JPH03141217A - Soft capsule - Google Patents
Soft capsuleInfo
- Publication number
- JPH03141217A JPH03141217A JP27614889A JP27614889A JPH03141217A JP H03141217 A JPH03141217 A JP H03141217A JP 27614889 A JP27614889 A JP 27614889A JP 27614889 A JP27614889 A JP 27614889A JP H03141217 A JPH03141217 A JP H03141217A
- Authority
- JP
- Japan
- Prior art keywords
- capsules
- coating film
- thermoplastic resin
- soft capsules
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 27
- 239000002775 capsule Substances 0.000 claims abstract description 23
- 229920005992 thermoplastic resin Polymers 0.000 claims abstract description 11
- 239000011248 coating agent Substances 0.000 abstract description 18
- 238000000576 coating method Methods 0.000 abstract description 18
- 238000004519 manufacturing process Methods 0.000 abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 11
- 239000003814 drug Substances 0.000 abstract description 3
- 239000005038 ethylene vinyl acetate Substances 0.000 abstract description 3
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 2
- 229920005670 poly(ethylene-vinyl chloride) Polymers 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000011162 core material Substances 0.000 description 18
- 239000007788 liquid Substances 0.000 description 16
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- 239000000126 substance Substances 0.000 description 8
- 108010010803 Gelatin Proteins 0.000 description 7
- 239000008273 gelatin Substances 0.000 description 7
- 229920000159 gelatin Polymers 0.000 description 7
- 235000019322 gelatine Nutrition 0.000 description 7
- 235000011852 gelatine desserts Nutrition 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 4
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 239000012188 paraffin wax Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- -1 polypropylene Polymers 0.000 description 3
- 238000004080 punching Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- IRIAEXORFWYRCZ-UHFFFAOYSA-N Butylbenzyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCC1=CC=CC=C1 IRIAEXORFWYRCZ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 description 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 description 1
- FYGDTMLNYKFZSV-WFYNLLPOSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,3s,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-WFYNLLPOSA-N 0.000 description 1
- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 description 1
- NXQMCAOPTPLPRL-UHFFFAOYSA-N 2-(2-benzoyloxyethoxy)ethyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCCOCCOC(=O)C1=CC=CC=C1 NXQMCAOPTPLPRL-UHFFFAOYSA-N 0.000 description 1
- OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- GOJCZVPJCKEBQV-UHFFFAOYSA-N Butyl phthalyl butylglycolate Chemical compound CCCCOC(=O)COC(=O)C1=CC=CC=C1C(=O)OCCCC GOJCZVPJCKEBQV-UHFFFAOYSA-N 0.000 description 1
- 239000004709 Chlorinated polyethylene Substances 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 1
- 239000001116 FEMA 4028 Substances 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
- 229930006722 beta-pinene Natural products 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- ZSBRYDJXHOFQMW-UHFFFAOYSA-N chloroethene;ethene;ethenyl acetate Chemical compound C=C.ClC=C.CC(=O)OC=C ZSBRYDJXHOFQMW-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- 150000004141 diterpene derivatives Chemical class 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000002952 polymeric resin Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、医薬品、医薬部外品、化粧品及び雑貨等に適
用されるソフトカプセルに関し、詳細には耐水性、耐油
性、経時安定性等に優れたソフトカプセルに関する。[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to soft capsules applied to pharmaceuticals, quasi-drugs, cosmetics, miscellaneous goods, etc. Regarding excellent soft capsules.
〔従来の技術及び発明が解決しようとする課題〕従来、
ソフトカプセルの皮膜は、一般にゼラチンを主成分とし
、これに適当な可塑剤を添加したものが用いられてきた
。この様な従来のソフトカプセルの皮膜は水溶性である
ため、芯物質として水溶液や親水性物質を含むローショ
ン、乳液、クリーム等を充填した場合、ゼラチン皮膜が
溶解、軟化等し、カプセルが崩壊してしまうという欠点
があった。[Problems to be solved by conventional techniques and inventions] Conventionally,
The membrane of soft capsules has generally been made of gelatin as a main component, to which an appropriate plasticizer has been added. The film of such conventional soft capsules is water-soluble, so when a lotion, emulsion, cream, etc. containing an aqueous solution or a hydrophilic substance is filled as the core material, the gelatin film dissolves, softens, etc., and the capsule collapses. There was a drawback that it could be stored away.
上記の欠点を克服するために、ゼラチンにアルデヒド等
を添加せしめることも試みられている。In order to overcome the above-mentioned drawbacks, attempts have been made to add aldehydes and the like to gelatin.
しかしながら、こうした方法によってもカプセルの崩壊
を充分に防止することはできず、崩壊を遅延させるのみ
であった。一方、親水性物質をβ−サイクロデキストリ
ンやβ−Ｄ−グルカンで包接した包接物を油分中に分散
し、これを更にカプセル内に充填する軟カプセル剤が報
告されている（特開昭６３−１３０５２８号）。しかし
ながら、この場合カプセルの皮膜は従来のままであるた
め、根本的な解決には至らないものであった。However, these methods could not sufficiently prevent the collapse of the capsules, but only delayed the collapse. On the other hand, soft capsules have been reported in which a clathrate in which a hydrophilic substance is clathrated with β-cyclodextrin or β-D-glucan is dispersed in oil and then filled into the capsule (Japanese Patent Laid-Open Publication No. 63-130528). However, in this case, the capsule film remained the same as before, so a fundamental solution could not be reached.
従って、耐油性のみならず、耐水性、経時安定性に優れ
たソフトカプセルが望まれていた。Therefore, there has been a desire for soft capsules that have not only oil resistance but also water resistance and stability over time.
本発明者らは上記実情に鑑み鋭意研究を行なった結果、
カプセル皮膜として特定の熱可塑性樹脂を用いることに
より、耐油性、耐水性及び経時安定性に優れ、更に透明
な外観及び適度な皮膜強度を有したソフトカプセルが得
られることを見出し、本発明を完成した。The inventors of the present invention conducted extensive research in view of the above circumstances, and as a result,
The inventors have discovered that by using a specific thermoplastic resin as the capsule film, soft capsules can be obtained that have excellent oil resistance, water resistance, and stability over time, as well as a transparent appearance and appropriate film strength, and have completed the present invention. .
すなわち本発明は、カプセル皮膜の主成分が軟化点１０
０℃以下の熱可塑性樹脂であることを特徴とするソフト
カプセルを提供するものである。That is, in the present invention, the main component of the capsule film has a softening point of 10
The present invention provides a soft capsule characterized by being made of a thermoplastic resin having a temperature of 0°C or lower.
本発明に用いる熱可塑性樹脂は軟化点が１００℃以下で
あれば特に制限されない。軟化点がこれより高い場合に
は成形されたカプセルが硬ずぎて使用しづらくなったり
、また成形が難しくなる。The thermoplastic resin used in the present invention is not particularly limited as long as it has a softening point of 100°C or less. If the softening point is higher than this, the molded capsule will become too hard to use, or will be difficult to mold.
好ましい熱可塑性樹脂として、具体的には、エチレン−
塩化ビニルコポリマー、エチレン−酢酸ビニルコポリマ
ー、エチレン酢酸ビニル−塩化ビニルグラフト重合樹脂
、塩化ビニリデン樹脂、酢酸ビニル樹脂、塩素化ポリエ
チレン及び塩素化ポリプロピレン等が挙げられる。これ
らは一種でも二種以上を混合して用いてもよい。Specifically, as a preferable thermoplastic resin, ethylene-
Examples include vinyl chloride copolymer, ethylene-vinyl acetate copolymer, ethylene vinyl acetate-vinyl chloride graft polymer resin, vinylidene chloride resin, vinyl acetate resin, chlorinated polyethylene, and chlorinated polypropylene. These may be used alone or in combination of two or more.
上記の樹脂には、本発明の効果を損なわない範囲で、必
要により塩素化パラフィン、ジエチレングリコール、ジ
ベンゾエート、ジオクチルフタレート、ブチルフタリル
ブチルグリコレート、ブチルベンジルフタレート等の可
塑剤：ロジングリセリンエステル、水添ロジン、水添ロ
ジングリセリンエステル、重合ロジン等のロジン類；α
−ピネン重合体、β−ピネン重合体、ジテルペン重合体
等のポリテルペン系重合体；パラフィンワックス、塩素
化パラフィン、マイクロクリスタリンτノックス、カス
ターワックス等のワックス類を添加し、皮膜強度や透明
性等の諸性質を変えることもでき、更に必要により色素
、酸化防止剤、紫外線吸収剤等を添加してもよい。The above resin may optionally contain plasticizers such as chlorinated paraffin, diethylene glycol, dibenzoate, dioctyl phthalate, butyl phthalyl butyl glycolate, butyl benzyl phthalate, rosin glycerin ester, water, etc., to the extent that the effects of the present invention are not impaired. Rosins such as additive rosin, hydrogenated rosin glycerin ester, polymerized rosin; α
- Polyterpene polymers such as pinene polymers, β-pinene polymers, and diterpene polymers; waxes such as paraffin wax, chlorinated paraffin, microcrystalline τ Knox, and castor wax are added to improve film strength, transparency, etc. Various properties can be changed, and if necessary, pigments, antioxidants, ultraviolet absorbers, etc. may be added.
本発明のソフトカプセルは、上記の熱可塑性樹脂及び下
記の溶剤を用いる以外は常法に従って製造することがで
きる。The soft capsules of the present invention can be manufactured according to conventional methods except for using the above-mentioned thermoplastic resin and the following solvent.
ここで用いる溶剤としては、ブタノール、酢酸エチル、
酢酸ブチル、ヘキサン、アセトン、トルエン、キシレン
等の有機溶剤が挙げられ、特にヘキサン、アセトンが好
ましい。これら溶剤は上記熱可塑性樹脂を主成分とする
皮膜成分を溶解し、皮膜液とするものである。Solvents used here include butanol, ethyl acetate,
Examples include organic solvents such as butyl acetate, hexane, acetone, toluene, and xylene, with hexane and acetone being particularly preferred. These solvents dissolve the coating component whose main component is the thermoplastic resin to form a coating liquid.
本発明のソフトカプセルの製造方法の具体例としては■
カプセル皮膜液を冷ローラー等によりシート化した後、
ロータリ一方式又は平板方式の二つの成型金型の圧切熱
接着によりカプセルを打ち抜きながら芯物質を充填しつ
つ該皮膜の切断面で直接接合する方法、■液滴がその表
面張力によって球形になる性質を利用して、上記カプセ
ル皮膜液と芯物質を二重オリフィスから冷却油中に押し
出し成型する方法等が挙げられる。As a specific example of the method for producing soft capsules of the present invention, ■
After forming the capsule film liquid into a sheet using a cold roller, etc.
A method in which capsules are punched out by pressure-cutting thermal adhesion between two rotary or flat molding molds, while being filled with core material and directly bonded at the cut surface of the film; ■ The property of liquid droplets to become spherical due to their surface tension; Examples include a method in which the capsule coating liquid and core material are extruded into cooling oil through a double orifice.
また本発明のソフトカプセルに封入することができる芯
物質としては、水溶液をはじめ、親水性物質、親油性物
質のいずれもが挙げられる。また、その性状も液状、懸
濁状、ペースト状、粉末状、頚粒状等のいずれでもよく
、例えば、化粧水、乳液、クリーム、化粧油、美白パウ
ダー、外用液、外用クリーム、軟膏等が挙げられる。Core substances that can be encapsulated in the soft capsules of the present invention include aqueous solutions, hydrophilic substances, and lipophilic substances. In addition, its properties may be liquid, suspension, paste, powder, granular, etc. Examples include lotion, emulsion, cream, cosmetic oil, whitening powder, external liquid, external cream, ointment, etc. It will be done.
かくして得られる本発明のソフトカプセルの形状、大き
さは特に制限はないが、形状としては球状、楕円体状等
が好ましく、大きさは製造工程や使用性等を考慮すると
直径２〜３０ｍｍの範囲が好ましい。またカプセル皮膜
の膜厚は０．１〜５ｍｍ、特に０．５〜２ｍｍが好まし
い。The shape and size of the soft capsule of the present invention thus obtained are not particularly limited, but the shape is preferably spherical, ellipsoidal, etc., and the size is preferably in the range of 2 to 30 mm in diameter considering the manufacturing process and usability. preferable. The thickness of the capsule film is preferably 0.1 to 5 mm, particularly 0.5 to 2 mm.
本発明ソフトカプセルは、用時ピン等で穴をあけるか、
指等で圧し潰すことにより芯物質を出して使用するのが
好ましい。When using the soft capsule of the present invention, make a hole with a pin etc.
It is preferable to use the core material by crushing it with your fingers or the like.
以下、実施例により本発明を更に詳細に説明するが、本
発明はこれらに限定されるものではない。EXAMPLES Hereinafter, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited thereto.
実施例１
以下の如く、皮膜液及び芯物質を調製し、これを下記製
法によりソフトカプセルとした。Example 1 A coating liquid and a core material were prepared as follows, and soft capsules were made using the manufacturing method described below.
く皮膜液〉
（重量％）
■エチレンー酢酸ビニルコポリマー”＋ ６０．０■
アセトン ４０．０計
１００．０Ｏ
軟化点 ５３℃
上記■及び■を７０℃にて加熱溶解して皮膜液とした。Film liquid〉 (wt%) ■Ethylene-vinyl acetate copolymer"+ 60.0■
Acetone 40.0 total
100.0O
Softening point: 53°C The above (1) and (2) were heated and dissolved at 70°C to obtain a coating liquid.
く芯物質（透明化粧水）〉
（重量％）
■香 料
０．０５■エチルアルコール
２０．００■精 製 水
７８．９５計
１００，０００〜■を攪拌混合し、均一
溶解させ、これに■を加え均一に混合し透明化粧水を得
た。Core substance (transparent lotion)〉 (% by weight) ■Fragrance
0.05 ■ Ethyl alcohol
20.00 ■ Purified water
78.95 total
100,000~■ were stirred and mixed to uniformly dissolve, and then ■ was added and mixed uniformly to obtain a transparent lotion.
くソフトカプセルの製法〉
上記皮膜液を冷ローラーにてシート化し、アセトンを除
去した後、ロータリー打抜法にて芯物質を充填し、ソフ
トカプセルを得た。Method for Producing Soft Capsules The film solution was formed into a sheet using a cold roller, acetone was removed, and a core material was filled using a rotary punching method to obtain soft capsules.
比較例１
以下の如く、ゼラチンを用いた皮膜液を調製し、芯物質
は実施例１で調製したものを用い、下記製法によりソフ
トカプセルを得た。Comparative Example 1 A coating solution using gelatin was prepared as described below, and the core material prepared in Example 1 was used to obtain soft capsules by the following manufacturing method.
く皮膜液〉
■ゼラチン
■グリセリン
■精 製 氷
（重量％）
４０、Ｏ
１２，０
４８，０
計 １００．０
上記■〜■を７０℃にて混合溶解婆せて皮膜液とした。*Gelatin *Glycerin *Purification Ice (wt%) 40, O 12.0 48.0 Total 100.0
The above-mentioned materials (1) to (2) were mixed and dissolved at 70°C to obtain a coating liquid.
くソフトカプセルの製法〉
皮膜液を冷ローラーにてシート化した後、ロータリー打
抜法で芯物質を充填し、ソフトカプセルを得た。Method for producing soft capsules> The film solution was formed into a sheet using a cold roller, and then a core material was filled using a rotary punching method to obtain soft capsules.
比較例２
以下の如く、ゼラチン及び水不溶化剤としてホルムアル
デヒドを用いた皮膜液を調製し、芯物質は実施例１で調
製したものを用い、比較例１と同様な製法でソフトカプ
セルを得た。Comparative Example 2 Soft capsules were obtained in the same manner as in Comparative Example 1, using gelatin and formaldehyde as a water insolubilizer to prepare a coating solution as described below, and using the core material prepared in Example 1 as the core material.
く皮膜液〉
■ゼラチン
■グリセリン
■ホルムアルデヒド
■精製水
計
上記成分■〜■を７
（重量％）
４０、Ｏ
１２，０
１０，０
３８，０
１００、０
０℃にて混合溶解した後、
１時間この温度を保持し、ゼラチンとホルムアルデヒド
を架橋せしめ皮膜液とした。Film liquid> ■Gelatin ■Glycerin ■Formaldehyde ■Purified water meter After mixing and dissolving the above components ■~■ at 7 (wt%) 40, O 12,0 10,0 38,0 100,0 0℃, 1 This temperature was maintained for a period of time to crosslink gelatin and formaldehyde to form a coating solution.
試験例１
実施例１、比較例１及び比較例２で得られた各ソフトカ
プセルを室温及び４０℃（相対湿度５０％）で、３ケ月
間保存し、変化を調べた。結果を第１表に示す。Test Example 1 The soft capsules obtained in Example 1, Comparative Example 1, and Comparative Example 2 were stored at room temperature and 40° C. (50% relative humidity) for 3 months, and changes were examined. The results are shown in Table 1.
第１表
比較例３
以下の如く、軟化点の高い熱可塑性樹脂を用いた皮膜液
を調製し、芯物質は実施例１で調製したものを用い、下
記製法によりカプセルを得た。Table 1 Comparative Example 3 A coating liquid was prepared using a thermoplastic resin with a high softening point as shown below, and capsules were obtained by the following manufacturing method using the core material prepared in Example 1.
く皮膜液〉
（重量％）
■アイオノマー樹脂（軟化点１１０℃） ６０．０■
トルエン ４０．０計
１００．０上記■及
び■を１００℃にて混合溶解させて皮膜液とした。Film liquid〉 (wt%) ■Ionomer resin (softening point 110℃) 60.0■
Toluene 40.0 total
100.0 The above (1) and (2) were mixed and dissolved at 100°C to obtain a coating liquid.
くカプセルの製法〉
皮膜液を冷ローラーにてシート化し、トルエンを除去し
た後、ロータリー打抜法にて芯物質を充填し、カプセル
を得た。Capsule Manufacturing Method The film solution was formed into a sheet using a cold roller, toluene was removed, and a core material was filled using a rotary punching method to obtain capsules.
上記の如くして得られたカプセルは、皮膜が硬く、穴を
あけたり、指等で圧し潰したりすることが困難であり、
使用しづらいものであった。The capsules obtained as described above have a hard film and are difficult to puncture or crush with fingers, etc.
It was difficult to use.
実施例２
以下の如く芯物質（クリーム）を調製し、皮膜液、製法
は実施例１と同様にしてソフトカプセルを得た。Example 2 A core material (cream) was prepared as described below, and soft capsules were obtained using the same method as in Example 1 to prepare a coating liquid.
く芯物質（クリーム）〉
（組成）
（重重％）
■ステアリン酸 ４．０■１
，３−ブタンジオール １３．。Core substance (cream)> (composition) (weight%) ■Stearic acid 4.0■1
,3-butanediol 13. .
■ミツロウ ３．０■パ
ラフインワツクス １０．０■流動パ
ラフイン ２０．０■精 製
水 ４８．。■Beeswax 3.0■Paraffin wax 10.0■Liquid paraffin 20.0■Refined
Water 48. .
■トリエタノールアミン ２．０ε１
１ｏｏ、。■Triethanolamine 2.0ε1
1oo,.
（製法） Ａ、 ■〜■を７０℃にて加熱混合溶解する。(Manufacturing method) A. Mix and dissolve by heating at 70°C.
口、 ■〜■を７０℃にて加熱混合する。Heat and mix ① to ② at 70°C.
Ｃ，ＡにＢを添加して乳化し、冷却、脱泡してクリーム
を得た。B was added to C and A and emulsified, cooled and defoamed to obtain a cream.
上記の如くして得られたソフトカプセルの外観及び安定
性は実施例１で得られたものとほぼ同様の優れたもので
あった。The appearance and stability of the soft capsules obtained as described above were almost the same as those obtained in Example 1.
実施例３
皮膜液及び芯物質は実施例１と同様にして調製し、この
２液を二重オリフィスから下降流として流れる冷却され
た流動パラフィン中に押し出し成形し−、シームレスカ
プセルを得た。Example 3 A coating liquid and a core material were prepared as in Example 1, and the two liquids were extruded into cooled liquid paraffin flowing downward through dual orifices to obtain seamless capsules.
得られたカプセルの安定性は実施例１のものと同一程度
の優れたカプセルであった。The stability of the obtained capsules was as good as that of Example 1.
本発明のソフトカプセルは、耐油性のみならず耐水性に
も優れているため、含水基剤や親水性物質も芯物質とす
ることができ、更に経時安定性も優れているため幅広い
分野で用いることができる。The soft capsules of the present invention are excellent not only in oil resistance but also in water resistance, so that water-containing bases and hydrophilic substances can be used as the core material, and they also have excellent stability over time, so they can be used in a wide range of fields. Can be done.
また、皮膜強度の調節が可能であり、適度の硬さのもの
が得られる、皮膜がヒートシール性を有するので従来の
製法がそのまま使用できる、透明なものが得られて外観
的にも優れるというような種々の優れた特徴を有する。In addition, the strength of the film can be adjusted, and a product with appropriate hardness can be obtained.The film has heat-sealing properties, so conventional manufacturing methods can be used as is.A transparent product can be obtained, which has an excellent appearance. It has various excellent features such as:
以 上 手続補正書（自発） 平成元年１１月２０日that's all Procedural amendment (voluntary) November 20, 1989
Claims (1)
塑性樹脂であることを特徴とするソフトカプセル。1. A soft capsule characterized in that the main component of the capsule film is a thermoplastic resin with a softening point of 100°C or less.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27614889A JPH03141217A (en) | 1989-10-25 | 1989-10-25 | Soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27614889A JPH03141217A (en) | 1989-10-25 | 1989-10-25 | Soft capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03141217A true JPH03141217A (en) | 1991-06-17 |
Family
ID=17565434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP27614889A Pending JPH03141217A (en) | 1989-10-25 | 1989-10-25 | Soft capsule |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03141217A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4518718Y1 (en) * | 1965-08-24 | 1970-07-29 | ||
| JPS6257492A (en) * | 1985-09-06 | 1987-03-13 | ライオン株式会社 | Enzyme-containing substance packed in hermetical state |
| JPS62205006A (en) * | 1986-03-04 | 1987-09-09 | Shiseido Co Ltd | Cosmetic |
| JPS62238210A (en) * | 1986-04-04 | 1987-10-19 | Pola Chem Ind Inc | Scrubbing cosmetic |
-
1989
- 1989-10-25 JP JP27614889A patent/JPH03141217A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4518718Y1 (en) * | 1965-08-24 | 1970-07-29 | ||
| JPS6257492A (en) * | 1985-09-06 | 1987-03-13 | ライオン株式会社 | Enzyme-containing substance packed in hermetical state |
| JPS62205006A (en) * | 1986-03-04 | 1987-09-09 | Shiseido Co Ltd | Cosmetic |
| JPS62238210A (en) * | 1986-04-04 | 1987-10-19 | Pola Chem Ind Inc | Scrubbing cosmetic |
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