JPH04202106A - Cosmetic and medicine for external use - Google Patents

Abstract

PURPOSE:To obtain a stable cosmetic and a medicine for external use, containing a specific trialkyl phosphate as an oily ingredient, excellent in extensibility and having refreshing touch. CONSTITUTION:A cosmetic and a medicine for external use containing a compound expressed by the formula (R is 6-10C alkyl) as an oily ingredient. The compound expressed by the formula is a chemically stable polar oil, having a low cloud point, high safety for human bodies and unique touch and excellent in solubility, compatibility, miscibility and further dispersibility of pigments, inorganic substances, etc., In addition to the compound expressed by the formula which is an essential ingredient, medicines, vitamins, ultraviolet light absorbers, preservatives, coloring matters, perfumes, etc., are added according to the purpose of use and employed as cosmetics, shampoos, rinses, urea creams, etc. For example, if a cleansing gel is prepared, the following characteristics are shown. Adaptability to the skin is good and the gel has light touch. When the aforementioned gel is anointed, the viscosity is rapidly lowered.

Description

Detailed Description of the Invention [Field of Industrial Application] The present invention relates to cosmetics and external preparations containing a specific trialkyl phosphate ester as an oily component, wherein the phosphate ester is used directly on the skin. It is useful as an oily component in cosmetics or external preparations, and as an oily component in oily or emulsion-type pharmaceuticals.

[Prior art and problems to be solved by the invention] Conventionally used oil-based components include fats and waxes, 2-synthetic ester oils, etc., but in general, fats and waxes have a high viscosity and a light specific gravity, making them difficult to use when used. It also has drawbacks such as being sticky and not spreading well. Synthetic ester oils sometimes have safety issues, and they also have problems with feel, deterioration, etc.

Trialkyl phosphate esters having an alkyl group having 14 to 18 carbon atoms have long been known as oily components, but because of the long alkyl group having 14 to 18 carbon atoms, the melting point (C1
The tricetyl phosphate ester of No. 4 has a high temperature (approximately 60°C), so there were restrictions on its handling and use. In addition, some of the hydroxyl groups of phosphoric acid remained and exhibited surface activity, and were chemically unstable. Furthermore, there were compounds such as trioleyl phosphate that were liquid at room temperature, but they were similarly avoided as substances that were unstable and caused color and odor, leading to a decrease in commercial value.

Except for trialkyl phosphate esters, which have high melting points, trioleyl phosphate esters are known to have excellent solubility, compatibility, miscibility, and dispersibility of pigments and inorganic substances as polar oils. However, trioleyl phosphate ester is hardly used due to the above-mentioned problems.

An object of the present invention is to provide cosmetics and external preparations that solve the problems of the prior art described above.

[Means for Solving the Problems] The present inventors have conducted extensive research in view of the above-mentioned circumstances, and have found that the oil is liquid at room temperature, chemically stable, has a low clouding point, and is polar, and is safe for the human body. When trialkyl phosphate esters are used as oil-based ingredients in cosmetics and external preparations, they have high solubility, compatibility, miscibility, and excellent dispersibility of pigments and inorganic substances, and have a unique feel. They discovered that excellent effects can be obtained and completed the present invention.

That is, the above objects of the present invention can be achieved by cosmetics and external preparations characterized by containing a liquid trialkyl phosphate ester represented by formula (a) as an oily component.

0-P (OR) 3 -(a) (R in formula (a) is an alkyl group having 6 to 10 carbon atoms.) Particularly preferably, R in formula (9) is a straight chain or a branched alkyl group having 6 to 10 carbon atoms.

The acid value of the trialkyl phosphate ester is preferably 1 or less, more preferably 0.2 or less.

[Preferred Embodiment] The liquid trialkyl phosphate ester used in the present invention is obtained by reacting a linear or branched alcohol having 6 to 10 carbon atoms with phosphorus oxychloride or the like.

It is purified by distillation.

Examples of the alcohol include linear alcohols such as normal hexyl alcohol, normal heptyl alcohol, normal octyl alcohol, normal nonyl alcohol, and normal decyl alcohol. These secondary alcohols, further include 4-methyl-2-pentanol, 2-methyl-1-hexanol, 2-ethyl-1-hexanol, 3,5,5. -trimethyl-1-
Branched alcohols such as hexanol and 3,7-dimethyl-1-octatool can be mentioned.

The liquid trialkyl phosphate ester used in the present invention had an acid value of 1 or less when measured using a method for measuring the acid value of fats and oils based on cosmetic raw materials. An acid value of 1 or less means that the composition consists essentially of trialkyl phosphate and contains almost no mono- or dialkyl phosphate. In particular, since the acid value affects the hydrolytic stability, the purity of the trialkyl phosphate ester should be higher, that is, the acid value should be as low as possible, preferably 0.2 or less. Furthermore, when the hydrolytic stability of the trialkyl phosphate ester of the present invention is measured using the method for measuring the saponification value of oils and fats based on cosmetic raw materials, the hydrolysis rate is 1.
It was less than 10% in time. Compared to natural fats and oils, which are completely hydrolyzed in about 30 minutes, it can be said that they are extremely stable.

Regarding skin irritation, a lint cloth coated with the oil-based component was applied to the forearm or upper arm layer side of 20 healthy people, and the cloth was fixed with a bandage, and the presence or absence of any change was determined after 24 hours. As a result, there was no change in any of the cases, and almost no irritation was observed.

In addition to the above-mentioned essential trialkyl phosphate esters, the cosmetics and external preparations of the present invention include drugs,
Vitamins, ultraviolet absorbers, antioxidants, preservatives, pigments, fragrances, etc. may be mixed and added. In addition, alcohol, fatty acids, fats and oils, wax, surfactants, other water-soluble polymers, resins, etc. may be mixed and added for the purpose of stabilizing homogeneity and adjusting viscosity.

Cosmetics and external preparations of the present invention include creams, emulsions, serums,
It can be suitably used in the fields of cosmetics such as cleansing gel, toiletry products such as shampoo and conditioner, and pharmaceuticals such as urea cream.

The trialkyl phosphate ester specified in the present invention is
It can be used for part or all of the oily components of cosmetics and external preparations containing oily components. The content of oily components in cosmetics and external preparations can be set at a predetermined content depending on the type of cosmetics and external preparations.

[Example] Hereinafter, the present invention will be explained in more detail using Examples. In addition, the content rate of each component in each of the following examples is shown by the value in the obtained cosmetic or external preparation.

Example 1 Cleansing gel (A) Decaglycerin monostearate 5% glycerin 15% (B) Liquid paraffin (
870) 37% Tris(2-ethylhexyl) monophosphate 40% (C) Purified water 3% Stir the (A) phase thoroughly and mix the (B) phase in advance with the (A) phase. Added with stirring. Furthermore, (C) was added to obtain a transparent gel-like composition.

The resulting transparent gel-like composition was stable, blended well with the skin, had a light feel, and was particularly a characteristic gel-like gel whose viscosity suddenly decreased when rubbed.

Example 2 Emulsion (A) Tris(3,3,5-trimethylhexyl) phosphate 5% squalane
5% stearic acid diglyceride
5% behenyl alcohol 2% decaglycerin monooleate 2% (B) glycerin 3% 1,3-butylene glycol 4% purified water
74% (A) phase is heated, dissolved and mixed. The warmed and mixed phase (B) was added to the phase (A) with stirring.

The emulsion composition was prepared by cooling while stirring.

This emulsion was very stable, spread well, and had a light texture.

Example 3 Lipstick (A) Ceresin 7% beeswax 6% carnauba wax
5% squalane
4% tris(octyl) monophosphate 4% polybutene 3% glycerin monooleate 3% (B) Pigment
8% pearl agent 1
0% castor oil 50% (A
) Phases were dissolved and mixed, and the (B) phase, which had been well mixed in advance, was kneaded into the (A) phase, and then molded to obtain 9 lipsticks.

The lipstick prepared using the above formulation had strong bending strength, little sweating, good smudge spread, and good adhesion.

Example 4 Medicinal gel (A) Polyoxyethylene (60) - Hydrogenated castor oil 5% polyoxyethylene (23) - Cetyl ether 5% lecithin
1% cetanol
5% glycerin
15% Tris (caprylic acid) - Glycerin 38% Tris (nonyl) - Phosphate ester 20% Cyclobix 1% (B) Purified water
After heating and dissolving the 10% (A) phase, the mixture was allowed to cool to room temperature, and the (B) phase was added little by little while stirring to obtain a gel composition.

The medicated gel prepared with the above formulation was stable over a wide temperature range from low to high temperatures, and had a remarkable therapeutic effect on athlete's foot.

Example 5 Vaseline ointment (A) White petrolatum 25% stearyl alcohol 20% propylene glycol 12% tris(octyl)-phosphate ester 8% polyoxyethylene (60) Monohydrogenated castor oil 5% monoglyceryl monostearate 1% hydrocortisone 1% propylparaben
0.1% methylparaben
0.1% (B) Purified water 2
After heating, dissolving and mixing the 7.8% (A) phase, the (B) phase was added little by little while stirring to obtain an ointment-like composition.

The petrolatum ointment obtained with the above formulation was stable and had reduced stickiness. It was a vaseline ointment that easily dispersed the drug evenly.

〔Effect of the invention〕

The cosmetics and external preparations of the present invention contain a liquid trialkyl phosphate ester represented by the above formula (a) as the oily component. The trialkyl phosphate ester is
It is a polar oil that is liquid at room temperature, chemically stable, has a low clouding point, and is highly safe for the human body.It has excellent solubility, compatibility, miscibility, and dispersibility of pigments and inorganic substances. It has a unique feel. Therefore, the cosmetics and external preparations of the present invention are excellent.

Claims (2)

[Claims] (1) Cosmetics and external preparations characterized by containing a liquid trialkyl phosphate represented by formula (a) as an oily component. O=P(OR)_3...(a) (R in formula (a) is an alkyl group having 6 to 10 carbon atoms.) (2) The cosmetic and external preparation according to claim 1, wherein R in formula (a) is a linear or branched alkyl group.