JPH0247443B2 - - Google Patents
Info
- Publication number
- JPH0247443B2 JPH0247443B2 JP57121843A JP12184382A JPH0247443B2 JP H0247443 B2 JPH0247443 B2 JP H0247443B2 JP 57121843 A JP57121843 A JP 57121843A JP 12184382 A JP12184382 A JP 12184382A JP H0247443 B2 JPH0247443 B2 JP H0247443B2
- Authority
- JP
- Japan
- Prior art keywords
- niobium
- composition
- tooth
- cavity
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 claims description 28
- 150000002821 niobium Chemical class 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 6
- AOLPZAHRYHXPLR-UHFFFAOYSA-I pentafluoroniobium Chemical group F[Nb](F)(F)(F)F AOLPZAHRYHXPLR-UHFFFAOYSA-I 0.000 claims description 5
- LDPWMGUFXYRDRG-UHFFFAOYSA-I niobium(5+) pentaacetate Chemical group [Nb+5].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O LDPWMGUFXYRDRG-UHFFFAOYSA-I 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 15
- 208000002925 dental caries Diseases 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- YHBDIEWMOMLKOO-UHFFFAOYSA-I pentachloroniobium Chemical compound Cl[Nb](Cl)(Cl)(Cl)Cl YHBDIEWMOMLKOO-UHFFFAOYSA-I 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- 239000000945 filler Substances 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 239000002344 surface layer Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 210000003298 dental enamel Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000001089 mineralizing effect Effects 0.000 description 3
- 239000010955 niobium Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- -1 Nb(OOCCH 3 ) 5 Chemical class 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011247 coating layer Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 2
- 229960000907 methylthioninium chloride Drugs 0.000 description 2
- IIDYTZRUUWUVQF-UHFFFAOYSA-D niobium(5+) pentasulfate Chemical compound [Nb+5].[Nb+5].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O IIDYTZRUUWUVQF-UHFFFAOYSA-D 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 229910017855 NH 4 F Inorganic materials 0.000 description 1
- 241001460678 Napo <wasp> Species 0.000 description 1
- 229910019800 NbF 5 Inorganic materials 0.000 description 1
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Landscapes
- Dental Preparations (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Description
本発明は、浸食やくさび型欠落あるいは臨床治
療のための切削等によつて露出された窩洞歯質部
分に充填剤を装填して行なう窩洞修復処置に先立
つて使用される予備処理用組成物であつて、前記
歯質露出部分に塗布することによつて不浸透性の
表面積を形成し得る様な組成物に関するものであ
る。
歯科治療においては、う蝕発生部分を機械的手
段によつて切削除去し、該切削部に充填剤を補填
することが多いが、該切削部は健全歯表面層に比
べて水等に対する封鎖性が悪く、充填剤で切削部
を覆うにしても、充填剤と歯牙の隙間から水等が
浸入し切削面にう蝕を再発させることがある。そ
こで従来、充填剤塗布に先立つて切削部歯面に
CaHPO4、Ca3（PO4）2、Ca（OH）2、NaF、
NH4F、SfF2、FeF3、SnF3、NaPO4F等の希釈
溶液からなる硬化用溶液を塗布して、該切削面に
不浸透性の表面層を形成する処置が施されており
相応の効果を発揮しているが、う蝕の再発を完全
に抑制している訳ではない。
本発明はこうした事情に着目してなされたもの
であつて、切削等によつて形成された窩洞に対し
て、いきなり充填剤を装填するのではなく、予め
何らかの薬剤を塗布して不浸透性を示す表面層を
形成し、しかる後充填剤を塗布すればよいとの着
想から、上記不浸透性表面を形成する為の前記薬
剤、即ち予備処置用組成物を提供しようと考え
種々検討の結果本発明に到達した。
即ち本発明の組成物とは、無機及び／又は有機
ニオブ塩を溶媒中に分散させてなる点に要旨を有
するものである。
本発明で使用されるニオブ塩としては、NbF5、
NbCl5、NbOF3・2KF・H2O、F5KNbO、Nb
（NH4）（SO4）2、Nb（NO3）5等の無機ニオブ塩及
びNb（OOCCH3）5等の有機ニオブ塩を挙げること
ができ、これらの１種あるいは２種以上を選択
し、適当な溶媒に分散させることにより本発明の
組成物を得ることができる。上記溶媒としては、
水、エタノール等に代表される親水性溶媒が好適
であるが、これらに限定される訳ではなく、人体
に悪影響を及ぼさず、且つ前記趣旨に適合するも
のであれば、いずれも使用することができる。更
に上記組成物に占るニオブ塩の濃度は、塩の種類
が切削の状況等によつて異なるが、0.001〜20重
量％（以下％という）程度が推奨される。即ち
0.001重量％未満では効果が全く期待されないか
らであり、一方患者が激痛を感ずる様な重症の窩
洞には、比較的高濃度の組成物を必要とするが、
この様な場合でも20％以下であれば十分効果を発
揮することができるからである。
上記の様に定義される本発明の組成物は水溶液
等任意の形態をとることができ、夫々の形態に応
じ種々の基材及び添加剤が利用されるが、例えば
水溶液として提供する場合には、まず始めに例え
ば塩化ニオブの５％エタノール溶液を調製し、予
備処理液（本発明組成物）として用意する。そし
てう蝕患部を切削して窩洞を形成した後、予備処
置液を窩洞に塗布する。所定時間放置した後、窩
洞にボウエン混成型あるいはポリカルボン酸型等
の有機充填物質を補填し形状を整えて処理は完了
する。
以上の様に処理された切削歯においては、予備
処置完了時点の切削歯質表面が、健全歯表面と同
等の不浸透性を示す。尚従来から用いられる鉱化
用溶液を、予備処置液塗布完了後に窩洞に塗布す
ると一層強固な表面層が得られる。又前記ニオブ
塩の内、フツ素を含むニオブ塩は鉱化用溶液とし
ても用いることができるので、窩洞に充填し歯質
を封緘すると共に、被覆層を形成させることもで
きる。
尚本発明組成物は前述の様に窩洞修復の為の予
備処理用以外に自己処理用としても利用できる。
即ち窩洞修復処置とは別に、家庭等において、切
損歯や修復部に本発明組成物を塗布することによ
り、う蝕の発生を防止することができる。この様
な自己処置用としては練歯磨き状とした本発明組
成物が好適であり、前記ニオブ塩の１種以上に、
防腐剤又は抗菌剤、消毒剤、香味剤、表面活性
剤、甘味剤、シツクナー、研磨剤、着色剤及び充
填剤等を配合して自己処置用組成物を調製し、こ
れを日常的に施用すると、切損歯表面の凸凹や歯
質露出部あるいは修復部における充填剤と歯質の
隙間等が埋められて、強固な表面層を形成するこ
とができる。
又本発明組成物は上記以外に例えば幼児等を対
象とするう蝕予備処置剤としても適用することが
できる。即ち従来こうしたう蝕予防処置において
は、フツ化ナトリウム、フツ化第１錫、珪フツ化
ナトリウム等の水溶性フツ化物が用いられていた
が、その効果は未だ十分とは言えない。しかるに
本来予備処理用であるべき本発明組成物をこうし
た用途に用いれば上記フツ化物の場合に比べはる
かに優れたう蝕予防効果を得ることができる。
尚本発明組成物を窩洞修復の為に実用するに当
つては、硬化用溶液と組合せてパツクにしておけ
ば、臨床に当つても簡便に適用することができ
る。即ち該パツクは本発明組成物を第１成分とし
て合成樹脂フイルムからなる袋に封入し、他方別
途硬化用溶液を第２成分として別の袋に封入し、
これらを一体的に単一包装したものである。
本発明は概略以上の様に構成されており、窩洞
修復に際して切削面に塗布することによつて該表
面に強固な不浸透性層を形成するので、修復部分
におけるう蝕の発生・再発を完全に防止すること
ができる。
以下本発明実施例について述べる。
実施例 １
染色浸透実験
0.1％のチモール水溶液中に貯蔵しておいた抜
去臼歯に、歯質に達する深さの円筒状窩洞を２個
穿孔した。窩洞を10％H2O2溶液中で２分間洗浄
し、更に水で洗浄した後、乾燥して対照窩洞（ｎ
＝10）とした。他方同上の処理を施した窩洞につ
いて、PH4.6〜4.8の８％フツ化ニオブ水溶液で処
理を施し空気乾燥し試験窩洞（ｎ＝10）とした。
各窩洞に５％メチレレンブルーを充填し遠心分離
機にかけ3000RPMで10分間遠心回転させた後、
試験歯を窩洞の中心を通る様に分割し断面を写真
撮影した。この写真を標準的投影法により64倍に
拡大し、メチレンブルーの浸透の程度を測面器に
測定したところ、対照窩洞の平均面積（染料浸透
度）が7.968mm2であつのに対し、試験窩洞の平均
面積か1.728mm2であり、歯質の不浸透性が飛躍的
に向上することが確認された。
実施例 ２
抜去臚歯を、10％H2O2水溶液中に２分間浸漬
した後、乾燥し、次いで５％塩化ニオブ水溶液で
処理した。乾燥後、鉱化用溶液を用いて４分間処
理し、乾燥・水洗・乾燥の操作を行ない被験歯と
した。被験歯を電子光学的に拡大して観察したと
ころ緊密な封緘状態の被覆層が確認された。
上記の様にニオブ塩溶液（本発明組成物）を用
いて歯質を処理すると、良好な封緘状態が得られ
るだけでなく、硬化用溶液からなる被覆層の歯面
への接着力も強化されることが分かつた。従つて
上記処理を施した歯質損傷部は優れた不浸透性を
示し、充填物質による影響あるいはう蝕発生菌の
産生する酸による刺撃に対しても抵抗性を有する
ことが明らかとなつた。
実施例 ３
塩化ニオブ(A)、フツ化ニオブ(B)、アンモニア化
硫酸ニオブ(C)の各５％水溶液及び蒸留水(D)を用意
し、夫々に抜去菌エナメル質を２時間浸漬した。
次いでエナメル質表面をパラフインで覆い直径３
mmの露出部を夫々設け、PH4.8の酢酸緩衝液中に
該露出部を夫々１、２及び３時間浸漬し溶解Ca
量を定量したところ第１表並びに第１図に示す結
果が得られた。
The present invention is a pretreatment composition that is used prior to a cavity restoration procedure in which a filling material is loaded into the tooth structure of a cavity exposed due to erosion, wedge-shaped chipping, or cutting for clinical treatment. In particular, the present invention relates to a composition that can form an impermeable surface area by applying it to the exposed tooth area. In dental treatment, caries-infested areas are often removed by mechanical means and fillers are added to the cut areas, but the cut areas have poor sealing properties against water etc. compared to healthy tooth surface layers. Even if the cut area is covered with a filling material, water may enter through the gap between the filling material and the tooth, causing caries to reoccur on the cut surface. Therefore, in the past, prior to applying filler, the tooth surface of the cutting area was
CaHPO4 , Ca3 ( PO4 ) 2 , Ca(OH) 2 , NaF,
A hardening solution consisting of a diluted solution of NH 4 F, SfF 2 , FeF 3 , SnF 3 , NaPO 4 F, etc. is applied to form an impermeable surface layer on the cut surface. However, it does not completely prevent the recurrence of dental caries. The present invention has been made with attention to these circumstances, and instead of suddenly loading a filler into a cavity formed by cutting, etc., it is made by applying some kind of chemical in advance to make it impermeable. Based on the idea that it would be sufficient to form a surface layer showing the above-mentioned properties and then apply a filler, we decided to provide the above-mentioned agent for forming the above-mentioned impermeable surface, that is, a composition for preliminary treatment.As a result of various studies, we have developed this book. invention has been achieved. That is, the composition of the present invention is characterized in that it is formed by dispersing an inorganic and/or organic niobium salt in a solvent. The niobium salts used in the present invention include NbF 5 ,
NbCl 5 , NbOF 3・2KF・H 2 O, F 5 KNbO, Nb
Examples include inorganic niobium salts such as (NH 4 )(SO 4 ) 2 and Nb(NO 3 ) 5 and organic niobium salts such as Nb(OOCCH 3 ) 5 , and one or more of these may be selected. The composition of the present invention can be obtained by dispersing it in a suitable solvent. As the above solvent,
Hydrophilic solvents such as water and ethanol are preferred, but are not limited to these; any solvent can be used as long as it does not have a negative effect on the human body and meets the above objectives. can. Further, the concentration of the niobium salt in the above composition varies depending on the type of salt and cutting conditions, but it is recommended that it be about 0.001 to 20% by weight (hereinafter referred to as %). That is,
This is because if it is less than 0.001% by weight, no effect can be expected; on the other hand, a relatively high concentration of the composition is required for severe cavities where the patient feels severe pain.
This is because even in such a case, a sufficient effect can be achieved if the amount is 20% or less. The composition of the present invention defined above can take any form such as an aqueous solution, and various base materials and additives may be used depending on each form. For example, when provided as an aqueous solution, First, for example, a 5% ethanol solution of niobium chloride is prepared and used as a pretreatment liquid (composition of the present invention). After cutting the caries-affected area to form a cavity, a preliminary treatment solution is applied to the cavity. After leaving it for a predetermined period of time, the cavity is filled with an organic filling material such as a Bowen hybrid type or a polycarboxylic acid type, and the shape is adjusted to complete the process. In the cut tooth treated as described above, the cut tooth surface at the time of completion of the preliminary treatment exhibits impermeability equivalent to that of a healthy tooth surface. If a conventionally used mineralizing solution is applied to the cavity after the application of the pretreatment solution is completed, an even stronger surface layer can be obtained. Among the niobium salts, the niobium salt containing fluorine can also be used as a mineralizing solution, so it can be filled into a cavity to seal the tooth substance and to form a covering layer. The composition of the present invention can be used not only for pretreatment for cavity repair as described above, but also for self-treatment.
That is, apart from the cavity repair treatment, the occurrence of dental caries can be prevented by applying the composition of the present invention to the incised tooth or the repaired area at home or the like. For such self-treatment, a toothpaste-like composition of the present invention is suitable, and one or more of the above niobium salts,
When a self-treatment composition is prepared by adding preservatives or antibacterial agents, disinfectants, flavoring agents, surfactants, sweeteners, thickeners, abrasives, coloring agents, fillers, etc., and applied on a daily basis, It is possible to fill the unevenness on the surface of the cut tooth and the gap between the filling material and the tooth substance in the exposed tooth part or the repaired part, thereby forming a strong surface layer. In addition to the above, the composition of the present invention can also be used as a caries pretreatment agent for infants and the like. That is, in the past, water-soluble fluorides such as sodium fluoride, stannous fluoride, and sodium fluorosilicate have been used in such caries prevention treatments, but their effects are still not sufficient. However, if the composition of the present invention, which should originally be used for pretreatment, is used for such purposes, it is possible to obtain a much superior caries preventive effect compared to the case of the above-mentioned fluoride. When the composition of the present invention is put to practical use for cavity repair, it can be easily applied clinically by combining it with a curing solution and making a pack. That is, the pack is made by enclosing the composition of the present invention as a first component in a bag made of a synthetic resin film, and separately enclosing a curing solution as a second component in another bag,
These are packaged in a single package. The present invention is roughly configured as described above, and when a cavity is repaired, it is applied to the cut surface to form a strong impermeable layer on the surface, thereby completely preventing the occurrence and recurrence of caries in the repaired area. can be prevented. Examples of the present invention will be described below. Example 1 Staining Penetration Experiment Two cylindrical cavities deep enough to reach the tooth structure were drilled into an extracted molar tooth that had been stored in a 0.1% thymol aqueous solution. The cavities were washed in 10% H 2 O 2 solution for 2 min, further washed with water, and then dried to form control cavities (n
= 10). On the other hand, the cavities subjected to the same treatment were treated with an 8% aqueous niobium fluoride solution having a pH of 4.6 to 4.8, and air-dried to form test cavities (n=10).
After filling each cavity with 5% methylene blue and centrifuging at 3000 RPM for 10 minutes,
The test tooth was divided through the center of the cavity and the cross section was photographed. This photograph was magnified 64 times using a standard projection method, and the degree of penetration of methylene blue was measured using a surface measuring instrument. The average area of the teeth was 1.728 mm2 , and it was confirmed that the impermeability of the tooth structure was dramatically improved. Example 2 Extracted teeth were immersed in a 10% H 2 O 2 aqueous solution for 2 minutes, dried, and then treated with a 5% niobium chloride aqueous solution. After drying, the tooth was treated with a mineralizing solution for 4 minutes, and then dried, washed with water, and dried to obtain a test tooth. When the test tooth was observed under electro-optical magnification, a tightly sealed coating layer was confirmed. When the tooth structure is treated with the niobium salt solution (composition of the present invention) as described above, not only a good sealing state is obtained, but also the adhesion of the coating layer made of the curing solution to the tooth surface is strengthened. I found out. Therefore, it has become clear that the damaged tooth tissue treated as described above exhibits excellent impermeability and is resistant to the effects of filling materials and to the impact of acids produced by cariogenic bacteria. . Example 3 5% aqueous solutions of each of niobium chloride (A), niobium fluoride (B), and ammoniated niobium sulfate (C) and distilled water (D) were prepared, and the bacteria-extracted enamel was immersed in each for 2 hours.
Next, cover the enamel surface with paraffin and
An exposed portion of 1 mm was prepared, and the exposed portion was immersed in an acetate buffer solution of PH4.8 for 1, 2, and 3 hours to dissolve dissolved Ca.
When the amount was quantified, the results shown in Table 1 and FIG. 1 were obtained.
【表】
第１表の結果からも明らかな様にニオブ塩に浸
漬することによつて歯エナメル質の耐酸性は飛躍
的に向上し、う蝕発生に対する予防効果が非常に
大きくなつている。
実施例 ４
塩化ニオブ 10.0
酢酸ニオブ 6.0
芳香族組成物類 0.1蒸留水 残部
（％）
全 量 100
上記組成物をう蝕の進行した歯頚部に適用する
ことによつて、患者の痛みをやわらげると共に、
良好な封緘状態を得ることができた。
実施例 ５
塩化ニオブ 5.0
フツ化ニオブ 0.2
エアロジル 3.0
水和された酸化アルミニウム 40.0
石英末 20.0
70％ソルビトール溶液 25.0
グリセロール 6.0
安息香酸ナトリウム 0.3
硫酸ラウリル 0.5
カルボキシセルロース 2.0蒸留水 残部
全 量 100（％）
充填剤を補填した窩洞修復部に、上記組成の練
歯磨剤を通常の歯磨剤と同様の手法に従い適用す
ることにより、修復状態を補完する効果を得るこ
とができる。
実施例 ６
実施例５の練歯磨剤の代わりに下記組成の練歯
磨剤を使用した場合にも実施例５の同様の効果が
得られた。
塩化ニオブ 4.0
酢酸ニオブ 1.5
リン酸カルシウム 40.0
モノフルオロリン酸ナトリウム 0.7
グリセリン 20.0
ソルビトール 10.0
硫酸ラウリルナトリウム 1.5
メチルセルロース 1.0
サツカリン 0.12
メチル−Ｐ−ヒドロキシベンゾエート 0.1
香 料 適量蒸留水 残部
全 量 100（％）[Table] As is clear from the results in Table 1, the acid resistance of tooth enamel is dramatically improved by immersion in niobium salt, and the preventive effect against the occurrence of dental caries is extremely large. Example 4 Niobium chloride 10.0 Niobium acetate 6.0 Aromatic compositions 0.1 Distilled water Balance (%) Total amount 100 By applying the above composition to the tooth neck where caries has progressed, the patient's pain is alleviated, and
A good sealing condition was obtained. Example 5 Niobium chloride 5.0 Niobium fluoride 0.2 Aerosil 3.0 Hydrated aluminum oxide 40.0 Quartz powder 20.0 70% sorbitol solution 25.0 Glycerol 6.0 Sodium benzoate 0.3 Lauryl sulfate 0.5 Carboxycellulose 2.0 Distilled water Remaining total amount 100 (%) Filler By applying a toothpaste having the above-mentioned composition to the repaired cavity in the same manner as a normal toothpaste, it is possible to obtain the effect of supplementing the repaired state. Example 6 The same effects as in Example 5 were obtained when a toothpaste having the following composition was used instead of the toothpaste in Example 5. Niobium chloride 4.0 Niobium acetate 1.5 Calcium phosphate 40.0 Sodium monofluorophosphate 0.7 Glycerin 20.0 Sorbitol 10.0 Sodium lauryl sulfate 1.5 Methylcellulose 1.0 Satucalin 0.12 Methyl-P-hydroxybenzoate 0.1 Flavor Appropriate amount of distilled water Remainder Total amount 100 (%)
第１図は、本発明組成物の耐酸性測定結果を示
すグラフである。
Ａ……塩化ニオブ、Ｂ……フツ化ニオブ、Ｃ…
…アンモニア化硫酸ニオブ、Ｄ……蒸留水。
FIG. 1 is a graph showing the acid resistance measurement results of the composition of the present invention. A... Niobium chloride, B... Niobium fluoride, C...
...ammoniated niobium sulfate, D...distilled water.
Claims (1)
る予備処理用組成物であつて、無機及び／又は有
機ニオブ塩を溶媒中に分散させてなることを特徴
とする窩洞修復のための予備処理用組成物。 ２ 特許請求の範囲第１項において、無機及び／
又は有機ニオブ塩の濃度が0.001〜20重量％であ
る窩洞修復のための予備処理用組成物。 ３ 特許請求の範囲第１又は２項において、ニオ
ブ塩がフツ化ニオブである窩洞修復のための予備
処置用組成物。 ４ 特許請求の範囲第１又は２項において、ニオ
ブ塩が酢酸ニオブである窩洞修復のための予備処
置用組成物。[Scope of Claims] 1. A pretreatment composition used prior to restoration of tooth structure having a cavity, which is characterized by comprising an inorganic and/or organic niobium salt dispersed in a solvent. Preparation composition for restoration. 2 In claim 1, inorganic and/or
Or a pretreatment composition for cavity repair, wherein the concentration of organic niobium salt is 0.001 to 20% by weight. 3. The composition for preliminary treatment for cavity repair according to claim 1 or 2, wherein the niobium salt is niobium fluoride. 4. The pretreatment composition for cavity repair according to claim 1 or 2, wherein the niobium salt is niobium acetate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57121843A JPS5913704A (en) | 1982-07-13 | 1982-07-13 | Pretreatment composition for restoration of dental cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57121843A JPS5913704A (en) | 1982-07-13 | 1982-07-13 | Pretreatment composition for restoration of dental cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5913704A JPS5913704A (en) | 1984-01-24 |
| JPH0247443B2 true JPH0247443B2 (en) | 1990-10-19 |
Family
ID=14821303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57121843A Granted JPS5913704A (en) | 1982-07-13 | 1982-07-13 | Pretreatment composition for restoration of dental cavity |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5913704A (en) |
-
1982
- 1982-07-13 JP JP57121843A patent/JPS5913704A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5913704A (en) | 1984-01-24 |
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