JPH03195561A - Manufacture of glucose-containing steam-sterilized liquid and tool used therefor - Google Patents
Manufacture of glucose-containing steam-sterilized liquid and tool used thereforInfo
- Publication number
- JPH03195561A JPH03195561A JP1337914A JP33791489A JPH03195561A JP H03195561 A JPH03195561 A JP H03195561A JP 1337914 A JP1337914 A JP 1337914A JP 33791489 A JP33791489 A JP 33791489A JP H03195561 A JPH03195561 A JP H03195561A
- Authority
- JP
- Japan
- Prior art keywords
- glucose
- liquid
- steam
- containers
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 58
- 239000008103 glucose Substances 0.000 title claims abstract description 58
- 239000007788 liquid Substances 0.000 title claims abstract description 54
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 230000001954 sterilising effect Effects 0.000 claims abstract description 26
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 23
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims abstract description 15
- 238000005979 thermal decomposition reaction Methods 0.000 claims description 13
- 238000005192 partition Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
- 238000000354 decomposition reaction Methods 0.000 abstract description 10
- 238000007789 sealing Methods 0.000 abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract description 4
- 229910019142 PO4 Inorganic materials 0.000 abstract description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract description 4
- 239000010452 phosphate Substances 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 238000004891 communication Methods 0.000 description 6
- 238000004555 blood preservation Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 239000003761 preservation solution Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 229960000643 adenine Drugs 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000000385 dialysis solution Substances 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- -1 As the pH decreases Substances 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
【発明の詳細な説明】
１産業上の利用分野〕
本発明は、グルコースを含有する蒸気滅菌された液を得
るための方法に関する。さらに詳しくは、グルコースの
熱分解を促進する成分を含む蒸気滅菌されたグルコース
溶液を得るための方法とそのための用具に関する。DETAILED DESCRIPTION OF THE INVENTION 1. Field of Industrial Application The present invention relates to a method for obtaining a steam-sterilized liquid containing glucose. More specifically, the present invention relates to a method for obtaining a steam-sterilized glucose solution containing a component that promotes the thermal decomposition of glucose, and a device therefor.
グルコースは、輸液剤、腹膜透析液、血液保存液など多
くの液状薬剤に成分の１つとして含まれている。これら
の液状薬剤は、ハソグや瓶に封入され、通常は蒸気滅菌
が施されている。Glucose is contained as one of the ingredients in many liquid drugs such as infusion solutions, peritoneal dialysis solutions, and blood preservation solutions. These liquid drugs are sealed in gaskets or bottles and are usually steam sterilized.
現在市販されているグルコース含有液状薬剤は、蒸気滅
菌を行ってもグルコースの分解はあまり起こらないので
、そのまま蒸気滅菌することが可能である。しかし、本
発明者らが新しい組成のグルコース含有液を蒸気滅菌し
たところ、大量のグルコースが分解してしまい、滅菌後
のグルコース濃度が大きく低下してしまった。そこでそ
の原因を追求したところ、組成の一部にグルコースの熱
分解を促進する成分があることをつきとめた。グルコー
スの熱分解が激しいと、滅菌後のグルコース濃度が変動
するために品質管理上問題があるばかりでなく、滅菌後
の液に多量の分解生成物が存在することになるので好ま
しくない。本発明者らが検討したところでは、このグル
コース分解は液のｐＨを酸性にすることによっである程
度抑制することができたが、基本的に中性領域にある生
体に対して酸性の液を使用するのは好ましいことではな
い。Glucose-containing liquid medicines currently on the market can be steam sterilized without much decomposition of glucose even after steam sterilization. However, when the present inventors steam-sterilized a glucose-containing liquid with a new composition, a large amount of glucose was decomposed, and the glucose concentration after sterilization was significantly reduced. In pursuit of the cause, they discovered that part of the composition contained a component that promoted the thermal decomposition of glucose. If the thermal decomposition of glucose is severe, the glucose concentration after sterilization will fluctuate, causing problems in terms of quality control, and a large amount of decomposition products will be present in the liquid after sterilization, which is undesirable. According to the studies conducted by the present inventors, this glucose decomposition could be suppressed to some extent by making the pH of the solution acidic. It is not desirable to use it.
本発明の目的は、このようなグルコースの熱分解を促進
する成分を含む蒸気滅菌されたグルコース含有液を、液
のｐＨ調整を行うことなく且つ多量のグルコースの分解
を伴うことなく製造する方法を提供することにある。ま
た本発明の他の目的は、そのような方法において使用す
る用具を提供するものである。The object of the present invention is to provide a method for producing a steam-sterilized glucose-containing liquid containing a component that promotes the thermal decomposition of glucose without adjusting the pH of the liquid and without decomposing a large amount of glucose. It is about providing. Another object of the invention is to provide a device for use in such a method.
本発明においては、グルコースの熱分解を促進する成分
をグルコースから分離した状態で蒸気滅菌し、滅菌後に
両者を密閉状態で混合することによって上記の目的を達
成した。In the present invention, the above object was achieved by steam sterilizing a component that promotes the thermal decomposition of glucose in a state separated from glucose, and then mixing the two in a sealed state after sterilization.
すなわち第１の発明は、グルコースを含有する第１の液
と、グルコースの熱分解を促進する成分を含有する第２
の液とを、外部より除去可能な隔壁を内部に有する導管
で接続された２つの容器にそれぞれ別個に収納して密封
し、次いで蒸気滅菌を行い、しかる後に前記隔壁を導管
外部から除去して第１の液と第２の液とを無菌的に混合
することを特徴とする蒸気滅菌されたグルコース含有液
の製造方法である。That is, the first invention includes a first liquid containing glucose and a second liquid containing a component that promotes thermal decomposition of glucose.
and the liquid are stored separately in two containers connected by a conduit having a partition wall inside which can be removed from the outside and sealed, then steam sterilized, and then the partition wall is removed from the outside of the pipe. This is a method for producing a steam-sterilized glucose-containing liquid, which is characterized by aseptically mixing a first liquid and a second liquid.
また第２の発明は、グルコース含有液を収納するための
第１の容器と、グルコースの熱分解を促進する成分を含
有する液を収納するための第２の容器と、これら２つの
容器を連結する導管と、該導管内に設けられた外部から
除去可能な隔壁とを有することを特徴とするグルコース
含有蒸気滅菌液の製造用具である。The second invention also provides a first container for storing a glucose-containing liquid, a second container for storing a liquid containing a component that promotes thermal decomposition of glucose, and a method for connecting these two containers. This is a device for producing a glucose-containing steam sterilization solution, characterized by having a conduit for the purpose of sterilization, and a partition wall provided in the conduit and removable from the outside.
（作 用〕
本発明によれば、グルコースは熱分解を促進する成分か
ら隔離された状態で蒸気滅菌されるので分解はほとんど
起こらず、その後に熱分解を促進する成分と混合するこ
とによって最終的な溶液を得ることができる。そして、
混合は密閉状態で行うので、滅菌状態を維持することが
できる。また、液を混合した後に導管をシールして切断
することにより２つの容器を分離すれば、単独の容器に
収納された蒸気滅菌液を得ることができる。(Function) According to the present invention, glucose is steam sterilized while being isolated from components that promote thermal decomposition, so that almost no decomposition occurs, and the glucose is then mixed with components that promote thermal decomposition to produce the final product. You can obtain a solution with
Since the mixing is done in a sealed state, sterilization can be maintained. Additionally, if the two containers are separated by sealing and cutting the conduit after mixing the liquids, a steam sterilization liquid contained in a single container can be obtained.
本発明の対象となるグルコースを含有する液としては、
各種の輸液剤、腹膜透析液および血液保存液などをあげ
ることができる。そして、これらの液におけるグルコー
スの濃度には特に制限はない。以下、血液保存液を例に
とって本発明をさらに具体的に説明する。The glucose-containing liquid targeted by the present invention includes:
Examples include various infusion agents, peritoneal dialysis solutions, and blood preservation solutions. There is no particular restriction on the concentration of glucose in these solutions. Hereinafter, the present invention will be explained in more detail by taking a blood preservation solution as an example.
全血または赤血球製剤の保存期間を延長するために、種
々の血液保存液が使用されるが、血液保存液は、血液バ
ッグに充填・密封したものを蒸気滅菌して使用に供する
。従来使用されている保存液には、塩化ナトリウム５ア
デニン、マンニトールおよびグルコースなどの成分が含
まれており、蒸気滅菌によってわずかにグルコースが分
解することがあるが、問題になるようなものではなかっ
た。ところが、保存性の改善のためにこれにクエン酸塩
やリン酸塩をさらに添加して蒸気滅菌を行うと、大量の
グルコースが分解してしまう。Various blood preservation solutions are used to extend the storage period of whole blood or red blood cell preparations, and blood preservation solutions are used after filling and sealing blood bags and steam sterilizing them. Conventionally used storage solutions contain ingredients such as sodium chloride 5-adenine, mannitol, and glucose, and while steam sterilization may slightly degrade glucose, this was not a problem. . However, when citrate or phosphate is further added to this and steam sterilized to improve its shelf life, a large amount of glucose decomposes.
この問題を解決するために、本発明においては、第１図
に示すように、前述したグルコースを含む組成の液を第
１の容器１（塩化ビニル樹脂製バッグ）に入れ、クエン
酸塩やリン酸塩を含む液を第２の容器２（塩化ビニル樹
脂製バッグ）に入れる。In order to solve this problem, in the present invention, as shown in FIG. The solution containing the acid salt is placed in the second container 2 (vinyl chloride resin bag).
そして、２つの容器を導管３（塩化ビニル製チューブ）
で連結し、導管内には外部から除去可能な隔壁４を設け
て、２つの容器内の溶液が混合しないようにしてお（。Then, connect the two containers to conduit 3 (vinyl chloride tube).
A partition wall 4 that can be removed from the outside is provided inside the conduit to prevent the solutions in the two containers from mixing.
そしてこの容器連結体を蒸気滅菌する。蒸気滅菌の条件
は、通常医薬品の滅菌等に採用されている条件で問題な
〈実施できる。This container assembly is then steam sterilized. Steam sterilization can be carried out under the conditions normally used for sterilizing pharmaceutical products.
滅菌が終了したならば、導管の隔壁４を除去して２つの
容器を連通状態にし、第２の容器から第１の容器に液を
移動させて両者を混合する。そして最後に導管を５の位
置でシールして切断すれば、容器１内に収納されたグル
コース含有液であってクエン酸塩やリン酸塩をも含む蒸
気滅菌済の液を得ることができる。また、混合した液を
一方の容器に全量収納するかわりに、半量ずつを２つの
容器に分割して収納し、導管をシールして容器同士を分
離するようにすれば、同時に滅菌済の液を収納した２つ
の容器を得るごとができる。Once sterilization has been completed, the septum 4 of the conduit is removed to bring the two containers into communication, and the liquid is transferred from the second container to the first container to mix them. Finally, by sealing and cutting the conduit at position 5, the steam-sterilized glucose-containing liquid contained in the container 1, which also contains citrate and phosphate, can be obtained. Also, instead of storing the entire amount of the mixed liquid in one container, it is possible to divide half the amount into two containers and separate the containers by sealing the conduit, allowing the sterilized liquid to be stored at the same time. It is possible to obtain two stored containers.
導管内に設ける隔壁としては、第２図に示すような連通
筒６が好適である。図に示すように、連通筒６は小径部
７と大径部８より構成されており、小径部は中実で大径
部は中空構造になっている。A communication tube 6 as shown in FIG. 2 is suitable as the partition wall provided in the conduit. As shown in the figure, the communication tube 6 is composed of a small diameter part 7 and a large diameter part 8, the small diameter part being solid and the large diameter part having a hollow structure.
連通筒は全体が硬質樹脂から形成されており、大径部外
表面は導管３の内表面に固着され、大径部と小径部の境
界付近には薄肉部９が設けられている。この状態では、
容器１ど容器２の内容液は完全に隔離されている。蒸気
滅菌が終了した後、導管を外部から折り曲げて連通筒の
薄肉部９の位置で破断すると、小径部は分離され大径部
の先端が開口して、２つの容器は連通状態となる。この
とき、分離した小径部７が容器１内に流れていかないよ
うにするために、連通筒を設けた位置よりも左側の導管
３゛は、内径が小径部７の外径より小さくしである。こ
のような構造の隔壁を設けることによって、簡便かつ確
実に本発明を実施することができる。なお、隔壁を設け
る位置は、導管の任意の位置でよい。The entire communication tube is made of hard resin, the outer surface of the large diameter portion is fixed to the inner surface of the conduit 3, and a thin wall portion 9 is provided near the boundary between the large diameter portion and the small diameter portion. In this state,
The contents of containers 1 and 2 are completely isolated. After steam sterilization is completed, when the conduit is bent from the outside and broken at the thin wall portion 9 of the communication tube, the small diameter portion is separated and the tip of the large diameter portion is opened, so that the two containers are in communication. At this time, in order to prevent the separated small diameter part 7 from flowing into the container 1, the inner diameter of the conduit 3' on the left side of the position where the communicating tube is provided is smaller than the outer diameter of the small diameter part 7. . By providing a partition wall having such a structure, the present invention can be carried out easily and reliably. Note that the partition wall may be provided at any position on the conduit.
次に、本発明の効果を試験例によってさらに具体的に説
明する。Next, the effects of the present invention will be explained in more detail using test examples.
試隻曇
表１に示す４種類の組成の液を調製し、これを容ｉｔ
３００ｄの塩化ビニル樹脂製バッグに１ｏａｄずつ充填
して１２１°Ｃで２０分間蒸気滅菌を行った。滅菌後に
グルコースの濃度を測定し、滅菌による減少率を求めた
。結果を表１に併せて示す。Prepare liquids with the four types of compositions shown in Table 1, and add
1 oad each was filled into a 300 d vinyl chloride resin bag and steam sterilized at 121°C for 20 minutes. After sterilization, the glucose concentration was measured and the rate of decrease due to sterilization was determined. The results are also shown in Table 1.
（以下余白）
表 １
次に、組成２〜４のものについて、塩化ナトリウム、ア
デニン、マンニトールおよびグルコースを含む第１の液
と、クエン酸ナトリウム単独（組成２）またはクエン酸
ナトリウム、リン酸２水素ナトリウムおよびリン酸水素
２ナトリウムを含む（組成３および４）第２の液とを、
第１の液６０ｍと第２の液４０ｄを混合したときに表１
の組成になるように調製し、第１図に示すのと同様のハ
ングシステムの２つのハングに、それぞれを別々に充填
して蒸気滅菌を行った。そして滅菌後に隔壁を除去して
両者を混合し、グルコース濃度を測定してグルコースの
減少率を求めた。結果を表２に示す。(Margin below) Table 1 Next, for compositions 2 to 4, the first liquid containing sodium chloride, adenine, mannitol, and glucose, and sodium citrate alone (composition 2) or sodium citrate and dihydrogen phosphate. a second liquid containing sodium and disodium hydrogen phosphate (compositions 3 and 4);
When 60 m of the first liquid and 40 d of the second liquid were mixed, Table 1
The composition was prepared to have the following composition, and the two hangs of a hang system similar to that shown in FIG. 1 were filled separately and steam sterilized. After sterilization, the septum was removed, the two were mixed, and the glucose concentration was measured to determine the glucose reduction rate. The results are shown in Table 2.
表 ２
１記の結果から明らかなように、クエン酸ナトリウムや
リン酸２水素ナトリウムおよびリン酸水素２ナトリウム
を含む組成２〜４の場合には、グルコースの分解が非常
に顕著である。As is clear from the results shown in Table 2-1, in compositions 2 to 4 containing sodium citrate, sodium dihydrogen phosphate, and disodium hydrogen phosphate, the decomposition of glucose is extremely significant.
表２の結果から明らかなように、本発明によればグルコ
ースの分解はほとんど起こらない。表１の結果と比較す
ると、発明の効果が一目瞭然である。As is clear from the results in Table 2, according to the present invention, glucose decomposition hardly occurs. When compared with the results in Table 1, the effects of the invention are obvious.
また、参考のために組成２〜４の液について、塩酸を添
加して液のｐＨを下げて羊−の液で蒸気滅菌を行うと、
ｐＨの低Ｆとともにグルコースの分解が起きにくくなり
、５．５以下ではいずれの組成のものもグルコースの減
少率を５％以ｔにすることができた。しかし、本発明に
比べて効果がやや劣るものであった。Also, for reference, if you add hydrochloric acid to lower the pH of the liquid and steam sterilize it with sheep's liquid,
As the pH decreases, glucose decomposition becomes less likely to occur, and at a pH of 5.5 or lower, glucose reduction rates of 5% or more were achieved for all compositions. However, the effect was slightly inferior to that of the present invention.
本発明によれば、グルコースの熱分解を促進する成分を
含むグルコース含有液の蒸気滅菌法製品を、グルコース
の熱分解を最小限に抑えた状態で得ることができる。し
たがって、所定のグルコースを含有する滅菌法の液を再
現性よく製造することができる。また、液のｐ Ｈを酸
性にする必要がなく、滅菌された液に多量のグルコース
分解生成物が含まれることもないので、安全性の面でも
好ましい。According to the present invention, a steam sterilization product of a glucose-containing liquid containing a component that promotes the thermal decomposition of glucose can be obtained with the thermal decomposition of glucose being minimized. Therefore, a sterilization solution containing a predetermined glucose can be produced with good reproducibility. Furthermore, it is preferable from the viewpoint of safety, since there is no need to make the pH of the liquid acidic and the sterilized liquid does not contain a large amount of glucose decomposition products.
第１図は、本発明の方法を実施するための用具の実施例
を示す簡略化された正面図であり、第２図は、その実施
例において導管内に設ける隔壁の実施例を示す部分断面
図である。
■、第１のバッグ ２．第２のバッグ３、導管
４．隔壁1 is a simplified front view of an embodiment of a device for carrying out the method of the invention, and FIG. 2 is a partially cross-sectional view of an embodiment of a septum provided in a conduit in that embodiment; FIG. It is a diagram. ■, 1st bag 2. Second bag 3, conduit
4. bulkhead
Claims (2)
熱分解を促進する成分を含有する第２の液とを、外部よ
り除去可能な隔壁を内部に有する導管で接続された２つ
の容器にそれぞれ別個に収納して密封し、次いで蒸気滅
菌を行い、しかる後に前記隔壁を導管外部から除去して
第１の液と第２の液とを無菌的に混合することを特徴と
する蒸気滅菌されたグルコース含有液の製造方法。(1) A first liquid containing glucose and a second liquid containing a component that promotes thermal decomposition of glucose are placed in two containers connected by a conduit that has a partition inside that can be removed from the outside. A method of steam sterilization characterized in that the first liquid and the second liquid are individually stored and sealed, then steam sterilized, and then the partition wall is removed from the outside of the conduit and the first liquid and the second liquid are mixed aseptically. A method for producing a glucose-containing liquid.
、グルコースの熱分解を促進する成分を含有する液を収
納するための第２の容器と、これら２つの容器を連結す
る導管と、該導管内に設けられた外部から除去可能な隔
壁とを有することを特徴とするグルコース含有蒸気滅菌
液の製造用具。(2) a first container for storing a glucose-containing liquid, a second container for storing a liquid containing a component that promotes thermal decomposition of glucose, and a conduit connecting these two containers; 1. A device for producing a glucose-containing steam sterilization liquid, comprising a partition wall provided in the conduit and removable from the outside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1337914A JPH03195561A (en) | 1989-12-26 | 1989-12-26 | Manufacture of glucose-containing steam-sterilized liquid and tool used therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1337914A JPH03195561A (en) | 1989-12-26 | 1989-12-26 | Manufacture of glucose-containing steam-sterilized liquid and tool used therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03195561A true JPH03195561A (en) | 1991-08-27 |
Family
ID=18313182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1337914A Pending JPH03195561A (en) | 1989-12-26 | 1989-12-26 | Manufacture of glucose-containing steam-sterilized liquid and tool used therefor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03195561A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009953A1 (en) * | 1997-08-22 | 1999-03-04 | Shimizu Pharmaceutical Co., Ltd. | Glucose-containing preparation |
| US6475529B2 (en) | 1999-09-10 | 2002-11-05 | Baxter International Inc. | Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy |
| US7011855B2 (en) | 1994-07-01 | 2006-03-14 | Baxter International Inc. | Biochemically balanced peritoneal dialysis solutions |
| US7122210B2 (en) | 2002-01-11 | 2006-10-17 | Baxter International Inc. | Bicarbonate-based solutions for dialysis therapies |
| US7445801B2 (en) | 2002-06-07 | 2008-11-04 | Baxter International Inc. | Stable bicarbonate-based solution in a single container |
| US8052631B2 (en) | 2005-01-28 | 2011-11-08 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions |
| US10842714B2 (en) | 2010-10-14 | 2020-11-24 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter chamber diffuser |
-
1989
- 1989-12-26 JP JP1337914A patent/JPH03195561A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7011855B2 (en) | 1994-07-01 | 2006-03-14 | Baxter International Inc. | Biochemically balanced peritoneal dialysis solutions |
| WO1999009953A1 (en) * | 1997-08-22 | 1999-03-04 | Shimizu Pharmaceutical Co., Ltd. | Glucose-containing preparation |
| US6475529B2 (en) | 1999-09-10 | 2002-11-05 | Baxter International Inc. | Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy |
| US7122210B2 (en) | 2002-01-11 | 2006-10-17 | Baxter International Inc. | Bicarbonate-based solutions for dialysis therapies |
| US7445801B2 (en) | 2002-06-07 | 2008-11-04 | Baxter International Inc. | Stable bicarbonate-based solution in a single container |
| US8052631B2 (en) | 2005-01-28 | 2011-11-08 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions |
| US8328784B2 (en) | 2005-01-28 | 2012-12-11 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions |
| US9180069B2 (en) | 2005-01-28 | 2015-11-10 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions |
| US10842714B2 (en) | 2010-10-14 | 2020-11-24 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter chamber diffuser |
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