JPH0382474A - Medical tube - Google Patents
Medical tubeInfo
- Publication number
- JPH0382474A JPH0382474A JP1219688A JP21968889A JPH0382474A JP H0382474 A JPH0382474 A JP H0382474A JP 1219688 A JP1219688 A JP 1219688A JP 21968889 A JP21968889 A JP 21968889A JP H0382474 A JPH0382474 A JP H0382474A
- Authority
- JP
- Japan
- Prior art keywords
- tube
- hydroxyapatite powder
- hydroxyapatite
- flexibility
- dispersed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000463 material Substances 0.000 claims abstract description 12
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 11
- 208000007536 Thrombosis Diseases 0.000 abstract description 7
- 239000002245 particle Substances 0.000 abstract description 2
- 239000000843 powder Substances 0.000 abstract description 2
- 230000002785 anti-thrombosis Effects 0.000 description 6
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 239000002473 artificial blood Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- PEVRKKOYEFPFMN-UHFFFAOYSA-N 1,1,2,3,3,3-hexafluoroprop-1-ene;1,1,2,2-tetrafluoroethene Chemical group FC(F)=C(F)F.FC(F)=C(F)C(F)(F)F PEVRKKOYEFPFMN-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 229920006026 co-polymeric resin Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
この発明は、血液チューブ、カテーテルや人工血管等の
抗血液凝固性を必要とする医療用チューブに関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to medical tubes that require anticoagulability, such as blood tubes, catheters, and artificial blood vessels.
カテーテルチューブや人工血管などは、体内に挿入され
たときには異物と認識され、血栓形成の原因となる。こ
のため、上記チューブの素材としては、フッ素樹脂、ポ
リウレタン、ポリエチレン等の生体適合性が良いとされ
ている高分子材料が主として使われている（特開昭６３
−１３９５６７号、特開昭６３−３０５８６０号、特開
昭６３−２５２１６９号等参照）。Catheter tubes, artificial blood vessels, and the like are recognized as foreign objects when inserted into the body, and can cause thrombus formation. For this reason, polymer materials that are said to have good biocompatibility, such as fluororesin, polyurethane, and polyethylene, are mainly used as materials for the tubes (Japanese Patent Laid-Open No. 63
-139567, JP-A-63-305860, JP-A-63-252169, etc.).
上記高分子材料は、他のものに比べると抗血栓性に優れ
てはいるものの、長期間の使用では血栓が生じ、いまだ
その抗血栓性は充分とは言えないものであった。Although the above-mentioned polymer materials have excellent antithrombotic properties compared to other materials, thrombus occurs when used for a long period of time, and the antithrombotic properties are still not sufficient.
そこで、特開昭６３−１６０８４５号に開示されるよう
に、生体との親和性がきわめて高いセラミックスでチュ
ーブを形成することも考えられるが、この場合、チュー
ブ状にするにはかなりの手間がかかり、しかも得られる
ものは可撓性が全くないため、ごく限られた場合にしか
使えないという課題があった。Therefore, as disclosed in JP-A-63-160845, it is conceivable to form the tube with ceramics that have extremely high affinity with living organisms, but in this case, it would take a lot of effort to make it into a tube shape. Moreover, the resulting product had no flexibility at all, so it could only be used in very limited cases.
この発明は、このような従来技術の課題に鑑み、柔軟で
抗血栓性の高い医療用チューブの提供をその目的とする
。In view of the problems of the prior art, an object of the present invention is to provide a medical tube that is flexible and has high antithrombotic properties.
上記目的を達成するため、この発明では、高分子材料か
らなるチューブの管壁の少なくとも表面部にヒドロキシ
アパタイト粉末を存在させてなる医療用チューブを構成
する。In order to achieve the above object, the present invention provides a medical tube in which hydroxyapatite powder is present on at least the surface portion of the tube wall of the tube made of a polymeric material.
この発明による医療用チューブでは、抗血栓性の高いヒ
ドロキシアパタイトの粉末が管壁の少なくとも表面部分
に分散し、粒子の一部分が表面に露出しているので、血
栓が形成されにくくなっている。また、ヒドロキシアパ
タイトは粉末の状態で管壁に分散しているから、チュー
ブの可撓性は良好に維持される。In the medical tube according to the present invention, hydroxyapatite powder with high antithrombotic properties is dispersed on at least the surface portion of the tube wall, and a portion of the particles are exposed on the surface, making it difficult for thrombus to form. Moreover, since hydroxyapatite is dispersed in the tube wall in a powder state, the flexibility of the tube is maintained well.
粉末状のヒドロキシアパタイト２０重量部を四フッ化エ
チレンー六フッ化プロピレン共重合樹脂（ＰＥＰ）８０
重量部に加え、これを２軸押出機で充分に混練した後、
通常の一軸押出機を用いて内径２．５■のチューブ状に
押出成形し、管壁内にヒドロキシアパタイトを一様に分
散させた本発明による医療用チューブを得た。20 parts by weight of powdered hydroxyapatite was mixed with 80 parts by weight of tetrafluoroethylene-hexafluoropropylene copolymer resin (PEP).
parts by weight, and after sufficiently kneading this with a twin-screw extruder,
A medical tube according to the present invention was obtained by extrusion molding into a tube having an inner diameter of 2.5 mm using a conventional single-screw extruder, and having hydroxyapatite uniformly dispersed in the tube wall.
次に、上記医療用チューブおよびヒドロキシアパタイト
を含まないＦＥＰチューブについて、それぞれ抗血栓性
を調べたところ、ヒドロキシアパタイト粉末を混入した
本発明の医療用チューブは、それを含まないものに比べ
て血栓が生じにくいことが確認された。Next, we investigated the antithrombotic properties of the above medical tube and the FEP tube that does not contain hydroxyapatite, and found that the medical tube of the present invention containing hydroxyapatite powder was less likely to cause blood clots than the tube that did not contain it. It was confirmed that this is unlikely to occur.
上記実施例では、デユープ素材としてＰＥＰを用いた場
合について説明したが、もちろんこれに限定されるもの
ではなく、他のフッ素系樹脂あるいはポリウレタンなど
の一般に医療用チューブ材料として使われている高分子
材料にも適用は可能である。なお、四フッ化エチレン樹
脂を使用する場合には、一般の熱溶融性樹脂とは成形加
工方法が異なり、高濃度で混入することができるので、
抗血栓性のきわめて高いものが得られる。In the above example, the case where PEP was used as the duplex material was explained, but the invention is of course not limited to this, and other polymeric materials commonly used as medical tube materials such as fluororesin or polyurethane may also be used. It can also be applied to In addition, when using tetrafluoroethylene resin, the molding method is different from general heat-melting resins, and it can be mixed in at high concentrations, so
A product with extremely high antithrombotic properties can be obtained.
また、ヒドロキシアパタイト粉末は、少なくとも血液と
接触する管壁の表面に露出していればよいので、必ずし
も実施例のように管壁全体に一様に分散させる必要はな
く、例えばヒドロキシアパタイトを含む樹脂層とそれを
含まない樹脂層の二層構造にしてもよい。この場合には
、その配合量を減らすことができるので、管壁全体に分
散したものに比べるとチューブの可撓性が高くなる。ヒ
ドロキシアパタイト粉末の配合量は、管壁を形成する高
分子材料の種類や入れ方によっても異なるが、高分子材
料に対して、２〜８０重量％の転回で選択される。Furthermore, since the hydroxyapatite powder only needs to be exposed at least on the surface of the tube wall that comes into contact with blood, it is not necessarily necessary to uniformly disperse the hydroxyapatite powder over the entire tube wall as in the example. It may have a two-layer structure consisting of a layer and a resin layer that does not contain the layer. In this case, since the amount of the compound can be reduced, the flexibility of the tube becomes higher than that when the compound is dispersed throughout the tube wall. The amount of hydroxyapatite powder to be blended varies depending on the type of polymeric material forming the tube wall and how it is added, but is selected at a turnover of 2 to 80% by weight based on the polymeric material.
以上説明したように、この発明の医療用チューブでは、
ヒドロキシアパタイト粉末を混入した高分子材料で管壁
を構成したから、体内に挿入した場合に血栓が生じに＜
＜、長期の使用が可能となり、しかもチューブの可撓性
も良好に維持されるという優れた効果が得られる。As explained above, in the medical tube of this invention,
The tube wall is made of a polymeric material mixed with hydroxyapatite powder, which prevents blood clots from forming when inserted into the body.
The excellent effects of being able to use the tube for a long period of time and maintaining good flexibility of the tube can be obtained.
Claims (1)
表面部にヒドロキシアパタイト粉末を存在させてなる医
療用チューブ。(1) A medical tube made of a polymeric material, with hydroxyapatite powder present on at least the surface of the tube wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1219688A JPH0382474A (en) | 1989-08-25 | 1989-08-25 | Medical tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1219688A JPH0382474A (en) | 1989-08-25 | 1989-08-25 | Medical tube |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0382474A true JPH0382474A (en) | 1991-04-08 |
Family
ID=16739410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1219688A Pending JPH0382474A (en) | 1989-08-25 | 1989-08-25 | Medical tube |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0382474A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995015775A1 (en) * | 1993-12-10 | 1995-06-15 | Kabushiki Kaisya Advance | Implantation material and process for producing the same |
| WO1996035461A1 (en) * | 1995-05-10 | 1996-11-14 | Kabushiki Kaisya Advance | Blood vessel substitute, tooth crown substitute, and process for producing the same |
| JPH10192321A (en) * | 1996-12-29 | 1998-07-28 | Ngk Spark Plug Co Ltd | Human body penetrating member |
-
1989
- 1989-08-25 JP JP1219688A patent/JPH0382474A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995015775A1 (en) * | 1993-12-10 | 1995-06-15 | Kabushiki Kaisya Advance | Implantation material and process for producing the same |
| US5766247A (en) * | 1993-12-10 | 1998-06-16 | Kabushiki Kaisya Advance | Process for producing a bioimbedding material |
| WO1996035461A1 (en) * | 1995-05-10 | 1996-11-14 | Kabushiki Kaisya Advance | Blood vessel substitute, tooth crown substitute, and process for producing the same |
| JPH10192321A (en) * | 1996-12-29 | 1998-07-28 | Ngk Spark Plug Co Ltd | Human body penetrating member |
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