JPH0358901A - Organ preservation device - Google Patents

Abstract

PURPOSE:To obtain an organ preservation device having an organ preservation chamber and a feed pump for sending perfusate, stabilizing an electric source supplied by equipping a switching device between an outer electric source and an inner electric source, a charging means to the inner electric source, electric source voltage detecting means and a means to control circuit action. CONSTITUTION:In an organ preservation device 1 consisting of an electrical device part 2 and a cold storage part 3, the cold storage part 3 is equipped with a perfusion closed circuit wherein an organ preservation chamber 5 is connected to a perfusion tube 9, a reservoir 6, a feed pump 12 in the electrical appliance part 2, a perfusion temperature sensor 8 and perfusion closed circuit connected to a bubble trap 7. In the electrical appliance part 2, when an outer DC electric source in an automobile is used, a cord 29 fitted with a connector for cigarette lighter is connected to an electric source connector 19, an electric current is sent to a perfusion indicator 13 and a perfusion temperature indicator 15 by a switch 24, a DC-DC converter 26, a voltage detector 27, the feed pump 12 and further a switch 16. When AC electric source is used as the outer electric source, an electric current is sent from an electric source cord 28 fitted with an AC plug, a buttery 25 is charged and is prepared for lack of voltage supply from the outside.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention provides a system for perfusing various organs extracted from a human body, etc., which is a donor, until the organs are transplanted into a human body, which is a donor, etc. This relates to an organ preservation device used for preservation and transportation while circulating fluid.

[Conventional technology]

An organ for transplant extracted from a donor is stored in an organ preservation device in a low temperature state and with perfusion fluid being circulated to maintain the freshness of the organ until it is transplanted.

The organ preservation device will be equipped with a fluid pump for perfusion, seven types of perfusate, and an electronic device to monitor perfusion fluid pressure, but these devices will be driven by an external AC or DC lightning source. I am using it.

Automobiles and airplanes are common means of transporting this organ storage device.

[Problem to be solved by the invention]

However, in the transportation mode of the conventional organ preservation device, the stability of the power supply is lacking, resulting in the following disadvantages.

For example, if we take transportation by car as shown in Japanese Patent Application Laid-Open No. 1-128901, the DC voltage obtained from the battery mounted on the car varies from 11 to
Fluctuations occur within a range of about 15V. On the other hand, since the organ preservation device is not provided with an appropriate means for responding to fluctuations in input voltage, electronic devices within the organ preservation device may malfunction due to fluctuations in input voltage. Due to malfunction, the rotation of the motor for the liquid pump became unstable,
Vigorous pulsating flow occurs in the perfusate, damaging the retained organ.

Next, since conventional organ preservation devices do not have a power supply between the hospital and the means of transportation such as a vehicle, the functions of the electronic devices during that time are forced to stop. This makes it impossible to circulate the low-temperature perfusion fluid, causing an increase in the temperature of the preserved organ, and making it impossible to maintain a predetermined metabolism, resulting in unexpected damage to the preserved organ.

The present invention is proposed to solve the above-mentioned disadvantages.
The object of the present invention is to stabilize an electronic device while supplying voltage to an organ preservation device, and to provide an organ preservation device that can supply voltage without interruption after an organ is housed.

[Means and effects for solving the problems] In order to achieve the above object, the present invention provides a transportable organ preservation device having at least an organ storage chamber and a liquid supply bomb for supplying perfusate. means for switching between and internal power supply, means for charging the internal power supply, means for detecting external or internal power supply voltage, and detecting output from the detecting means to detect - in the holding device.
A means for controlling the one-way operation is provided.

In this way, by means of detecting the supply voltage to the liquid pump and controlling the circuit operation based on the detected output from the detecting means, it is possible to prevent malfunctions of electronic devices due to unstable output of the power supply via the external power supply input terminal. I can figure it out. Furthermore, by means of switching between an external power source and an internal power source, and by means of charging the internal power source, it is possible to drive the organ preservation device even when an external power source cannot be used. [Embodiment] Fig. 1 shows a first embodiment of the present invention. 1 is a cross-sectional schematic diagram showing the internal structure of the organ preservation device 1. FIG. The V&D storage device 1 is broadly divided into an electrical equipment section 2 and a cold storage section 3, which are coupled via a coupling member 4 so as to be able to drive a perfusion circuit. The cold storage unit 3 is provided with an organ storage chamber 5 for storing organs 10, and the organ storage chamber 5 is connected to a reservoir 6 for storing perfusion fluid via a perfusion tube 9. A liquid feeding pump 12 provided in the electrical equipment section 2 is connected to the liquid feeding bomb 12, and a bubble trap 7 is connected to the liquid feeding bomb 12 via a perfusion tube 9 via a perfusion temperature sensor 8. It is connected to the organ storage chamber 5 to form a series of closed perfusion circuits.

The electrical equipment section 2 is provided with a power supply section 11, which can receive voltage supply from an external power source via a cigarette lighter connector cord 29 and an AC plug cord 28, and has a battery. Note that 18 and 19 are power connectors.

A liquid supply pump 12 is connected to the power supply section 11, and further connected to a perfusion pressure display 13 and a perfusion liquid temperature display 15 via a manual switch 16, and further connected to a display 17. The perfusion fluid temperature display l5 and the perfusion temperature sensor 8 are electrically connected, the perfusion pressure display 13 is electrically connected to the perfusion pressure sensor 14, and the perfusion pressure sensor 14 is connected to the perfusion pressure display 13. Connector 2
Branch tube 2 to the bubble I-lamp 7 via 1
They are connected via 0.

FIG. 2 shows the electrical equipment section 2 in more detail. To explain only the inside of the power supply part 1l, which is not explained in detail in FIG. 1, an insulation transformer 22 is connected to the power supply connector 1, and a charger 2
3 is connected, and a changeover switch 24 is connected to the charger 23. The power supply connector 19 is connected to the switch 24, and a battery 25 is also connected thereto. Further, the changeover switch 24 is connected to a DC-10C converter 26 and to a voltage detector 27. Further, the DC converter 26 is connected to the liquid supply bomb 12 and the indicator 17 in sequence, and is also connected to the voltage detector 27, which is electrically connected to the indicator 17. It is connected to.

To explain the operation of this embodiment with such precautions,
First, when using an external DC power source in a car, connect the cigarette lighter connector cord 29 to the power connector 19 and set the voltage to {J. I-Accept the linen. The current passes through the changeover switch 24 and is connected to the DC-DC converter 2.
6, guided to voltage detector 27; The output from the DC-DC converter 26 is guided to the liquid pump 12, the display 17, and the manual switch l6. The output from the voltage detector 27 is led to the indicator I7 and is connected to the oc-oc converter 2.
6 human power lightning pressure is displayed.

By turning the manual switch 16 ON and OFF, the perfusion pressure indicator 13, the perfusion liquid temperature indicator 15, and the DC-DC converter 26 are made conductive or non-conductive.

In the above operating state, when the liquid supply bomb 12 is activated, the perfusion fluid flows through a series of perfusion circuits including the organ 10, and the organ can be maintained and stored in a normal state while monitoring the temperature and pressure of the perfusion fluid. can.

Next, when using an AC power source as an external power source, connect the power cord 28 with an AC plug to the power connector }8 to receive voltage supply. Then, the current flows through the isolation transformer 22,
Through the charger 23 and the changeover switch 24, the oc-
It is led to an OC converter 26 and a voltage detector 27. At the same time, the charger 23 and the battery 25 are electrically connected and charged by the changeover switch 24. When no voltage is supplied from an external power source, the changeover switch 24 connects the vanteri 25 to the DC-DC converter 26 and voltage detector 27 . In these cases, by driving the liquid pump 12, the perfusion liquid flows appropriately through the perfusion circuit, as described above.

In this way, according to this embodiment, the perfusion circuit can be operated whether the external power source is AC or DC, and even if there is no external power source, the battery 25 can sufficiently operate for a short time. It is possible. In addition, voltage detector 2
7. The DC-DC converter 26 allows stable voltage to be supplied to electronic devices even when the voltage of the DC power source is unstable. In addition, if the human power voltage of the DC-DC converter 26 drops, it is possible to prevent the voltage from being supplied to the perfusion pressure display 13 and the irrigation liquid temperature display 15 via a manual switch, so that the DC power supply can be switched off. Consumption can be prevented.

FIG. 3 shows an electrical component according to a second embodiment of the present invention, and parts corresponding to those in the first embodiment are designated by the same reference numerals (
The same applies to the following examples).

In this embodiment, an AC input relay 31 is provided in the power supply unit 11, and this is connected to a power connector 30, and a cigarette lighter connector cord 29 or an AC plug-equipped power cord 28 is connected to the power connector 30. It looks like this. The AC input relay 31 further connects the charger 2
3 and a DC-DC converter 26,
It is connected to a voltage detector 27. Banoteri number 25,
It is connected to the charger 23, DC-DC converter 26, voltage detector 27, and AC input relay 3I.

The indicator 17 is connected to the voltage detector 27, and the manual switch 16 is connected to the DC-DC converter 26 and the perfusion pressure indicator 1.
3. Connected to perfusion temperature indicator l5 and indicator l7.

Furthermore, the liquid sending bomb 12 and the voltage detector 27 are connected to the DC −
It is connected to a DC converter 26.

FIG. 4 shows the vicinity of the AC input relay 3l in detail. One side of the human power electric line from the DC or AC power source is connected to the charger 23 via the secondary open contact 32 of the AC input relay 3l, and
DC via the secondary closing contact 33 of the input relay 7331
- connected to the DC converter 26;

The other input electrical line is the charger 23, DC-D
It is directly connected to C converter 2G. The primary coil of the AC input relay 31 is connected between the two electric lines for human power.

In this embodiment configured in this way, when the external power source is AC, the AC human power relay 3l operates, the secondary side opening contact 32 becomes conductive and the secondary side closing contact 33 becomes non-conductive. . Then, current is supplied to the charger 23. On the other hand, when the external power source is DC, the AC human-powered relay 3l does not operate, the secondary open contact 32 becomes non-conductive, and the secondary closed contact 33 becomes conductive. Then, a current is directly supplied to the DC-DC converter 26 from an external power source.

Therefore, compared to the first embodiment, the configuration of the power supply section 11 can be simplified and the number of parts can be reduced.

FIG. 5 shows the electrical equipment section according to the third embodiment of the present invention, in which a power connector 19 to which a cigarette lighter cord 29 is connected is connected to a changeover switch 24, and an AC plug is attached. A power connector l8 to which a power cord 28 is connected is connected to a changeover switch 24 via an isolation transformer 22. and changeover switch 2
4 are respectively connected to a charger 23, a battery 25, a DC-AC inharter 35, a voltage detector 27, a manual switch 16, and a liquid supply pump 12.

Furthermore, the charger 23 is connected to the battery 25, and the liquid supply pump 12 is connected to the DC-AC in-hark 35 and the voltage detector 2.
It is connected to 7. Manual switch ■6 is DC - AC
i is connected to the inverter 35, and is also connected to the display l6, the rinsing liquid temperature indicator 15, and the rinsing pressure sensor 14.
It is connected to the lIa flow pressure indicator 13. Further display l
7 is connected to a voltage detector 27.

To explain the operation of this embodiment, which has been carefully considered as described above, when the external power source is DC, the current is led through the cigarette lighter connector cord 29, passes through the changeover switch 24, and is converted to DC-AC. Guided to Inharta 35. D
The output from the C-AC inverter 35 is guided to the manual switch 16, liquid feed pump l2, and voltage detector 27.

On the other hand, when the external power source is AC, the current is led through the power cord 28 with an AC plug, passes through the isolation transformer 22,
The voltage is guided through the changeover switch 24 to the limb transport bomb 12, voltage detector 27, and manual switch 16, respectively. At the same time, a current is introduced to the charger 23 via the switching switch 24, and the battery 25 is charged.

If there is no human power from an external power source, selector switch 2
4 through the battery 25, voltage detector 27, DC-AC
Inharter 35 is made conductive. The output of the DC-AC inharter 35 is then guided to a manual switch l6, a liquid pump l2, and a voltage detector 27.

In each of the above cases, by operating the manual switch 16, it is possible to conduct or insulate between the DC-AC inharter 35, the S color edge transformer 22, and each display. Note that the manual switch 16 is turned on depending on the threshold value.
- Voltage detector 27 with automatic switch to OFF
The switch may be operated by the output of . This embodiment is effective when the driving power source is an alternating current.

FIG. 6 shows a fourth embodiment of the present invention, in which an accessory unit 36 is connected to the organ preservation device of the first embodiment.

In order to connect the organ preservation device taken down from the transportation means to the attached unit 36, a heat exchanger 38 and a PLL sensor 40, which are provided in series with the attached unit 36, are connected to the perfusion circuit between the reservoir 6 and the liquid supply bomb 12. , the gas exchange section 42 is connected. The heat exchanger 38 is connected to a liquid temperature adjustment section 39 via a coolant circulation tube 44. The insulation transformer 37 includes a liquid temperature adjustment section 39, an I'l1 control section 40, and an AC socket 46.
, a DC power source section 45, and a perfusion restriction section 43. Visceral 23 storage device perfusion fluid temperature indicator l5
is connected to the liquid temperature adjustment section 39, and 1) I1 control section 4l
is connected to the gas exchange section 42 and the PH sensor 40. The perfusion pressure control unit 43 is connected to the perfusion pressure sensor 14 and the liquid supply pump 12 of the organ preservation device, and the DC power supply unit 45 is connected to a DC socket.

Since the present embodiment is configured as described above, the organ preservation device can receive voltage supply from an external power source via the DC socket 47 and AC socket 46 of the attached unit 1-36. Then, before the perfusion liquid is supplied from the liner bar 6 to the liquid sending bomb 12, it is heat exchanged in a heat exchanger 38, and Pll.
p u /Jill is determined in the sensor 40, and gas is exchanged in the gas exchange section 42. In this case, heat exchange 2
The degree of heat exchange in "ft3B" is adjusted by the liquid temperature adjustment section 39, and the degree of gas exchange in the gas exchange section 42 is adjusted by the Pll control section 41.

In this way, according to this embodiment, the temperature of the perfusate, which is important for organs, can be maintained appropriately for a long period of time, and
It also becomes possible to control Pl+ of the perfusate.

FIG. 7 shows an electrical equipment section according to a fifth embodiment of the present invention. In this embodiment, a motor control section 48 is provided, and a DC
- Connected to the DC converter 26, voltage detector 27, and pump DC motor 54. Furthermore, a storage section 49 is provided, and D
It is connected to the C-DC converter 26, the perfusion pressure indicator 13, the perfusion liquid temperature indicator 15, the voltage detector 27, and the inductors 50 and 51. Further, a numeric keypad 52 is connected to the connector 50, and a display 53 is connected to the connector 5l.

With the above configuration, the voltage manually applied to the pump DC motor 54 is controlled by the motor controller 1 wholesaler 48 based on the voltage detected by the voltage detector 27. In this case, the lower the voltage detected by the voltage detector 27, the lower the voltage input to the pump DC moke 54.

On the other hand, the storage unit 49 receives an instruction from the numeric keypad 52 41, and outputs a signal correlated to the perfusion pressure from the perfusion pressure display l3, and a signal correlated to the irrigation liquid temperature and night temperature from the semi-flow liquid temperature display l5. A signal correlated to the number of revolutions of the motor is stored from the Bonfire DC motor 47, and a signal correlated to the human power voltage of the DC-DC converter 26 is stored from the voltage detection 827.

The storage unit 5l receives the instruction from the numeric keypad 52 and displays the stored contents on the display 53.

In this way, in this example, by memorizing the storage environment of the organ, it can be compared with the progress of the transplanted organ, and it can be used as study material for understanding the appropriate storage environment. .

〔Effect of the invention〕

As described above, according to the present invention, the malfunction of the electronic device is prevented by means for detecting the power supply voltage and the means for controlling the electronic device using the detection output from the power supply voltage, and a stable perfusion fluid is supplied to the preserved organ to ensure proper operation. Organs can be preserved. Further, even when there is no external power source, the electronic device can be driven by the internal power source to prevent damage to organs.

[Brief explanation of drawings]

FIG. 1 is a cross-sectional schematic diagram of the entire organ preservation device according to the first embodiment of the present invention, FIG. 2 is a schematic diagram of the electric cap part, and FIG. 3 is a schematic cross-sectional diagram of the organ preservation device according to the second embodiment of the present invention. FIG. 4 is a schematic diagram of the vicinity of the electrical equipment, FIG. 5 is a schematic diagram of the electrical equipment section according to the third embodiment of the present invention, and FIG. 6 is a schematic diagram of the electrical equipment of the present invention. FIG. 7 is a schematic diagram of the entire apparatus according to the fourth embodiment. FIG. 7 is a schematic diagram of the electrical equipment section according to the fifth embodiment of the present invention. ■． ．． ．． Organ preservation device 2. ．． ．． Electrical equipment section 3. ．． ．． Cold storage section 5. ．． ．． Organ storage room6. ．． ．． Reservoir 7. ．． ．． bubble trap9. ．． ．． Irrigation tube 10. ．． ．． Organs 11. ．． ．． Power supply section 12. ．． ．． Drop-off night bonfire 1B, 19. ．． ．． Power supply connector 23. ．． ．． Charger 24. ．． ．． Switching Suinochi 25. ．． ．． Battery 26. ．． , D(,-DC converter 27... Voltage detector 28... Power cord with 8C plug 29... Cigarette lighter connector attached Fig. 1 Fig. 3 Fig. 4 Fig. 23 76

Claims (1)

[Claims] 1. In a transportable organ storage device having at least an organ storage chamber and a liquid pump for supplying perfusate, means for switching between an external power source and an internal power source for the storage device, a means for charging the internal power source, An organ preservation device comprising an external or internal power supply voltage detection means and a means for controlling circuit operation within the preservation device based on a detection output from the detection means.