JPH0246615B2 - - Google Patents
Info
- Publication number
- JPH0246615B2 JPH0246615B2 JP57179608A JP17960882A JPH0246615B2 JP H0246615 B2 JPH0246615 B2 JP H0246615B2 JP 57179608 A JP57179608 A JP 57179608A JP 17960882 A JP17960882 A JP 17960882A JP H0246615 B2 JPH0246615 B2 JP H0246615B2
- Authority
- JP
- Japan
- Prior art keywords
- weight
- parts
- ethylene
- copolymer
- vinyl chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 17
- 239000005977 Ethylene Substances 0.000 claims description 17
- 229920000642 polymer Polymers 0.000 claims description 17
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims description 16
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 14
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 12
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 12
- 229920001577 copolymer Polymers 0.000 claims description 12
- 229920001038 ethylene copolymer Polymers 0.000 claims description 10
- 229920001400 block copolymer Polymers 0.000 claims description 9
- 239000011342 resin composition Substances 0.000 claims description 8
- 238000006116 polymerization reaction Methods 0.000 claims description 6
- 125000002897 diene group Chemical group 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 15
- 238000001802 infusion Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000004014 plasticizer Substances 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 3
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 3
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 3
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 3
- 150000001993 dienes Chemical class 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 235000012424 soybean oil Nutrition 0.000 description 3
- 239000003549 soybean oil Substances 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 3
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical group CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- ZFMQKOWCDKKBIF-UHFFFAOYSA-N bis(3,5-difluorophenyl)phosphane Chemical compound FC1=CC(F)=CC(PC=2C=C(F)C=C(F)C=2)=C1 ZFMQKOWCDKKBIF-UHFFFAOYSA-N 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- -1 for example Substances 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 229920001897 terpolymer Polymers 0.000 description 2
- 239000004709 Chlorinated polyethylene Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- XYLMUPLGERFSHI-UHFFFAOYSA-N alpha-Methylstyrene Chemical compound CC(=C)C1=CC=CC=C1 XYLMUPLGERFSHI-UHFFFAOYSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 239000012760 heat stabilizer Substances 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000012785 packaging film Substances 0.000 description 1
- 229920006280 packaging film Polymers 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001084 poly(chloroprene) Polymers 0.000 description 1
- 229920002589 poly(vinylethylene) polymer Polymers 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Description
本発明は医療用樹脂組成物に関し、詳しくは、
透明性、耐熱性、耐候性、低温柔軟性、成型加工
性、シール加工性、耐ブロツキング性に優れたオ
ートクレーブ滅菌可能な医療用樹脂組成物に関す
る。
従来塩化ビニル樹脂系に、ジオクチルフタレー
ト、ジオクチルアジペート等の可塑剤が多量に配
合された組成物が、柔軟でありながら優れた強度
物性を持つため、多くの分野で使用されてきた。
しかしながらこのような組成物は可塑剤が多量
に配合されているため長期間使用する間に、ある
いは、加熱状態で使用する間に可塑剤が移行し、
柔軟性が失われ脆化する欠点を有していた。又、
医療分野等で血液バツグ、輸液バツグ等に使用す
る際には、上記の可塑剤が血液や輸液中に溶出
し、このためこれらの材料を用いて治療を受ける
人達の健康がおびやかされる問題点が存在してい
た。
従来軟質塩化ビニル樹脂の有する上記欠点を解
消するために、例えば塩素ポリエチレンを塩化ビ
ニル樹脂に混合した組成物、エチレン・酢酸ビニ
ル共重合体に塩化ビニルをグラフト共重合させた
樹脂等が採用されてきた。しかしこれらのいずれ
においても透明性、耐熱性の諸性質が充分改善さ
れなかつた。
本発明者らは、上記問題点を解決するため塩化
ビニル、エチレン共重合体からなる塩化ビニル系
樹脂にエチレン・酢酸ビニル・一酸化炭素共重合
体を配合し、更に特定のブロツク共重合体を加え
た系について種々検討を行なつた結果、可塑剤を
加えなくても、柔軟であつて、しかも透明性に優
れ、且つ、耐熱性、耐候性、低温柔軟性に優れた
特性を有し、しかもオートクレーブ滅菌可能な組
成物が得られることを見出し本発明を完成するに
至つた。
本発明の要旨は、
(イ) 重合度が600〜3000で、エチレン含有量２〜
15重量％の塩化ビニル・エチレン共重合体、
(ロ) エチレン・酢酸ビニル・一酸化炭素共重合
体、
(ハ) 式Ａ−Ｂ−Ａで表わされるブロツク共重合体
であつて、Ａはスチレン系重合体、Ｂはジエン
系重合体である共重合体、
上記(イ)、(ロ)、(ハ)を成分とし、上記(イ)100重量
部
に対し上記(ロ)が５〜200重量部含有され、かつ、
上記(イ)及び(ロ)の合計量100重量部に対し上記(ハ)が
15〜150重量部含有されてなるオートクレーブ滅
菌可能な医療用樹脂組成物に存する。
次に本発明医療用樹脂組成物について更に詳細
に説明する。
本発明においては塩化ビニル系樹脂として、重
合度が600〜3000でエチレン含有量２〜15重量％
の塩化ビニル・エチレン共重合体が用いられる。
又、本発明においては、エチレン・酢酸ビニ
ル・一酸化炭素共重合体が用いられるが、この共
重合体としてはエチレン含量が40乃至85重量％、
酢酸ビニル含量が15乃至50重量％、一酸化炭素含
量が５乃至20重量％の範囲のものが好適である。
又、該エチレン・酢酸ビニル・一酸化炭素共重合
体の分子量としては、重量平均分子量が２万乃至
100万のものが好適である。
上記の塩化ビニル・エチレン共重合体及びエチ
レン・酢酸ビニル・一酸化炭素共重合体を混合す
ることにより、柔軟性に富む樹脂組成物が得られ
る。しかし、該組成物においては、高温における
強度低下、低温における柔軟性の低下が大きいと
いう欠点を有している。又、該樹脂組成物より得
られる成形物の表面は粘着性が大きく、自着性が
大きいという欠点を有していた。
本発明者らは、特定のブロツク共重合体が該組
成部に対して極めて優れた相溶性を有し、且つ上
記の問題点がいずれも解消されることを発見し
た。本発明において用いられるブロツク共重合体
としては式Ａ−Ｂ−Ａで示されるものである。こ
の式におけるＡ部分のスチレン系重合体として
は、スチレン、α−メチルスチレン等であり、又
Ｂ部分のジエン系重合体としては、1.4−ポリブ
タジエン、1.2−ポリブタジエン、ポリイソプレ
ン、ポリクロロプレン等のいずれであつてもよ
い。これらのジエン系重合体部分の重量平均分子
量は１万乃至10万の範囲が好適である。スチレン
系重合体はＢ部分の両側につながつて居り、Ａ部
分を形成している。片側のスチレン系重合体の部
分は重量平均分子量２千乃至５万の範囲が好適で
ある。
該ブロツクポリマーにおけるスチレン系重合体
とジエン系重合体との組成比率は重量比率で５対
95乃至30対70の範囲にあることが好適である。
又、該ブロツクポリマー全体としての重合度は
１万乃至50万の範囲にあることが好適である。
上記の塩化ビニル・エチレン共重合体、及びエ
チレン・酢酸ビニル・一酸化炭素共重合体の重量
比率は100対５、乃至、100対200の範囲となされ
る。
該塩化ビニル・エチレン共重合体及びエチレ
ン・酢酸ビニル・一酸化炭素共重合体の混合物
100重量部に対する該ブロツク共重合体の使用量
は15重量部乃至150重量部の範囲となされる。
ブロツクポリマーの上記比率が15重量部より少
いと、ブロツキング性が強くあらわれ、且つ加熱
時における膜強度の低下、形崩れ等が起り易く、
耐熱性の乏しい成形物しか得られない。また該ブ
ロツクポリマーの上記比率が150重量部を越える
と、誘電率の低下にもとづき高周波加工が困難と
なり、又、耐磨耗性が著しく低下する。
上記の塩化ビニル・エチレン共重合体、エチレ
ン・酢酸ビニル・一酸化炭素共重合体及びブロツ
ク共重合体は通常の溶融混練の手段により混合さ
れる。例えばミキシングロール、押出型混練機等
により混練することができる。
本発明組成物の熱安定性を維持するために安定
剤を添加することが好ましい。例えば、ステアリ
ン酸カルシウム、ステアリン酸亜鉛、ステアリン
酸マグネシウム、エポキシ化大豆油、酸化マグネ
シウム等の熱安定剤を使用できる。
又、フエノール系、亜燐酸エステル系の抗酸化
剤を適宜使用することができる。
その他、少量ならば、例えばジオクチルフタレ
ート、ジオクチルアジペート等の可塑剤を添加す
ることができる。
本発明医療用樹脂組成物は透明であり、且つ柔
軟性に優れている。しかも耐熱性が極めて良好で
オートクレーブによる滅菌が可能であるため、従
来使用が困難であつた多くの分野に展開すること
ができる。
特に好適な応用途は、オートクレーブ内に蒸気
滅菌を必要とする医療器材、例えば、血液バツ
グ、輸液バツグ、カテーテル、血液回路、人工心
臓用回路、手術手袋等である。
その他、レザー、食器包装用フイルム、テープ
基材、電線被覆材料、絶縁材料等に使用すること
ができる。
実施例 １
重合度1070、エチレン含量７重量％の塩化ビニ
ル・エチレン共重合体、エチレン、酢酸ビニル・
一酸化炭素三元共重合体（エチレン対酢酸ビニル
対一酸化炭素の組成比率が64対24対12）、及びブ
ロツクポリマーとして式Ａ−Ｂ−ＡにおけるＡ部
分がスチレンポリマー、Ｂ部分がイソプレン重合
体であり、スチレンの重量比率が14％であるブロ
ツク共重合体を用いた。上記塩化ビニル・エチレ
ン共重合体100重量部に対し、上記三元共重合体
を50重量部、及び上記ブロツク共重合体を15重量
部加え、安定剤として、カルシウムステアレート
粉末を0.1重量部、亜鉛ステアレート粉末を0.2重
量部、エポキシ化大豆油を10重量部加えた。
上記混合物をミキシングロールより、ロール温
度150℃で５分間混合し、シートを作成した。こ
のシートを160℃、100Kg／cm2の圧力条件でプレス
しシートを作成した。
第１表の実施例１の欄より明らかなように本発
明による組成物は従来材料と比較して全く遜色の
ない柔軟性を持ち、耐油性や移行性の測定値に見
られるように優れた物性を有し、特に、オートク
レーブ内での蒸気加熱による耐久性が極めて優れ
ていた。実施例１と全く同様の組成比率及び操作
によりプレスシートを作成した。
第１表の実施例１の欄より明らかなように本発
明による組成物は従来材料と比較して、全く孫色
のない透明性及び柔軟性を持ち、耐油性や移行性
の測定値に見られるように優れた物性を有し、特
にオートクレーブ内での蒸気加熱による耐久性が
極めて優れていた。
実施例 ２
実施例１において作成したロールシートを細か
く裁断して角状ペレツトを作成した。このペレツ
トを用いて、厚さ0.45m/mのシートを押出成形
により作成した。このシートを高周波シール加工
により長さ16cm、幅12cmの寸法のバツグを作成し
た。このようにして作成したバツグが輸液用容器
として適するか否かを調べるため以下の試験を実
施した。
該バツグ材料から溶出される成分の分析及び安
全性を知るため日本薬局方「一般試験法」のなか
の輸液用プラスチツク容器試験法に準拠して、溶
出物試験及び溶血性試験を実施した。
また、該バツグがオートクレーブ蒸気加熱に耐
えるか否かを知るため、該バツグ内に生理食塩水
200mlを入れた状態で、オートクレーブに入れ、
121℃で20分間加圧蒸気内で放置した。
以上の結果を第表に示した。第表の結果か
ら明らかなように本発明組成物によつて作製した
バツグは輸液用バツグとして極めて適したもので
あることが明らかとなつた。
比較例
重合度1400のポリ塩化ビニル100重量部に、ジ
オクチルフタレート55重量部を加え、安定剤とし
てカルシウムステアレート粉末0.1重量部、亜鉛
ステアレート粉末0.2重量部、エポキシ化大豆油
10重量部を加えた。
実施例１と同様にしてシートを作成し、各種物
性を測定した結果を表の比較例の欄に示す。
The present invention relates to a medical resin composition, and more specifically,
The present invention relates to an autoclave-sterilizable medical resin composition that has excellent transparency, heat resistance, weather resistance, low-temperature flexibility, moldability, sealability, and blocking resistance. Conventionally, compositions containing a vinyl chloride resin and a large amount of plasticizers such as dioctyl phthalate and dioctyl adipate have been used in many fields because they are flexible but have excellent strength properties. However, since such compositions contain a large amount of plasticizer, the plasticizer migrates during long-term use or when used under heating.
It had the disadvantage of losing flexibility and becoming brittle. or,
When used in blood bags, infusion bags, etc. in the medical field, the above-mentioned plasticizers elute into the blood and infusions, which poses the problem of endangering the health of people receiving treatment using these materials. It existed. In order to eliminate the above-mentioned drawbacks of conventional soft vinyl chloride resins, for example, compositions in which chlorinated polyethylene is mixed with vinyl chloride resin, resins in which vinyl chloride is graft copolymerized with ethylene/vinyl acetate copolymer, etc. have been adopted. Ta. However, in none of these cases were the properties such as transparency and heat resistance sufficiently improved. In order to solve the above problems, the present inventors blended an ethylene/vinyl acetate/carbon monoxide copolymer into a vinyl chloride resin made of a vinyl chloride/ethylene copolymer, and further added a specific block copolymer. As a result of various studies on the added system, we found that it is flexible and has excellent transparency without adding a plasticizer, and has excellent properties in heat resistance, weather resistance, and low temperature flexibility. In addition, they discovered that a composition that can be sterilized in an autoclave was obtained, leading to the completion of the present invention. The gist of the present invention is that (a) the degree of polymerization is 600-3000 and the ethylene content is 2-3000;
15% by weight vinyl chloride/ethylene copolymer, (b) ethylene/vinyl acetate/carbon monoxide copolymer, (c) a block copolymer represented by the formula A-B-A, where A is styrene. A copolymer in which B is a diene-based polymer, the above (a), (b), and (c) are the components, and the above (b) is 5 to 200 parts by weight per 100 parts by weight of the above (a). contains a portion, and
The above (c) is added to the total amount of 100 parts by weight of the above (a) and (b).
The present invention is an autoclave-sterilizable medical resin composition containing 15 to 150 parts by weight. Next, the medical resin composition of the present invention will be explained in more detail. In the present invention, the vinyl chloride resin has a polymerization degree of 600 to 3000 and an ethylene content of 2 to 15% by weight.
A vinyl chloride/ethylene copolymer is used. Further, in the present invention, an ethylene/vinyl acetate/carbon monoxide copolymer is used, and this copolymer has an ethylene content of 40 to 85% by weight,
Preferably, the vinyl acetate content is in the range of 15 to 50% by weight, and the carbon monoxide content is in the range of 5 to 20% by weight.
Furthermore, the molecular weight of the ethylene/vinyl acetate/carbon monoxide copolymer is such that the weight average molecular weight is 20,000 to 20,000.
1 million is preferred. By mixing the vinyl chloride/ethylene copolymer and the ethylene/vinyl acetate/carbon monoxide copolymer described above, a highly flexible resin composition can be obtained. However, this composition has the drawbacks of a large decrease in strength at high temperatures and a large decrease in flexibility at low temperatures. In addition, the surface of the molded product obtained from the resin composition had the disadvantage of being highly adhesive and highly self-adhesive. The present inventors have discovered that a particular block copolymer has extremely good compatibility with the composition, and all of the above problems are solved. The block copolymer used in the present invention is represented by the formula ABA. In this formula, the styrene polymer in the A part is styrene, α-methylstyrene, etc., and the diene polymer in the B part is 1,4-polybutadiene, 1,2-polybutadiene, polyisoprene, polychloroprene, etc. It may be. The weight average molecular weight of these diene polymer portions is preferably in the range of 10,000 to 100,000. The styrenic polymer is connected to both sides of the B section to form the A section. The weight average molecular weight of the styrene polymer portion on one side is preferably in the range of 2,000 to 50,000. The composition ratio of the styrene polymer and diene polymer in the block polymer is 5:5 by weight.
A range of 95 to 30:70 is preferred. Further, the degree of polymerization of the block polymer as a whole is preferably in the range of 10,000 to 500,000. The weight ratio of the vinyl chloride/ethylene copolymer and the ethylene/vinyl acetate/carbon monoxide copolymer is in the range of 100:5 to 100:200. The vinyl chloride/ethylene copolymer and the mixture of ethylene/vinyl acetate/carbon monoxide copolymer
The amount of the block copolymer used per 100 parts by weight is in the range of 15 to 150 parts by weight. If the above ratio of the block polymer is less than 15 parts by weight, blocking properties will appear strongly, and the film will tend to lose its strength and lose its shape during heating.
Only molded products with poor heat resistance can be obtained. If the above ratio of the block polymer exceeds 150 parts by weight, high frequency processing becomes difficult due to a decrease in dielectric constant, and wear resistance is significantly reduced. The above-mentioned vinyl chloride/ethylene copolymer, ethylene/vinyl acetate/carbon monoxide copolymer and block copolymer are mixed by ordinary melt-kneading means. For example, kneading can be performed using a mixing roll, an extrusion type kneader, or the like. It is preferred to add a stabilizer to maintain the thermal stability of the composition of the invention. For example, heat stabilizers such as calcium stearate, zinc stearate, magnesium stearate, epoxidized soybean oil, magnesium oxide, and the like can be used. Furthermore, phenol-based and phosphorous acid ester-based antioxidants can be used as appropriate. In addition, a small amount of plasticizers such as dioctyl phthalate and dioctyl adipate can be added. The medical resin composition of the present invention is transparent and has excellent flexibility. Moreover, it has extremely good heat resistance and can be sterilized by autoclaving, so it can be used in many fields where it has been difficult to use in the past. Particularly suitable applications include medical equipment that requires steam sterilization in an autoclave, such as blood bags, infusion bags, catheters, blood circuits, artificial heart circuits, surgical gloves, and the like. In addition, it can be used for leather, tableware packaging films, tape base materials, wire coating materials, insulating materials, etc. Example 1 Vinyl chloride/ethylene copolymer with polymerization degree of 1070 and ethylene content of 7% by weight, ethylene, vinyl acetate/
Carbon monoxide terpolymer (composition ratio of ethylene to vinyl acetate to carbon monoxide is 64 to 24 to 12), and as a block polymer in the formula A-B-A, the A part is a styrene polymer and the B part is an isoprene polymer. A block copolymer having a styrene weight ratio of 14% was used. To 100 parts by weight of the above vinyl chloride/ethylene copolymer, 50 parts by weight of the above terpolymer and 15 parts by weight of the above block copolymer were added, and 0.1 part by weight of calcium stearate powder was added as a stabilizer. 0.2 parts by weight of zinc stearate powder and 10 parts by weight of epoxidized soybean oil were added. The above mixture was mixed using a mixing roll for 5 minutes at a roll temperature of 150°C to prepare a sheet. This sheet was pressed at 160° C. and a pressure of 100 Kg/cm 2 to produce a sheet. As is clear from the column of Example 1 in Table 1, the composition according to the present invention has flexibility comparable to that of conventional materials, and has excellent oil resistance and migration properties as seen in the measured values. It has excellent physical properties, especially its durability when heated with steam in an autoclave. A press sheet was prepared using the same composition ratio and operation as in Example 1. As is clear from the column of Example 1 in Table 1, the composition according to the present invention has transparency and flexibility with no trace of color, compared to conventional materials, and is seen in the measured values of oil resistance and migration. It had excellent physical properties as shown in Figure 1, and was particularly durable when heated with steam in an autoclave. Example 2 The rolled sheet prepared in Example 1 was cut into small pieces to form square pellets. Using this pellet, a sheet with a thickness of 0.45 m/m was produced by extrusion molding. This sheet was subjected to high-frequency sealing to create a bag with dimensions of 16 cm in length and 12 cm in width. The following test was conducted to determine whether the bag thus prepared was suitable as an infusion container. In order to analyze the components eluted from the bag material and find out its safety, an eluted substance test and a hemolytic test were carried out in accordance with the plastic container test method for infusions in the Japanese Pharmacopoeia's "General Test Methods". Also, in order to know whether the bag can withstand autoclave steam heating, saline solution is added to the bag.
Put 200ml into the autoclave,
It was left in pressurized steam for 20 minutes at 121°C. The above results are shown in Table 1. As is clear from the results in Table 1, the bags prepared using the composition of the present invention are extremely suitable as bags for infusions. Comparative example 55 parts by weight of dioctyl phthalate was added to 100 parts by weight of polyvinyl chloride with a degree of polymerization of 1400, and 0.1 parts by weight of calcium stearate powder, 0.2 parts by weight of zinc stearate powder, and epoxidized soybean oil were added as stabilizers.
10 parts by weight were added. A sheet was prepared in the same manner as in Example 1, and various physical properties were measured. The results are shown in the Comparative Example column of the table.
【表】【table】
【表】【table】
【表】【table】
Claims (1)
２〜15重量％の塩化ビニル・エチレン共重合
体、 (ロ) エチレン・酢酸ビニル・一酸化炭素共重合
体、 (ハ) 式Ａ−Ｂ−Ａで表わされるブロツク共重合体
であつて、Ａはスチレン系重合体、Ｂはジエン
系重合体である共重合体、 上記(イ)、(ロ)、(ハ)を成分とし、上記(イ)100重量
部
に対し上記(ロ)が５〜200重量部含有され、かつ、
上記(イ)及び(ロ)の合計量100重量部に対し上記(ハ)が
15〜150重量部含有されてなるオートクレーブ滅
菌可能な医療用樹脂組成物。[Scope of Claims] 1 (a) A vinyl chloride/ethylene copolymer with a degree of polymerization of 600 to 3,000 and an ethylene content of 2 to 15% by weight, (b) an ethylene/vinyl acetate/carbon monoxide copolymer, (c) A block copolymer represented by the formula A-B-A, where A is a styrene polymer and B is a diene polymer; ), the above (b) is contained in 5 to 200 parts by weight per 100 parts by weight of the above (a), and
The above (c) is added to the total amount of 100 parts by weight of the above (a) and (b).
An autoclave-sterilizable medical resin composition containing 15 to 150 parts by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57179608A JPS5968362A (en) | 1982-10-13 | 1982-10-13 | Thermoplastic resin composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57179608A JPS5968362A (en) | 1982-10-13 | 1982-10-13 | Thermoplastic resin composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5968362A JPS5968362A (en) | 1984-04-18 |
| JPH0246615B2 true JPH0246615B2 (en) | 1990-10-16 |
Family
ID=16068717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57179608A Granted JPS5968362A (en) | 1982-10-13 | 1982-10-13 | Thermoplastic resin composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5968362A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69414212T2 (en) * | 1993-03-01 | 1999-06-02 | Allegiance Corp | GLOVES BASED ON SEQUENTIAL COPOLYMERS |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5181845A (en) * | 1975-01-14 | 1976-07-17 | Chisso Corp | NANNENSEIJUSHISOSEIBUTSU |
-
1982
- 1982-10-13 JP JP57179608A patent/JPS5968362A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5181845A (en) * | 1975-01-14 | 1976-07-17 | Chisso Corp | NANNENSEIJUSHISOSEIBUTSU |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5968362A (en) | 1984-04-18 |
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