JPH03123726A - Tablet and mortar for its production - Google Patents

Abstract

PURPOSE:To obtain hardly rollable, readily applicable tablets being easily administered by aged people, producible without reducing production efficiency by forming a specific slant part to partially make cut on the side of outer periphery on one side of main body of spherical tablets. CONSTITUTION:A plane or curved surface slant part to partially make cut on the side of outer periphery is formed on one side of main body of spherical tablets so that main body of spherical tablets is hardly rolled. The tablets have >=6mm and <=10mm diameters in terms of ready administration and easy handleability. Since the tablets are made in a state where rotary movement of spherical tablet has position of the center of gravity not at revolving shaft and not at surface of grounded outer periphery side, balance is broken and movement distance is lessened.

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The present invention relates to a tablet structure that is basically circular but does not roll easily, and a punch for producing the same.

(Prior Art) In an aging society that has become increasingly serious in recent years, it is necessary to develop pharmaceutical tablets that are easy for elderly people to take.

Orally administered preparations are particularly easy to administer to elderly people, as they take many medications and are more likely to develop swallowing disorders due to decreased motility at the junction of the esophagus and trachea and decreased reflex to cough up foreign objects from the trachea. need to be considered. Furthermore, since the motor function of the fingertips deteriorates, ease of taking the product out of the packaging and ease of picking it up are also important usability factors.

In fact, in medical settings for the elderly, there is a desire for small tablets that are easy to swallow, as well as a desire for a shape that is difficult to roll, such as an oval, since circular tablets are difficult to roll or pinch.

(Problems to be Solved by the Invention) Tablets that are not normally circular in shape, such as oval or capsule shapes, i.e. irregularly shaped tablets, do have the advantage of being difficult to roll, but in the tablet manufacturing process, round tablet compression Whereas the punch can freely rotate in the axial direction, in the case of irregularly shaped tablets, the direction of the tableting punch is always restricted.
This poses problems such as significant wear and tear on the tableting punches, resulting in a decrease in production efficiency and, in some cases, in the quality of the tablets.

Therefore, circular tablets are excellent in pursuit of productivity and high quality. In addition, irregularly shaped tablets may be difficult to swallow depending on the orientation of the tablet when taken, so round tablets that are as small as possible are superior in terms of ease of swallowing. Therefore, as a result of intensive research into tablets that are easy to handle without sacrificing the excellent advantages of round tablets, we have found that they can be produced under the same manufacturing conditions as regular round tablets, that is, under the free rotation of the tableting punch without restricting its direction. However, we were able to find a structure for a pharmaceutical tablet that is difficult to roll, has excellent handling, and has an easy-to-swallow shape. The present invention provides a new tablet structure that will meet the aging society of the future.

(Means for Solving the Problems) In order to solve the above problems, the center of gravity G of a partially cut out circular tablet is made eccentric from the center of the geometric circle, or at least 10% or more of the circumference is It is constructed so that when the outer peripheral side surface of the tablet is in contact with the ground, the center of gravity is not located directly above the perpendicular line to the ground surface.

That is, when shown in a developed view of the outer peripheral side surface, it becomes as shown in FIG. 13.

Further, the shape of the pressing surface of the upper punch used in the tableting machine for compressing the above-mentioned tablets is also appropriately prepared depending on the shape of the tablet.

Based on the present invention, tablets preferably have a diameter of 6 mm or more and 10 mm or less for ease of swallowing and handling.

(Function) Ordinary circular locks touch the ground on their outer periphery and rotate easily. In the present invention, when the circular lock rotates, the center of gravity may not be on the axis of rotation or on the normal line of the outer circumferential surface when in contact with the ground, so the balance is likely to be lost and the distance traveled becomes small. In addition, this tablet has a property of being difficult to roll, so it is easy to handle, and has an easy-to-swallow shape, making it easy to use. Furthermore, since it can be manufactured under basically the same conditions as ordinary circular tablets, it can be obtained without reducing production efficiency.

The present invention will be explained in detail below using examples shown in the drawings.

(Example 1) In FIGS. 1(a) to (C) and FIG. 2, l is a circular tablet body, and the curved surface 2A, which is the side surface thereof, has a part extending over a part of the outer circumferential side surface 3. The slope portion 4 is provided by forming the shape into a notch.

Even if the width of the outer circumferential side surface 3 changes thinly due to the formation of the slope portion 4 as shown in FIG. 1(C), it will never become zero and ΔI will always remain.

Although the slope portion 4 is a flat surface in this embodiment, it can also be formed into another shape or a convex curved surface.

Reference numeral 5 indicates an arc-shaped boundary line between the curved surface 2 and the slope portion 4.

Reference numeral 6 indicates a score line, and by making the tablet body 1 bilaterally symmetrical with respect to the score line 6, it is possible to divide the tablet body into equal parts.This score line 6 may be provided as needed, or may be omitted when unnecessary.

7 is the other side of the tablet main body 1 and has a curved surface.

Therefore, in the posture shown in FIG. 1(C), the center of gravity G of the tablet body 1 cannot be orthogonally projected onto the ground contact part of the outer circumferential side surface 3, and it immediately becomes unstable and falls in the direction of arrow A. I will do it. (The state shown by the dashed line at the top of FIG. 1(C)) In addition, in this state, the tablet body 1 can be easily picked up with fingers, which improves handling.

As shown in FIG. 2, the outer peripheral side surface 3 of the tablet body 1 was placed on the ground and rolled about 30 cm on a slope Q with an inclination angle of 3 degrees, and then the distance ax (mm) of rolling on a horizontal surface R was measured.
The tablet body 1 had a shorter rolling distance than a normal circular tablet of the same diameter and weight, and the average value was less than 60% as shown in Table 1 below. In addition, the tablet body l
If it touches the ground on the outer peripheral side surface 3 and starts rolling in the state shown in Figure 1 (C), it will stop moving before it rolls on the slope Q due to instability, so Figure 1 (C) The test was started with the device upside down.

This example shows the rolling distance 1 when the tablet body 1 rolls.
In addition to being able to shorten tx, it also has the effect of making it difficult to start rolling.

Table 1 Horizontal rolling distance after rolling down a slope (mm
) In each of the following embodiments, the same parts as in the first embodiment are given the same numbers.

(Embodiment 2) In FIGS. 3(a) to 3(C) and FIG. 4, the features of this embodiment are as follows:
and are connected to each other through a straight boundary line 5, and a chamfered portion 8 is formed on the edge, and as in the first embodiment, the sloped portion 4 is placed downward as shown in FIG. 3(e). When the tablet body 1 is held upright on the outer peripheral side surface 3, the center of gravity G of the tablet body 1 cannot be orthogonally projected onto the outer peripheral side surface 3 which is in contact with the ground directly below, and the tablet body 1 immediately falls in the direction of the arrow A. In other words,
The area where the center of gravity G is not on the perpendicular to the part of the outer circumferential side surface 3 of the tablet body 1 that is in contact with the ground is at least 10% of the entire circle (see FIG. 13).

At this time, as shown in FIG. 4, the outer circumferential side surface 3 of the tablet body L of the present invention is grounded and a slope Q having an inclination angle α of 3° is placed at a depth of 44 m.
m, width d: Now, create a groove S of about 3 mm, roll it a distance L: about 30 cm along the groove S, and then roll it on the horizontal surface R.
When the rolling distance i@x (mm) was measured, the tablet body 1
has a rolling distance # compared to a regular round tablet of the same diameter and weight.
X becomes shorter, and its average value is 30% as shown in Table 2.
The value was less than .

Table 2: Horizontal-rolling distance (mm) after rolling on a grooved slope (Example 3) As shown in Figures 5(a) to 5(C), the characteristics of this example are as follows: One side 2 of the main body l is entirely cut out in a diagonal shape, with only a sloped portion 4, and the other side 7 is made flat, and its effect is similar to that of the first and second embodiments.
It is.

(Embodiment 4) The feature of this embodiment is that a plurality of polyhedral slope portions 4A, 4B, 4
It is located at a point where C14D and Φ are formed and divided into planes, and the other side surface 7 is made flat, and at that time, only one sloped portion 4A of them is approximately 10% of the circumference of the outer peripheral side surface 3. Since the notch intervenes, the effect is substantially the same as that of the first to third embodiments. (See Figure 13) (Example 5) The feature of this example is that one side 2 of the tablet body l is eccentric from the center of the circle to the outer peripheral side 3 as shown in Figures 7 (a) to (C). This embodiment has the advantage that a convex curved surface is formed as the slope portion 4 having the peak T, and the other side surface 7 is a convex curved surface with a gentle curvature, and the effect thereof is similar to that of the first embodiment.

In addition, in the first to fifth embodiments, the center of gravity G is approximately 25 radii from the geometric center of the tablet body 1 toward the outer circumferential side surface 3.
% or more, and when the outer circumferential side surface 3 is in contact with the ground, the center of gravity G cannot be orthographically projected onto the outer circumferential side surface 3 over at least 105 parts of the circumference due to the presence of the slope portion 4, and the present invention The key point lies precisely in this point.

(See Figure 13) (Example 6) The feature of this example is that one side 2 of the tablet body 1 is a curved surface 2A, as shown in Figures 8 (a) to (c), and the side surface 2A is approximately symmetrical to the left and right. Since the concave curved surface 4 as the slope part 4 is provided in the half-moon shape, and the concave curved surface 4 partially intervenes in the outer circumferential side surface 3, the center of gravity G cannot be orthogonally projected onto the outer circumferential side surface 3. In other words, the center of gravity G cannot be orthographically projected onto the outer circumferential side surface 3. When the outer circumferential side surface 3 of L is in contact with the ground, the center of gravity G is located at a point that does not lie on the perpendicular line to which approximately 10% of the circumference of the outer circumferential side surface 3 that is in contact with the ground is in contact with the ground. (See Figure 13) At that time, the center of gravity G lies on the geometric center of the circle.

(Example 7) As shown in FIGS. 9(a) to 9(c), the feature of this example is that one side of the tablet body 1 is formed as a convex curved slope portion 4 having a plurality of curvatures, and the lower surface 7 is It has a convex surface with a gentle curvature, and the slope portion 4 has a large radius of curvature in the X-axis direction in FIG. 9(a) and a small radius of curvature in the Y-axis direction.

Therefore, in the Y-axis direction with a small radius of curvature, the outer peripheral side surface 3
At that time, the center of gravity G is located on the geometric center of the circle.

(Example 8) The feature of this example is that the curved surface 2A and the lower surface 7 of the tablet body 1 are curved in the same direction, so that the cross-sectional shape is approximately arch-like. This is due to the fact that it is molded, and its function and effect are substantially the same as those of the first to seventh embodiments.

(Example 9) This example relates to an upper punch used in a tableting machine for producing the above-mentioned specially shaped tablets as shown in FIGS. 11(a) to (C).

10A is a cylindrical upper punch having a pressing surface portion 11 formed at its lower end. This pressing surface portion 11 is formed at least on a first pressing surface 11A, which is a curved or flat surface corresponding to the curved surface 2A or flat surface 2B forming one side 2 of the tablet body 1, and a flat or curved slope portion 4 of the tablet body 1. It is composed of a corresponding flat or curved second pressing surface 11B. IIC
is a third pressing surface and is an inclined portion corresponding to the chamfered portion 8 of the tablet body l.

10B is a lower punch which forms a curved or flat pressure receiving surface 110 corresponding to the other side surface 7 of the tablet body 1.

Further, as a configuration of a known tablet press, there is a single-shot tablet press 14 (as shown in FIG. 12(a)), which is a type in which filling, measuring, compressing, discharging, etc. of raw material W into a mortar 12 is performed at one place on the table. Suitable for small-scale production and research, it is easy to press large tablets and special-shaped tablets, and high-pressure tableting is also possible).
Turntable 1 as shown in FIGS. 12(b) to (C)
There is a rotary tableting Ia15 in which filling and dispensing are performed while the dies 12 arranged around the outer periphery of the tablet rotate once.

The upper punch 10A of this embodiment is used in these known tablet machines,
This is to manufacture tablets with special shapes that are difficult to roll. Incidentally, although these tablets are mainly intended for medical use, it does not depart from the spirit of the present invention even if they are adopted as quasi-drugs.

(Effects of the Invention) The present invention has the following unique effects based on each of the embodiments described above.

In claim 1, a tablet that is difficult to roll is obtained, and
It has the advantage of being easy to use, easy to handle, and easy to swallow.

According to claim 5, tablets that are difficult to roll can be easily produced.

[Brief explanation of drawings]

Figures 1(a) to (C) and Figure 2 show a first embodiment of the present invention, where Figure 1(a) is an overall perspective view of the tablet of the present invention, and Figure 1(b) is a perspective view of the entire tablet of the present invention. is also the overall plan view, Figure 1 (C
) is also a side view, and FIG. 2 is a schematic diagram illustrating how the tablet rolls. 3(a) to 4(C) and FIG. 4 show a second embodiment of the present invention. FIGS. 5(a) to 5(C) show a third embodiment. FIGS. 6(a) to 6(C) show a fourth embodiment. FIGS. 7(a) to (C) show a fifth embodiment. FIGS. 8(a) to 8(C) show a sixth embodiment. FIGS. 9(a) to 9(C) show a seventh embodiment. FIGS. 10(a) to 10(C) show the fourth embodiment. Figures 11(a) to (C) and Figures 12(a) to (c)
) shows the ninth embodiment, and FIGS. 11(a) to (C) show the relationship between the upper punch and the lower punch of the present invention. FIGS. 12(a) to 12(C) are schematic diagrams of a known tablet press. FIG. 13 is a developed view of the outer peripheral side of the tablet. lφ...Tablet body 3...Outer circumferential side 2...-side 4...Slope portion 7-...Other side 10A/Puntle on labor dispute

Claims (3)

[Claims] (1) A tablet characterized by forming a flat or curved slope on one side of the circular tablet body so as to cut out a part of the outer circumferential side surface to make the tablet body difficult to roll. (2) A tablet characterized by forming a pair of flat or curved slopes on one side of the circular tablet body at symmetrical positions with respect to the center of the circle, making the tablet body difficult to roll. (3) When the tablet body is orthogonally projected onto a certain plane, it becomes a circle, and has an outer circumferential side surface that is continuous in a direction perpendicular to the plane, and the center of gravity is not orthographically projected onto the center of the circle, or at least on the circumference. A tablet characterized in that the center of gravity cannot be orthogonally projected onto the outer circumferential side in a portion of 10% or more, making the tablet body difficult to roll (4) A plurality of presses are applied to the lower end of the cylindrical upper punch 10A. A curved surface 2A that forms the surface portion 11, and the first pressing surface 11A forms one side 2 of the tablet body 1.
Or it is a curved surface or a plane corresponding to the plane 2B, and the second pressing surface 11B is the plane or curved slope portion 4 of the tablet body 1.
A punch for making tablets with a flat or curved slope corresponding to