane (propellant 12). , 1,1-dichloro-1,1,2
, 2-tetrafluoroethane (propellant 114), 1-chloro-1,1-difluoro-2,2,2-trifluoroethane (propellant 1.15), 1-chloro-1°1-difluoroethylene ( propellant 142B), 1-difluoroethane (propellant 152A), monochlorodifluoromethane and mixtures thereof. Isobutane, used alone or mixed with other hydrocarbons, is preferred for the aerosol compositions of the invention.

3. Deodorizing Stick The solid composition of the present invention is in stick form as known in the art, typically comprising a liquid base material and a coagulating agent. These deodorizing sticks are commonly described as either gel sticks or wax sticks, depending on the specific liquid base material and coagulant used.

Generally, the liquid base material is present at a level of about 10 to about 9796. Coagulants are typically present at levels of about 1% to about 7%.

As will be apparent to those skilled in the art, the choice of the particular liquid base material and the appropriate coagulant will vary depending on the particular type and rheology of the deodorizing stick desired. Various liquid base materials and coagulants useful herein, as well as sticks made from these materials, are described in the following documents, all of which are incorporated herein by reference:
S, Plcchncr, “Antipcrspiran
ts and Codorants” (antiperspirants and deodorants), 2. Cosmetics, 5science a
ndTechnology, 373-418 (M,B
alsam and E, Sagarincd, +972)
;C, Pox, “Gel and 5ticks R
cviev and LIpdaLe” (considerations and latest information on gels and sticks), 99.Cosmetics
& Toiletries, 19-52 (1984)
;N.

Geria, 'Por■ulaLion of' 5L
ick AnLipersspiranLsand De
odoranLs” (stick antiperspirant and deodorant formulation), 99.Cosmetics & ToileLr
ies, 55-99 (1984);
and 5ticks For II lulary” (
gel and stick formulations), 99. Cosmetics
& Toiletrles, 77-87 (1984)
.

, the liquid base material used in wax deodorant sticks usually also functions as an emollient, improving the cosmetic acceptability of the deodorant stick. Such emollients include fatty acid and fatty alcohol esters, water-insoluble ethers and alcohols, polyorganosiloxanes, and mixtures thereof. Polyorganosiloxane is one of the preferred liquid base materials useful in the wax deodorizing sticks of the present invention.

Coagulants useful in the wax deodorizing sticks of the present invention are wax materials, typically incorporated at levels of about 5 to about 5096. Such wax materials of use herein include high excitation point waxes having melting points of about 65 DEG to 102 DEG C. Low melting waxes having melting points of about 37-75°C are also preferred. As such low melting point wax,
These include fatty acids, fatty alcohols, fatty acid esters, fatty acid amides and mixtures thereof. stearyl alcohol,
Cetyl alcohol and mixtures thereof are also particularly preferred wax materials useful in the deodorizing stick compositions of the present invention. Among those useful in the wax-type deodorizing sticks of the present invention, liquid base materials and coagulants are disclosed in the following U.S. Patent No. R15nau, dated September 20, 1977, which is hereby incorporated by reference: No. 4.04 (No. 1,792; 1979)
No. 4,151,272 issued to Geary et al.
No. 4,280,994 issued to Turney on July 28, 1981, November 1978.
U.S. Pat.

The gel deodorizing stick of the present invention contains a liquid base material selected to also exhibit desirable cosmetic properties such as emollient and/or cooling values when applied to the skin. Liquid base materials useful in such gel sticks include water, lower-hydric alcohols, polyhydric alcohols, and mixtures thereof. Such substances include ethanol, isopropanol, n-propanol, n-
Butanol, isobutanol, t-butanol, ethylene glycol, propylene glycol, trimethylene glycol, glycerin, 1,3-butanediol, 1,
4-butanediol and mixtures thereof. Ethanol, propylene glycol, and mixtures thereof are the preferred liquid base materials for the gaskets of this invention.

Coagulating agents useful in the gel deodorizing sticks of the present invention are generally surface-active compounds that solidify or coagulate the liquid-based material into a gel to form a network. Such coagulants typically include soaps, higher fatty acid amides of alkylamines, benzylidene sorbitol, propionates and lactates, waxes, and mixtures thereof. The preferred coagulant for the gel deodorizing stick of the present invention is nonionic in nature. A preferred coagulant useful in the gel deodorizing sticks of the present invention is benzylidene sorbitol, particularly dibenzaldehyde monosorbitol acetal.

Such materials come from a variety of sources, such as Gel All-D (Gcll A11-D”) [Shin Nippon Kagaku (N
cw Japan Chemical Company
.

Ltd.] and Millitics ()li l l 1
thix ■) [Miliken Chemical Division of Milliken & Company,
Division or Millikan &comp
It is commercially available as [manufactured by any]. Liquid base materials and coagulants among those useful in the gel type deodorizing sticks of the present invention are disclosed in the following patent specification: 1959 8J]1, all of which are incorporated herein by reference.
U.S. Patent Section 2 issued to 5 latcr in 8 U.J.
No. 900,306, dated June 7, 1966, by Barto.
U.S. Patent Section 3°255.082 issued to n; 19
U.S. Patent Section 4,137 issued to Rubjno et al. on Jan. 30, 1979, I.1. No. 306, issued May 15, IQ79, to Roelt et al., U.S. Patent Section 4
, No. 154, 816; Yub dated October 70, 1980.
U.S. Patent Section 4.226.889, issued to AS, 1
U.S. Pat.
U.S. Patent Section 4,383,9 issued to Teng et al.
No. 88; U.S. Patent No. 4,504,465, 198 issued to Sampson et al.
Lucbb et al., European Patent Application No. 107,330, published May 21, 1989;
US Pat. No. 4,816,261 issued to be et al.

A preferred gel stick formulated with benzylidene sorbitol and cetyl alcohol is disclosed in U.S. Patent Section 4.743, issued to McCall on May 10, 1988;
No. 444 (incorporated herein by reference)
It is written in.

The deodorizing sticks of the invention, especially wax type deodorizing sticks, may contain inert filler substances. Such substances include talc, colloidal silica [e.g., Cabot Corp.
) Sales of Cab-O-Sil (Cab-0-8 ■)]
, clays (e.g. bentonite) and mixtures thereof. Such filler substances were introduced in November 2, 1978.
1 [U.S. Patent Section 4,12 issued to Davy et al.
No. 6,679 (incorporated herein by reference) and May published August 1984, No. 291I.
European Patent Application No. 117,070, incorporated herein by reference.

Deodorizing compositions of the invention that are applied topically to the skin may, in addition to the 1,3-diketone deodorants of the invention, also contain optional ingredients that function as additional "active" ingredients when deposited on the skin. . However, such additional active ingredients: 1.
Preferably, it does not substantially interfere with the deodorizing activity of the 3-diketone. Active ingredients are not particularly limited, but include antibacterial agents,
Examples include bactericides and fungicides, and other deodorants such as antiperspirants. The active ingredient must be stable in the formulation of the composition. Preferably, a "safety standard" amount of active ingredient is used. Various active ingredients among those useful in the present invention are described in U.S. Pat. ing.

Preferred antiperspirant materials useful in the deodorizing compositions of the present invention include aluminum and zirconium salts such as aluminum halide, aluminum hydroxyhalide, oxidized zirconyl halide, zirconyl hydroxyhalide, and mixtures thereof. Among the antiperspirant substances for H, Beckme published on July 11, 1984.
yer et al., European Patent Application No. 28,853, incorporated herein by reference. Such materials are typically included at a level of about 15% to about 40%, based on the total weight of the composition.

Other optional antiperspirants include U.S. Patent Section 4,226, issued to Packman, 10JI7/1980.
85 (Specification No. 1 and Pa. dated November 18, 1980)
U.S. Patent Section 4,234, '56 issued to ckman
Ethanolamines, ethylenediamines, alkylamines, phenothiazines and piperazines, or pharmaceutically acceptable salts thereof, as described in Specification No. 6 (both of which are incorporated herein by reference) There are antihistamines selected from the group of. Still other optional antiperspirants include MacMi l, April 4, 1967;
U.S. Patent issued to Jan Section 3. No. 312,709; June 20, 1967, MacMi I
US Patent Issued to Fan Section 3. '326,768
Issue specification: MacMi on October 23, 1973
U.S. Patent Section 3,767.78 issued to l fan
Specification No. 6; and November 1, 1971. :MorreL
L+,::Published Saleta National Patent No. 3,624,200
Specification (all incorporated herein by reference)
There are a variety of anticholinergic agents, such as the belladonna alkaloids scopolamine and esters of atropine disclosed in .

As will be appreciated by those skilled in the art, certain antiperspirant substances described above may be ineffective in or destabilize the compositions of the present invention. Accordingly, the compositions of the present invention contain at least about 6. A buffer may be included to maintain a pH of 0. Such a buffer is 197
No. 4,154°816 issued to Roch l et al. on May 15, 1982;
U.S. Patent No. 4,3 issued to Rochl on May 24th.
No. 46,079; and U.S. Pat. No. 4,518 issued May 21, 1985 to Schamper et al.
, 582, all of which are incorporated herein by reference.

Some preferred compositions of the invention also contain safe and effective amounts of deodorizers other than 1,3-diketone deodorizers, such as antimicrobial agents (e.g., bactericides and fungicides) or mixtures thereof. Such other deodorants (by weight of the composition) contain about 0
．． Usually present at levels of 1-10%. Other suitable deodorizers include cetyltrimethylammonium bromide,
Cetylpyridinium chloride, benzethonium chloride, diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride, N-laurylsarcosine sodium, N-polymethylsarcosine sodium, lauroylsarcosine, N-myristoylglycine, N-lauroylsarcosine potassium, stearyltrimethylammonium chloride and their There are mixtures of bacteriostatic quaternary ammonium compounds. Other suitable deodorizing agents include 2.4.4--)lichloro-2'-hydroxydiphenyl ether, zinc pyrithione (:ZPT) and sodium bicarbonate. Other particularly preferred deodorizers include those disclosed in U.S. Pat. There are also diaminoalkylamides such as lysine hexadecylamide.

Other optional ingredients of the deodorizing composition of the present invention include fragrances, pigments, dyes, colorants, and ultraviolet absorbers.

The deodorizing compositions of the present invention are manufactured by various techniques well known in the art. For example, such techniques for producing solid deodorizing compositions are described by °'Gels and SticksFo.
rmulary” (gel and stick treatment%), 99
'.

Co5IIletics & ToileLries,
77-87 (1984), which is incorporated herein for consideration.

4. Creams, Ointments and Lotions The cream, cartilage and lotion compositions of the present invention typically include one or more emollients as a component of the topical carrier. As used herein, "emollient" refers to substances used to prevent or reduce dryness and protect the skin. A variety of suitable emollients are known and can be used in the present invention. sagar+n, cosmct+cs, sc+cnc, incorporated herein by reference
c and TOellnOIOgy, 211dEdi
tion, Vol. I, pp. 32-43 (1972)
contains various examples of suitable substances. Examples of types of emollients for whitening include: hydrocarbon oils and waxes; silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane, water-soluble and alcohol-soluble silicone glycol copolymers; vegetable and Triglyceride esters such as animal fats and oils; acetoglyceride esters such as acetylated monoglycerides; ethoxylated glycerides such as ethoxylated glyceryl monostearate; 10 to 20 carbon atoms
alkyl esters of fatty acids having 10 to 2 carbon atoms;
alkenyl esters of fatty acids having 0; carbon atoms 10
fatty alcohols having from 10 to 20 carbon atoms; fatty alcohol ethers; ether-esters such as fatty acid esters of ethoxylated fatty alcohols; lanolin and derivatives; polyhydric alcohols and polyethyl derivatives; polyhydric alcohol esters; Wax esters such as beeswax, spermaceti, myristyl myristate, stearyl stearate; beeswax derivatives; vegetable waxes such as carnauba and candelilla wax; phospholipids such as lecithin and derivatives; cholesterol and cholesterol fatty acid esters sterols; amides such as fatty acid amides, ethoxylated fatty acid amides, solid fatty acid alkanolamides.

Particularly useful emollients for skin conditioning are glycerol, hexanetriol, butanetriol, lactic acid and its salts, urea, pyrrolidone carboxylic acid and its salts, amino acids, guanidine, diglycerol, and triglycerol.

The lotions of the invention in solution form typically contain about 0.01
to about 20%, preferably about 0.1 to about 5% 1,3-diketone deodorant; about 1 to about 2096, preferably about 5 to about 10% emollient; about 50 to about 90%; Preferably it contains about 60 to about 80% water. The cream of the present invention in solution form typically has a concentration of about 0.01 to about 2096, preferably about 0.09. 1 to about 5% 1,3-diketone deodorant; about 5 to about 5096, preferably about 10 to about 20% emollient;
Contains about 45 to about 85% water, preferably about 50 to about 75% water.

The ointments of the present invention contain a single base of animal or vegetable oil or semi-solid hydrocarbon (oily). The ointment may also include an absorbent ointment base that absorbs water to form an emulsion. Examples of such ointment bases are anhydrous lanolin and hydrophilic petrolatum. Emulsion ointment bases may be oil-in-water or water-in-oil emulsions. Ointment carriers may also be water soluble. Examples of such ointment carriers include ingredients such as glycol ethers, propylene glycol, polyoxylstearates and polysorbates. Ointments typically contain from about 2 to about 1026 emollients and from about 0.1 to about 226 thickening agents. A more detailed disclosure of thickening agents useful herein is provided by Scgarin, Co5r.
actics, 5cicncc and Tcchno
Logy.

2nd IEdition, Vol. 1. pp, 72-
73 (1972), which is incorporated herein by reference.

When the topical carrier of the present invention is formulated as an emulsion, typically about 1% to about 10%, preferably about 2% to about 5% of the carrier is an emulsifier.

The emulsifier may be nonionic, anionic or cationic. Suitable emulsifiers are e.g.
No. 3, issued to Djckcrt et al.
No. 755,560; U.S. Pat. No. 4,421,76 issued to Dixon et al. on December 20, 1983.
Q specification: and McCu[cheon's, Dete
rgents and emulsifiers.

North American Edition, pa.
ges 317-324 (198B), the disclosures of which are incorporated herein by reference. Preferred emulsifiers are anionic or nonionic, although other types can also be used.

Single emulsion skin care formulations such as oil-in-water and water-in-oil lotions and creams are well known in the cosmetic industry and are also useful in the present invention. Reference-40 = U.S. Pat. No. 4,254., issued to Pakuda et al., dated March 3, 1981, which is incorporated herein by reference.
Multiphase emulsion compositions, such as the water-in-oil-in-water type disclosed in No. 105, are also useful in the present invention. Generally, such jli- or multiphase emulsions confess water, emollients and emulsifiers as essential ingredients.

Also useful in the present invention are two-phase emulsion carriers confessed to the silicone oil-in-water emulsion compositions disclosed in European Patent Application No. 281,3C14 (noted above). More specifically, such a -phase emulsion carrier system comprises: a) a silicone liquid continuous phase consisting essentially of at least one liquid organopolysiloxane;
b) an aqueous discontinuous phase comprising an oil-in-water emulsion of a palm-acceptable oily liquid non-particulate phase dispersed in a liquid phase, from about 30 to about 80% by weight'') 0 (in a vehicle) and c) an effective dispersion amount of dimethicone copolyol from about 0.5 to about 5% by weight (in the vehicle) to disperse (b) in (a).

Another emulsion carrier useful in the compositions of the present invention is a microemulsion carrier.

Such carriers include about 9% to about 15% squalane, about 25% to about 40% silicone oil, about 8% to about 2026% fatty alcohol, about 15% to about 3026% polyoxyethylene sorbitan monofatty acid [trade name Tween ( TVcon
o)] or other nonionic substances and from about 7 to about 2
Contains 0% water.

Lotions and creams can be formulated as emulsions and solutions. Typically, such lotions in emulsion form contain from about 0.01 to about 20%, preferably from about 0.1 to about 5%, of a 1,3-diketone deodorant;
~ about 20%, preferably about 5 to about 10% emollient;
from about 25 to about 7596, preferably from about 45 to about 95% water; and from about 1 to about 1096, preferably from about 2 to about 5% emulsifier. Such reams in emulsion form typically range from about 0.01 to about 20%, preferably from about 0.1 to about 20%.
about 5% 1,3-diketone deodorant; about 1 to about 20%, preferably about 5 to about 10% emollient; about 20 to about 80% emollient;
%, preferably from about 30 to about 70% water; and from about 1 to about 1
0%, preferably about 2 to about 5% emulsifier.

5. Skin Cleansing In addition to the deodorizing compositions described above, the deodorizing compositions of the present invention include skin cleansing deodorizing compositions, which contain a 1,3-diketone compound and a safe and effective amount for topical application to human skin. and a topical carrier containing a surfactant. The term "safe and effective amounts of surfactants for topical application to human skin" refers to surfactants that are not only effective skin cleansers, but also can be used without undue toxicity, irritation, allergic reactions, etc. . The skin cleansing deodorizing composition of the present invention preferably has a 1.3-
diketone deodorizer and about 1 to about 90%, preferably about 50%
~90% of human skin topical applications contain surfactants.

The physical form of the skin cleansing deodorizing composition is not important. The composition can be formulated, for example, as a cosmetic solid, liquid, paste or mousse. The cosmetic solid body is
This is most preferred as it is the most commonly used form of cleansing agent for cleaning the skin.

Those skilled in the art will appreciate that active ingredients applied to the skin from skin cleansing compositions may not typically deposit involuntarily on the skin due to factors such as washing after application of such products. will. 1 on the skin
, 3-diketone is not achieved, the composition is still highly effective in suppressing non-microbial malodor already formed in the axillary or crotch area. Non-microbial malodor control when combined with skin cleansing compositions is beneficial since malodorous skin conditions can persist even after the affected axillary and crotch areas have been cleaned with conventional skin cleansing compositions. It shows a particularly large effect.

1. A safe and effective amount of surfactants compatible with the 3-diketone deodorizer may also be used, such as surfactants selected from anionic, nonionic, zwitterionic, amphoteric, ampholyte surfactants and mixtures of these surfactants. Can be used in compositions of the invention. Such surfactants are well known to those skilled in the detergent industry. Suitable surfactants are for example McC
utehconoS.

Detergents and EIIlslf'
1ers, North American・Ed, p.
agcs 317-324 (19H), which is incorporated herein by reference. It is not believed that the particular surfactant is important in obtaining the wellbore microbial malodor effect of the present invention.

The skin cleansing and deodorizing composition of the present invention comprises the above substances,
Antibacterial and fungicidal agents further include the materials described in U.S. Pat. No. 3,256,200 issued June 14, 1966 to Rcl lcr et al. agent; the above substances plus mineral oil, about 100%
White melting point of ~170°F.

paraffin wax, fatty sorbitan ester (October 26, 1976, incorporated herein by reference)
U.S. Patent No. 3,988 issued to 5eiden with
, 255), lanolin and lanolin derivatives, esters such as isopropyl myristate, triglycerides such as coconut oil or hydrogenated tallow; the volume and quality of the lather produced by the composition (creamy free fatty acids, such as Coconutura fatty acids, preferably at a level of about 10% or higher; air fresheners, dyes, pigments, polymeric skin sensitizers [e.g.
rp,) Jaguar C-1,4-
cationic quaternized guar gum such as S], humectants, thickeners, preservatives, alkali agents, propoxylated glycerol derivatives skin conditioning agents or other cosmetic adjuvants. Materials conventionally used in cleansing compositions can optionally be formulated at their industry established levels.

Skin cleansing compositions formulated as cosmetic bar soaps typically contain from about 50 to about 9026 surfactants. Moisture is usually present at a level of about 5 to about 2096. Skin cleansing compositions formulated as liquids typically contain about 1
Contains 0 to about 30% surfactant and about 60 to about 90% water. Skin cleansing compositions formulated as pastes typically contain about 20% to about 60% surfactant and about 30% surfactant.
Contains ~50% water. Pastes and liquids usually also contain organic thickeners such as natural rubbers and polymers.

An example of a soap-based cosmetic bar composition is US Pat. No. 3,567, issued to Megson et al. on April 27, 1971.
．． No. 749, which is incorporated herein by reference. Examples of synthetic base cosmetic solids that can be used in preparing the compositions of the invention include: June 6, 1961
No. 2, issued to Lundberg et al.
．． No. 987,484, which is incorporated herein by reference. Other examples of soap/synthetic based cosmetic solids are given in Chaff, December 25, 1962.
U.S. Pat. No. 3,070,547 issued to C.C.C. and U.S. Pat. No. 376.229, which are incorporated herein by reference. An example of a soap-based liquid cleansing composition that can be used in making the liquid compositions of the present invention is U.S. Pat.
No. 33, which is incorporated herein by reference. Examples of synthetic-based liquid cleansing compositions that can be used in preparing the compositions of the present invention include
No. 4,338,211, issued June 61-1, 2005, 5tiros, which is incorporated herein by reference. The paste composition is
U.S. Pat. No. 4.31, incorporated herein by reference.
0.433 and 4,338.211 by appropriate reduction of the level of water. An example of an ultra-mild skin cleansing composition that can be used to prepare the composition of the present invention is
No. 4,67 issued to Small et al.
No. 3,525, which is incorporated herein by reference.

An example of a skin cleansing mousse composition containing ethoxylated nonionic and wholly or partially esterified polyol nonionic surfactants and also having skin conditioning ingredients such as emollients and skin moisturizers was published in 1987.
US Pat. In addition to disclosing examples of skin cleansing compositions of the present invention, the above-incorporated patent specification discloses that the compositions of the present invention can be used in combination with both soap-based and detergent-based surfactants. Various surfactants are also disclosed. The skin cleansing deodorizing composition of the present invention is produced by blending a 1,3-diketone deodorizing agent into the same composition as above.

B. Laundry Product Compositions Another aspect of the present invention relates to laundry product compositions comprising the 1,3-diketone deodorizers of the present invention and laundry product carriers. Carriers for laundry products can be in liquid, granular or solid form and contain liquid and granular detergents and wash additive, rinse additive and dryer additive substrates, such as fabric conditioning and/or detergent ingredients. Other ingredients may also be included. Laundry product compositions include 1,3-diketone deodorizers that deodorize and wash or rinse off clothing (odor removal) or deposited on clothing to control non-microbial odors (odor removal) during the laundry step. Prevention) is prescribed in either to remain.

The laundry product compositions of the present invention are believed to be particularly beneficial in reducing non-microbial malodor substances adsorbed onto fabrics.

Typically, such laundry product compositions contain about 0.001
Contains ~20% 1,3-diketone deodorizer. Laundry product compositions formulated for odor removal preferably contain about 0.
0.001 to about 1%, more preferably about 0.001 to about 1%. (']('
)5 to about 0.596, even more preferably about 0.01 to
Contains about 0.196 1,3-diketone deodorizer. Laundry product compositions formulated for odor control 11 preferably contain from about 0.01 to about 10%, more preferably from about 0.1 to about 59%.
Contains No. 6 1°3-diketone deodorizer.

As used herein, "laundry product compositions" include compositions such as liquid and granular laundry detergents, liquid and granular fabric conditioning, and washer or dryer additive substrates, which include fabric conditioners and/or detergents. It may also contain ingredients.

Such compositions include the 1,3-diketone agent of the present invention, but typically also include one or more of the following ingredients:

Cleaning surfactant (2) The detergent composition of the present invention contains an organic surfactant ("surfactant") in order to exhibit the cleaning effect normally associated with the use of such a product.

Examples of detersive surfactants that can be used herein include well-known synthetic anionic, nonionic, amphoteric and zwitterionic surfactants. Typical examples of these are alkylbenzene sulfonates, alkyl and alkyl ether sulfates, paraffin sulfonates, olefin sulfonates, amine oxides, α-sulfonates of fatty acids and fatty acid esters, alkyl glycosides, ethoxylated alcohols and ethoxylated alkylphenols. is well known in the detergent industry. Generally, such detersive surfactants have alkyl groups in the C9-C18 range, although anionic detersive surfactants can be used in the form of their sodium, potassium or triethanolammonium salts.

Standard texts such as the McCutchcon index contain detailed lists of such typical detersive surfactants. CII"CI4 alkylbenzene sulfonate"+2-Cl3 paraffin sulfonate"
ll-Cl3 alkino sulphates and alkyl ether sulfates are particularly preferred in compositions of this type.

Water-soluble soaps such as common sodium and hypoturium coconut or tallow soaps well known in the art are useful herein.

Unsaturated soaps such as alkyl soaps may also be used, especially in liquid formulations. Saturated or unsaturated C9''01B hydrocarbyl succinates are also effective.

Anionic substances such as alkylbenzene sulfonates, alkyl sulfates and paraffin sulfonates and C
The mixture with C1'' CI8 ethoxylated alcohol surfactant provides broad spectrum = 52-tol soil and dirt through-the-wash from fabrics.
rOugll-ilile-vasll) preferred for cleansing.

Combinations of anionic, cationic and nonionic surfactants can also commonly be used. Such combinations or combinations of anionic and nonionic surfactants alone are also preferred for liquid detergent compositions. Such surfactants are commonly used in acid form and are neutralized during the manufacture of liquid detergent compositions. Preferred anionic surfactants for liquid detergent compositions include linear alkylbenzene sulfonates, alkyl sulfates, and alkyl ethoxylated sulfates. Preferred nonionic surfactants include alkyl polyethoxylated alcohols.

Anionic surfactants are preferred for use as detersive surfactants in granular detergent compositions. Preferred anionic surfactants include linear alkylbenzene sulfonates and alkyl sulfates. Combinations of anionic and nonionic detersive surfactant detergents are also particularly useful for granular detergent applications.

Detergent compositions typically contain from about 10 to about 60% water-soluble detersive surfactant. Suitable surfactant and detergent compositions are disclosed in U.S. Pat. No. 4,294,710, both of which are incorporated herein by reference.

Two conventional builders used in the practice of this invention include amine chelating agents and phosphonate chelating agents.
- various sequestering agents such as alkylene aminophosphonates and tripolyphosphate-1 such as diethylenetriaminepentaacetic acid, ethylenediaminetetraphosphonic acid, and "pyro" builders well known in the art. Importantly, a variety of non-phosphorous builders can be used. For example, although not limited to these, 1 to
10μ Zeolite A (ZeoliLe A), 2.
These include 2-oxodisuccinate, tartrate mono- and disuccinate, citrate, C8-014 hydrocarbyl succinate, sodium carbonate and mixtures thereof. Inorganic salts such as sodium sulfate may also be present.

A list of builders useful herein can be found in the above-cited US Pat. No. 4,704,233.

BACKGROUND OF THE INVENTION A variety of well-known bleaching agents (particularly fiber and fabric bleaches) are well known and can be used as components of carriers for laundry products. Thorium perborate and tetrahydrate are preferred for laundry products, but percarbonates and persulfates are also useful. Aqueous hypochlorite is also a routine additive in many laundry operations.

As mentioned above, white as a component of the composition of the present invention.

The bleaching agents that can be used are limited to those that are compatible with the 1,3-diketone compound in the composition.

Detergent adjuvant compositions can contain a variety of ingredients to aid their cleaning performance. For example, the laundry compositions preferably also contain enzymes to enhance their through-the-wash cleaning performance on various soils and soils. Amylase and protease enzymes suitable for detergent applications are well known in the art and in commercial liquid and granular detergents. Commercially available detergent enzymes (preferably a mixture of amylase and protease) are typically used in the present compositions at levels of 0.001-2% and higher.

Historically, in addition to the above ingredients, the compositions can also contain various other optional ingredients typically used in commercial products to provide aesthetic or additional product performance benefits. Typical ingredients include pH adjusters, fragrances, dyes, bleaches, fluorescent brighteners, polyester soil release agents, hydrotropes, gel control agents, freeze-thaw stabilizers, fungicides, preservatives, and foam control agents. , bleach accelerators, etc.

Fabric softeners, particularly clays and mixtures of clays with various amines and quaternary ammonium compounds, can all be used in the present compositions. Such matters are well known from the patent literature and from commercial practice.

The compositions are manufactured using conventional techniques well known to formulators of commercial detergent and bleach products.

Fabric conditioning agents, when present in laundry product compositions, typically range from about 1 to about 359 oz, preferably from about 6 to about 25% of the composition. The specific fabric conditioning agent utilized is not believed to be critical to the invention, and any canned conditioning agent known in the art is believed to be applicable. For example, 1
Quaternary ammonium fabric conditioner as disclosed in U.S. Patent No. 3,936,537 issued to Naskervi Ile et al.
tertiary amines as disclosed in British Patent No. 1,514,276 of
British Patent No. 1.0 published on July 26 B (-J)
No. 77.103 and No. 1,077.1.04 and Ca5vc filed on February 8, 1988 (-J
Amine-anion pair complexes as disclosed in U.S. Patent Application No. 153.172 to I.

U.S. Patent m4.1311 issued December 1977 to 5torn et al. 062.647 specification and Pro
British Patent Section 1.4.83,6 assigned to CTCR & Gamble and published August 241-1 1977
Smectite (sII) as described in specification No. 27
lcct 1tc) type clay flexible system.

Aqueous dispersions useful for direct application to clothing in aerosol form include 1,3-diketone deodorizers, about 0. 1-10%
of water, about 0.01 to about 5% of a suitable organic solvent, and the balance a suitable propellant. Examples of such propellants are chlorinated, fluorinated and chlorofluorinated low molecular weight hydrocarbons. Nitrogen oxide, carbon dioxide, isobutane and propane can also be used as propellant gases. These propellants are used at levels sufficient to propel the contents of the container. Suitable organic materials useful as a solvent or part of a solvent system are: propylene glycol, polyethylene glycol (M,W, 200-600), polypropylene glycol (M,W).

425-2025'), glycerin, sorbitol ester, 1,2,6-hexandriol, diethyl tartrate, butanediol and mixtures thereof. The balance of the composition is a liquid carrier, preferably the carrier is water or a mixture of water and a -hydric alcohol.

Liquid fabric treatment compositions can be prepared by mixing the 1,3-diketone deodorizer alone or with other ingredients in a solvent.

The deodorizer of the present invention can be added to the granule carrier by mixing the deodorant with the other composition components in solution before being spray-dried, and then spray-drying the mixture in a conventional manner. On the other hand, granular or powdered laundry product compositions may be prepared by tri-blending the deodorizer with other composition ingredients.

C9 Fabric Treatment Compositions Another aspect of the invention is a fabric treatment composition comprising a 1,3-diketone agent of the invention and a fabric treatment carrier for deposition onto clothing or fabrics worn close to the skin. Regarding the composition. The "f11 fabric processing carrier" used here typically contains one or more of the following components: a fluorescent brightener, a surfactant (preferably nonionic or anionic), or
Contains organic ester. It is believed that canned food treatment compositions may inhibit or reduce the formation of non-microbial malodors due to axillary or crotch area sweat adsorbed to the garment. As a carrier for fabric treatment, the 1,3-diketone deodorant may be deposited onto the garment before washing or drying the garment, or the deodorant may be deposited onto the garment before the garment is used or worn. There are liquid and granular fabric conditioning compositions and stain and/or odor removal compositions that are formulated to remain deposited during at least the initial period of time that they are worn or used.

Typically, such compositions will contain from about 0.01 to about 20%, preferably about 0.01% to about 20%, of the 1,3-diketone compound of the invention.
1 to about 1096.

D. Sanitary products and diapers Another aspect of the present invention is a non-microbial malodor control device comprising an adsorbent substrate carrier of a sanitary product or diaper product (including adult incontinence) and a deodorizer of the present invention = 60 = Regarding the composition. As used herein, "adsorption base carrier" means an adsorption layer or core of material including wood pulp fibers, cotton fibers, polyester fibers, or other liquid or solid adsorption materials. Deodorizing compositions containing the deodorizing agent of the present invention for use in suppressing urine-based and menstrual fluid-based malodors include, but are not limited to, sanitary products such as sanitary napkins and panty liners, and diapers for infants and adults. . Another aspect of the invention provides toilet bowls and cosmetic utensils;
Provided are deodorizers and deodorizing/preservative compositions for sanitary products and bedding, which contain the deodorizer and fragrance or antibacterial agent of the present invention.

E. Method The present invention involves topical application of a safe effective dose of 18 or more 1,3-diketone compositions of the present invention to skin areas subject to secretion of both apocrine and ephrine sweat, namely the axillary and groin regions of the body. Also provided are methods for controlling or inhibiting malodor, preferably human sweat malodor.

Methods using the compositions of the present invention to control non-microbial malodors include topical application of the compositions of the present invention, or the compositions have a concentration of from about 0.002 to about 4. OLIlg, preferably about 0.
01 to about 1. It is preferred that the deodorant is applied such that 0.0 cm of deodorant is applied per skin IC.

Historically, the present invention has been applied to parts of clothing or fabrics according to 1 and 3 of the present invention.
- Provides a method for controlling non-microbial malodors in clothing and fabrics by depositing safe and effective amounts of diketone agents. Preferably, the deodorizing composition is applied to the garment in areas that, when worn, typically come into contact with both the ephrine and apocrine glands, particularly the axillary and crotch areas. Preferably from about 0.002 to about 4.0 mg, preferably about 0.00 mg.
0.01 to about 1.0 cm of 1.3-diketone deodorizer is deposited per 1 c of clothing or fabric.

The invention also provides a method of contacting an article of clothing or fabric with an aqueous detergent solution containing from 0.1 to about 2% by weight of the detergent composition of the invention. Fabrics to be laundered are agitated in these solutions, preferably in automatic washing machines, to provide cleaning, soil removal, fabric care benefits, and odor control.

The composition can also be applied to the article by tamping the garment or fabric with the composition in an automatic washer/dryer.

The present invention also provides a method for suppressing malodor by contacting or depositing the 1,3-diketone deodorant of the present invention on sanitary products that come into contact with urine, feces, and/or menstrual fluid. A preferred method further involves contacting or depositing a deodorant onto the sanitary product containing the adsorbent substrate carrier.

The above non-limiting examples describe compositions of the present invention.

Compositions for topical administration are prepared as described above: Example 1 Ingredients
quantity dipropylene glycol
28% Sodium Stearate
6% propylene glycol (3) myristyl ester 21% cyclodecamethylpentasiloxane +99°ethanol
24.7% 5-chloro-
2-(2,4-dichlorophenoxy)phenol 0
, 3% Meldrum acid
1.09ii100.0% -6'3-Meldrum's acid is mixed with the other above ingredients for use as a deodorizer using methods known in the art.

Dimedone or other 1,3-diketone compounds useful in the compositions of the invention may replace the 1,3-diketones in the compositions.

Example 2 Ingredients
QuantityCyclodecamethylpentasiloxane
39% dipropylene glycol
2596 Propylene glycol (3) myristyl ester 2096 Fragrance
1.4% ethanol
13.6% Meldrum acid 1.
09°100.096 Meldrum's acid is mixed with the other above ingredients for use as a deodorizer using methods known in the art.

Dimedone or other 1,3-diketone compounds useful in the compositions of this invention may replace the 1,3-diketones in the present compositions.

Example 3 Ingredients
Total propylene carbonate
8.700 propylene glycol
4.3% dipropylene glycol
36% PEG-61090 Propylene Glycol (3) Myristyl Ester
1000 millitics 925 *4.9% ethanol
24.8965-Chloro-2-(2,4-dichlorophenoxy)phenol o, a? ,.

meldrum acid
1.096100.096 * Milliken Chemicals
icals) [Inman, South Carolina] The supplied Meldrum acid is mixed with the other ingredients listed above for use as a deodorizer using methods well known in the art.

Dimedone or other 1,3-diketone compounds useful in the compositions of this invention may replace the 1,3-diketones described above in the present compositions.

Example 4 Ingredients
amount ethyl acetate
30.7% cyclodecamethylpentasiloxane
68965-Chloro-2-(2,4-dichlorophenoxy)phenol 0.396 Meldrum's acid 1.096
The 100.0% Meldrum acid is mixed with the other ingredients listed above for use as a deodorizer using methods known in the art.

Dimedone or other 1,3-diketone compounds useful in the compositions of this invention may replace the 1,3-diketones in the present compositions.

Example 5 Ingredients
amount ethyl acetate
30.79゜Cyclodecamethylpentasiloxane
68065-Chloro-2-(2,4-dichlorophenoxy)phenol 0.396 Meldrum's acid 1.0%
The 100.0% Meldrum acid is mixed with the other ingredients listed above for use as a deodorizer using methods known in the art.

Dimedone or other 1,3-diketone compounds used in the compositions of the present invention may replace the 1,3-diketones in the present compositions.

Example 6 Ingredients
amount acetone
30.796 Cyclodecamethylpentasiloxane
68% 5-chloro-2-(2,4-dichlorophenoxy)phenol 0.396 Meldrum's acid 1.09
6100.0% Meldrum's acid is mixed with the other ingredients listed above for use as a deodorizer using methods known in the art.

Dimedone or other 1,3-diketone compounds useful in the compositions of the present invention may replace the 1,3-diketones described above in the present compositions.

The purpose of this example is to illustrate the effectiveness of the present invention in reducing or inhibiting non-microbial malodors.

Example 7 - Another granular detergent composition of the invention contains the following ingredients:
minutes
9δ (wL) 12.3 Sodium linear alkylbenzene sulfonate 15.8014-C15
Sodium alkyl sulfate
6.8C12-C13 alcohol ethoxylate (EO
8) 0.5 sodium tripolyphosphate 6.
8 Sodium pyrophosphate
13.1 Sodium pyrophosphate acid
12.4 Sodium silicate (NaO/5102 ratio 1.6)
7. (i polyethylene glycol 800
B 0,6 Sodium polyacrylate (M, W, 4500)
3.4 Protease enzyme*l, 8 Sodium perborate tetrahydrate
1.9 Sodium sulfate
14.42.2-Dimethyl-1,3-dioxane-4,6-dione
0.05 balance (includes water, brightener, fragrance, foam suppressant) 14.85100.0 1% aqueous solution pH 9.2 at 20°C *Anson Reported in 'l'-position/g An aqueous clarification mix of the detergent composition is prepared and spray dried with the exception of sodium pyrophosphate, enzymes, and fragrances, which are mixed to contain the ingredients at the indicated levels.

Example 8 Another granular detergent composition for household laundry is as follows: Ingredients
G96) C14-015 Sodium alkyl sulfate
13.3C13 Sodium linear alkylbenzene sulfonate 5.7C12
-C13 alkyl polyethoxylate ([i,5)
1.0 Sodium toluenesulfonate
1.0*1 bird/TDS sodium salt, TMS:TDS weight ratio 8G/14
25. ON-Hydroxyethylethylenediamine sodium triacetate 2.0 Sodium polyacrylate (average M, W, approximately 5000) 2.
0 Sodium carbonate
20.3 Sodium silicate
5.8 points IJ4 tyrene glycol (average M, W, approximately 8000)
I, 02.2-dimethyl-1,3-dioxane-
4,6-dione 0,05 sodium sulfate 1
Gongmu, Water and Others” 2
2.85100.0 *1'MS/TDS - TMS to TDS weight ratio 85/1
A mixture of tartaric acid monosuccinate and tartaric acid disuccinate in the pentasodium salt form. Various ingredients including fragrances, buffering agents, coloring agents, opacifying agents, etc. are combined with a sufficient excess of water (total volume of approximately 4 L%) under continuous mixing. Additionally, an aqueous slurry is formed and then spray dried to form the composition.

Example 9 Another liquid detergent composition for domestic laundry is as follows: Ingredients
Amount (9δ) CI4-CI5 alkyl polyethoxy (
2,5) Potassium sulfate 8,3C12-C14 alkyldimethylamine oxide 3.3
Potassium toluenesulfonate
5.07-ethanolamine
2.3TMS/TDS) Reethanolamine salt, 85/15 TMS/TOS
L5.01.2-dihydroxy-3,5-disulfobenzene potassium salt 1.5 Potassium polyacrylate (average M, W, about 9000) 1
．． 52.2-dimethyl-1,3-dioxane-4,6-
Zeon 0. O1 water and others*
(i3.0
9100.0 1 Ingredients, including fragrances, buffers, colorants, opacifiers, etc., are added together with continuous mixing to form a composition.

Example 10 Fabric conditioning agent ingredients
! (%) ditallow dimethylammonium chloride (DT
DMAC) 3,7methyl-1-
Tallow amidoethyl 2-Tallow imidazoline 3.
72.2-dimethyl-1,3-dioxane-4,6-dione 0. lWater and other
92.5too,
.

The disclosed 1,3-diketone compounds inhibit human perspiration as well as a variety of other malodors. Such other malodors include, but are not limited to, environmental odors and chemical odors. In addition, the disclosed 1°3-diketone compounds can be used in a variety of porous and non-porous materials including, but not limited to, plastics, hair, glass, porcelain, fabrics, fibers of various compositions, foods and beverages. Suppresses negative odors generated from or deposited on porous surfaces. Such negative odors can be eliminated by applying 1,3-diketone compounds to these surfaces before, during or after the odor is generated, or by applying 1,3-diketone compounds to these surfaces during manufacturing. May be suppressed. “Odor” used here
By "controlling malodors or negative odors" is meant preventing, inhibiting or converting the formation of such odors.

“Negative odor or malodor” as used here is:
Refers to an undesirable odor emanating from a specific surface or product.

The inventors have discovered that the disclosed 1,3-diketone compounds, preferably 2,2-dimethyl-1,3-dioxane-4,
It was further determined that 6-diones are highly effective in controlling malodors associated with laundry cleaning products. Although the mechanism involved in this deodorization is unknown, it is thought to be something other than interaction with the vitamin B6 reaction. Such a surprising application is extremely useful in laundry product compositions that do not contain fragrances, since these compositions may contain, but are not limited to, those containing solvents, enzymes, surfactants, or contaminants. This is because they often have negative odors emanating from their alternatives. In addition to deodorizing these negative odors, 1,3-diketone deodorizers enhance positive odors in laundry products such as air fresheners.

The present invention also relates to compositions effective in controlling malodors associated with chemical formulations of laundry cleaning products. A laundry product composition with a low negative laundry product odor is about 0.00
1 to about 20% 1,3-diketone compound.

The present invention further relates to an effective method for controlling malodors associated with chemical treatment of laundry cleaning products. A method for controlling negative laundry product odors includes the inclusion of from about 0.001 to about 20% of a 1,3-diketone compound in a laundry product composition.

Applicant's representative: Mr. Sato

Claims (1)

[Claims] 1. A deodorizing composition for suppressing bad odor caused by perspiration, which includes: a) a safe and effective amount of a 1,3-diketone compound having the following general formula: ▲ Numerical formula, chemical formula, table, etc. ▼ [In the above formula, each W is independently selected from the group consisting of O, S and (CH_2)_n (n = 1 to 3); each X is independently selected from hydrogen, halogen, 1 carbon atom
substituted or unsubstituted alkyl having 3 to 12 atoms, including 0 to 3 heteroatoms in the ring, or wherein the two X moieties are covalently bonded; a) forming a heteroalkyl, aryl or heteroaryl ring; and b) a topical carrier. 2, W is each independently O and (CH_2)_n (n=1
-3); X is each independently selected from the group consisting of hydrogen and substituted or unsubstituted alkyl having 1 to 5 carbon atoms, according to claim 1. Composition. 3. The deodorizing composition for suppressing sweat malodor according to claim 2, wherein at least one W is O; each X is independently selected from the group consisting of hydrogen and unsubstituted or substituted alkanyl. 4. The deodorizing composition for suppressing bad odor from perspiration according to claim 2, wherein both Ws are CH_2; each X is independently selected from the group consisting of hydrogen, methyl, or ethyl. The 5,1,3-diketone compound is spiro[4,5]-6,
10-dioxa-7,9-dioxodecane and spiro[
5,5]-1,5-dioxa-2,4-dioxoundecane. The deodorizing composition for suppressing bad odor caused by perspiration according to claim 1. 6,1,3-diketone compound is 2,2-dimethyl-1,
The deodorizing composition for suppressing bad odor from perspiration according to claim 4, which is 3-dioxane-4,6-dione. 7. The deodorizing composition for suppressing sweating malodor according to claim 1, 2, 4, or 6, further comprising an antibacterial deodorizing agent. 8, a) Safe and effective amount of 1,3-diketone compound having the following general formula: ▲ Numerical formula, chemical formula, table, etc. ▼ [In the above formula, each W independently represents O, S and (CH_2)_n( each X is independently selected from the group consisting of hydrogen, halogen, substituted or unsubstituted alkyl having from about 1 to about 5 carbon atoms; the X moiety is covalently bonded to form a substituted or unsubstituted alkyl, heteroalkyl, aryl or heteroaryl ring having from 3 to 12 atoms, including from 0 to about 3 heteroatoms in the ring; and b) laundering. A deodorizing laundry product composition comprising: a carrier for the product; 9. A method for controlling malodor from clothing, comprising depositing a safe and effective amount of the composition of claim 8 onto the clothing. 10, a) Safe and effective amount of 1,3-diketone compound having the following general formula: ▲ There are mathematical formulas, chemical formulas, tables, etc. ▼ [In the above formula, each W independently represents O, S and (CH_2)_n( n = 1 to 3); each X independently represents hydrogen, halogen, or 1 carbon atom;
substituted or unsubstituted alkyl having from 3 to 12 atoms, including from 0 to about 3 heteroatoms in the ring, or wherein the two X moieties are covalently bonded , heteroalkyl, aryl or heteroaryl ring]; and b) a carrier for fabric treatment; and is suitable for application to clothing worn on or near the skin. Fabric treatment composition. 11. Both Ws are O; and each X is independently selected from the group consisting of hydrogen, methyl or ethyl.
The deodorizing composition described in . 12. A method for suppressing malodor from clothing, comprising depositing a safe and effective amount of the composition according to claim 10 or 11 on the clothing.