JPH02254359A - Production of ion exchange column - Google Patents
Production of ion exchange columnInfo
- Publication number
- JPH02254359A JPH02254359A JP1077876A JP7787689A JPH02254359A JP H02254359 A JPH02254359 A JP H02254359A JP 1077876 A JP1077876 A JP 1077876A JP 7787689 A JP7787689 A JP 7787689A JP H02254359 A JPH02254359 A JP H02254359A
- Authority
- JP
- Japan
- Prior art keywords
- ion exchange
- tube
- exchange resin
- heat
- fibrous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000005342 ion exchange Methods 0.000 title claims description 18
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000003456 ion exchange resin Substances 0.000 claims abstract description 33
- 229920003303 ion-exchange polymer Polymers 0.000 claims abstract description 33
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 238000010438 heat treatment Methods 0.000 claims description 3
- -1 polyethylene Polymers 0.000 description 8
- 239000004698 Polyethylene Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
この発明は、各種イオンの定量分析や、液体クロマトグ
ラフィーや、イオン交換クロマトグラフィー等において
使用するのに適したイオン交換カラムを製造する方法に
関する。Detailed Description of the Invention (Industrial Application Field) The present invention relates to a method for manufacturing an ion exchange column suitable for use in quantitative analysis of various ions, liquid chromatography, ion exchange chromatography, etc. .
（従来の技術）
従来、イオンを定量分析するときに、イオン交換カラム
を用いて目的とするイオンを濃縮することが行われてい
る。(Prior Art) Conventionally, when quantitatively analyzing ions, an ion exchange column has been used to concentrate target ions.
かかる目的に使用するイオン交換カラムとしては、粒状
イオン交換樹脂を充填したものがあるが、粒状イオン交
換樹脂は単位体積当りのイオン交換容量が小さく、濃縮
に時間がかかったり、微量成分の濃縮が正確に行いにく
いといった問題があるため、たとえば特開昭５４−１５
８９９７号公報に記載されるように、繊維状イオン交換
樹脂を使用することが多い。Ion exchange columns used for this purpose include those filled with granular ion exchange resin, but granular ion exchange resin has a small ion exchange capacity per unit volume, takes time to concentrate, and has difficulty concentrating trace components. Because of the problem that it is difficult to do it accurately, for example,
As described in Japanese Patent No. 8997, fibrous ion exchange resins are often used.
そのようなイオン交換カラムは、繊維状イオン交換樹脂
をカラムに充填することによって作られるが、繊維状で
あるために充填むらによる空隙ができやすく、充填量を
一定にするのが極めて難しい。また、繊維状イオン交換
樹脂の固定が難しいために、捕捉したイオンを溶離液で
溶出し、分析するようなときに、溶離液の圧力によって
繊維状イオン交換樹脂が移動し、圧力が変動して分析ピ
ークがシャープにならないといった問題がある。Such an ion exchange column is made by packing a fibrous ion exchange resin into the column, but since it is fibrous, voids are easily formed due to uneven packing, and it is extremely difficult to maintain a constant packing amount. In addition, because it is difficult to fix fibrous ion exchange resin, when the captured ions are eluted with an eluent and analyzed, the fibrous ion exchange resin moves due to the pressure of the eluent, causing the pressure to fluctuate. There is a problem that analysis peaks are not sharp.
（発明が解決しようとする課題）
この発明の目的は、従来の方法の上述した問題点を解決
し、繊維状イオン交換樹脂を、密に、かつ、一定の充填
量で充填できるばかりか、その固定を良好に行うことが
できる、イオン交換カラムの製造方法を提供するにある
。(Problems to be Solved by the Invention) The purpose of the present invention is to solve the above-mentioned problems of the conventional method, and to not only make it possible to fill the fibrous ion exchange resin densely and with a constant filling amount, but also to An object of the present invention is to provide a method for manufacturing an ion exchange column that can perform fixation well.
（課題を解決するための手段）
上記目的を達成するために、この発明は、熱収縮性チュ
ーブに所望量の繊維状イオン交換樹脂を充填した後、上
記チューブを加熱して収縮させることを特徴とする、イ
オン交換カラムの製造方法を提供する。(Means for Solving the Problems) In order to achieve the above object, the present invention is characterized in that after filling a heat-shrinkable tube with a desired amount of fibrous ion exchange resin, the tube is heated to shrink the tube. A method for manufacturing an ion exchange column is provided.
この発明の詳細な説明するに、この発明においては、ま
ず、チューブと、イオン交換樹脂とを用意する。To explain the present invention in detail, first, a tube and an ion exchange resin are prepared.
上記チューブは、１００〜２５０℃程度に加熱すると収
縮する、すなわち、熱収縮性の、たとえばポリエチレン
、ポリ四フッ化エチレン、ポリ塩化ビニル、シリコンゴ
ム等のポリマーからなっている。なかでも、加熱時に、
後述するイオン交換樹脂を変性させたり、使用時に不要
な成分を溶出したりしにくいポリエチレンからなるもの
であるのが好ましい。The tube is made of a heat-shrinkable polymer such as polyethylene, polytetrafluoroethylene, polyvinyl chloride, silicone rubber, etc., which shrinks when heated to about 100 to 250°C. Among them, during heating,
It is preferably made of polyethylene, which does not easily modify the ion exchange resin described below or elute unnecessary components during use.
一方、イオン交換樹脂は、太さが１〜５００ ｐｍ。On the other hand, the thickness of ion exchange resin is 1 to 500 pm.
好ましくは１０〜１００１ｔｍ、長さが０．１〜１０Ｑ
ｍｍ、好ましくは０． ５〜５０ｍｍの繊維状で、ス
チレンとジビニルベンゼンとの共重合体に所望のイオン
交換基を導入したようなものや、アクリル、ポリエチレ
ン、ポリビニルアルコール等の樹脂に所望のイオン交換
基を導入したようなものや、補強用ポリマー、たとえば
ポリエチレンを島成分とし、所望のイオン交換基を導入
したポリマー、たとえばポリスチレンにイオン交換基を
導入したポリマーを海成分とする、いわゆる多芯海島型
複合繊維からなるもの等を使用することができる。イオ
ン交換基としては、スルホン酸基、カルボン酸基、４級
アンモニウム基、１〜３級アミン等がある。Preferably 10-1001tm, length 0.1-10Q
mm, preferably 0. It is a 5-50 mm fibrous material, such as a copolymer of styrene and divinylbenzene with a desired ion exchange group introduced, or a resin such as acrylic, polyethylene, or polyvinyl alcohol with a desired ion exchange group introduced. It consists of a so-called multicore sea-island type composite fiber, in which the island component is a reinforcing polymer, such as polyethylene, and the sea component is a polymer with desired ion exchange groups introduced, such as a polymer with ion exchange groups introduced into polystyrene. You can use things such as Examples of ion exchange groups include sulfonic acid groups, carboxylic acid groups, quaternary ammonium groups, and primary to tertiary amines.
さて、この発明においては、上述したチューブに、一定
長さの上記繊維状イオン交換樹脂を充填する。このとき
、チューブの太さや長さは、充填する繊維状イオン交換
樹脂の量に基いて選定する。Now, in this invention, the above-mentioned tube is filled with the above-mentioned fibrous ion exchange resin of a certain length. At this time, the thickness and length of the tube are selected based on the amount of fibrous ion exchange resin to be filled.
また、繊維状イオン交換樹脂の量は、所望するイオン交
換容量に基いて選定する。Additionally, the amount of fibrous ion exchange resin is selected based on the desired ion exchange capacity.
繊維状イオン交換樹脂は、チューブの長さ方向に引き揃
えて充填しても、ランダムな塊状で充填しても、いずれ
でもよい。なお、充填に際して、繊維状イオン交換樹脂
に水を含浸させると、扱いやすくなるばかりでなく、後
の加熱、収縮時に繊維状イオン交換樹脂に加わる熱を低
減できるようになるので好ましい。The fibrous ion exchange resin may be filled in the tube in a manner that it is aligned in the length direction of the tube, or in the form of random lumps. It is preferable to impregnate the fibrous ion exchange resin with water during filling, as this not only makes it easier to handle, but also reduces the heat applied to the fibrous ion exchange resin during subsequent heating and shrinkage.
次に、繊維状イオン交換樹脂を充填したチューブを加熱
し、熱収縮させる。この熱収縮によって繊維状イオン交
換樹脂間に取り込まれていた空気が追い出され、また、
熱収縮に伴う力によって繊維状イオン交換樹脂の充填密
度が高められるとともに、管内に良好に保持されるよう
になる。熱収縮後、チューブの各端部に連結管を取り付
ければ、分析機器等に装着し得る態様となるが、各端部
に、あらかじめ、多孔板、たとえばポリ四フッ化エチレ
ン製ポーラスフィルタを装着した連結管を内挿しておき
、それから加熱を行うようにすれば、チューブと連結管
との一体化を同時に行うことができるので好ましい。多
孔板の使用は、充填端における繊維状イオン交換樹脂の
くずれや移動をより確実に阻止するうえでも好ましい。Next, the tube filled with the fibrous ion exchange resin is heated to cause it to shrink. Due to this heat contraction, the air trapped between the fibrous ion exchange resins is expelled, and
The force associated with thermal contraction increases the packing density of the fibrous ion exchange resin and allows it to be retained well within the tube. After heat shrinking, if a connecting pipe is attached to each end of the tube, it can be attached to an analytical instrument, etc., but it is necessary to attach a perforated plate, such as a porous filter made of polytetrafluoroethylene, to each end in advance. It is preferable to insert the connecting tube and then heat it, since the tube and the connecting tube can be integrated at the same time. The use of a perforated plate is also preferable in order to more reliably prevent the fibrous ion exchange resin from collapsing or moving at the filling end.
図面は、この方法によって得たイオン交換カラムの一例
を示すもので、熱収縮したチューブ１内に繊維状イオン
交換樹脂２が保持され、また、チューブ１の各端部には
、フィルタ３（３−）を有する連結管４（４−）が、管
１の熱収縮と同時に一体化されている。The drawing shows an example of an ion exchange column obtained by this method, in which a fibrous ion exchange resin 2 is held in a heat-shrinked tube 1, and a filter 3 (3) is provided at each end of the tube 1. A connecting pipe 4 (4-) having a diameter of -) is integrated at the same time as the pipe 1 is thermally shrunk.
（実 施 例）
繊維状イオン交換樹脂として、４級アンモニウム基を交
換基とする、太さ４０μｍ１長さｉｎｍの、東し株式会
社製繊維状イオン交換樹脂ＴｌＮ−２００を用意した。(Example) As a fibrous ion exchange resin, a fibrous ion exchange resin TIN-200 manufactured by Toshi Co., Ltd., having a thickness of 40 μm and a length of inm, which has a quaternary ammonium group as an exchange group, was prepared.
次に、２５ｇの上記繊維状イオン交換樹脂を水に浸した
後、内径３ ｍｍ、長さ３０ｍｍのポリエチレン製チュ
ーブの中央部に充填し、そのチューブの両端に、ポリ四
フッ化エチレン製ポーラスフィルタを装着した、外径２
１Ｉ１１の連結管を挿入し、しかる後ドライヤで加熱し
て上記チューブを熱収縮させ、図面に示すようなイオン
交換カラムを得た。Next, after soaking 25 g of the above fibrous ion exchange resin in water, it was filled in the center of a polyethylene tube with an inner diameter of 3 mm and a length of 30 mm, and porous filters made of polytetrafluoroethylene were attached to both ends of the tube. with outer diameter 2
A 1I11 connecting tube was inserted, and then heated with a dryer to heat shrink the tube to obtain an ion exchange column as shown in the drawing.
（発明の効果）
この発明は、熱収縮性チューブに所望量の繊維状イオン
交換樹脂を充填した後、上記チューブを加熱して熱収縮
させるので、熱収縮に伴う力によって、繊維状イオン交
換樹脂を、密に、かつ、−定の充填量で充填することが
できるばかりか、その固定を良好に行うことができるよ
うになる。(Effects of the Invention) In this invention, after filling a heat-shrinkable tube with a desired amount of fibrous ion-exchange resin, the tube is heated and heat-shrinked, so that the fibrous ion-exchange resin is Not only can it be filled densely and with a constant filling amount, but it can also be fixed well.
図面は、この発明の方法によって得たイオン交換カラム
の一例を示す概略縦断面図である。
１：熱収縮後のチューブ
２：繊維状イオン交換樹脂
３．３′：フィルタ
４．４′：連結管The drawing is a schematic longitudinal sectional view showing an example of an ion exchange column obtained by the method of the present invention. 1: Tube after heat shrinkage 2: Fibrous ion exchange resin 3.3': Filter 4.4': Connecting pipe
Claims (1)
填した後、上記チューブを加熱して収縮させることを特
徴とする、イオン交換カラムの製造方法。A method for producing an ion exchange column, which comprises filling a heat-shrinkable tube with a desired amount of fibrous ion-exchange resin, and then heating and shrinking the tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1077876A JPH0743360B2 (en) | 1989-03-28 | 1989-03-28 | Ion exchange column manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1077876A JPH0743360B2 (en) | 1989-03-28 | 1989-03-28 | Ion exchange column manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02254359A true JPH02254359A (en) | 1990-10-15 |
| JPH0743360B2 JPH0743360B2 (en) | 1995-05-15 |
Family
ID=13646262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1077876A Expired - Lifetime JPH0743360B2 (en) | 1989-03-28 | 1989-03-28 | Ion exchange column manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0743360B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002139484A (en) * | 2000-11-01 | 2002-05-17 | Shinwa Kako Kk | Separating column for chromatography, solid-phase extracting medium, and sample injecting system for chromatography |
| JP2006098396A (en) * | 2004-08-30 | 2006-04-13 | Taiton Kk | Pipette tip and manufacturing method thereof |
| JP2008510142A (en) * | 2004-08-10 | 2008-04-03 | クレムソン ユニヴァーシティー | Monolithic structure containing polymer fibers for chemical separation by liquid chromatography |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54158997A (en) * | 1978-06-05 | 1979-12-15 | Mitsubishi Rayon Co | Ionnexchange chromatographic column and making method thereof |
| JPS624440A (en) * | 1985-07-01 | 1987-01-10 | ピ−ピ−ジ− インダストリ−ズ，インコ−ポレ−テツド | Glass fiber filling reaction vessel and manufacture thereof |
-
1989
- 1989-03-28 JP JP1077876A patent/JPH0743360B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54158997A (en) * | 1978-06-05 | 1979-12-15 | Mitsubishi Rayon Co | Ionnexchange chromatographic column and making method thereof |
| JPS624440A (en) * | 1985-07-01 | 1987-01-10 | ピ−ピ−ジ− インダストリ−ズ，インコ−ポレ−テツド | Glass fiber filling reaction vessel and manufacture thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002139484A (en) * | 2000-11-01 | 2002-05-17 | Shinwa Kako Kk | Separating column for chromatography, solid-phase extracting medium, and sample injecting system for chromatography |
| JP2008510142A (en) * | 2004-08-10 | 2008-04-03 | クレムソン ユニヴァーシティー | Monolithic structure containing polymer fibers for chemical separation by liquid chromatography |
| JP2006098396A (en) * | 2004-08-30 | 2006-04-13 | Taiton Kk | Pipette tip and manufacturing method thereof |
| JP4728739B2 (en) * | 2004-08-30 | 2011-07-20 | ヘラマンタイトン株式会社 | Pipette tip manufacturing method |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0743360B2 (en) | 1995-05-15 |
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