JPH03210265A - Antimicrobial packaging system for blood bag - Google Patents

Abstract

PURPOSE:To prevent phenomena, such as mildewing of the interior of a packaging container or the surface of a blood bag and sticking of many pieces of various germs thereto, by packaging the blood bag with an antimicrobial film or water absorptive sheet imparted with an antimicrobial property and further, packaging the same with a packaging material having a high barrier property. CONSTITUTION:The blood bag 1 is packaged with the antimicrobial film or water adsorptive sheet 2 having the antimicrobial property. Any film which has the antimicrobial property and can sufficiently suppress the propagation of mildew, various germs, etc., in the package is usable as the antimicrobial film and the water absorptive film having the antimicrobial property. Film-like materials; for example, resin films, paper and cloth impregnated or stuck with a sterilizer are used. Materials having the high barrier property; for example, a polypropylene-ethylene-vinyl alcohol copolymer-polypropylene laminated film and a resin laminated film having a vapor deposited aluminum layer are used for the packaging material to be used for the uppermost layer. The infiltration of the mildew, general germs, outdoor air, etc., from the outside is prevented.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a novel blood bag antibacterial packaging system. More specifically, the present invention is an antibacterial blood bag packaging system in which a blood bag is wrapped in an antibacterial film or an antibacterial water-absorbing sheet, and is a packaging system useful for storing and transporting blood.

[Prior art]

Blood bags have been used for storing and transporting blood, and also for direct transfusion from the bag as a blood container during blood transfusion into the human body. Blood bags containing blood have been further packaged during storage and transportation to prevent damage to the blood bags during storage and transportation and to facilitate handling.

However, during long-term storage and transportation, mold and bacteria may get mixed in and multiply inside the packaging, causing phenomena such as mold growth and large numbers of bacteria adhering to the inside of the packaging container and the surface of the blood bag. often occurred. This created a problem that made it impossible to use it for human treatment.

[Problem to be solved by the invention]

The present invention was proposed in order to solve these conventional drawbacks, and even during long-term storage and transportation, phenomena such as mold growing inside the packaging container or on the surface of the blood bag and a large number of germs adhering to it. This is to prevent

[Means to solve the problem]

The present invention was obtained as a result of studies in view of the above circumstances.

The present invention consists of the following configuration.

l) An antibacterial packaging system for blood bags, which is characterized in that the blood bag is packaged with an antibacterial film or a water-absorbent sheet imparted with antibacterial properties, and is further packaged with a packaging material having high barrier properties.

2) An antibacterial packaging system in which the antibacterial film or water absorbent sheet imparted with antibacterial properties is packaged in close contact with a blood bag.

3) An antibacterial packaging system, wherein the packaging using the packaging material with high barrier properties is comprised of a tray with high barrier properties and a lid material with high barrier properties.

4) An antibacterial packaging system characterized in that the packaging made of the packaging material with high barrier properties is made of a laminated film bag having an aluminum layer.

5) An antibacterial packaging system in which a deoxidizing material is enclosed within the packaging.

6) An antibacterial packaging system in which the antibacterial film or water-absorbing sheet imparted with antibacterial properties and a packaging material with high barrier properties are integrated.

7) The antibacterial film or antibacterial water-absorbing sheet has a specific surface area of 150rrr/g or more and retains metal ions having an antibacterial effect through ion exchange;
From an antibacterial water absorbing sheet in which zeolite solid particles and a super absorbent resin having the following molar ratio of 5ift/Altos are sandwiched between two membranes, at least one of which is water permeable. This is an antibacterial packaging system.

In other words, the present invention mainly consists of a blood bag, an antibacterial film or antibacterial water-absorbing sheet covering the outer surface of the blood bag, and a packaging material with high barrier properties that wraps and encloses the entire blood bag. It is.

Next, each element constituting the blood bag antibacterial packaging system of the present invention will be explained in detail.

Known blood bags of the present invention can be used, and there are no limitations in shape, structure, material, etc. Materials include vinyl chloride resin, ethylene-vinyl acetate copolymer (EVA), Polyethylene etc. are used.

As antibacterial films and water-absorbing sheets with antibacterial properties,
Any material may be used as long as it has at least antibacterial properties and can sufficiently inhibit the growth of mold and bacteria inside the packaging, such as film-like materials encapsulated, impregnated, or attached with a disinfectant, such as resin film or paper. , cloth, etc. can be used.

When using disinfectants, from the perspective of the blood bag packaging system, halogen disinfectants, oxygen disinfectants, surfactants, aldehyde disinfectants, alcohol/phenol disinfectants, epoxides, and biguanides are recommended. Substances that are harmful to the human body, such as disinfectants, should be avoided.

The antibacterial film or water-absorbing sheet with antibacterial properties used in the present invention has a specific surface area of 150 rtf/g or more and a 5iOz/Alz03 molar ratio of 14 or less, which retains metal ions having an antibacterial effect by ion exchange. It is particularly desirable to use an antibacterial water-absorbing sheet in which the zeolite solid particles and the superabsorbent resin are sandwiched between two membranes, at least one of which is water permeable.

This sheet is harmless to the human body and also has sufficient antibacterial properties.

Here, the zeolite solid particles having antibacterial effect are:
One or more metal ions having an antibacterial effect are retained in the ion-exchangeable portion of natural or synthetic zeolite made of aluminosilicate. Preferred examples of metal ions having antibacterial effects include silver, copper, zinc, tin, lead, bismuth, cadmium, chromium, and mercury, with silver, copper, and zinc being preferred. The above-mentioned antibacterial metals can be used alone or in combination.

As the zeolite material having a SiO□/AlzO:+ molar ratio of 14 or less, either natural or synthetic zeolite can be used. For example, natural zeolite is Analcine (5iOz/81203-3).
．． 6-5.6), Chabazite
:5ioz/^1 zOz-3,2~6.0 and 6.
4-7.6), clinoptilolite (C1lno-p
tilolite: 5iOz/AlzOs-8,5~1
0.5), Erionite (Erionite:5iO
z/A1zO3-5,8~7.4), Fujasite (
Faujasite: 5iOz/A1zO+-4,2~
4.6), Mordenite (5iO
z/A1.0:+-8,34~10.0),Phillipsite:5iOz/81z
Oi-2,6 to 4.4) and the like. These typical natural zeolites are suitable for the present invention. On the other hand, a typical synthetic zeolide is A-type zeolide (S
iOz/8lzO -1,4~2.4), X-type zeolide (SiOz/A]zOs-2~3), Y-type zeolide (Si(h/^1,0.-3~6) , mordenite (SiO□/81Jz to 9-10), etc.
These synthetic zeolites are suitable as the zeolite material of the present invention. Particularly preferred are synthetic A-type zeolides, X-type zeolides, Y-type zeolides, clinoptilolites and synthetic or natural mordenites.

The shape of the zeolite is preferably in the form of powder particles, and the particle size may be appropriately selected depending on the application. For example, several microns - several 1
0 micron, several hundred microns or more, or 5
It can be less than a micron, especially less than 2 microns.

The superabsorbent resin used is starch.

Acrylate graft polymer, carboxymethylcellulose crosslinked product, vinyl alcohol/acrylate copolymer, polyacrylonitrile hydrolyzate, crosslinked polyacrylate, modified polyvinyl alcohol, acrylate polymer, acrylate/acrylate Examples include resins having high water absorption properties such as IJ/L, amide copolymers, and isobutylene/maleic anhydride copolymers. It is also possible to use two or more of the above superabsorbent resins. The amount of super absorbent resin per sheet is preferably 0.1 to 200 g, particularly preferably 1 to 50 g.

The super absorbent resin is preferably in the form of powder or granules independent of the antibacterial zeolite solid particles, for example, 5 to 500
The microparticles are mixed with antibacterial zeolite solid particles and sandwiched between two membranes. Alternatively, it is possible to use a granular body in which the surface of antibacterial zeolite solid particles is coated with a superabsorbent resin by appropriate means such as coating.

As the water-permeable membrane, paper, wet nonwoven fabric, dry nonwoven fabric, cellophane, polyvinyl alcohol, woven film with micropores, etc. can be used.

As the water-impermeable membrane, a conventional synthetic resin film such as polyolefin, polyester, polyamide or the like can be used. Whether one of the two membranes is water-impermeable or both membranes are water-permeable can be arbitrarily selected depending on the field of use of the sheet of the present invention. Each cell can be an assembly of a plurality of membranes, such as a laminate, for example a laminate of paper and perforated polyethylene film.

Each membrane can also be a composite of a base fabric coated with, for example, polyvinyl alcohol. In the present invention, the term membrane is used in a meaning that includes the above.

The two membranes sandwiching the antibacterial zeolite solid particles and the superabsorbent resin are bonded to each other by appropriate means. Preferably, a film that becomes adhesive when heated is selected, or an adhesive is further used to bond the film by heat-pressing. As the adhesive, ethylene-vinyl acetate copolymer is particularly preferred, and polyethylene and polypropylene can also be used as the adhesive. The two membranes can also be joined together by mechanical means, such as suturing.

The present invention provides a hygienically preferable antibacterial water-absorbing sheet in which mold and bacteria do not grow on or around the surface of the sheet that absorbs water.

This antibacterial film or antibacterial water-absorbing sheet is preferably in close contact with the outer surface of the blood bag,
By doing so, it is possible to effectively suppress the growth of mold and bacteria on the outer surface of the blood bag.

In order to provide adhesiveness between the sheet or film and the blood bag, it is desirable to use vacuum packaging in the packaging system of the present invention.

However, it goes without saying that air-containing packaging can also be used.

The outermost packaging material of the packaging system of the present invention is made of a material with high barrier properties, and prevents mold, germs, outside air, etc. from entering from the outside. For these, a laminate having a laminate structure in which a plurality of layered materials are bonded together is usually used. For example, a polypropylene-EVOH-polypropylene laminate film or a resin laminate film having an aluminum vapor-deposited layer can be used.

Such a packaging material with high gas barrier properties can be used, for example, in the form of a pouch or a tray with a lid. It is also possible to package several blood bags in one tray or pouch.

The antibacterial film or the water-absorbing sheet imparted with antibacterial properties and the packaging material with high barrier properties that wrap the outside thereof may be integrated by known means. When using this integrated packaging material, it is preferable to use vacuum packaging because it can ensure sufficient adhesion between the antibacterial film or sheet and the blood bag.

In carrying out the packaging system of the present invention, it is more effective to encapsulate an oxygen absorber, Ageless, in the packaging.

The drawing shows an embodiment of the invention.

〔Effect of the invention〕

The antibacterial packaging system for blood bags according to the present invention suppresses the growth of mold and bacteria inside the packaging, and preserves blood bags.
This has the effect of providing a blood bag that can be transported safely, is free from contamination, and can be used clinically with peace of mind.

[Brief explanation of drawings]

FIG. 1 shows the process of packaging a blood bag in a pouch. Figure 2.3 schematically shows a cross section of the package. l... Blood bag 2... Antibacterial sheet 3... Oxygen absorber 4... Laminated packaging bag with aluminum layer 5... Tray 6... Blood diagram diagram diagram diagram

Claims (1)

[Scope of Claims] 1. Antibacterial properties of a blood bag characterized by packaging the blood bag with an antibacterial film or a water-absorbing sheet imparted with antibacterial properties, and further packaging with a packaging material with high barrier properties. packaging system. 2. Claim 1, wherein the antibacterial film or the antibacterial water-absorbing sheet is packaged in close contact with the blood bag.
Antimicrobial packaging system as described in . 3. The antibacterial packaging system according to claim 1 or 2, wherein the packaging using the packaging material with high barrier properties is comprised of a tray with high barrier properties and a lid material with high barrier properties. 4. The antibacterial packaging system according to claim 1 or 2, wherein the packaging using the packaging material with high barrier properties is made of a laminated film bag having an aluminum layer. 5. The antibacterial packaging system according to any one of claims 1 to 4, wherein a deoxidizing material is enclosed within the packaging. 6. The antibacterial packaging system according to any one of claims 1 to 5, wherein the antibacterial film or the water-absorbing sheet imparted with antibacterial properties and a packaging material with high barrier properties are integrated. 7. The antibacterial film or antibacterial water-absorbing sheet has a specific surface area of 150 m^2/g or more and retains metal ions having an antibacterial effect through ion exchange;
From an antibacterial water absorbing sheet in which zeolite solid particles and super absorbent resin having the following SiO_2/Al_2O_3 molar ratio are sandwiched between two membranes, at least one of which is water permeable. The antibacterial packaging system according to any one of claims 1 to 6.