JPH04108553U - X-ray contrast catheter - Google Patents
X-ray contrast catheterInfo
- Publication number
- JPH04108553U JPH04108553U JP1769591U JP1769591U JPH04108553U JP H04108553 U JPH04108553 U JP H04108553U JP 1769591 U JP1769591 U JP 1769591U JP 1769591 U JP1769591 U JP 1769591U JP H04108553 U JPH04108553 U JP H04108553U
- Authority
- JP
- Japan
- Prior art keywords
- ray contrast
- catheter
- shape memory
- polymer
- ray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000431 shape-memory polymer Polymers 0.000 claims abstract description 18
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229920000642 polymer Polymers 0.000 abstract description 15
- 230000036760 body temperature Effects 0.000 abstract description 12
- 239000002872 contrast media Substances 0.000 abstract description 12
- 230000009477 glass transition Effects 0.000 abstract description 6
- 239000007788 liquid Substances 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 238000004898 kneading Methods 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 3
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000003780 insertion Methods 0.000 description 8
- 230000037431 insertion Effects 0.000 description 8
- 239000000463 material Substances 0.000 description 4
- -1 vinyl tungstate Chemical compound 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 229910000014 Bismuth subcarbonate Inorganic materials 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 229910000416 bismuth oxide Inorganic materials 0.000 description 2
- MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 description 2
- 229940036358 bismuth subcarbonate Drugs 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- TYIXMATWDRGMPF-UHFFFAOYSA-N dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Bi+3].[Bi+3] TYIXMATWDRGMPF-UHFFFAOYSA-N 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 229910052715 tantalum Inorganic materials 0.000 description 2
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 2
- WCVOGSZTONGSQY-UHFFFAOYSA-N 2,4,6-trichloroanisole Chemical compound COC1=C(Cl)C=C(Cl)C=C1Cl WCVOGSZTONGSQY-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- JHXKRIRFYBPWGE-UHFFFAOYSA-K bismuth chloride Chemical compound Cl[Bi](Cl)Cl JHXKRIRFYBPWGE-UHFFFAOYSA-K 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 229920000840 ethylene tetrafluoroethylene copolymer Polymers 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 150000001247 metal acetylides Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Abstract
(57)【要約】
【構成】 外周肉厚に等角度間隔を置いて設けた４つの
筋状Ｘ線造影部32と、ウレタン系形状記憶ポリマーから
なる形状記憶部31とを有するカテーテル。
【効果】 Ｘ線造影部32は、形状記憶ポリマーよりもガ
ラス転移温度が低いポリマーとＸ線造影剤とからなり、
その製造に当たって、混合・混練が容易に行える。ま
た、体内挿入後に体温により温められ予め記憶させてお
いた形状に復元し、体内の狭小領域への進入や液体の注
入または吸入などの操作を容易に行うことができる。さ
らに、Ｘ線造影の際にカテーテルの位置が明瞭である。
(57) [Summary] [Structure] A catheter that has four streak-like X-ray contrast sections 32 provided at equal angular intervals on the outer circumference, and a shape memory section 31 made of a urethane-based shape memory polymer. [Effect] The X-ray contrast section 32 is made of a polymer with a glass transition temperature lower than that of the shape memory polymer and an X-ray contrast agent.
In its production, mixing and kneading can be easily performed. Furthermore, after being inserted into the body, it is warmed by body temperature and restored to a pre-memorized shape, making it easy to enter narrow areas inside the body and perform operations such as injecting or inhaling liquid. Furthermore, the position of the catheter is clearly visible during X-ray imaging.
Description
【０００１】0001
本考案はＸ線造影性のカテーテルに関するものである。 The present invention relates to an X-ray contrast catheter.
【０００２】0002
カテーテルは、一般に血管、気管、卵管、尿管などや各種臓器内に挿入して、 液体の注入または吸入、或いは通路の開存確保などを目的として使用される。 血管などや種々の臓器にはかなりの狭小領域があり、細部の領域内に進入させ て広範な適用部位に対応させようとする場合には、カテーテルは可能な限り細径 であることが都合がよい。 Catheters are generally inserted into blood vessels, tracheas, fallopian tubes, ureters, etc., and into various organs. It is used for the purpose of injecting or inhaling liquids, or ensuring the patency of passages. Blood vessels and various organs have quite narrow areas, and it is difficult to penetrate into detailed areas. catheters should be made as small as possible to accommodate a wide range of application sites. It is convenient that
【０００３】 しかし、細径にすると適用部位が広範となり、且つ挿入が容易になるが、細径 化に随伴して、液体の単位時間当たりの注入・吸入量の低下、局部拡張機能の損 失などが生起してくる。0003 However, if the diameter is made smaller, it can be applied to a wider range of areas and is easier to insert, but the smaller diameter Along with this, the amount of liquid injected and inhaled per unit time decreases, and local dilatory function is impaired. Loss etc. will occur.
【０００４】 そのために、カテーテルは挿入時にはできるだけ細径であることが好ましく、 一方では挿入終了後に行う液体の注入・吸入、局部拡張、開存確保などの機能を 発揮するには太径であることが優先する。0004 For this reason, it is preferable that the diameter of the catheter be as small as possible when inserted. On the other hand, it has functions such as injecting and inhaling liquid, local expansion, and ensuring patency after insertion. In order to exert its full potential, priority is given to a large diameter.
【０００５】 かかる事情から本考案者らは、形状記憶ポリマーからなるカテーテルを提供し た（特開平2-144073号公報、同144074号公報参照）。これらのカテーテルは、体 内挿入後に体温により温められ予め記憶させておいた形状に復元し、体内の狭小 領域への進入や液体の注入または吸入などの操作を容易に行うことができるよう になる。[0005] Under these circumstances, the present inventors provided a catheter made of a shape memory polymer. (Refer to Japanese Patent Application Laid-open Nos. 2-144073 and 144074). These catheters After insertion, it is warmed by body temperature and restores to the pre-memorized shape, reducing the narrowness inside the body. to facilitate operations such as entering the area and injecting or inhaling liquids. become.
【０００６】 一方、カテーテルの中には、挿入位置をＸ線透視下で確認するために、硫酸バ リウム、金、銀、タンタル、次炭酸ビスマス、酸化ビスマス、タングステン酸ビ スマスなどのＸ線造影剤を添加してＸ線遮蔽作用を付与する必要があるものもあ り、その中にはＸ線造影ラインの入った留置針、ＥＤカテーテル、ＩＶＨカテー テルなどがある。[0006] On the other hand, some catheters contain a sulfuric acid bath to confirm the insertion position under X-ray fluoroscopy. aluminum, gold, silver, tantalum, bismuth subcarbonate, bismuth oxide, vinyl tungstate Some products require the addition of an X-ray contrast agent such as Sumas to provide an X-ray shielding effect. This includes an indwelling needle with an X-ray contrast line, an ED catheter, and an IVH catheter. There are tell etc.
【０００７】[0007]
ところで、形状記憶性、体温で柔らかくなる特性およびＸ線造影性を有するカ テーテルは、最近の多機能化の開発傾向に沿うことになり、好ましいものである 。これらの特性を備えたカテーテルを製造すべく、形状記憶ポリマーにＸ線造影 剤を混合・混練し、これを押出成形する試みがなされている。 By the way, there is a color that has shape memory, softens with body temperature, and has X-ray contrast properties. Tetel is favorable as it follows the recent development trend of multi-functionality. . To create catheters with these properties, shape-memory polymers are made with X-ray contrast. Attempts have been made to mix and knead the ingredients and extrude the mixture.
【０００８】 しかしながら、上記ポリマーは種類にも依るが、一般にガラス転移温度（Ｔｇ ）が20〜50℃程度と高温域に属し、かかる高Ｔｇの形状記憶ポリマーにＸ線造影 剤を混合した場合、ポリマーと造影剤が反応し、ポリマーが分解（発泡）する。 特に、ポリマーの種類によっては分解反応が著しく、混練が不可能になることも ある。そのため、上記の特性を付与したカテーテルは製造困難であり、これら特 性を高度に有するカテーテルは未だ提供されていないのが実情である。 従って、本考案の目的は、上記問題点を克服したＸ線造影性のカテーテルを提 供することにある。[0008] However, the above polymers generally have a glass transition temperature (Tg), although it depends on the type. ) belongs to the high temperature range of about 20 to 50℃, and X-ray contrast is applied to shape memory polymers with such high Tg. When the agents are mixed, the polymer and contrast agent react, causing the polymer to decompose (foam). In particular, depending on the type of polymer, the decomposition reaction may be severe and kneading may become impossible. be. Therefore, it is difficult to manufacture catheters with the above characteristics; The reality is that a highly functional catheter has not yet been provided. Therefore, the purpose of the present invention is to provide an X-ray contrast catheter that overcomes the above problems. It is about providing.
【０００９】[0009]
上記目的を達成するために、本考案のカテーテルは、肉厚の一部にＸ線造影部 を有し、該肉厚の他の部分に主としてウレタン系形状記憶ポリマーからなる形状 記憶部を有することを特徴とするものである。 In order to achieve the above purpose, the catheter of the present invention has an X-ray contrast area in a part of the wall thickness. , and the other part of the wall has a shape mainly made of urethane-based shape memory polymer. The device is characterized by having a storage section.
【００１０】 本考案のカテーテルは人間を始めとする哺乳類動物（たとえば、ウシ、ウサギ 、ウマ、ヒツジ、サル、イヌ、ネコなど）などに適用可能である。従って、本考 案において体温とは、これら動物の各々の体温を意味し、動物種によりその温度 は異なる。0010 The catheter of the present invention can be used in mammals including humans (e.g., cows, rabbits, etc.). , horses, sheep, monkeys, dogs, cats, etc.). Therefore, the main idea In the draft, body temperature means the body temperature of each of these animals, and the temperature varies depending on the animal species. is different.
【００１１】 本考案において、ガラス転移温度は、ＪＩＳ Ｋ７１２１−１９８７“プラス チックの転移温度測定方法”に基づき、示差走査熱量測定により昇温速度10℃／ 分、Ｎ2 ガス雰囲気下で測定した値である。なお、この測定方法において、２以 上の多数の吸収ピークを有する材料については、十分な柔軟性を発現するに至る 吸収ピークのうちの最低温度をもってガラス転移点と定める。[0011] In the present invention, the glass transition temperature is a value measured by differential scanning calorimetry at a heating rate of 10°C/min in an N 2 gas atmosphere based on JIS K7121-1987 "Method for Measuring Plastic Transition Temperature". be. In this measurement method, for materials having multiple absorption peaks of two or more, the glass transition point is defined as the lowest temperature among the absorption peaks at which sufficient flexibility is exhibited.
【００１２】 形状記憶部の主たる構成材料であるウレタン系形状記憶ポリマーは、被挿入対 象の体温をｔ0 とすると、（ｔ0 −15）〜（ｔ0 ＋15）℃、特に（ｔ0 −７）〜 （ｔ0 ＋７）℃、更に（ｔ0 −５）〜（ｔ0 ＋３）℃の範囲のガラス転移温度を 有するものが好ましい。例えば、上記対象が人間の場合、平均体温を36.5℃とし て、21.5〜51.5℃、好ましくは29.5〜43.5℃、特に好ましくは31.5〜39.5℃のも のである。また、挿入対象の体温に加温された状態において0.01〜50kgf ／mm2 、特に0.1 〜10kgf ／mm2 の弾性率を保持するものが好ましい。[0012] The urethane-based shape memory polymer, which is the main constituent material of the shape memory part, has a temperature of ( t 0 -15 ) to (t 0 +15)°C, especially (t 0 -7), where t 0 is the body temperature of the inserted object. ) to (t 0 +7)°C, preferably having a glass transition temperature in the range of (t 0 -5) to (t 0 +3)°C. For example, when the subject is a human, the average body temperature is 36.5°C, and the temperature is 21.5 to 51.5°C, preferably 29.5 to 43.5°C, particularly preferably 31.5 to 39.5°C. Further, it is preferable that the material maintains an elastic modulus of 0.01 to 50 kgf/mm 2 , particularly 0.1 to 10 kgf/mm 2 when heated to the body temperature of the insertion target.
【００１３】 本考案のカテーテルは、その全体ではなく、一部のみをＸ線造影部としている ので、その製造にあたって、Ｘ線造影剤を高Ｔｇの形状記憶ポリマーと混合する 必要がなく、通常（形状記憶ポリマーよりも低Ｔｇ）のカテーテル材用として使 用されているポリマーと混合すればよいので、ポリマーが造影剤と反応して分解 することがない。 これに対し、Ｘ線造影部以外の部分に係る高Ｔｇのウレタン系形状記憶ポリマ ーからなる形状記憶部を有しており、形状記憶性および体内挿入後に柔らかくな る特性が確保される。[0013] The catheter of this invention uses only a part of it as an X-ray contrast area, not the whole of it. Therefore, in its production, an X-ray contrast agent is mixed with a high Tg shape memory polymer. Can be used as a catheter material (lower Tg than shape memory polymers) All you have to do is mix it with the polymer being used, so the polymer will react with the contrast agent and decompose. There's nothing to do. In contrast, high Tg urethane shape memory polymers for areas other than the X-ray contrast area It has a shape memory part consisting of characteristics are ensured.
【００１４】 本考案のカテーテルでは、Ｘ線造影部が肉厚の一部に存するが、これを設ける 態様は形状記憶性および体内挿入後に柔らかくなる特性を損なうことなく、Ｘ線 造影性を保持していれば特に制限されない。[0014] In the catheter of this invention, the X-ray contrast part exists in a part of the wall thickness, but this The aspect is X-ray resistant without compromising its shape memory and softness properties after insertion into the body. There are no particular restrictions as long as contrast properties are maintained.
【００１５】 一般にカテーテルは断面形状がドーナッツ状であるため、この場合には例えば 、以下の実施例に示す如き外周肉厚の一部をＸ線造影部としてもよいが、Ｘ線造 影部を半分よりも多くしていくと、形状記憶性および体内挿入後に柔らかくなる 特性が徐々に失われるから、Ｘ線造影部は外周肉厚の半分以下であることが好ま しい。[0015] Catheters generally have a donut-shaped cross-section, so in this case, for example, , a part of the outer peripheral wall thickness may be used as an X-ray contrast area as shown in the following example; If the shadow area is increased by more than half, it will have shape memory and become soft after insertion into the body. Since the characteristics are gradually lost, it is preferable that the X-ray contrast area be less than half the thickness of the outer circumference. Yes.
【００１６】 Ｘ線造影部はカテーテルの全長に渡って設けることが、造影の際にカテーテル の位置がより明瞭となり望ましい。しかしながら、Ｘ線造影部はカテーテルの全 長に渡って必ずしも連続に設ける必要はなく、不連続であっても構わない。 また、Ｘ線造影部は一本のみならず、複数の直線（または破線）として設けて もよく、例えば、外周肉厚において複数の筋状のＸ線造影部を等角度間隔置いて 設けてもよい。[0016] The X-ray contrast area should be provided along the entire length of the catheter. This is desirable because the position of the area becomes clearer. However, the X-ray contrast area is They do not necessarily need to be provided continuously over a long period of time, and may be discontinuous. In addition, the X-ray contrast area is provided not only as one line but also as multiple straight lines (or broken lines). For example, multiple striped X-ray contrast areas are spaced at equal angular intervals on the outer wall thickness. It may be provided.
【００１７】 Ｘ線造影部に混入させるＸ線造影剤としては通常用いられているものであれば 特に限定はなく、金、銀、白金、タングステン、タンタル、モリブデン、ビスマ ス、イリジウムまたはそれらの酸化物、炭化物、窒化物、硼化物など、具体的に は硫酸バリウム、次炭酸ビスマス、酸化ビスマス、タングステン酸ビスマスが例 示される。[0017] If it is a commonly used X-ray contrast agent to be mixed into the X-ray contrast area. There are no particular limitations, including gold, silver, platinum, tungsten, tantalum, molybdenum, and bisma. Iridium or their oxides, carbides, nitrides, borides, etc. Examples include barium sulfate, bismuth subcarbonate, bismuth oxide, and bismuth tungstate. shown.
【００１８】 これらの造影剤を混合するポリマーも当該技術分野で使用されている既知のも のであれば特に限定はないが、上記の高Ｔｇのウレタン系形状記憶ポリマーと融 点、粘度に大差がなく、且つ相溶性が良好であるものが好ましい。かかるポリマ ーとしては、ポリイミド、ポリエチレン、ポリウレタン、ポリテトラフルオロエ チレン、エチレンテトラフルオロエチレン、ポリ塩化ビニル、ポリアミド、液晶 ポリマーなどが挙げられる。これらポリマーとＸ線造影剤との配合比は、造影可 能となる範囲内で適宜決定される。[0018] The polymers with which these contrast agents are mixed may also be those known in the art. There is no particular limitation if the above-mentioned high Tg urethane shape memory polymer and It is preferable that there is no significant difference in point and viscosity and that the compatibility is good. Such polymer Examples include polyimide, polyethylene, polyurethane, and polytetrafluoroethylene. Tyrene, ethylenetetrafluoroethylene, polyvinyl chloride, polyamide, liquid crystal Examples include polymers. The blending ratio of these polymers and X-ray contrast agents is This will be determined as appropriate within the scope of the project.
【００１９】 上記の各ポリマーおよびＸ線造影剤にてカテーテルを製造する場合、例えばカ テーテルの全長に渡って連続するＸ線造影部を設ける場合には、次のようにして 行う。 １つのダイスを使用し、このダイスの一部から形状記憶ポリマーを押出成形す ると同時に、ダイスの残部からＸ線造影剤と通常の（形状記憶ポリマーよりもＴ ｇが低い）ポリマーとの混合物を押出成形し、押出直後に両押出物を接合すれば よい。 更に、形状を記憶させるには、加熱などの手段にて所望とする変形復元状態（ 太径やフック状など）に成形した後、融点以下に冷却することによって形状を記 憶させる。次に、融点以下の温度で延伸などの手段にて所定の形状とすればよい 。[0019] When manufacturing catheters using each of the above polymers and X-ray contrast agents, for example, When providing a continuous X-ray contrast area along the entire length of the catheter, proceed as follows. conduct. Use one die and extrude shape memory polymer from part of this die. At the same time, the remainder of the die contains X-ray contrast agent and conventional (than shape memory polymer) If you extrude a mixture with a polymer (with low g) and join both extrudates immediately after extrusion, good. Furthermore, in order to memorize the shape, the desired deformed and restored state ( After forming into a large diameter, hook shape, etc., the shape is recorded by cooling it below the melting point. Make me remember. Next, it may be formed into the desired shape by stretching or other means at a temperature below the melting point. .
【００２０】 本考案のカテーテルは被挿入対象の体温乃至その近傍温度域内にＴｇを有する 。従って、本考案のカテーテルは、体内挿入前は体温以下（室温）の環境下にあ り、適度の剛性を有するので挿入容易である。また、体内挿入後は体温により温 められ、形状記憶部の構成ポリマーがガラス域からゴム域に達してゴム状弾性を 呈するので、柔軟性が一層良好になり、体内細胞組織を傷つけ難くなる。この体 内挿入後に柔らかくなる特性およびＸ線造影性を有していることから、本考案の カテーテルは、その用途としてカニューラ留置針、ＥＤカテーテル、ＩＶＨカテ ーテルなどに最適である。[0020] The catheter of the present invention has a Tg within the temperature range of the inserted subject's body temperature or its vicinity. . Therefore, the catheter of this invention must be kept in an environment below body temperature (room temperature) before being inserted into the body. It has appropriate rigidity and is easy to insert. Also, after insertion into the body, it will be warmed by body temperature. The polymer forming the shape memory region reaches from the glass region to the rubber region and exhibits rubber-like elasticity. As a result, the flexibility is improved and it becomes difficult to damage the body's tissues. this body Because it has the property of becoming soft after internal insertion and has X-ray contrast properties, the present invention Catheters are used for indwelling cannula needles, ED catheters, and IVH catheters. It is ideal for use as a telephone.
【００２１】[0021]
以下、本考案のカテーテルを実施例に基づいて説明する。 その一実施例を図１に示す。当カテーテルは、外観は通常のものと全く同様で 、最も単純な構造のものである。尚、形状記憶部11はダイアリィＭＭ３３０１〔 三菱重工社製〕からなり、Ｘ線造影部12はアジベート系ポリウレタン〔商品名； Ｅ７８５ＰＮＡＴ（日本ミラクトラン社製）、Ｔｇ：−40℃〕100PHRおよび三酸 化ビスマス30PHR からなる。Ｘ線造影部12は外周肉厚の約１／４を占め、カテー テルの全長に渡って連続している。 Hereinafter, the catheter of the present invention will be explained based on examples. An example thereof is shown in FIG. This catheter looks exactly the same as a regular catheter. , has the simplest structure. In addition, the shape memory part 11 is diary MM3301 [ manufactured by Mitsubishi Heavy Industries, Ltd.], and the X-ray contrast section 12 is made of adibate polyurethane [trade name; E785PNAT (manufactured by Nippon Miractran), Tg: -40℃] 100PHR and triacid Consisting of 30PHR of bismuth chloride. The X-ray contrast area 12 occupies approximately 1/4 of the outer wall thickness, and It is continuous over the entire length of the tell.
【００２２】 図２は別実施例を示す。本カテーテルは、Ｘ線造影部22の外周肉厚に対する占 有率が図１のものよりも低く、しかも全長に渡って等間隔を置いて存在する。[0022] FIG. 2 shows another embodiment. This catheter has a ratio of the outer circumferential wall thickness of the The prevalence is lower than that in Fig. 1, and they exist at equal intervals over the entire length.
【００２３】 図３は更に別実施例を示し、４つの筋状Ｘ線造影部32を外周肉厚に等角度間隔 を置いて設けたものである。[0023] FIG. 3 shows yet another embodiment, in which four striped X-ray contrast regions 32 are arranged at equal angular intervals on the outer circumference. It was established by placing
【００２４】[0024]
本考案のカテーテルは、肉厚の一部がＸ線造影部であり、当該Ｘ線造影部は形 状記憶ポリマーよりもＴｇの低いポリマーとＸ線造影剤とからなり、その製造に 当たって、混合・混練が容易に行える。従って、造影剤と高ガラス転移温度の形 状記憶ポリマーを混合する必要はないから、従来のように造影剤との反応によっ て形状記憶ポリマーの分解は起こらない。 In the catheter of the present invention, part of the wall thickness is an X-ray contrast area, and the X-ray contrast area is shaped It consists of a polymer with a lower Tg than the shape memory polymer and an X-ray contrast agent, and its production requires Mixing and kneading can be easily performed by hitting the product. Therefore, the form of contrast agent and high glass transition temperature There is no need to mix the shape memory polymer, so unlike conventional methods, it is Decomposition of the shape memory polymer does not occur.
【００２５】 また、カテーテルの肉厚の他の部分に、主としてウレタン系形状記憶ポリマー からなる形状記憶部を有しており、体内挿入後に体温により温められ予め記憶さ せておいた形状に復元し、体内の狭小領域への進入や液体の注入または吸入など の操作を容易に行うことができるようになる。[0025] In addition, other parts of the catheter wall thickness are mainly made of urethane-based shape memory polymer. It has a shape memory part, which is warmed by body temperature after being inserted into the body and stored in advance. It restores its original shape and enters into narrow areas within the body, injecting or inhaling liquids, etc. You will be able to perform operations easily.
【００２６】 特に、Ｘ線造影部がカテーテルの全長に渡っている場合、造影の際にカテーテ ルの位置がより明瞭となり望ましい。[0026] In particular, if the X-ray contrast area spans the entire length of the catheter, This is desirable because the position of the key becomes clearer.
【図面の簡単な説明】[Brief explanation of drawings]
【図１】本考案のカテーテルの一実施例を示す一部省略
斜視図である。FIG. 1 is a partially omitted perspective view showing an embodiment of the catheter of the present invention.
【図２】別実施例を示す一部省略斜視図である。FIG. 2 is a partially omitted perspective view showing another embodiment.
【図３】更に別実施例を示す一部省略斜視図である。FIG. 3 is a partially omitted perspective view showing still another embodiment.
１１、２１、３１：形状記憶部 １２、２２、３２：Ｘ線造影部 11, 21, 31: Shape memory section 12, 22, 32: X-ray contrast section
Claims (2)
の他の部分に主としてウレタン系形状記憶ポリマーから
なる形状記憶部を有することを特徴とするカテーテル。1. A catheter characterized in that it has an X-ray contrast part in a part of its wall thickness, and a shape memory part mainly made of a urethane-based shape memory polymer in another part of its wall thickness.
を設けたことを特徴とする請求項１記載のカテーテル。2. The catheter according to claim 1, wherein an X-ray contrast section is provided over the entire length of the catheter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1991017695U JP2534949Y2 (en) | 1991-02-28 | 1991-02-28 | X-ray contrast catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1991017695U JP2534949Y2 (en) | 1991-02-28 | 1991-02-28 | X-ray contrast catheter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04108553U true JPH04108553U (en) | 1992-09-18 |
| JP2534949Y2 JP2534949Y2 (en) | 1997-05-07 |
Family
ID=31904406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1991017695U Expired - Fee Related JP2534949Y2 (en) | 1991-02-28 | 1991-02-28 | X-ray contrast catheter |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2534949Y2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08173543A (en) * | 1994-09-19 | 1996-07-09 | Cordis Europ Nv | Catheter that can be seen by magnetic resonance image |
| JP2010279546A (en) * | 2009-06-04 | 2010-12-16 | Terumo Corp | Imaging marker and catheter |
| WO2013157409A1 (en) * | 2012-04-20 | 2013-10-24 | オリンパス株式会社 | Elastomer molding for medical instrument |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6418377A (en) * | 1987-07-14 | 1989-01-23 | Mitsubishi Electric Corp | Image storage device |
| JPH0349767A (en) * | 1989-07-18 | 1991-03-04 | Nissho Corp | Catheter using shape memory resin |
-
1991
- 1991-02-28 JP JP1991017695U patent/JP2534949Y2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6418377A (en) * | 1987-07-14 | 1989-01-23 | Mitsubishi Electric Corp | Image storage device |
| JPH0349767A (en) * | 1989-07-18 | 1991-03-04 | Nissho Corp | Catheter using shape memory resin |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08173543A (en) * | 1994-09-19 | 1996-07-09 | Cordis Europ Nv | Catheter that can be seen by magnetic resonance image |
| JP2010279546A (en) * | 2009-06-04 | 2010-12-16 | Terumo Corp | Imaging marker and catheter |
| WO2013157409A1 (en) * | 2012-04-20 | 2013-10-24 | オリンパス株式会社 | Elastomer molding for medical instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2534949Y2 (en) | 1997-05-07 |
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