JPH0370498B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION In order to continuously manufacture plaster packages to be administered through skin permeation, the present invention involves continuously storing a measured amount of a drug at intervals in a portion of a sheet. This invention relates to a method for covering a plaster package with a piece of cover sheet and punching out the resulting plaster package.

In one embodiment of the plaster package, the plaster package consists of a part to be placed on the skin and a part to be peeled off and discarded, and the part to be placed on the skin includes a foam rubber-like skin adhesive sheet, a cover sheet piece, and a measuring portion. The part that is peeled off and thrown away is made up of a carrier foil and an intermediate layer sheet. The carrier foil can be provided with a peeling tab.

In another embodiment, a small deep dish portion is not formed on the carrier foil, but a cover sheet piece is preformed in a small deep dish shape according to the shape of the drug placed on the carrier foil, and is placed over the drug.
Bonded to carrier foil. In addition, an intermediate layer sheet and a skin adhesive sheet are added to this structure.

One such method is a French patent
Known from Public Relations No. 2082820. In the method of this French patent, an adhesive strip is used as carrier foil. That is, it is used by being connected to an endless metal band with holes the size of the package. A cellophane plate is attached to the carrier foil in the region of the holes in the endless strip, a drug is dispensed onto the cellophane plate, and after being coated with the drug the carrier foil is punched out of the endless strip.

In the process of this French patent, only the adhesive strip is ultimately punched out through holes provided in the metal carrier strip. This is actually an extremely difficult task. Apart from that, in this method at least the edge of the hole in the metal strip is affixed with an adhesive strip with the adhesive side facing the metal strip.

Skin-permeable plasters have been known for a long time, sometimes for the treatment of rheumatoid arthritis, and the drug is made into a strong paste and applied onto a suitable textile fabric, with the adhesive side usually split into two parts. It is covered with a cover sheet that can be separated and pulled apart.

This type of plaster is cut into relatively large shapes and sold in paper bags shaped like letter envelopes. Sometimes this type of plaster is treated with light and light so that it remains effective even when stored for a long time.
Sometimes it's in an airtight bag.

Eventually, it was discovered that other drugs that should not directly act on bones and muscles can also be administered through the skin (ie, skin permeation). In other words, do not take it or use it for sitting. In such cases, those parts may be injured.

However, this type of drug patch requires, on the one hand, precise dosing, and, on the other hand, in order for the drug to be effective for a long time, it must be able to act only towards the skin. A special packaging form is assumed, in which the product remains hermetically sealed after being applied to the skin, and is also hermetically sealed before application. In the meantime, this type of packaging was developed. It also guarantees the desired therapeutic effect. Such a package has a structure of the type mentioned at the outset,
It is in a format suitable for sale and can be applied immediately after being divided.

This type of plaster packaging usually consists of a total of five components, which can be sealed to each other in a certain manner and which are still relatively flat.
Because the coating is not thick, this type of packaging is not easy to manufacture and cannot be continuously produced as desired. In particular, one of the components must adhere to the skin on one side, and the adhesive potential itself cannot be restored by the gel, which is no longer adhesive after curing. This gel contains drugs. That is, it is necessary to take into consideration the processing of sheets with adhesive ability in the entire manufacturing process. This cannot easily be done with the method of the French patent, at least for the reasons already mentioned.

Therefore, the basic problem of the present invention is to provide a method for continuous production of this type of plaster packaging, in which the sheets forming the plaster packaging are successively joined in multiple layers in one step, and during that time the sheets are filled with drugs. The purpose is to punch out the resulting package.

The structure of one embodiment of the plaster package is illustrated in FIGS. 1 to 3, and FIG. 1 shows the part of the plaster package that is placed on the skin. Reference numeral 4 is a foam rubber-like skin adhesive sheet, 3' is a cover sheet piece, and 5 is a measured amount of medicine. FIG. 2 shows the part of the plaster package that is to be peeled off and discarded. Here, numeral 2 is an intermediate layer sheet with holes, 1 is a carrier foil, 5' is a small deep dish portion, and 15 is a peeling piece provided on the carrier foil. And Figure 3 shows these Figures 1 and 2.
A cross-section of the entire plaster package consisting of what is shown in the figure is shown.

The object of the invention is to separate the interlayer sheet and the skin-adhesive sheet in the form of a strip, which are layered together, before joining the carrier foil with the dosed drug and the cover sheet piece taken from the deposition magazine of the closed station. Then, a hole of the same size as the measured amount of drug is made in the intermediate layer sheet, and the perforated intermediate layer sheet and the carrier foil containing the measured amount of drug are guided together so that they intertwine around the measured amount of drug. This is accomplished by punching out a plaster package made by continuously storing measured amounts of the drug at intervals in a portion of a strip-shaped carrier foil, on which the adhesive side of the skin-adhesive sheet is adhered. be done.

According to another configuration of the present invention, the above-mentioned problem can be solved by making holes in the intermediate layer sheet in advance and guiding it together with the carrier foil so that they are bonded to each other, and then the measured amount of drug is covered by the intermediate layer sheet. This dose of drug is covered with a pre-punched cover sheet piece placed in the area of the carrier foil that is not covered, and the cover sheet piece is sealed around the dose of drug to the carrier box and then separated from the intermediate layer sheet. This problem can be solved by punching out a plaster package made of a skin-adhesive sheet.

The problem also includes accommodating a metered dose of drug in a carrier foil, covering the metered dose with a cover sheet piece, sealing the cover sheet piece to the carrier foil around the metered dose, and then sealing the cover sheet piece with the cover sheet piece. An intermediate layer sheet with holes of the same size is fed, this is sealed on a carrier foil, and the protective sheet, which is the intermediate layer sheet, and the separated skin adhesion sheet are placed over the sealed cover sheet piece. This problem is solved by gluing the adhesive side and punching out the resulting plaster package.

The problem is further solved by accommodating a measured amount of drug on an intermediate layer sheet laminated with carrier foil, covering this measured amount of drug with a cover sheet piece, and surrounding the measured amount of drug with the carrier foil, intermediate layer sheet, and cover. This problem is solved by sealing the sheet pieces together, then applying the adhesive side of the skin-adhesive sheet over the intermediate layer sheet, and punching out the resulting plaster package.

What is common to each of the above methods is that each strip that becomes a single plaster package required for administering a plaster is manufactured individually, and then these strips are used in the next step to contain the measured amount of medicine. Rather than joining each other,
It is advantageous to carry out this in one step, including the filling operation, by joining the bodies in stages while forming the plaster package.

Each method described in each claim can be easily carried out by using members and devices known in packaging mechanics. The known elements used for this purpose, such as punching holes, sealing tools, dosing stations, cover sheet stacking devices, transfer stacking devices, storage roll holders for foil belts or the like, are immediately available. Because it is possible. The known elements mentioned above can be controlled, arranged and driven in accordance with the working cycle at each stage in a suitably adapted machine frame.

The following materials are of particular concern for individual packaging components: i.e. ● Continuous aluminum carrier foil that can be separated from the roll;
optionally with an application side laminate, which prevents the adhesion of the drug; ● also aluminum foil for pre-stamped cover sheet pieces, with sealing wax at least in the sealing edge area; ● a continuous carrier; Silicone paper for interlayer sheets that can be sealed with foil; ●Thin, elastic foam-rubber-like foil with adhesive adhesive on one side for use as skin-adhesive foil.

The deep drawing of a continuous carrier foil into a flat plate is carried out in particular within the framework of the process described above. This is because the drug-containing gel-like material, which is deposited in the form of relatively large, dense drops, is then compacted into a small dish shape and hardened under slight pressure. This prevents the dose from flowing into the edge area of the plaster package which is subsequently sealed. If it flows in, it will not be completely sealed.

The sealing of the plaster package components is ensured by the fact that the respective drug charges, which are dosed according to the width of the carrier foil, are arranged one after the other in a row or adjacently in several rows at a sufficient distance from each other. and leaves a large enough edge area available for gluing.

Deposition or dosing of a drug in the form of a gel means that the drug is applied to the carrier foil in the hardened state, both in the form of a paste and also in the form of a wafer.
However, it is especially metered in in the form of an uncured paste. After all, this can be handled more easily using equipment, and nothing can be done to prevent slippage of the drug formulation in the further process (which can be punched out of a hardened gel strip, for example). This is because there is no need to take additional measures.

Apart from the modification of claim 9, holes are made in advance in the intermediate layer sheet made of silicone and paper. The diameter is slightly larger than the diameter of the pre-punched cover sheet piece. That is, in such a plaster package there is a ring-shaped interlayer sheet. The completed, still connected unitary package can be easily split, thus facilitating exposure of the drug. To facilitate such division, it is advantageous to provide a tear-off tab with a notch in the edge of the carrier foil of each plaster package. The adhesion capacity of the sealing area and the adhesive area is then adjusted in such a way that, for example, after dividing into circular plaster packages, the package is divided into two parts.

The part that can be applied to the skin consists of an elastic foam rubber-like skin adhesive sheet. At the center of this skin-adhesive sheet is a piece of cover sheet. This cover sheet strip is smaller in diameter than the skin adhesive sheet and has a smaller diameter cured dosage medicament thereon.
This measured amount of drug is then applied onto the skin, and then slowly dissolves under the influence of body temperature and penetrates into the skin. The drug is then covered by the cover sheet strip and can escape to the other side. Since the adhesive edge of the skin adhesive sheet is wide, it does not protrude into the armpit. The dumping part of the separated plaster package consists of the carrier foil and the intermediate sheet which remains sealed.

A detailed description will be given based on figures showing some embodiments. In the example of FIG. 4, on the left side of the machine frame there are a roll 1' of carrier foil 1 and a roll 4' of foam rubber-like skin adhesive sheet 4. At the same time, an intermediate layer sheet 2 or a protective sheet 2'' is wrapped around the skin adhesion sheet roll to prevent adhesion.

After passing through the compensating roll guide 14, the carrier foil 1 is first provided with flat small basins 5' in a deep drawing station 6 and then into these small basins in a filling station 7 with a plaster-like metered dose of drug. Put in. In the closing station 8, the pre-punched cover sheet piece 3' is removed from the stacking magazine;
In addition, a thick droplet-like measured dose is placed on the drug and lightly pressed down, so that the still deformable mass of drug is evenly distributed in the small basin 5' and substantially fills it (FIG. 3). . The next station is a combination of a drilling station 9 and a sealing station 10, and only the intermediate layer sheet 2 separated from the skin adhering sheet 4 for drilling passes through the upper part of this station and is guided downward. guided together with a carrier foil having a small deep-drawn dish portion 5' of the same size and filled with a drug;
Both are sealed at the bottom of this station. The two aluminum components are thus sealed and the perforated interlayer sheet 2 is sealed one over the other onto the carrier foil 1. The next station is the coding station 11, which is of no interest here to go into detail, behind which the skin-adhesive sheet 4 is placed with its adhesive side onto the carrier foil after the separation of the still unperforated intermediate layer sheet 2 by means of the separating bar 13. It will be done. Next, plaster packages are punched out into circular shapes from this entire strip at a singulation station 12 and transported to a cardboard packaging facility for distribution and sales (not shown). As can be seen from the figure, in this case, the intermediate layer sheet 2 is reversed against the original running direction, so that a piece of the intermediate layer sheet of an appropriate length comes first, and the adhesive sheet portion behind the separation bar 13 It must be cut first.

In FIG. 5, corresponding stations and seats are given the same reference numerals. The progress of the above method will be explained as follows.

The unperforated interlayer sheet 2 lies on a special roll 2'. This particular roll resulted from the peeling off from the skin-adhesive sheet 4 in a previous step. Holes are punched in the intermediate layer sheet 2 at the punching station 9, after which this sheet enters the sealing station 10 together with the carrier foil 1 as the perforated intermediate layer sheet 2. Behind this sealing station, in a deep drawing station 6, a flat sub-dish 5' of the same size as the hole in the perforated intermediate layer sheet 2 is provided in the carrier foil 1. The drug is filled in the station 7 and then a cover sheet piece 3' is placed and subsequently sealed to the carrier foil 1. Subsequently, the skin-adhesive sheet 4 is placed and the individual packages are punched out at a singulation station 12.

FIG. 6 shows another modification. In this case, the carrier foil 1 is first deep-drawn in a deep-drawing station 6 to form a small deep dish, filled with the drug in a filling station 7 and covered with a cover sheet in a closing station 8, in which the carrier foil and the cover sheet piece are separated. They are mutually sealed at a sealing station 10. The intermediate layer sheet 2 is conveyed through a punching station 9 to a carrier foil 1 filled with drug and covered. After sealing the perforated intermediate layer sheet 2 at the sealing station 10, the skin-adhesive sheet 4 is attached after being freed from its protective sheet 2'' as described above, and the protective sheet is attached as an intermediate layer sheet roll 2'. moved,
It is used as the intermediate layer sheet 2. Single packages are then punched out at a singulation station 12.

The method of FIG. 7 is quite similar to that of FIG. The difference is that in the case of Fig. 7, the measured amount of drug 5
has been cured and is preformed and placed on the carrier foil 1 at the station 7. A cover sheet piece 3' is preformed in the form of a small saucer and placed over the metered dose in the closing station 8, or after a simple placement it is added and sealed. Thereafter, as in the previous example, the guiding and sealing of the perforated intermediate layer sheet 2, the attachment of the skin-adhesive sheet 4, and the punching of the entire single package at the singulation station 12 are carried out in this order.

In the case of the modification shown in FIG. 8, the holes in the intermediate layer sheet 2 may not be provided. This is because this intermediate layer sheet covered with carrier foil 1 enters the machine together with the carrier foil. That is, the measured amount of medicine 5 is placed on the intermediate layer sheet at the station 7. The cover sheet piece 3' is optionally preformed in the shape of a small dish, and the intermediate layer sheet is placed over the dosed drug and sealed. The application of the skin-adhesive sheet 4 and the punching out of the single packages then take place in the singulation station 12.

9 to 11 show the processing states of individual sheets that occur in the method shown in FIG. 4.

[Brief explanation of drawings]

Fig. 1 is a plan view of the part of the package to be placed on the skin, Fig. 2 is a plan view of the part of the package to be peeled off and discarded, and Fig. 3 is a highly enlarged cross-sectional view of the entire package;
4 to 8 are schematic diagrams showing the various arrangements of processing stations required for carrying out the different methods, and FIGS. 9 to 11 show the individual processing states of the sheet that occur in the case of the method shown in FIG. 4. FIG. The advantage of this invention is that multilayer packaging bodies can be continuously manufactured in one step, including processing of adhesive sheets. Symbols in the figure, 1... Carrier foil, 2... Intermediate layer sheet, 2''... Protective sheet, 3'... Cover sheet piece, 4... Skin adhesion sheet, 5... Measuring amount drug,
5'...Small deep dish section, 7...Filling station, 8
...Closing station, 9...Drilling station, 10...Sealing station, 12...Individuation station, 14...Compensation roll guide.

Claims (1)

[Scope of Claims] 1. Consists of a part that is attached to the skin and a part that is peeled off and discarded.The part that is attached to the skin includes a drug, a cover sheet piece that covers the drug, and a thin, elastic sheet above the drug. The plaster packaging consists of a foamed rubber-like skin adhesive sheet, and the part that is peeled off and thrown away is a carrier foil that contains the drug, and a ring-shaped intermediate layer sheet that prevents adhesion between the carrier foil and the skin adhesive sheet. In a method for continuously manufacturing a body, a strip-shaped interlayer sheet 2 and a skin-adhesive sheet 4, which are fed together, a carrier foil 1 with a dose of drug 5 and a cover sheet piece removed from a depositing magazine of a closed station. 3', the intermediate layer sheet 2 is separated and a hole of the same size as the measured amount of drug 5 is made, and the carrier foil 1 containing the perforated intermediate layer sheet 2 and the measured amount of drug 5 is separated. are guided together and joined to each other around the measured amount of drug, and the adhesion side of the skin adhesion sheet 4 is placed on top of it. A method characterized by punching out a plaster package formed by continuous filling in one part. 2. Claim 1, comprising a small deep dish portion 5' that is deep-drawn into a flat shape on the carrier foil 1 before storing the measured amount of medicine.
The method described in. 3. It consists of a part that is attached to the skin and a part that is peeled off and thrown away.The part that is attached to the skin consists of the drug, a piece of cover sheet that covers the drug, and a thin, elastic foam rubber-like skin adhesive on top of the drug. Continuously manufactures a plaster package consisting of a sheet, the part of which is peeled off and disposed of is a single foil containing the drug, and a ring-shaped intermediate layer sheet to prevent adhesion between this carrier foil and the skin adhesion sheet. In the method of A dose of drug contained in the area of the carrier foil 1 that is not covered by the intermediate layer sheet 2 is covered with a pre-stamped cover sheet piece 3', and the cover sheet piece 3' is placed around the metered dose of drug to cover the carrier foil. After sealing in box 1,
Skin adhesion sheet 4 with protective sheet 2'' removed
A method characterized by punching out a plaster package made by continuously placing measured amounts of the drug at intervals on a portion of a band-shaped carrier foil that is the outer skin. 4. Claim 3, wherein the carrier foil 1 is provided with a small deep-dish portion 5' that is deep-drawn into a flat shape before storing the measured amount of medicine.
The method described in. 5. The method according to claim 3, wherein the protective sheet 2 separated from the skin adhesive sheet 4 is used as the intermediate layer sheet 2. 6. It consists of a part that is attached to the skin and a part that is peeled off and discarded.The part that is attached to the skin consists of the drug, a piece of cover sheet that covers the drug, and a thin, elastic foam rubber-like skin adhesive on top of the drug. Continuously manufacture plaster packages consisting of a carrier foil containing a drug and a ring-shaped intermediate layer sheet to prevent adhesion between the carrier foil and the skin adhesion sheet, the part of which is peeled off and thrown away. In this method, a measured amount of drug 5 is stored in a carrier foil 1, this measured amount of drug 5 is covered with a cover sheet piece 3' and sealed around the measured amount of drug 5 to the carrier foil 1, and then a skin adhesion sheet is placed. The intermediate layer sheet 2, which has holes of the same size as the measurable drug, is separated from the carrier foil 1 and fed.
A measured amount of the drug is sealed around the drug 5, and then the adhering side of the skin adhesion sheet 4 from which the protective sheet 2'' has been separated is placed on the cover sheet piece 3' and the intermediate layer sheet 2. A method characterized by punching out a plaster package formed by continuously accommodating a portion of a band-shaped carrier foil, which is an outer shell, at intervals. Claim 6, comprising a narrowed small deep dish portion 5'.
The method described in. 8. The method according to claim 6, wherein the protective sheet 2 separated from the skin adhesive sheet 4 is used as the intermediate layer sheet 2. 9 Consists of a part that is attached to the skin and a part that is peeled off and thrown away.The part that is attached to the skin consists of the drug, a cover sheet piece that covers the drug, and a thin, elastic foam rubber-like skin adhesive on top of the drug. In a method for continuously manufacturing a plaster package, the part of which is peeled off and discarded is a carrier foil, and an intermediate layer sheet for preventing adhesion between the carrier foil and the skin adhesive sheet. A measured amount of drug is stored on the intermediate layer sheet 2 laminated with the above, and this measured amount of drug is covered with a cover sheet piece 3'. 3' is sealed, and then the adhesive side of the skin adhesive sheet 4 is placed on the cover sheet piece 3'. A method characterized by punching out a plaster package.