JPH0411712Y2 - - Google Patents

Description

[Detailed description of the invention] (Technical field) The present invention relates to a device that can easily obtain a sterile drug solution in the fields of medicine, biochemistry, bacteriology, etc. This invention relates to a sterile cap that can be attached to the mouth of a container to easily obtain a sterile drug solution.

(Background Art) Conventionally, medicinal solutions used in small quantities in the fields of medicine, biochemistry, bacteriology, etc., for example, medicinal solutions for medical and hygiene purposes used in medical institutions such as hospitals or given to patients, are generally In many cases, the drug is purchased from a pharmaceutical manufacturer in a large container, and then used by appropriately dividing and dispensing the required amount.

However, when dispensing and using the medicinal solution stored in such a large container as appropriate, there is no problem immediately after opening a new container;
When used in small quantities over a long period of time after opening, the stored drug solution is likely to be contaminated by bacteria, etc. that enter through the opening of the container, and such bacterial contamination can put the drug solution in a dangerous condition. It was said that there was a big problem.

(Solution Means) Here, the present invention has been made against the background of the above-mentioned circumstances, and its purpose is to provide a sterile solution by attaching it to the mouth of a container containing a predetermined medicinal solution. To easily and quickly obtain a drug solution in a sterile state, and to easily obtain a drug solution in a sterile state without lifting or tilting the container even when the container is contained in a container such as a large bottle that cannot be compressed. The goal is to provide a sterile cap that can

In order to achieve this purpose, the sterile cap according to the present invention is characterized by: (a) a cap body that is attached to the mouth of a container containing a predetermined drug solution and closes the mouth; (b) air pressure feeding means for forcefully feeding air into the container through the cap body in order to increase the internal pressure of the container and send the medicinal solution inside the container to the outside of the container; It is provided to penetrate and communicate with the inside of the container, and the end on the inside side of the container is inserted into the stored drug solution and opened, so that as the internal pressure of the container increases by the air pressure feeding means, (d) a drug solution delivery channel for sending out the drug solution stored in the container to the outside; The structure includes a porous membrane that sterilizes the medical solution sent out through the medical solution delivery channel by rising.

(Effect of the invention) In the sterile cap constructed according to the present invention, air is forced into the container by the pneumatic feeding means, so that the medicinal solution contained inside the cap is transferred through the porous membrane. Through the filtration (sterilization) action of the porous membrane, it is possible to obtain a chemical solution that completely solves the problem of bacterial contamination.

In other words, by attaching such a sterile cap to a container after opening, a sterile drug solution can be easily obtained for a long period of time even after opening, and problems caused by bacterial contamination can be extremely effectively avoided. be.

In addition, in the case of such a sterile cap, since the drug solution is delivered out of the container by the action of air pressure, there is no need to tilt the container or apply pressure when delivering the drug solution, so there is no need to apply pressure. It can be used extremely well even in large containers made of glass or the like, and it is possible to easily obtain a sterile drug solution.

(Examples) Hereinafter, in order to clarify the present invention more specifically, examples of the present invention will be described in detail with reference to the drawings.

First, FIG. 1 shows a usage diagram of a sterile cap constructed according to the present invention. In this figure, 10 is a cap main body, which is screwed onto the opening 16 of a container 14 containing a predetermined chemical solution 13 at a screw portion 12 provided at the lower part of the cap main body. 16 openings are airtightly closed.

Further, the cap body 10 is provided with an air supply hole 20 in the lid portion 18 for communicating the inside and outside spaces of the cap body 10, and a connecting pipe 21 is integrally provided within the air supply hole 20. is inserted and fixed. Then, check valves are provided at both end openings of the outer opening of the connecting pipe 21, and air absorbed at one opening is sent out from the other opening by repeated pressing operations, as is known in the art. A rubber air supply bulb 22 is attached, and by pressing the air supply bulb 22, air is forced into the cap body 10 through the connecting pipe 21.

That is, with the cap body 10 screwed onto the mouth 16 of the container 14, by repeatedly pressing the air supply bulb 22, the connecting pipe 2
Air is forced into the container 14 through the container 14,
As a result, the air pressure within the container 14 is increased. As is clear from this, in this embodiment, the air supplying balloon 22 constitutes an air pressure feeding means for forcing air into the container 14 through the cap body 10.

A pressure release valve 26 is provided in the air communication path 24 that communicates the air supply bulb 22 with the connection pipe 21, and by opening the pressure release valve 26, the inside of the cap body 10, ie, The increase in internal pressure within the container 14 to which the cap body 10 is screwed can be released.

In addition, particularly in this embodiment, a flat membrane-shaped porous membrane filter (sterilization) is provided at the inner opening end surface of the connection pipe 21 to filter and sterilize the air pumped by the air supply bulb 22. A filter 28 is provided. This porous membrane filter 28 is
It is a hydrophobic porous membrane such as a Teflon membrane that has a membrane diameter that allows air to pass through but not bacteria in the air. Specifically, bacteria that exist in the air usually bind to fine particles. Therefore, those having a membrane diameter of about 0.45 μm or less are preferably used.

That is, the porous membrane filter 28 allows the air communication passage 2 to be opened by pressing the air supply bulb 22.
4 and the connecting pipe 21 are sterilized, and the sterile air enters the cap body 1.
0, that is, into the container 14.

Further, the cap body 10 is integrally provided with a delivery hose 30 that passes through the lid portion 18 and constitutes a chemical solution delivery flow path, and the cap main body 10 is screwed into the container 14. Under such conditions, the inside of the container 14 can be communicated with the outside through the delivery hose 30. Note that it is preferable that the delivery hose 30 be made of a flexible material for reasons such as ease of operations such as dispensing.
It is formed with a length sufficient to reach the lower part of the container 14 and be inserted into the drug solution 13 contained therein.

In addition, the container 14 in the delivery hose 30
At the end of the side that opens to the outside, the delivery hose 3
A delivery port body 32 that together with 0 constitutes a drug solution delivery channel.
is integrally attached. As shown in FIG. 2, the outlet body 32 is provided with a hollow fiber module 34 therein. Such a hollow fiber module 34 is made by bending and bundling a plurality of porous hollow fibers 36 into a loop shape (U-shape), and bonding and fixing the opening side end with a suitable adhesive such as polyurethane resin. The thread holding part 38 is fitted onto the inner circumferential surface of the outlet body 32 in the holding part 38, and is fixedly or removably attached thereto.

That is, in such a hollow fiber module 34, both end openings of each hollow fiber 36 are connected to the outlet body 3.
2, and the openings of the hollow fibers 36 and the delivery port body 32
The inner surface of the hollow fiber module 34 is maintained liquid-tightly and air-tightly by the holding portion 38, so that the chemical solution sent out through the delivery hose 30 can penetrate the hollow fibers 36 constituting the hollow fiber module 34. The chemical solution is allowed to pass through and flow out from the chemical solution outlet 40.

Here, the plurality of hollow fibers 36 constituting the hollow fiber module 34 each have a hole with a diameter that allows the chemical solution 13 contained in the container 14 to pass through, but does not allow bacteria to pass through. For example, it has a membrane diameter that allows bacteria to be removed. The membrane diameter that can remove this bacteria is desirably one that can inhibit Pseudomonas deminium ATCC19146, and is usually 0.2 to 0.3 μm.
A suitable material is one that blocks standard particles of .

Further, as the porous hollow fibers 36, a polymer material such as polyolefin, polyvinyl alcohol, polysulfone, polyacrylonitrile, cellulose acetate, polymethyl methacrylate, polyamide, etc. is used, and a known method such as a micro phase separation method or a stretching method is used. Any porous hollow fiber obtained according to the method can be used satisfactorily.

Note that when the chemical solution 13 is an aqueous solution, a hydrophilic porous membrane is used as the porous hollow fiber 36, and when a hydrophobic porous membrane such as polyolefin is used for an aqueous solution, The hydrophobic porous membrane will be subjected to a known hydrophilic treatment. Further, when the chemical solution 13 is an oil-based chemical solution such as olive oil, it is preferable to use a hydrophobic porous membrane as the porous hollow fibers 36.

Therefore, as shown in FIG. 1, the sterile cap structured as described above is screwed onto the opening 16 of the container 14 containing a predetermined medicinal solution 13. By repeatedly pressing the air balloon 22 at the bottom, the internal pressure of the container 14 is increased, thereby causing the contained drug solution 13 to increase.
is delivered through the delivery hose 30 and the delivery port body 32, and is allowed to flow out from the chemical solution outlet 40.

Then, the delivered drug solution 13 is transferred to the delivery port body 32.
Hollow fiber 3 of hollow fiber module 34 housed within
6, it is sterilized by the filtration function of the hollow fibers 36, so that it can be obtained as a sterile chemical solution. In addition,
After the required amount of the chemical solution has flowed out, the pressure release valve 26 provided in the air communication path 24 is opened to release the pressure inside the container 14, thereby stopping the flow of the chemical solution. becomes.

In other words, by using such a sterile capsule, it is possible to easily obtain a sterile drug solution at all times, and problems caused by bacterial contamination during long-term storage of drug solutions can be extremely effectively avoided. You get it.

In particular, for such sterile caps,
The delivery port body 32 is equipped with a porous hollow fiber 36 as a porous membrane that sterilizes the delivered chemical solution 13.
Since the delivery hose 30 is disposed at the outer end of the container 14, problems due to bacterial contamination in the delivery channels 30, 32 can be advantageously eliminated, and the drug solution 13 in the container 14 can be transferred to other small containers. It is advantageous when dispensing to a container with a narrow neck, the cap can be easily installed in a container with a narrow neck, and the porous hollow fiber 36 (outlet body 32) can be easily replaced. Therefore, it can have a great effect. Of course, it is of course possible to extend the tip of the chemical liquid delivery port 40, for example, to provide an extended flow path by further connecting a hose or the like to the tip of the outflow port, if necessary.

In addition, in the sterile cap of this embodiment, the porous membrane filter 28 provided in the air supply hole 20 prevents bacterial contamination during air supply. Bacterial growth can be effectively controlled and the container 14
Immediately after the container 14 is opened, or if the drug solution 13 is a drug solution that can be treated by heat sterilization, immediately after the container 14 is subjected to a sterilization process such as an autoclave treatment while the drug solution 13 is contained, By attaching such a sterile cap, the chemical solution 13
can be well maintained under sterile conditions for a long period of time. However, when the sterile cap itself is made of a heat-resistant material, when the sterile cap is attached to the container 14,
It is also possible to perform autoclave treatment.

Furthermore, by using such a sterile cap, the container 14 and the sterile cap are subjected to sterilization treatment such as autoclave treatment, and then a medicinal solution is mixed in the container 14 in a clean bench or the like. This makes it possible to easily prepare such drug solutions under sterile conditions.

In addition, in the case of such a sterile cap, the medicinal solution 13 is sent out of the container 14 by the action of the air pressure supplied into the container 14 by the pressing operation of the air supply balloon 22. Therefore, when the medicinal solution is delivered, There is no need to tilt or pressurize the container 14, and therefore, even if the container 14 is a large container made of glass or the like that cannot be compressed, the drug solution 13 can be delivered extremely easily. It is.

Furthermore, since such a sterile cap is equipped with all the functions for obtaining a sterile drug solution, installation is completed by simply screwing the sterile cap on, and its operation is extremely easy. It has excellent usability because it can be used by attaching various existing aseptically filled medical liquid containers as is.

Furthermore, in the sterile cap of this embodiment, the porous membrane that sterilizes the chemical solution 13 delivered through the delivery hose 30 is composed of a plurality of hollow fibers 36, so that a large amount of filtration is possible. This makes it possible to easily obtain a large area, and thereby the amount of outflow of the chemical solution per unit time can be sufficiently increased. In addition to being able to effectively set the amount,
The device can be advantageously made more compact, and the ease of handling and use can be improved.

Referring now to FIG. 3, another embodiment of a sterile cap constructed in accordance with the present invention is shown. In this embodiment, members having the same structure as those in the first embodiment are designated by the same reference numerals, and detailed explanation thereof will be omitted.

As is clear from FIG. 3, the sterile cap in this example is provided with a communication hole 42 that vertically passes through the center thereof, and a , rubber stopper 4
4 is hermetically fitted and attached. In addition, in the figure, 46 is a cover attached to the rubber stopper 44 to cover its externally exposed surface.

That is, in the sterile cap of this embodiment having such a structure, as shown in FIG.
By piercing the rubber stopper 44 with the needle 50, the prescribed drug solution contained in the syringe 48 can be supplied into the container 14 through the injection needle 50 without removing the cap body 10 from the container 14. be. In FIG. 3, reference numeral 52 denotes a well-known membrane housing a flat porous membrane 53 that removes bacteria present in the drug solution when the drug solution contained in the syringe 48 is injected into the container 14. This is a sterile filter.

Therefore, with the sterile cap of this embodiment having such a structure, as in the first embodiment, it is possible to store and supply the stored drug solution 13 in a sterile state, and By attaching such a sterile cap to the container 14, another drug solution can be supplied into the container 14 using the syringe 48 while maintaining the inside of the container 14 in a sterile state. This makes it possible to prepare drug solutions under sterile conditions without using any other equipment.

Mixing of medical solutions under sterile conditions using such a sterile cap is carried out after the container 14 to which the sterile cap is attached is sterilized with the container 14 empty, or after the drug solution 13 is heated. If the chemical liquid can be sterilized, the chemical liquid 13 contained in the container 14 to which the sterile cap is attached is sterilized, and then the chemical liquid 13 is placed in an autoclave or the like. This method can be advantageously applied when preparing medicinal solutions that cannot be sterilized, and its excellent effects can be exhibited. After sterilizing the container 14 and the sterile cap, the medicinal solution to be prepared is poured into the syringe 48.
It is also effective when injecting and compounding with sterile filtration. However, in the case of such a sterile cap, even the medicinal solution after preparation is sterilized by the hollow fibers 36 when it flows out, so even if bacteria should be mixed into the medicinal solution, the danger can be effectively avoided. This means that it can be done.

Although the embodiments of the present invention have been described in detail above, these are literal illustrations, and the present invention is not to be construed as being limited to such specific examples.

For example, the cap body 10 in the above embodiment
In both cases, the container 14 is attached to the mouth 16 by screwing, but the lower part is made of an elastic material such as rubber, and the outer circumferential surface is made of a belt or the like. By tightening it, it is possible to attach it airtightly, and by adopting such a structure, it becomes possible to accommodate containers 14 having mouth portions 16 of different diameters.

In addition, by forming a plurality of screw grooves in the screw portion 12 of the cap body 10, the diameter of which becomes larger toward the bottom, containers of various diameters can be used.
It is also possible to accommodate the mouth portion 16 of No. 4.

Furthermore, in the above embodiments, the air balloon 22 was used as the air pressure feeding means, but other means, such as a single bulb rubber or double bulb rubber equipped with a check valve, or a pump-type air feeding device may also be used. Of course, it is also possible to adopt such methods.

Further, the pressure release valve 26 for releasing the positive pressure in the container 14 is not necessarily necessary in cases where it is not necessary to accurately specify the amount of the outflowing chemical solution.

Further, although the porous membrane filter 28 that sterilizes the air supplied into the container 14 is not essential in the present invention, it is desirable to install it in order to keep the drug solution 13 in the container 14 in a sterile state. .
However, even if such a porous membrane filter 28 is not provided, the hollow fiber 3 disposed within the chemical liquid delivery flow path
6, a sterile drug solution can be obtained.

Furthermore, in the embodiment described above, the hollow fibers 36 were used as porous membranes for sterilizing the delivered chemical solution 13, but it is also possible to use flat membranes.

Although not listed in detail, the present invention may be implemented with various changes, modifications, improvements, etc. based on the knowledge of those skilled in the art, and such embodiments may be implemented in accordance with the present invention. It goes without saying that any of these are included within the scope of the present invention as long as they do not deviate from the spirit.

[Brief explanation of the drawing]

FIG. 1 is a partial cross-sectional explanatory view showing how a sterile cap, which is an embodiment of the present invention, is attached to a container, and FIG. 2 is a longitudinal cross-sectional view showing a delivery port body used in such a sterile cap. . Further, FIG. 3 is a partially sectional explanatory view corresponding to FIG. 1, showing another embodiment of the sterile cap according to the present invention. 10...Cap body, 12...Screw part, 13
...Medical solution, 14... Container, 16... Mouth part, 18...
... Lid body part, 20 ... Air supply hole, 22 ... Air supply bulb, 26 ... Pressure release valve, 28 ... Porous membrane filter, 30 ... Delivery hose, 32 ... Delivery port body, 34 ... Hollow fiber module, 36... Porous hollow fiber, 40... Chemical solution outlet, 42... Communication hole,
44...Rubber stopper, 48...Syringe, 50...Syringe needle.

Claims (1)

[Scope of Claim for Utility Model Registration] (1) A cap body that is attached to the mouth of a container containing a predetermined medicinal solution to close the mouth, and a cap body that increases the internal pressure of the container to force the medicinal solution inside the container out of the container. an air pressure feeding means for forcing air into the container through the cap body for delivery; and an air pressure feeding means that is provided to penetrate the cap body inwardly and outwardly to communicate the inside of the container with the outside and to communicate the inside of the container with the inside of the container. a drug solution delivery channel whose end portion is inserted into the stored drug solution and opened to send out the drug solution contained in the container to the outside as the internal pressure of the container increases by the air pressure feeding means; a porous membrane that is disposed in the end channel on the outside of the container in the drug solution delivery channel and sterilizes the drug solution delivered through the drug solution delivery channel by increasing the internal pressure of the container by the air pressure feeding means; A sterile cap comprising: (2) A utility model registration request in which the cap is provided with a communication hole that is closed with a rubber stopper, and a prescribed drug solution can be supplied into the container through a syringe needle inserted into the rubber stopper. A sterile cap according to item 1. (3) The sterile cap according to claim 1 or 2, wherein a sterilization filter is disposed in the air pressure feeding path into the container by the air pressure feeding means.