JPH0288073A - Blood plasma separator and control device for the same separator - Google Patents

Abstract

PURPOSE:To easily charge a tube to be clamped between a tube press member and a tube support member and to extremely simplify a mounting work by a method wherein a soft tube for intercoupling a blood plasma separator body and a blood storage tank can be selectively pressed from the outside of a casing to open and close a flow passage. CONSTITUTION:A disposable unit 92 has a casing formed by a flat rectangular substance. A tube 112 extended from a physiological salt solution bag 62 is connected to the portion in the vicinity of the corner part of the unit. A tube 114, positioned in a space formed between a press member 100 and rollers 94a and 94b of a blood pump 66, is exposed to the outside so that blood can be fed in a wormlike manner under running of the blood pump 66. Further, a tube 11b coupled to a blood plasma bag 58, a tube 118 for returning blood to a blood donor 52, a tube 120 for collecting blood, and a tube 122 through which an anticoagulant is fed to the blood donor 52 are connected to the other side part of the casing.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a plasma separator and a control device thereof, and more specifically, blood is collected from a patient, etc., and the blood is passed through a filter to separate blood cell components and plasma components. In a donor pheresis type plasma separator that separates blood into blood, the plasma separator, which consists of a reservoir, a filter, and a tube that connects these, is disposable, and the blood flow path opening/closing means used for blood collection, blood return, etc. The present invention relates to a plasma separator and a control device thereof, in which tubes and the like can be easily installed and removed.

[Background of the Invention] Donor pheresis devices have conventionally been used as plasma separation devices that collect blood from blood donors and separate plasma components from the collected blood. This donor pheresis device connects a blood collection means such as a blood collection needle to the donor's blood vessel, stores the blood collected from the donor in a reservoir (blood storage part), and then connects the blood collection device to a filter that is a plasma separator. This device separates collected blood into blood cell components and plasma components by circulating blood between the blood cells and the plasma. In this case, the configuration is such that the blood cell components are returned to the donor's body, while the plasma components are stored for purposes such as treatment.

For this reason, the donor pheresis device includes a blood pump for drawing blood from a donor for blood collection and plasma separation, a circulation pump for circulating the collected blood between a reservoir and a filter, and a plasma component. An actuator such as a plasma pump is provided at a predetermined location to guide the plasma from the filter to the plasma reservoir. On the other hand, at predetermined locations of the blood passages connecting the reservoir, filter, and plasma storage part with each of the above pumps, there are chambers to prevent air bubbles from entering the blood, clamps to control the opening/closing of the passages, and atmospheric pressure. A release valve etc. is provided.

In such a plasma separation device, before blood collection, a priming process is usually performed in which each part is washed with physiological saline, and then blood is collected using a blood collection means and plasma is collected using a filter (separation and collection of plasma components). After that, a washing blood return operation is performed in which the plasma-separated blood is returned to the donor while the physiological saline is supplied to each part again for washing.

In order to automatically perform this type of plasma separation work, the apparatus shown in FIG. 1 is preferably used. The configuration and operation of this plasma separator will be schematically explained below.

That is, in FIG. 1, reference numeral 10 indicates a plasma separation device, and the plasma separation device 10 includes a reservoir 14 for storing blood B collected from a blood donor 12, and a plasma separation device for separating plasma component P from the blood B. Filter 16 as a container
and a collection stirring bag 18 for collecting the separated plasma component P. Blood B drawn out by the action of a blood collection pump 22 from a blood collection means 20 such as a blood collection needle connected to an artery or vein of the blood donor 12 is stored in the reservoir 14 via a clamp 24 . The collected blood B is introduced into the filter 16 via the chamber 28 by the action of the circulation pump 26, and the plasma component P is introduced from one output passage of the filter 16.
is stored in the plasma collection bag 18 by the action of the plasma pump 300. On the other hand, the other output passage of the filter 16 for deriving the blood cell component Q in the blood B communicates with the reservoir 14 via the clamp 32 and is also connected to the blood sampling means 20 via the chamber 34 and the clamp 36. Q is configured to return blood to the donor 12.

That is, in order to perform plasma separation, first, during blood collection, the clamps 24 and 32 are opened, the clamp 36 is closed, and blood B is pumped into the reservoir 14 under the driving action of the blood collection pump 22.
The blood in the reservoir 14 is circulated through the chamber 28, the filter 16, and the reservoir 14 under the driving action of the circulation pump 26 while storing the blood.

Then, under the driving action of the plasma pump 30, the plasma separated by the filter 16 is stored in the blood collection bang 18.

On the other hand, when returning blood, the clamps 24 and 32
is closed, and the clamp 36 is opened. Therefore,
When the circulation pump 26 is driven, the concentrated red blood cell components in the chamber 28 are returned to the blood donor 12 via the chamber 28, the filter 16, and the chamber 34. At this time, the plasma component P separated by the filter 16 is stored in the blood sampling bag 18 under the driving action of the plasma pump 30.

As described above, in the prior art, the opening and closing of the clamps 24, 32, and 36 are selectively controlled during blood collection and blood return. Substantially, the concrete construction of the clamping mechanism used in this clamp 24, 32, 36 is shown in FIG. That is, reference numeral 40 is a housing surrounding a solenoid, and a rectangular tube presser 44 is fixed to the tip of a rod 42 that moves forward and backward by controlling the supply of electricity to the solenoid. On the other hand, a holding member 46 that stands up after being bent from one end of the housing 40 is provided, and a tube receiving member 48 is provided inside the holding member 46 so as to face the tube presser 44.

Therefore, in the configuration shown in FIG. 1, for example, when the clamp 24 is configured as shown in FIG.
9 is manually inserted between the tube receiving member 48 and the tube presser 44. Then, if the solenoid in the housing 40 is energized as necessary, the tube holder 44 firmly presses the tube 49 against the tube receiving member 48 under the displacement action of the rod 42, and the tube 49 is in a clamped state. It will be maintained.

On the other hand, if the energization to the solenoid in the housing 40 is canceled, the tube holder 44 performs a closing operation, and therefore, the tube 49 is of course in an unclamped state.

By the way, in the clamp mechanism configured as described above, for example, when the tube 49 is connected to the blood donor 12, it must always be accurately positioned between the tube holder and the tube receiving member. Therefore, as the number of clamp mechanisms increases, the task of positioning and loading the tube itself relative to the clamp mechanism becomes extremely complicated. As is well known, in a plasma separation device, at least the blood sampling means, reservoir, filter, plasma sampling bag, etc. It cannot be used repeatedly.

This is to prevent pathogenic bacteria specific to the blood donor from being transferred to other blood donors by using the device multiple times. Therefore, if there are a large number of blood donors, loading and unloading the tubes as described above becomes a heavy labor burden for medical personnel. Moreover, when trying to use a clamping mechanism with the above-mentioned configuration, the structure becomes extremely complicated and loading is not easy, making handling cumbersome, and the device inevitably becomes large, which exposes various drawbacks. ing.

[Object of the Invention] The present invention has been made to overcome the various disadvantages described above, and includes a tube holder and a tube receiving member that are separated from each other with respect to a tube for flowing blood. A plasma separator is constructed by integrating a filter, a reservoir, etc. into a housing, and on the other hand,
A solenoid and a tube holder are arranged at appropriate locations in the plasma separator main body, and when the plasma separator consisting of the tube receiving member, filter, and reservoir is integrated into the plasma separator main body, the tubes are automatically By configuring the tube receiving member to face the presser foot, and by making these tube receiving members, filters, reservoirs, etc. disposable, the blood circuit constituting the plasma separator can be easily loaded. A plasma separator and its control that are easy to handle, suitable for downsizing, and can be manufactured at a lower cost by simply removing the plasma separator from the plasma separator main body in a short time after work is completed. The purpose is to provide equipment.

[Hands for Achieving the Objects] To achieve the above objects, the present invention provides a plasma separator, the plasma separator comprising a casing and a blood sampling means disposed inside the casing. a plasma separator main body for separating plasma components and blood cell components; a blood storage tank connected to the plasma separator main body for temporarily storing blood cell components; and at least the blood sampling means and plasma separation device. The device has a unit configuration including a flexible tube that interconnects the device body and the blood reservoir, and is configured to open and close the flow path by selectively pressing the tube from the outside of the casing. It is characterized by

The present invention also provides a control device for incorporating and controlling a plasma separator. It is characterized by having a drive source for transferring the blood from the blood tank to the blood storage tank.

[Embodiments] Next, preferred embodiments of the plasma separator according to the present invention in relation to a plasma separation device incorporating it will be listed,
A detailed description will be given below with reference to the accompanying drawings.

First, FIG. 3 is a schematic diagram of the plasma separation system according to this embodiment. In the figure, reference numeral 50 indicates a plasma separator, and the plasma separator 50 includes a filter 54 as a plasma separation mechanism that separates plasma component P from blood B collected from a blood donor 52, and a filter 54 that separates plasma component P from blood B collected from a blood donor 52. A reservoir 56 for temporarily storing the separated blood cell component Q, a plasma bag 58 for collecting the separated plasma component P, and an anticoagulant bag for adding an anticoagulant such as ACD to the blood at a predetermined ratio. 60 and a physiological saline bag 62.

Blood B drawn out from the filter 54 by the rotating action of a blood pump 66, preferably a roller pump or the like, from a blood collection means 64 such as a blood collection needle connected to an artery or vein of the blood donor 52, is supplied to the filter 54 when the clamp 68 is in an open state. It will be introduced as In this case, an anticoagulant such as ACD is drawn out from the anticoagulant bag 60 by the action of the ACD pump 70 and added to the blood B at a predetermined ratio. Blood B inside the filter 54
is separated into plasma component P and blood cell component Q, the plasma component P is stored in the plasma bag 58 under the action of the plasma pump 72, and the blood cell component Q is temporarily stored in the reservoir 56 under the action of the clamp 74. be done. In this case, the output side of the filter 54 is branched and connected to the blood sampling means 64 via a clamp 76, and the output side of the reservoir 56 is connected via a clamp 78 to the front stage of the blood pump 66. Also,
The physiological saline bag 62 is connected to the blood passage between the blood pump 66 and the blood collection means 64 via a clamp 80, and functions to fill the blood passage with physiological saline during priming and when returning blood for washing.

Therefore, in the plasma separator according to the present invention, the filter 54, the reservoir 56, and the tube for communicating these are integrally configured to be disposable. Therefore, its specific configuration is shown in FIG. 4 and subsequent figures in relation to a plasma separation device incorporating it.

FIG. 4 shows a specific example of the configuration of the plasma separator and plasma separation device, which has a substantially rectangular shape. Note that this plasma separator is shown with the lid member removed in order to clarify the internal structure. Therefore, the blood pump 66, A
CD pump 70, plasma pump 72 or clamp 68
．． A controller panel 90 for performing energization/deenergization control such as 74, 76, 78, 80, etc. is provided.

A disposable unit 92 as a plasma separator is provided near one lower corner of the rectangular plasma separator 50. A blood pump 66 is disposed above the disposable unit 92.
The rotation shaft 66a of No. 6 is rotatable in the direction of the arrow. In fact, a holding member 96 that rotatably holds a first roller 94a and a second roller 94b is fixed to the rotating shaft 66a, and these rollers 94a and 94b are opened and closed by a hinge member 98, and the rollers 94a and 94b are a presser member 1 defining a space between which a blood tube to be described later is fitted;
It is configured to face 00. Furthermore, on the left side of the blood pump 66 is a plasma pump 7 of a similar type.
A holding member 102 similar to that of the blood pump 66 is fixed to the rotating shaft 72a of the plasma pump 72. Rollers 104a to 104d are rotatably fixed to the holding member 102, respectively. These rollers 104a to 104d are configured to be pulled by the rotation of the plasma pump 72 and squeeze the attached tube under the cooperation of a presser member 105 similar to the presser member 100.

An ACD pump 70 is disposed on the side of the casing constituting the plasma separator 50, and a presser member 10 is disposed opposite to the ACD pump 70.
7, and an anticoagulant bag 60 and a physiological saline bag 62 are disposed above it. A plasma bag 58 is held on the other side of the housing. A tube 108 extending from the anticoagulant bag 60 is connected to the AC
A tube connected to the D pump 70 and extending from the plasma bag 58 extends to the plasma pump 72 side. A tube extending from the saline bag 62 is connected to a disposable unit 92. Therefore,
The details of this disposable unit 92 will be explained below.

As can be easily understood from FIG. 6, the disposable unit 92 has a casing 1 made of a flat rectangular body.
It has 10. Near one corner of the casing 110 is a tube 11 extending from the physiological saline bag 62.
2 are connected.

The top of the casing 110 is disposed in a space defined between the presser member 100 and the rollers 94a and 94b of the blood pump 66, and is configured to emotionally feed blood under the rotational action of the blood pump 66. tube 1 so that
14 is exposed to the outside.

As can be easily understood from the figure, in this case tube 1
14 has a curved shape. Furthermore, casing 11
From the other side of 0, a tube 116 connected to the plasma bag 58, a blood return tube 118 for returning blood to the donor 52, a tube 120 for blood collection, and an anticoagulant are sent to the donor 52. A tube 122 is connected to the tube.

The internal structure of such a disposable unit 92 is shown in FIG. In this case, the reservoir 56 is located on the left side of the figure in FIG. A filter 54 is provided. A four-way branch pipe 130 is arranged in the upper central part of the casing 110, and this four-way branch pipe 130 is connected to a tube 112 connected to a physiological saline bag 62, a tube 132 connected to a reservoir 56, and a filter 54. Tube 114 and blood collection tube 120 are connected. In fact, the casing 110 has a recess 14
0 is defined, and using this recess 140, the plasma pump 7
A connector 142 is provided for connecting the tube 116 connected to the connector 2. One surface of the casing 110 includes a first opening 150, a second opening 152, a third opening 154, into which a pressing member for a clamp, which will be described later, enters.
A fourth opening 156 and a fifth opening 158 are formed, respectively. In this case, the first opening 150 is configured such that a pressing member constituting the clamp 68 can be accessed, and similarly, the second opening 152 is configured such that the clamp 74 and the third opening 15 are accessible.
4 has a clamp 78 , and the fourth opening 156 has a clamp 78 .
6. The fifth opening 158 is configured such that a pressing member constituting the clamp 80 can enter therein. A flat and elongated protrusion 160 is integrally formed at the upper end of the casing 110. Holes 162a are provided at both ends of this protrusion 160, respectively.

162b is provided.

In fact, in FIG. 4, the disposable unit 9
2 is shown exposed to the outside, but when it is installed, it is firmly fixed using a lid member. The lid member will be described together with a cover member provided with a receiving member that presses each tube in cooperation with the pressing member.

FIGS. 10 to 12 show partial sectional views of this lid member and cover member. First, in the wall portion 170 on the main body side of the plasma separator 50 that is integrally formed with the panel 90, two guide pins 17 are inserted corresponding to the holes 162a and 162b.
2a and 172b are formed in a protruding manner.

Further, solenoids 174 to 182 are provided corresponding to the tube holding openings 150 to 158.

That is, when the disposable unit 92 is attached to the wall portion 170, the flat pressing members 184 to 192, which are attached to the rod tips of the solenoids 174 to 182, are exposed at positions corresponding to the openings 150 to 158. is configured to enter.

On the other hand, tube receiving members 196 to 204 are formed protruding from the inside of a cover member 194 constituting the disposable unit 92 in correspondence with the tube holding members 184 to 192, respectively. As can be easily understood from FIGS. 10 and 11, the tube receiving members 196 to 204 are integrally formed with the disposable unit 92, and have a protruding body with a slightly rounded tip. It has a predetermined length, ie, a length that is sufficient to receive the tube.

Furthermore, in the plasma separator 50 according to the present invention, the disposable unit 92 is pressed and fixed by the lid member 210. In fact, in this embodiment, from the wall 170 of the plasma separator 50, a pair of retaining members 212a,
212b protrudes outward, and one holding member 212a
A lid member 210 is rotatably attached to the tip of the lid member 210 . A clamping means 214 that engages with one end of the lid member 210 is provided at the tip of the other holding member 212b. This clamping means 214 is attached to the disposable unit 9 from the wall 170.
Achieves the function of preventing 2 from floating up.

In this case, the inner surface of the lid member 210 is provided with bullets (HE materials 220a to 22
Attach the 0d to the specified location.

In the figure, reference numerals 230 and 232 indicate holes in which pressure gauges that engage the tubes and detect the pressure of blood flowing down the tubes face.

The plasma separator and its control device according to the present invention are basically constructed as described above, and the operation and effects thereof will be explained next.

First, the disposable unit 92 is attached to the plasma separator 50.
Attach it to the main body side. In this case, the hole 16 of the protrusion 160 extending outward from the disposable unit 92
2a and 162b are fitted into guide pins 172a and 172b, respectively. This allows the disposable unit 92 to be positioned. Therefore, the lid member 2
10 is rotated and the disposable unit 92 is fixed by the clamp means 214. This is essentially achieved by clamping the distal end of the lid member 210 by the clamping means 214. At this time, the tube receiving members 196 to 204 respectively face the tube holding members 184 to 192 extending inward from the disposable unit 92 from the solenoids 174 to 182, and the tube holding members 196 to 204 and the tube holding member 18
There will be tubes between 4 and 192.

In this case, the tube receiving members 196 to 204
In order to maintain a constant distance between the tube holding members 184 and 192, the elastic members 220a to 220d always press the disposable unit 92 toward the wall portion 170 by their elastic force. Therefore, the tube receiving members 196 to 204 and the tube holding members 184 to 192
The interval between is always constant. This means that solenoid 17
4 to 182 are selectively biased and the tube holding member 1
This means that when the tubes 84 to 192 are about to be displaced toward the corresponding tube receiving members 196 to 204, the pressing force against the tube itself, that is, the clamping force is always constant.

After the setting is completed in this way, for example, an anticoagulant bag 60, a physiological saline bag 62, and a blood collection bag 58 are attached to the main body side of the plasma separator 50, and each of them extends from the disposable unit 92. The tube member is coupled to the tube member. And disposable unit 92
The rollers 94a, 9 extend outwardly in a curved manner from
4. Holding member 1 against tube 114 installed opposite to b.
00 rotates and becomes locked, while the plasma pump 72
A tube 116 is similarly arranged in a curved manner on the side, thus completing all setting operations.

Therefore, next, the substantial operation of this plasma separator 50 will be explained.

First, priming, in which each part of the apparatus is filled with physiological saline prior to blood collection, will be explained. During this priming, clamp 68 and clamps 76, 78 are kept closed, and other clamps 74 and 80 are opened. That is, regarding the clamps 68, 76, and 78, the corresponding solenoids are energized to displace the tube pressing member toward the tube receiving member and close the tube at that location. For clamps 74, 80, on the other hand, the corresponding solenoids are de-energized so that their tubes are open to fluid passage. Therefore, the blood pump 66 is operated. As a result, the physiological saline from the physiological saline bag 62 passes through the tube 112, the four-way branch pipe 130, etc., and the required amount of physiological saline is supplied inside the filter 54 and the reservoir 56 (first priming step). Next, in order to prime the tip of the blood collection means 64 such as a blood collection needle, the tube 120 and the blood collection means 64 are placed at a lower position than the physiological saline bung 62, and the clamp 80 and the clamp 68 are opened, and the other clamp 74 is opened. .76.78
Close. Therefore, the physiological saline is supplied to the tip of the blood sampling means 64 (second priming step).

Clamps 80.76 and 78 are then opened and the other clamp 74.68 is closed to drive blood pump 66 in the forward direction. This is to perform priming up to the blood return passage (third priming step).

Therefore, when starting blood sampling, first
8 and clamp 74 are opened, and the remaining clamps 80, 76 and 78 are closed. Blood B is drawn out from the donor 52 via the blood collection means 64 by the rotation of the blood pump 66, and at the same time, by 700 rotations of the ACD pump, an anticoagulant such as ACD is delivered to the blood at a predetermined ratio from the anticoagulant bag 60. added. Blood B to which the anticoagulant has been added is introduced into a filter 54, where it is separated into plasma component P and blood cell component Q. The plasma component P is then introduced into the plasma bag 58 through the tube 116 under the rotational action of the plasma pump 72, while
The blood cell component Q is temporarily stored in the reservoir 56 via the tube 136. That is, the rotating shaft 72a rotates due to the bias of the plasma pump 72, and the rollers 104a to 104 rotate.
d squeezes the tube 116. As a result, the desired plasma component P is stored in the plasma bag 58. It goes without saying that the filter 54 is one that does not allow molecules related to the blood cell component Q to pass through to the plasma bag 58 side, but allows only molecules related to the plasma component P to pass through.

Next, the process of returning blood cell component Q will be explained. First of all,
Blood pump 66 and ACD pump 70 are stopped.

Then, with clamps 68.74 and 80 closed, clamp 78.76 is opened. As a result,
A closed circuit is constructed from reservoir 56, clamp 78, blood pump 66, filter 54, clamp 76, and donor 52. Therefore, if the blood pump 66 is rotated in the normal direction, the blood B is returned to the blood donor 52 along the aforementioned path.

After the blood return process has started as described above, the clamping means 21
4 and take out the disposable unit 92 to the outside. And a filter 54, a reservoir 56,
The various bags and the tubes that connect them will be thrown away after their initial purpose has been achieved.

[Effects of the Invention] As described above, according to the present invention, a disposable unit including a reservoir and a filter is configured to be detachable with one touch from a plasma separator main body. Therefore, by attaching the disposable unit to the main body of the plasma separator, the tube to be clamped is easily and reliably loaded between the tube holding member and the tube receiving member, and the attachment work is extremely simplified. Furthermore, this disposable unit can be manufactured at a low cost because it can be integrally formed with, for example, a synthetic sealant.Furthermore, even after plasma separation, tubes and the like can be separated from the clamping means. Since it can be removed in one piece without having to remove it separately, it also has the advantage of speeding up the plasma separation work.

Although the present invention has been described above with reference to preferred embodiments, the present invention is not limited to these embodiments.
For example, the solenoid constituting the clamp mechanism may be constructed using a different drive source such as a motor, and in this case, it is also possible to use a limit switch for positioning, without departing from the gist of the present invention. Of course, various improvements and changes in design are possible within the scope.

[Brief explanation of drawings]

Fig. 1 is a schematic explanatory diagram of a plasma separation system according to the prior art, Fig. 2 is a perspective explanatory diagram of a tube lamp mechanism used in the prior art, and Fig. 3 is a system configuration of a plasma separation device according to the present invention. 4 is a schematic front view of the disposable unit of the plasma separator according to the present invention with the lid member removed; FIG. 5 is a schematic front view of the disposable unit of the plasma separator according to the present invention with the lid member closed. FIG. 6 is a perspective view of a disposable unit incorporated in the plasma separation device according to the present invention, FIG. 7 is a front view of the disposable unit shown in FIG. 6, and FIG. 8 is a perspective view of the disposable unit shown in FIG. 6. 9 is an explanatory rear view of the disposable unit shown in FIG. 6 with the cover member removed; FIG. 10 is a part of the disposable unit shown in FIG. 6 and the main body of the plasma separator. 11 is a partial cross-sectional view with the internal structure of the disposable unit and plasma separator body shown in FIG. 6 omitted, and FIG. 12 is a cross-sectional view of the silicone rubber, disposable unit, and lid shown in FIG. FIG. 3 is a partially enlarged cross-sectional view showing the relationship. 50...Plasma separator 52...Blood donor 54
...Filter 56...Reservoir 58.
...Plasma bag 60...Anticoagulant bag 6
2...Physiological saline bag 66...Blood pump 7
2...Plasma pump 92...Disposable unit 100...Press member 110...Casing 130...Four-way branch pipes 172a, 172b...Guide bin 194...
Cover members 196 to 204...Tube receiving member 210...Lid member 214...Clamping means patent applicant Terumo Corporation

Claims (1)

[Scope of Claims] (1) A plasma separator, wherein the plasma separator includes a casing, the plasma separator is disposed inside the casing, is connectable to a blood collection means, and is configured to separate plasma components and blood cell components. a plasma separator main body, a blood reservoir connected to the plasma separator main body for temporarily storing blood cell components, and a flexible material that interconnects at least the blood collecting means, the plasma separator main body, and the blood reservoir. What is claimed is: 1. A plasma separator, characterized in that the plasma separator has a unit configuration including a tube, and is configured such that the flow path thereof can be opened and closed by selectively pressing the tube from the outside of the casing. (2) The plasma separator according to claim 1, wherein the casing is provided with a plurality of openings through which the tubes are exposed to the outside. (3) In the plasma separator according to claim 1 or 2, the plasma separator main body substantially consists of a filter, and the filter is connected to a tube for feeding blood cell components to a blood reservoir downstream thereof. A plasma separator characterized by: (4) In the plasma separator according to claim 3, after the filter receives the blood cell components returned from the blood storage tank during blood return,
A plasma separator characterized in that it is connected to a tube for returning the blood cell components to a blood donor. (5) In the plasma separator according to any one of claims 1 to 4, the plasma separator main body is connected to a blood collection means connected to a blood donor, and the output side of the plasma separator main body is branched to store plasma. connected to the means and a blood reservoir for storing blood cell components;
Furthermore, the plasma separator is characterized in that the blood reservoir is connected to a blood return tube connected to the upstream side of the plasma separator main body. (6) The plasma separator according to claim 5, wherein the blood return tube is connected to blood sampling means after passing through the plasma separator body. (7) In the plasma separator according to any one of claims 1 to 6, a four-way branch pipe is interposed between the blood collection means and the plasma separator main body, and the output side of the blood collection means and the physiological A plasma separator characterized in that an output side of a saline bag, a blood return tube extending from a blood storage tank, and an input side of a plasma separator main body are connected. (8) The plasma separator according to any one of claims 1 to 7, wherein the casing is provided with a protruding tube receiving member for reliably pressing the tube. (9) In the plasma separator according to claim 1,
The plasma separator main body has a blood inflow port connected to the blood sampling means via a first tube, a first blood cell component outlet connected to the blood storage tank via a second tube, and a third blood cell component outlet connected to the blood sampling device.
A second blood cell component outflow port and a plasma component outflow port are connected to each other via a tube, one end of a pump tube attachable to the blood pump is connected to the blood inflow port, and the blood sampling means A four-way branch pipe is interposed between the four-way branch pipe and the plasma separator main body, a first terminal of the four-way branch pipe is connected to the blood collection means, and a second terminal of the four-way branch pipe is connected via a fourth tube. the third terminal of the four-way branch tube to the other end of the pump tube extending from the blood pump, and the fourth terminal of the four-way branch tube
is connected to a fifth tube extending from the blood cell component outlet of the blood reservoir, and the first to fifth tubes are connected to the casing.
1. A plasma separator comprising at least first to fifth openings into which pressing means enter in order to freely close the tube from the outside. (10) A control device for incorporating and controlling the plasma separator according to any one of claims 1 to 9, wherein the control device includes a clamp means for freely closing each tube, and a blood sampling device. A control device comprising a drive source for transferring blood obtained from a plasma separator body to a blood storage tank. (11) In the apparatus according to claim 10, a first clamp means is provided for opening and closing the tube connecting the blood collection means and the plasma separator main body, and the plasma separator main body and the blood storage tank are connected. A second clamp means is provided for opening and closing the tube, and a third clamp means is provided for opening and closing the tube connecting the blood reservoir and the plasma separator body, and further downstream of the first clamp means. and a fourth clamp means for opening and closing the tube connected to the physiological saline bag on the upstream side of the plasma separator main body, and connected to the blood collection means from the output side of the plasma separator main body. A control device comprising a fifth clamp means for opening and closing the tube. (12) In the apparatus according to claim 11, the clamp means enters the opening defined in the casing of the plasma separator and closes the tube by cooperating with a receiving member formed on the inner wall of the casing. A control device comprising a pressing means. (13) The control device according to claim 11 or 12, wherein the pressing means is displaceable by a solenoid. (14) A control device according to any one of claims 10 to 13, characterized in that the device has means for fixing and holding the plasma separator. (15) The control device according to claim 14, wherein the means for fixing and holding the plasma separator is a fixing cover having at least one elastic member disposed on the surface that contacts the casing.