JPH0372948B2 - - Google Patents
Info
- Publication number
- JPH0372948B2 JPH0372948B2 JP56075733A JP7573381A JPH0372948B2 JP H0372948 B2 JPH0372948 B2 JP H0372948B2 JP 56075733 A JP56075733 A JP 56075733A JP 7573381 A JP7573381 A JP 7573381A JP H0372948 B2 JPH0372948 B2 JP H0372948B2
- Authority
- JP
- Japan
- Prior art keywords
- calibration
- section
- serum
- calibration serum
- biochemical analyzer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000002966 serum Anatomy 0.000 claims description 37
- 238000012742 biochemical analysis Methods 0.000 claims description 5
- 238000011088 calibration curve Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 238000005375 photometry Methods 0.000 claims description 4
- 239000012086 standard solution Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000006866 deterioration Effects 0.000 description 5
- 238000001704 evaporation Methods 0.000 description 5
- 230000008020 evaporation Effects 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000003507 refrigerant Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
【発明の詳細な説明】
本発明は標準血清又は試料等（以下較正用血清
という）によつて較正を行なう試料の生化学分析
のための自動生化学分析装置に関するものであ
る。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an automatic biochemical analyzer for biochemical analysis of a sample in which calibration is performed using a standard serum or sample (hereinafter referred to as calibration serum).
較正用血清を用いて試料の生化学分析を行なう
自動生化学分析装置は、臨床検査において酵素の
活性を分析して病気の診断や治療過程の把握等の
ために使用されるものである。このような自動生
化学分析装置は、検体から採取した血液等（以
下、試料という）を順次一つずつ試料容器に分注
し、そしてこれら試料容器に、分析項目に対応す
る試薬を注入して反応させ、この反応した試料に
特定の光をあて、透過量を測光して分析を行なう
ものである。分析に際しては、予め較正用血清を
前記同様に測光して検量線を求め、この検量線と
前記試料の測光データとに基づいて分析がなされ
ることとなる。また測光中に測光部の特性等が変
化するので、前記検量線は較正用血清により逐次
較正されるようになつている。 Automatic biochemical analyzers that perform biochemical analysis of samples using calibration serum are used in clinical tests to analyze enzyme activity and diagnose diseases and understand treatment processes. Such an automatic biochemical analyzer sequentially dispenses blood, etc. collected from a specimen (hereinafter referred to as a sample) into sample containers, and then injects reagents corresponding to the analysis items into these sample containers. The reaction is performed, the reacted sample is exposed to specific light, and the amount of light transmitted is measured and analyzed. In the analysis, a calibration curve is obtained by photometrically measuring the calibration serum in advance in the same manner as described above, and the analysis is performed based on this calibration curve and the photometric data of the sample. Furthermore, since the characteristics of the photometric section change during photometry, the calibration curve is successively calibrated using a calibration serum.
このような自動生化学分析装置に使用される較
正用血清は、従来較正用血清を入れた容器を位置
決めして保持するだけの設置台に載置されて該装
置に内蔵されていた。 Calibration serum used in such an automatic biochemical analyzer has conventionally been built into the apparatus and placed on a stand that merely positions and holds a container containing the calibration serum.
しかしながら多数の検体の試料を長時間かけて
分析するような場合、較正用血清が蒸発し、さら
に本来冷凍若しくは冷蔵すべき較正用血清を室温
で放置するため較正用血清が劣化し、検量線の適
正な較正ができず、ひいては信頼性のある分析が
できないという欠点があつた。また較正用血清の
蒸発と劣化を防止するために較正時以外は冷蔵庫
に保管するようにすれば操作が煩雑になるという
欠点もあつた。 However, when a large number of samples are analyzed over a long period of time, the calibration serum evaporates, and the calibration serum deteriorates due to being left at room temperature, which should normally be frozen or refrigerated, resulting in changes in the calibration curve. The drawback was that proper calibration was not possible, and therefore reliable analysis was not possible. Furthermore, if the calibration serum is stored in a refrigerator except during calibration in order to prevent evaporation and deterioration, the operation becomes complicated.
本発明は上記事情に基づいてなされたものであ
り、標準液となる較正用血清の蒸発及び劣化を防
止することができ、ひいては生化学分析の効率と
信頼性を向上することができる較正用血清等を収
納する収納機構を備えた自動生化学分析装置を提
供することを目的とする。 The present invention has been made based on the above circumstances, and provides a calibration serum that can prevent the evaporation and deterioration of the calibration serum that serves as a standard solution, thereby improving the efficiency and reliability of biochemical analysis. An object of the present invention is to provide an automatic biochemical analyzer equipped with a storage mechanism for storing the following items.
以下本発明の自動生化学分析装置における較正
用血清収納機構を図面を参照しながら説明する。 The calibration serum storage mechanism in the automatic biochemical analyzer of the present invention will be described below with reference to the drawings.
第１図は本発明の自動生化学分析装置における
較正用血清収納機構の一実施例を示す概略説明図
である。図において１は較正用血清であり、例え
ば方形状の容器２に入れられている。この容器２
は、例えば少なくとも容器２を位置決めして着脱
自在に収納する収納孔３ａを有する収納部３に収
納されるようになつている。そしてこのようにし
て収納保持されている較正用血清１を冷却するた
めの冷却部として例えば前記収納部３の底面にペ
ルチエ素子４の吸熱面が図示しないサーマルコン
パウンドを介して適宜の手段によつて取付けられ
ている。従つて前記収納部３は熱伝導性の良好な
銅やアルミニウムで製造すれば較正用血清１より
の吸熱を効果的に行なうことができる。また前記
ペルチエ素子４によつて吸熱した熱を発散させる
ための放熱機能をも有するアングル状のブラケツ
ト５がベース６に立設された支柱７の第１図示右
側上部に取付けられており、このブラケツト５の
上面に図示しないサーマルコンパウンドを介して
前記ペルチエ素子４の放熱面が適宜の手段により
取付けられている。そしてこのようにして位置決
めされて保持されるようになつている前記容器２
に入れられている較正用血清１の蒸発を防止する
ための蓋部として例えば前記容器２の注入口に密
着して密閉することのできる軟質ゴム製のパツキ
ン８を取付けたアーム９が回転レバー１０に取付
けられている。この回転レバー１０は、前記支柱
７に設けられているモータホルダ１１に載置され
たモータ１２によつて（実際には図示しない減速
機を介して回転力が伝達される）適宜回動し、自
動的に前記容器２の注入口が開閉されるようにな
つている。なお前記収納部３の適宜の位置に図示
しない温度センサが設けられており、これよりの
信号に基づき図示しない生化学自動分析装置の制
御部を介して前記ペルチエ素子４に供給される電
流が制御されるようになつている。また前記モー
タ１０も図示しない生化学自動分析装置の制御部
を介して適宜駆動されるようになつている。 FIG. 1 is a schematic explanatory diagram showing one embodiment of a calibration serum storage mechanism in an automatic biochemical analyzer of the present invention. In the figure, reference numeral 1 indicates a calibration serum, which is placed in a rectangular container 2, for example. This container 2
For example, the container 2 is stored in a storage section 3 having a storage hole 3a for positioning and removably storing at least the container 2. As a cooling section for cooling the calibration serum 1 stored and held in this manner, for example, the heat absorbing surface of the Peltier element 4 is attached to the bottom surface of the storage section 3 by appropriate means via a thermal compound (not shown). installed. Therefore, if the storage section 3 is made of copper or aluminum having good thermal conductivity, it can effectively absorb heat from the calibration serum 1. Further, an angled bracket 5 having a heat dissipation function for dissipating the heat absorbed by the Peltier element 4 is attached to the upper right side of the support 7 erected on the base 6 in the first drawing. The heat dissipating surface of the Peltier element 4 is attached to the upper surface of the Peltier element 5 by appropriate means via a thermal compound (not shown). The container 2 is positioned and held in this manner.
An arm 9 is attached to a rotary lever 10 with a soft rubber gasket 8 that can be tightly sealed to the injection port of the container 2 as a lid to prevent evaporation of the calibration serum 1 contained in the container 2. installed on. This rotary lever 10 is rotated as appropriate by a motor 12 mounted on a motor holder 11 provided on the support column 7 (actually, the rotational force is transmitted via a not-shown reducer), The injection port of the container 2 is automatically opened and closed. A temperature sensor (not shown) is provided at an appropriate position in the storage section 3, and the current supplied to the Peltier element 4 is controlled based on a signal from the temperature sensor via a control section of an automatic biochemical analyzer (not shown). It is becoming more and more common. Further, the motor 10 is also appropriately driven via a control section of an automatic biochemical analyzer (not shown).
このように構成された較正用血清収納機構は図
示しない自動生化学分析装置内又は外部の適宜の
位置に装着されて使用されることとなり、較正用
血清１を使用しないときは、第１図に示すように
容器２はパツキン８によつて密閉されている。従
つて較正用血清１が蒸発することはない。また前
記ペルチエ素子４に電流が供給されると、熱ポン
プ作用により収納部３より熱がペルチエ素子４の
吸熱面に吸収されて反対側の放熱面に伝達され、
伝達された熱はブラケツト５を介して空気中に発
散される。従つて収納部３の温度が下がり較正用
血清１が冷却される。なおペルチエ素子４に供給
される電流は、前記図示しない温度センサと図示
しない制御部とによつて制御されているので、較
正用血清１を設定温度まで冷却して恒温保持する
ことが可能である。このようにして較正用血清１
を冷却できるので較正用血清１の劣化を有効に防
止でき、しかもペルチエ素子４を使用しているの
で小型化の要請にも適合する。前記較正用血清１
を使用する場合には、前記図示しない制御部を介
して適宜前記モータ１２を駆動してアームを第１
図示矢印Ａ方向に回動し、前記パツキン８を容器
２から離脱する。そして図示しない生化学自動分
析装置に内蔵されている図示しないノズル等の適
宜の手段を介して較正用血清１が取出されるよう
になる。 The calibration serum storage mechanism configured in this way is used by being attached to an appropriate position inside or outside an automatic biochemical analyzer (not shown). When the calibration serum 1 is not used, it is used as shown in FIG. As shown, the container 2 is sealed with a gasket 8. Therefore, the calibration serum 1 will not evaporate. Further, when a current is supplied to the Peltier element 4, heat is absorbed from the storage part 3 by the heat pumping action into the heat absorption surface of the Peltier element 4, and is transmitted to the heat radiation surface on the opposite side.
The transferred heat is dissipated into the air via the bracket 5. Therefore, the temperature of the storage section 3 is lowered and the calibration serum 1 is cooled. Note that since the current supplied to the Peltier element 4 is controlled by the temperature sensor (not shown) and the control unit (not shown), it is possible to cool the calibration serum 1 to a set temperature and maintain it at a constant temperature. . In this way, calibration serum 1
Since the calibration serum 1 can be cooled, deterioration of the calibration serum 1 can be effectively prevented, and since the Peltier element 4 is used, it also meets the demand for miniaturization. Said calibration serum 1
When using the arm, the motor 12 is appropriately driven via the control section (not shown) to move the arm to the first position.
The gasket 8 is rotated in the direction of arrow A in the figure to remove the gasket 8 from the container 2. Then, the calibration serum 1 is taken out through an appropriate means such as a nozzle (not shown) built into an automatic biochemical analyzer (not shown).
このように構成すれば較正用血清の蒸発及び劣
化を防止することができ、さらには緊急検体に対
しても迅速な分析を行なうことができ自動生化学
分析装置の信頼性をも向上することができる。 With this configuration, it is possible to prevent the evaporation and deterioration of the calibration serum, and furthermore, it is possible to quickly analyze even emergency samples, and the reliability of the automatic biochemical analyzer can be improved. can.
第２図は本発明の生化学自動分析装置における
較正用血清収納機構の他の実施例を示す概略説明
図である。第１図と同一部材については同一符号
を付して詳細な説明を省略する。第１図に示すも
のと異なる構成は、前記収納部３に収納保持され
ている較正用血清１を冷却するための冷却部とし
て、前記ペルチエ素子４の代わりに前記収納部３
の内部に冷媒通路１３を設け、この冷媒通路１３
に適宜設けた図示しない冷却装置よりも冷媒１４
を通して循環するように構成したことである。こ
のように構成すれば冷却能力を飛躍的に向上する
ことが可能である。 FIG. 2 is a schematic explanatory diagram showing another embodiment of the calibration serum storage mechanism in the automatic biochemical analyzer of the present invention. Components that are the same as those in FIG. 1 are given the same reference numerals and detailed explanations will be omitted. A different configuration from that shown in FIG.
A refrigerant passage 13 is provided inside the refrigerant passage 13.
refrigerant 14 than a cooling device (not shown) provided as appropriate.
The structure was designed so that it circulates through. With this configuration, it is possible to dramatically improve the cooling capacity.
上記実施例は一例であり各部材につき同一機能
を有する他の部材に置換えられることは言うまで
もない。 It goes without saying that the above embodiment is just an example, and each member can be replaced with another member having the same function.
以上の説明から明らかなように本発明の自動生
化学分析装置における較正用血清設置台にあつて
は、標準液としての較正用血清の蒸発及び劣化を
防止することができ、ひいては生化学分析の効率
と信頼性とを向上することができる等の優れた効
果を有するものである。 As is clear from the above explanation, the calibration serum installation stand in the automatic biochemical analyzer of the present invention can prevent the evaporation and deterioration of the calibration serum as a standard solution, and can further improve the performance of biochemical analysis. This has excellent effects such as being able to improve efficiency and reliability.
第１図は本発明の自動生化学分析装置における
較正用血清収納機構の一実施例を示す概略説明
図、第２図は本発明の自動生化学分析装置におけ
る較正用血清収納機構の他の実施例を示す概略説
明図である。
１…較正用血清、２…容器、３…収納部、４…
ペルチエ素子、５…ブラケツト、６…ベース、７
…支柱、８…パツキン、９…アーム、１０…回転
レバー、１１…モータホルダ、１２…モータ、１
３…冷媒通路、１４…冷媒。
FIG. 1 is a schematic explanatory diagram showing one embodiment of the calibration serum storage mechanism in the automatic biochemical analyzer of the present invention, and FIG. 2 is another embodiment of the calibration serum storage mechanism in the automatic biochemical analyzer of the present invention. It is a schematic explanatory diagram showing an example. 1... Calibration serum, 2... Container, 3... Storage section, 4...
Peltier element, 5...Bracket, 6...Base, 7
...Strut, 8...Puttle, 9...Arm, 10...Rotary lever, 11...Motor holder, 12...Motor, 1
3... Refrigerant passage, 14... Refrigerant.
Claims (1)
透過光量の測定に基づき行う自動生化学分析装置
において、前記透過光量の測光値から試料の特定
成分濃度を求めるための検量線の較正のため前記
測光部に吸引、導出される標準液となる較正用血
清を収納する収納部と、前記収納部の密閉状態を
保持する蓋部と、前記収納部を冷却するため前記
収納部に連接して設けられた冷却部と、前記測光
部への前記較正用血清の吸引、導出に応じて前記
蓋部による前記収納部の密閉状態の保持又は解除
を制御する制御部とを備えたことを特徴とする自
動生化学分析装置。1. In an automatic biochemical analyzer that performs biochemical analysis of a sample based on the measurement of the amount of transmitted light of the sample led to a photometry section, calibration of a calibration curve for determining the concentration of a specific component of the sample from the photometric value of the amount of transmitted light. a storage section for storing a calibration serum serving as a standard solution to be drawn into and led out to the photometry section; a lid section for keeping the storage section in a sealed state; and a lid section connected to the storage section for cooling the storage section. and a control unit that controls maintaining or releasing the sealed state of the storage unit by the lid unit according to suction and extraction of the calibration serum to the photometry unit. Automatic biochemical analyzer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7573381A JPS57191552A (en) | 1981-05-21 | 1981-05-21 | Set board of blood serum for calibration of biochemical automatic analysing apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7573381A JPS57191552A (en) | 1981-05-21 | 1981-05-21 | Set board of blood serum for calibration of biochemical automatic analysing apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57191552A JPS57191552A (en) | 1982-11-25 |
| JPH0372948B2 true JPH0372948B2 (en) | 1991-11-20 |
Family
ID=13584762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7573381A Granted JPS57191552A (en) | 1981-05-21 | 1981-05-21 | Set board of blood serum for calibration of biochemical automatic analysing apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57191552A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2611975B2 (en) * | 1986-06-10 | 1997-05-21 | 株式会社東芝 | Liquid level detector of automatic chemical analyzer |
| JPS6372557U (en) * | 1986-10-30 | 1988-05-14 | ||
| JPH01153963A (en) * | 1987-12-11 | 1989-06-16 | Nittec Co Ltd | Liquid cooling device for automatic analyzer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53100891A (en) * | 1977-02-15 | 1978-09-02 | Nippon Tectron Kk | Clinical automatic chemical analyzer |
| JPS55129744A (en) * | 1979-03-30 | 1980-10-07 | Olympus Optical Co Ltd | Serum automatic coating unit with serum dry prevention set |
| JPS5631349A (en) * | 1979-08-21 | 1981-03-30 | Hitachi Ltd | Rotary electric machine with electric blower built in |
-
1981
- 1981-05-21 JP JP7573381A patent/JPS57191552A/en active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53100891A (en) * | 1977-02-15 | 1978-09-02 | Nippon Tectron Kk | Clinical automatic chemical analyzer |
| JPS55129744A (en) * | 1979-03-30 | 1980-10-07 | Olympus Optical Co Ltd | Serum automatic coating unit with serum dry prevention set |
| JPS5631349A (en) * | 1979-08-21 | 1981-03-30 | Hitachi Ltd | Rotary electric machine with electric blower built in |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57191552A (en) | 1982-11-25 |
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