JPH03279311A - External preparation of skin - Google Patents

Abstract

PURPOSE:To obtain an external preparation of skin having excellent touch in use and high moisture retaining effects by blending a hydroxyalkylated cyclodextrin with glycerin. CONSTITUTION:An external preparation of skin containing 1-5wt.% hydroxyalkylated cyclodextrin (HACD) and 3-20wt.% (preferably 5-15wt.%). Hydroxyethylated beta-CD or hydroxypropylated beta-CD is preferable as HACD in terms of price, readiness of production, utility, water solubility, etc. The external preparation of skin can be blended with various components generally used cosmetics, drugs, etc., in a range of not damaging effects and can take a dosage form such as solubilized base, emulsion base, ointment base, dispersion base, powder product, etc.

Description

[Detailed Description of the Invention] [Industrial Field of Application] The present invention provides an external preparation for skin, and more specifically, a preparation for external use on the skin, which has an excellent feel when used,
Concerning external skin preparations with high moisturizing effects.

[Prior Art] Retention of moisture in the skin is an essential factor for keeping the skin healthy, and many cosmetics and pharmaceuticals aimed at moisturizing are commercially available. Research into substances involved in moisturizing has been actively conducted, and a number of moisturizing agents have been provided. In particular, glycerin has excellent water retention and water absorption properties, so it is widely used in cosmetics and pharmaceuticals.

[Problems to be Solved by the Invention] However, although glycerin has a high moisturizing ability, if the amount of glycerin is too large, it may have disadvantages in terms of usability such as stickiness, and the amount of glycerin that can be added is limited when considering the characteristics of external preparations for the skin. ing. The present inventors conducted extensive research in view of the above circumstances, and found that the above drawbacks could be solved by using hydroxyalkylated cyclodextrin and glycerin in combination. The present invention relates to an external preparation for skin, characterized in that it contains % by weight.

Hereinafter, the configuration of the present invention will be explained in detail.

The hydroxyalkylated cyclodextrin (hereinafter abbreviated as HACD) used in the present invention is a cyclodextrin, which is conventionally well known as a cyclic oligosaccharide, and has a hydroxyalkyl group introduced into the hydroxyl group to increase the water solubility. .

As the hydroxyalkyl group, substituents such as hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, dihydroxypropyl are mainly used, and as a result of these substitution reactions, hydroxymethylcyclodextrin, hydroxyethylcyclodextrin, hydroxypropylcyclodextrin , hydroxybutylcyclodextrin, dihydroxypropylcyclodextrin, and the like can be obtained.

Cyclodextrin (hereinafter abbreviated as CD) is a CD (hereinafter abbreviated as CD) that has an α, β, and γ structure depending on the number of glucose.
Hereinafter, they will be abbreviated as α-CD, β-CD, and 7-CD. ), but the present invention is directed to one or two of these CDs.
More than one species is hydroxyalkylated and used. Usually β
-CD is used, but α and γ-CD may also be used as the mother nucleus. A starch decomposition product containing α, β, and 7 CDs at the same time can also be used.

Among these HACDs, price, ease of manufacture, usability,
Considering water solubility, hydroxyethylated β-CD
or hydroxypropylated β-CD is preferred, but is not limited thereto.

In addition, hydroxyethylated CD or hydroxypropylated CD is a mixture of α, β, and γ in the manufacturing state, but even as a mixture, α, β, 7
Isolated hydroxypropylated CD can also be used.

Several methods have been known for manufacturing HACD, and one example will be shown below.

β-CD (manufactured by Nihon Shokuhin Kagaku, trade name: Celldex N)
Dissolve 100g in 20% NaOH aqueous solution 1501,
While maintaining the temperature at 0°C, propylene oxide 501 was gradually added dropwise, and the reaction was continued with stirring for 20 hours. After the reaction was completed, the solution was neutralized to pH 6.0 with hydrochloric acid, placed in a dialysis membrane tube, and desalted under running water for 24 hours. Thereafter, it was dried in a freeze dryer to obtain about 90 g of hydroxypropylated β-cyclodextrin.

C of this hydroxypropylated β-cyclodextrin
The degree of conversion per D was 5.1.

The blending amount of HACD in the present invention is not particularly limited, but is 0.1% by weight (hereinafter referred to as %) to 1% by weight based on the total amount of the skin external preparation.
0%, preferably 1% to 5%. If it is less than 0.1%, the effect will not be exhibited, and if it exceeds 10%, the usability will become sticky and the effect of improving the feeling of use will be weakened.

HACD may be blended into the cosmetic of the present invention as it is, or ingredients that are poorly soluble in water, such as oils, ultraviolet absorbers, and fragrances, may be included in HACD in advance and then blended.

Glycerin used in the present invention is a type of polyhydric alcohol having three hydroxyl groups in the molecule.

The amount of glycerin added to the skin external preparation of the present invention is 3% to
20%, preferably 5% to 15%. If it is less than 3%, the effect cannot be fully exhibited, and if it exceeds 20%, it becomes sticky in terms of usability, which is not preferable.

In addition to the above-mentioned essential ingredients, the external skin preparation of the present invention may optionally contain various ingredients commonly used in cosmetics, pharmaceuticals, etc., i.e., aqueous ingredients, to the extent that the effects of the present invention are not impaired.
Powder components, oils, surfactants, humectants, thickeners, preservatives, antioxidants, fragrances, colorants, ultraviolet absorbers, drugs, etc. can be blended.

Further, the dosage form of the skin external preparation of the present invention is arbitrary, and may be, for example, a solubilized skin lotion type, an emulsified type such as a milky lotion or a cream, or a dosage form such as an ointment, a dispersion liquid, or a powder product.

[Examples] The present invention will be described in detail below with reference to Examples and Comparative Examples. The present invention is not limited thereby.

The blending amount is in weight%. The effect was measured using the following method.

A sensory test was conducted using the prepared samples by a panel of 10 experts on moistness and stickiness. The evaluation results will be shown in the following format.

o: More than 8 out of 10 people answered that it was good O: 6 out of 10 people
△: 4 out of 10 people answered that it was good. ×: Less than 4 out of 10 people answered that it was good. Example 1, Comparative Examples 1 to 3 Makeup with the formula shown in Table 1 Water was prepared by conventional methods.

As is clear from Table 1, Example 1 had an excellent moisturizing effect, was not sticky, and the skin condition seemed to be improved.

Example 2 Cream A, stearic acid 10.0 Stearyl alcohol 4.0 Butyl stearate 8.0 Glycerin triethylhexanoate 2.0 Fragrance 0.4 Preservatives
Appropriate amount B, dipropylene glycol 10. O glycerin
20.0 Hydroxypropylated β-cyclodextrin 10.0 Potassium hydroxide 0.4 Trisodium edetate 0.05 Purified water
The remaining oil phase part A and water phase part B are each heated to 70°C to completely dissolve them. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain cream. This cream was moist, non-sticky, and had excellent moisturizing effects.

Example 3 Whitening Cream A, Cetanol Petrolatum Isopropyl Myristate Squalane Stearic Acid Monoglycerin Ester POE (20 mol) Sorbitan Monostearate Fragrance Vitamin E Acetate Preservative B, Glycerin Hydroxyethylated β-Cyclodextrin Dipropylene Glycol 4.0 7 .0 8.0 15.0 2.2 2.8 0.3 0.05 Adequate amount 3.0 5.0 5.0 Edetate disodium 0.01 Ascorbic acid phosphate magnesium salt 3.0 Purified water
A cream was obtained according to the rest of Example 2. This product had an excellent moisturizing effect and was non-sticky and had a good feel when used.

Example 4 Emulsion A, squalane oleyl oleate vaseline sorbitan sesquioleate polyoxyethylene (20 mol) oleyl ether fragrance preservative B, 1.3 butylene glycol hydroxyprobylated β-cyclodextrin glycerin 5.0 3.0 2 .0 0.8 1.2 0.3 Appropriate amount 5.0 0.1 3.0 Ethanol 3.0 Ruboxyvinylborrimer 0.2 Potassium hydroxide 0.1 Sodium hexametaphosphate 0.05 Purified water
A milky lotion was obtained according to the rest of Example 2.

This product had an excellent moisturizing effect and was non-sticky and had a good feel when used.

Example 5 Foundation A, cetanol deodorized lanolin jojoba oil vaseline squalane stearic acid monoglycerin ester stearyl glycyrrhetinate POE (60 mol) hydrogenated castor oil POE (20 mol) cetyl ether 3.5 4.0 5.0 2.0 6.0 2.5 0.01 1.5 1.0 Preservatives Appropriate amount of fragrance
0.3B, hydroxypropylated cyclodextrin mixture 5.0 Glycerin 15.0 Mixed powder 12.0 Trisodium edetate 0.2 Purified water
A foundation was obtained according to the rest of Example 2.

This product had an excellent moisturizing effect and was non-sticky and had a good feel when used.

Example 6 Lotion A, ethanol POE (20 mol) oleyl alcohol ether 2-ethylhexyl-P-dimethylaminobenzoate 5.0 2.0 0.18 Fragrance B, 1.3 butylene glycol 0.05 10.0 Hydroxymethylated β-cyclodextrin 1.0 Glycerin 5.0 Purified water
The remaining alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion.

This product felt moist but not sticky at all, and had a high moisturizing effect.

Example 7 Hair tonic A, ethanol POE (100 mol) Hydrogenated castor oil Carrot extract Loofah extract Fragrance B, Glycerin Hydroxybutylated Cyc04 Kistrin mixture 2-Hydroxy-4 methoxypensohenone Purified water According to Example 6 Got a hair tonic.

60.0 2.0 0.1 0.1 0.2 3.0 1.0 0.1 Remaining This product had a moist but non-sticky feel and had a high moisturizing effect.

[Effects of the Invention] By blending hydroxyalkylated cyclodextrin and glycerin, the skin external preparation of the present invention has an excellent feel when used and has a high moisturizing effect.

Claims (1)

[Claims] (1) An external preparation for skin, characterized in that it contains hydroxyalkylated cyclodextrin and 3% to 20% by weight of glycerin.