JPH0288045A - Body fluid pretreating apparatus - Google Patents
Body fluid pretreating apparatusInfo
- Publication number
- JPH0288045A JPH0288045A JP63239644A JP23964488A JPH0288045A JP H0288045 A JPH0288045 A JP H0288045A JP 63239644 A JP63239644 A JP 63239644A JP 23964488 A JP23964488 A JP 23964488A JP H0288045 A JPH0288045 A JP H0288045A
- Authority
- JP
- Japan
- Prior art keywords
- body fluid
- cylindrical container
- blood
- body fluids
- needle part
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001124 body fluid Anatomy 0.000 title claims abstract description 36
- 239000010839 body fluid Substances 0.000 title claims abstract description 36
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 16
- 239000003463 adsorbent Substances 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 238000005070 sampling Methods 0.000 claims abstract 4
- 238000007789 sealing Methods 0.000 claims 2
- 210000004369 blood Anatomy 0.000 abstract description 16
- 239000008280 blood Substances 0.000 abstract description 16
- 239000000126 substance Substances 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 239000000945 filler Substances 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 238000011109 contamination Methods 0.000 abstract description 2
- 125000000524 functional group Chemical group 0.000 abstract description 2
- 229920002379 silicone rubber Polymers 0.000 abstract description 2
- -1 e.g. Substances 0.000 abstract 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003245 coal Substances 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 description 7
- 239000000306 component Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000012266 Needlestick injury Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012611 container material Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- DNTNDFLIKUKKOC-UHFFFAOYSA-N gabexate methanesulfonate Chemical compound CS([O-])(=O)=O.CCOC(=O)C1=CC=C(OC(=O)CCCCCN=C(N)[NH3+])C=C1 DNTNDFLIKUKKOC-UHFFFAOYSA-N 0.000 description 1
- 238000004388 gamma ray sterilization Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
- A61M2005/3109—Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
【発明の詳細な説明】
〈発明の利用分野〉
本発明は医学的な診断のため血液等の体液を前処理する
医療品に関するものであり、さらに詳しくは、体液中の
特定成分を測定するのに共存する分析阻害物質を除去又
は失活させる器具を促供するものである。[Detailed Description of the Invention] <Field of Application of the Invention> The present invention relates to a medical product for pretreating body fluids such as blood for medical diagnosis. The purpose is to provide a device that removes or deactivates analysis-inhibiting substances that coexist with the analyte.
〈従来技術〉
近年診断医学分析の発達にめざましいものがあり特に血
液中の血液成分、薬物、感染菌の測定において分析法１
分析機器の進歩が著しい。<Prior art> In recent years, there has been a remarkable development in diagnostic medical analysis, and analysis method 1 is particularly important for measuring blood components, drugs, and infectious bacteria in blood.
There has been remarkable progress in analytical instruments.
しかし人体から血液を採取して、分析装置で特定成分を
分析する場合、種々の前処理たとえば血球成分の分離９
分析阻害物質の除去、特定Ｉｆ１１漿領域の分取等を行
って、分析装置で測定する場合が多い。この前処理の時
、試料が汚染したり、共存成分が目的成分を時間の経過
と共に消失又は変化させたりして、正しい分析結果が得
られないことがしばしばある。又−旦採取した血液を前
処理にかける操作も繁雑であり、かつ前処理装置自体も
複雑で大きなものとなることが多い。However, when blood is collected from the human body and analyzed for specific components using an analyzer, various pretreatments such as separation of blood cell components are required.
In many cases, analysis-inhibiting substances are removed, a specific If11 plasma region is fractionated, and the results are measured using an analyzer. During this pretreatment, correct analytical results often cannot be obtained because the sample becomes contaminated or the target component disappears or changes with the passage of time due to coexisting components. Furthermore, the operation of subjecting the collected blood to pretreatment is complicated, and the pretreatment device itself is often complex and large.
〈発明の目的〉
本発明者らは、従゛来の血液分析法におけるかかる欠点
を改良することを目的として鋭意研究を行っだ結果、人
体から血液を採取する器具に血液の前処理機能を付与す
ることを見い出し、本発明に到達したものである。<Purpose of the Invention> As a result of intensive research aimed at improving the drawbacks of conventional blood analysis methods, the present inventors have succeeded in adding a blood pretreatment function to an instrument for collecting blood from the human body. This is what we have discovered and arrived at the present invention.
〈発明の構成〉
本発明は、体液前処理剤を収納した筒状容器からなる体
液前処理器であって、該筒状容器の一端には体液採取用
細管が設けられ、該筒状容器の他端には該容器の内壁に
密着しながら往復運動し得るピストン手段が設けられた
体液前処理器である。<Structure of the Invention> The present invention is a body fluid pretreatment device consisting of a cylindrical container containing a body fluid pretreatment agent, in which a thin tube for body fluid collection is provided at one end of the cylindrical container, and a body fluid collection tube is provided at one end of the cylindrical container. The body fluid pretreatment device is provided with a piston means that can reciprocate while being in close contact with the inner wall of the container at the other end.
以下本発明について図面を用いて詳細に説明する。The present invention will be described in detail below with reference to the drawings.
即ち本発明の体液前処理器は図面にその好ましい実施態
様を示す通り、筒状容器３に前処理剤１を収納し、筒状
容器部３の片側に、人体の血管に挿入して血液等の体液
を採取するための細管としての４部４がある。またその
反対側に体液を吸引するための又は押し出すためピスト
ン部６を有する。That is, the body fluid pretreatment device of the present invention, as shown in a preferred embodiment in the drawings, stores a pretreatment agent 1 in a cylindrical container 3, and inserts it into a blood vessel of the human body into one side of the cylindrical container portion 3 to collect blood, etc. There are four parts 4 that serve as tubules for collecting body fluids. It also has a piston part 6 on the opposite side for sucking in or pushing out body fluids.
さらに針部４の先端の汚染、液もれ、破損を防止するた
めカバー７があり、その内部に針の先端がつきささって
密閉を保つような、シリコンゴム等の弾性体８が付与さ
れていれば、上記の機能を達成するうえでさらに望まし
い。又筒状容器３に収納させている前処理充填剤１が針
部４の内部に入りこみ体液の採取が困難になると考えら
せる場合は内管への侵入を防止するため網状物４を取り
つける必要がある。ピストン部６に関しても液。Furthermore, there is a cover 7 to prevent the tip of the needle part 4 from contamination, leakage, and damage, and an elastic body 8 such as silicone rubber is provided inside the cover 7 so that the tip of the needle sticks and maintains a tight seal. It is even more desirable to achieve the above functions. In addition, if the pretreatment filler 1 stored in the cylindrical container 3 enters the inside of the needle part 4 and makes it difficult to collect body fluids, it is necessary to attach a mesh 4 to prevent it from entering the inner tube. There is. The piston part 6 is also liquid.
空気等が摺動部より洩れないように容器内壁に密着が保
たれる構造になっている必要がある。The structure must maintain close contact with the inner wall of the container to prevent air, etc. from leaking through the sliding parts.
本発明の体液前処理器は、人体より直接体液を採取する
とき人体に害がないよう、通常は全体が滅菌されている
必要がある。滅菌は高圧蒸気滅菌。The body fluid pretreatment device of the present invention usually needs to be completely sterilized so as not to cause harm to the human body when body fluid is directly collected from the human body. Sterilization is high pressure steam sterilization.
γ線滅菌等、容器材質、内容物等が変質、劣化しない滅
菌法であればどれでもよい。Any sterilization method such as γ-ray sterilization that does not alter or deteriorate the container material, contents, etc. may be used.
又前処理剤としては、生体成分、薬物等を吸着除去する
活性炭、イオン変換樹脂等の吸着剤が用いられ、必要に
応じてさらに表面に官能基を有し特定の成分と反応結合
する選択吸着剤など目的に応じた充填物が用いられる。In addition, as a pretreatment agent, adsorbents such as activated carbon and ion conversion resins that adsorb and remove biological components, drugs, etc. are used, and if necessary, selective adsorption agents that have functional groups on the surface and react and bond with specific components are used. Fillers such as agents are used depending on the purpose.
また前処理剤の形状は試料のにこり９分析機器へもれ、
注射剤の詰りなど取り扱いのうえで粉状より粒状が好ま
しい。In addition, the shape of the pretreatment agent will prevent the sample from leaking into the analysis equipment.
Granular form is preferable to powder form for handling purposes such as clogging of injections.
ざらに前処理の効果を上げるため、前処理剤の表面半透
膜等を被覆して、除去すべき成分を選択的に吸着等する
ことが望ましい。In order to roughly increase the effect of the pretreatment, it is desirable to coat the surface of the pretreatment agent with a semipermeable membrane or the like to selectively adsorb the components to be removed.
前処理剤以外の内容物としては、前処理剤の効果を高め
るため、即ち体液が前処理剤と接触しやずいように、少
なくとも大部分の前処理剤の表面をぬらす程度の量の液
体が存在することが望ましい。その液体としては、蒸留
水、生理食塩水又は他の溶液がめげられるが、誤って人
体に入った場合でも無害なものが望ましい。As for the contents other than the pretreatment agent, in order to enhance the effect of the pretreatment agent, that is, to prevent body fluids from coming into contact with the pretreatment agent, an amount of liquid that at least wets most of the surface of the pretreatment agent is included. It is desirable to exist. The liquid may be distilled water, saline, or other solutions, but preferably one that is harmless even if it accidentally enters the human body.
本発明における体液には血液の他、腹水等が含まれるが
多くの場合血液をいう。体液が血液の場合には、血液を
採取した際に血液が凝固を起こし、前処理効果が得られ
ない場合は抗凝固剤（ヘパリン、ＰＵＴ、ＦＯＹ、プロ
スタグランジン）を内容物として加えることが望ましい
。In the present invention, body fluid includes ascites and the like in addition to blood, but in many cases refers to blood. If the body fluid is blood, if the blood coagulates when the blood is collected and the pretreatment effect is not obtained, anticoagulants (heparin, PUT, FOY, prostaglandin) may be added as contents. desirable.
〈発明の効果〉 本発明の体液前処理器は、取扱いが簡便で輸送。<Effect of the invention> The body fluid pretreatment device of the present invention is easy to handle and transport.
保管にも便利であり、安全に使用しうるちのであって、
容易に製造することかできる。ざらに迅速に血液等の体
液の前処理が行えるので、例えば培養試験の前に抗生物
質等の分析阻害物質を除去して、分析精度の向上及び迅
速な診断による患者への医学的処置が可能である。It is convenient to store and safe to use,
Can be easily manufactured. Since pretreatment of blood and other body fluids can be carried out very quickly, for example, it is possible to remove analysis-inhibiting substances such as antibiotics before a culture test, improving analysis accuracy and providing medical treatment to patients through rapid diagnosis. It is.
図には、本発明の体液前処理器の好ましい実施態様を、
模式的にその断面図により例示したものである。図中、
１が吸着剤であり、２がヘパリン含有生理食塩水であり
、３が筒状容器であり、４が体液採取用細管であり、６
がピストン手段であり、７がカバー手段であり、８が弾
性物質である。
特許出願人 帝 人 株 式 会 礼The figure shows a preferred embodiment of the body fluid pretreatment device of the present invention,
This is schematically illustrated by a sectional view thereof. In the figure,
1 is an adsorbent, 2 is heparin-containing physiological saline, 3 is a cylindrical container, 4 is a thin tube for body fluid collection, and 6
is a piston means, 7 is a cover means, and 8 is an elastic material. Patent applicant Teijin Ltd.
Claims (3)
処理器であつて、該筒状容器の一端には体液採取用細管
が設けられ、該筒状容器の他端には該容器の内壁に密着
しながら往復運動し得るピストン手段が設けられた体液
前処理器。(1) A body fluid pretreatment device consisting of a cylindrical container containing a body fluid pretreatment agent, wherein one end of the cylindrical container is provided with a thin tube for body fluid collection, and the other end of the cylindrical container is provided with a thin tube for body fluid collection. A body fluid pretreatment device provided with a piston means capable of reciprocating while being in close contact with the inner wall of the body fluid pretreatment device.
、液体と共に該筒状容器内に収納されている請求項１の
体液前処理器。(2) The body fluid pretreatment device according to claim 1, wherein the body fluid pretreatment agent is a granular or fibrous adsorbent and is housed in the cylindrical container together with the liquid.
得る密閉手段を具備した該細管のカバー手段が設けられ
ている請求項１の体液前処理器。(3) The body fluid pretreatment device according to claim 1, further comprising a cover means for the body fluid sampling thin tube, which is provided with a sealing means capable of sealing the tip of the body fluid sampling thin tube before use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63239644A JPH0288045A (en) | 1988-09-27 | 1988-09-27 | Body fluid pretreating apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63239644A JPH0288045A (en) | 1988-09-27 | 1988-09-27 | Body fluid pretreating apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0288045A true JPH0288045A (en) | 1990-03-28 |
Family
ID=17047778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63239644A Pending JPH0288045A (en) | 1988-09-27 | 1988-09-27 | Body fluid pretreating apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0288045A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006518251A (en) * | 2003-02-13 | 2006-08-10 | ベクトン・ディキンソン・アンド・カンパニー | Apparatus for removing components during blood collection and use thereof |
-
1988
- 1988-09-27 JP JP63239644A patent/JPH0288045A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006518251A (en) * | 2003-02-13 | 2006-08-10 | ベクトン・ディキンソン・アンド・カンパニー | Apparatus for removing components during blood collection and use thereof |
| JP2011158480A (en) * | 2003-02-13 | 2011-08-18 | Becton Dickinson & Co | Devices for component removal during blood collection, and uses thereof |
| US8603345B2 (en) | 2003-02-13 | 2013-12-10 | Becton, Dickinson And Company | Devices for component removal during blood collection, and uses thereof |
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