JPH0220607B2 - - Google Patents
Info
- Publication number
- JPH0220607B2 JPH0220607B2 JP58067104A JP6710483A JPH0220607B2 JP H0220607 B2 JPH0220607 B2 JP H0220607B2 JP 58067104 A JP58067104 A JP 58067104A JP 6710483 A JP6710483 A JP 6710483A JP H0220607 B2 JPH0220607 B2 JP H0220607B2
- Authority
- JP
- Japan
- Prior art keywords
- feed
- present
- colistin
- composition
- oraquindocus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 14
- 241001465754 Metazoa Species 0.000 claims description 12
- 108010078777 Colistin Proteins 0.000 claims description 8
- 229960003346 colistin Drugs 0.000 claims description 7
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 claims description 7
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 claims description 7
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 claims description 7
- 230000001737 promoting effect Effects 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000004584 weight gain Effects 0.000 description 4
- 235000019786 weight gain Nutrition 0.000 description 4
- 241000287828 Gallus gallus Species 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 235000013330 chicken meat Nutrition 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000021050 feed intake Nutrition 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 239000005996 Blood meal Substances 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 235000019735 Meat-and-bone meal Nutrition 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- TURHTASYUMWZCC-UHFFFAOYSA-N Olaquindox [BAN:INN] Chemical compound C1=CC=C2N([O-])C(C)=C(C(=O)NCCO)[N+](=O)C2=C1 TURHTASYUMWZCC-UHFFFAOYSA-N 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 235000019764 Soybean Meal Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241001454747 Streptomyces aureus Species 0.000 description 1
- 235000009430 Thespesia populnea Nutrition 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 231100000460 acute oral toxicity Toxicity 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- -1 chalk Substances 0.000 description 1
- 229960001127 colistin sulfate Drugs 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- ZESIAEVDVPWEKB-ORCFLVBFSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O ZESIAEVDVPWEKB-ORCFLVBFSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229950010210 olaquindox Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Fodder In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本発明は動物用発育促進組成物、より詳しくは
一般式（）
（式中R1，R2，R3およびR4は低級アルキル基を
示す。）
で表わされる化合物の一種又は二種以上とオラキ
ンドツクス又はコリスチンを有効成分として含有
する動物用発育促進組成物に関する。
本発明者らは先に前記一般式（）で表わされ
る化合物に動物の発育促進効果のあることを見い
出した（特開昭54−40178）。さらに研究を重ねた
結果、前記一般式（）で表わされる化合物とオ
ラキンドツクス又はコリスチンを同時に動物に投
与すると、それぞれ単独に投与した場合より優れ
た発育促進効果のあることを見い出した。
本発明は上記知見により完成されたものであ
る。
本発明で使用される一般式（）で表わされる
化合物は、例えばスイス化学会誌（Helvetica
Chi−mica Acta）38巻第1445〜1448頁、（1955
年）、同誌45巻第129〜138頁（1962年）、および同
誌45巻、第620〜630ページ（1962年）等に記載さ
れた公知化合物である。代表的化合物を表１に掲
げる。
The present invention relates to a growth promoting composition for animals, more specifically, the general formula () (In the formula, R 1 , R 2 , R 3 and R 4 represent a lower alkyl group.) The present invention relates to an animal growth promoting composition containing one or more compounds represented by the following formula and Oraquindocus or colistin as active ingredients. The present inventors previously discovered that the compound represented by the above general formula () has a growth promoting effect on animals (Japanese Patent Application Laid-open No. 54-40178). As a result of further research, it was discovered that when the compound represented by the above general formula () and olaquindox or colistin were simultaneously administered to animals, a growth promoting effect was superior to when each was administered alone. The present invention has been completed based on the above findings. The compound represented by the general formula () used in the present invention is, for example,
Chi-mica Acta) Vol. 38, pp. 1445-1448, (1955
It is a known compound described in the same magazine, vol. 45, pages 129-138 (1962), and the same magazine, vol. 45, pages 620-630 (1962). Representative compounds are listed in Table 1.
【表】
上記化合物は、急性経口毒性（LD50）がマウ
スでは25000mg／Kg以上、ラツトでは2500mg／Kg
以上、ウズラでは2000mg／Kg以上と極めて低毒性
であるので、安全性の非常に高いものである。
これらの化合物はストレプトマイセス・オウレ
ウス（Streptomyces aureus）（FERM−P233）
を栄養培地に培養することによつて得ることがで
きる。（特公昭49−45597号公報参照）。この方法
によつて得られるものは通常これらの化合物の混
合物であり、培養条件をかえることにより種々の
割合、組成の混合物が得られるが通常約10％のNo.
３の化合物、約40％のNo.４の化合物および約50％
のNo.５の化合物を主成分とする混合物として得ら
れ、このものはポリナクチン複合体（一般名）と
称されている。
又、この化合物は製造方法あるいは精製処理の
相違によつてその理化学的性質がやや異なる種々
の立体異性体と考えられる同一式の物質が認めら
れる場合もあるが、いづれも本発明において区別
されることなく用いることが出来る。
本発明で使用するオラキンドツクスコリスチン
は豚や鶏に対して成長促進効果のあることが知ら
れており、双方とも飼料添加物として市販されて
いる物質である。
本発明の発育促進組成物が対象とする動物とし
ては、例えば、豚、鶏、牛などの家畜類があげら
れる。
本発明組成物は前記一般式（）で表わされる
化合物１部に対し、オラキンドツクス又はコリス
チン50〜0.01部を混合、又はこれらと生理的に無
害な固体又は液体担体混合することによつて、
又、それらを市販の飼料と混合することにより得
ることができる。
本発明の組成物は錠剤、カプセル剤、顆粒剤、
ペレツト巨丸剤などの固体状製剤又は液状製剤な
どの形とした後、又はそのまま動物に投与しても
よい。
ここで用いられる固体担体としては、例えば小
麦粗粉、大豆粗粉、脱脂米糠、タルク、カオリ
ン、白亜、珪藻土等があげられる。このほか必要
に応じて乳化剤、分散剤、懸濁剤、湿潤剤等の補
助剤又は添加剤を使用してもよい。
本発明組成物の動物への投与量は有効成分とし
て例えば0.004〜20mg／Kg／day、好ましくは0.02
〜８mg／Kg／day、さらに好ましくは0.04〜２
mg／Kg／day程度である。
本発明の組成物が飼料である場合、その飼料中
に含有する有効成分の量は0.1〜500ppm、好まし
くは0.5〜200ppm、さらに好ましくは１〜
100ppm程度である。
ここで用いる飼料は市販されている家畜用の飼
料であればいづれでもよく、又トウモロコシ、マ
イロなどの穀類、大豆粕などの食用油粕類、フス
マ、米ヌカなどの糟糠類、コーングルテンミー
ル、澱粉粕、しよう油粕、糖蜜などの製造粕類、
肉骨粉、魚粉、ホエー、脱脂粉乳、血粉、フエザ
ーミール、動物性油脂などの動物質類などの飼料
原料を適当な割合に混合し、さらにミネラル、ビ
タミン、アミノ酸などの飼料添加物を添加して作
つた飼料であつてもよい。
以下、本発明の組成物が優れた効果を有するこ
とを実験例により説明する。
実験例 １
(1) 実験方法
５週令のLH種の子豚を用い、表−２に示さ
れる基礎飼料にポリナクチン複合体とオラキン
ドツクスとからなる組成物（組成比１：１）を
濃度が10ppmとなるように添加した飼料を子豚
に給与（１日３回自由摂取）し、12週間の試験
を行つた。動物数は１群４頭とし、４回くり返
し試験を行つた。体重及び飼料摂取量を２週間
毎に測定し、増体重及び飼料要求率を算出し
た。
なお、ポリナクチン複合体、オラキンドツク
スをそれぞれ10ppm単独添加した飼料及び無添
加の飼料を給与した区を対照とした。[Table] The above compound has an acute oral toxicity (LD 50 ) of 25,000 mg/Kg or more in mice and 2,500 mg/Kg in rats.
As mentioned above, the toxicity to quail is extremely low at 2000 mg/Kg or more, so it is extremely safe. These compounds are found in Streptomyces aureus (FERM-P233)
can be obtained by culturing in a nutrient medium. (Refer to Special Publication No. 49-45597). What is obtained by this method is usually a mixture of these compounds, and mixtures with various proportions and compositions can be obtained by changing the culture conditions, but usually about 10% No.
No. 3 compound, about 40% No. 4 compound and about 50%
It is obtained as a mixture containing compound No. 5 as the main component, and this mixture is called polynactin complex (common name). Furthermore, due to differences in the manufacturing method or purification process, substances with the same formula that are considered to be various stereoisomers with slightly different physical and chemical properties may be recognized, but these are distinguished in the present invention. It can be used without any trouble. Oraquindocus colistin used in the present invention is known to have a growth promoting effect on pigs and chickens, and both are commercially available as feed additives. Examples of animals targeted by the growth promoting composition of the present invention include livestock such as pigs, chickens, and cows. The composition of the present invention can be prepared by mixing 50 to 0.01 parts of Orakindox or colistin with 1 part of the compound represented by the general formula (), or by mixing these with a physiologically harmless solid or liquid carrier.
They can also be obtained by mixing them with commercially available feed. The composition of the present invention includes tablets, capsules, granules,
It may be administered to animals after being formed into a solid preparation such as a pellet pellet or a liquid preparation, or as it is. Examples of the solid carrier used here include wheat flour, soybean flour, defatted rice bran, talc, kaolin, chalk, diatomaceous earth, and the like. In addition, auxiliary agents or additives such as emulsifiers, dispersants, suspending agents, and wetting agents may be used as necessary. The dose of the composition of the present invention to be administered to animals is, for example, 0.004 to 20 mg/Kg/day, preferably 0.02 mg/Kg/day as the active ingredient.
~8mg/Kg/day, more preferably 0.04~2
It is about mg/Kg/day. When the composition of the present invention is a feed, the amount of the active ingredient contained in the feed is 0.1 to 500 ppm, preferably 0.5 to 200 ppm, more preferably 1 to 500 ppm.
It is about 100ppm. The feed used here may be any commercially available feed for livestock, including grains such as corn and milo, edible oil meal such as soybean meal, bran such as bran and rice bran, corn gluten meal, and starch. Manufacturing lees such as lees, soybean oil lees, and molasses,
It is made by mixing feed ingredients such as meat and bone meal, fish meal, whey, skimmed milk powder, blood meal, feather meal, animal substances such as animal fats and oils in appropriate proportions, and then adding feed additives such as minerals, vitamins, and amino acids. It may also be ivy feed. The excellent effects of the composition of the present invention will be explained below using experimental examples. Experimental example 1 (1) Experimental method Using 5-week-old LH piglets, a composition consisting of polynactin complex and oraquindocus (composition ratio 1:1) was added to the basal feed shown in Table 2 at a concentration of 10 ppm. A 12-week study was conducted by feeding piglets with feed supplemented with the following values (ad libitum three times a day). The number of animals was 4 per group, and the test was repeated 4 times. Body weight and feed intake were measured every two weeks, and weight gain and feed conversion rate were calculated. In addition, control groups were fed feed containing 10 ppm of polynactin complex and Oraquindocus alone, and feed containing no additives.
【表】 (2) 結果 結果を表−３に示す。【table】 (2) Results The results are shown in Table-3.
【表】
この表から明らかなようにポリナクチン複合
体：オラキンドツクスをそれぞれ単独添加した
区では10％程度の増体効果を示し、又、飼料要
求率も95前後であるに対し、双方を併用した区
では30％もの増体効果を示し、又、飼料要求率
も89と大巾に改善されており、優れた成績を示
した。
実験例 ２
(1) 実験方法
生後５日令のハバート種雛を用い、表−４に
示される基礎飼料にポリナクチン複合体とオラ
キンドツクス又はコリスチンをそれぞれ濃度
5ppm総量10ppmとなるように添加した飼料を
鶏に給与し、８週間の試験を行つた。動物数は
１群20羽で、４回くり返し試験を行つた。体重
及び飼料摂取量を２週間毎に測定し増体重及び
飼料要求率を算出した。
なお、ポリナクチン複合体、オラキンドツク
ス、コリスチンをそれぞれ10ppm添加した飼料
及び無添加の飼料を給与した区を対照とした。[Table] As is clear from this table, the group in which polynactin complex and oraquindocus were added alone showed a weight gain effect of about 10%, and the feed conversion ratio was around 95, whereas the group in which both were added together showed a weight gain effect of about 10%. showed excellent results, with a 30% increase in body weight and a greatly improved feed conversion rate of 89. Experimental example 2 (1) Experimental method Using 5-day-old Hubbart chicks, the concentrations of polynactin complex and Oraquindocus or colistin were added to the basal feed shown in Table 4.
Chickens were fed feed containing 5 ppm and 10 ppm in total, and an 8-week test was conducted. The number of animals was 20 per group, and the test was repeated four times. Body weight and feed intake were measured every two weeks, and weight gain and feed conversion rate were calculated. In addition, the control groups were fed feed containing 10 ppm each of polynactin complex, oraquindocus, and colistin, and feed containing no additives.
【表】【table】
【表】 (2) 結果 結果を表−５に示す。【table】 (2) Results The results are shown in Table-5.
【表】
この表から明らかなようにポリナクチン複合体
と硫酸コリスチン又はオラキンドツクスと併用し
た区はそれぞれ単味区より優れた発育効果を示し
た。[Table] As is clear from this table, the combination of polynactin complex and colistin sulfate or Oraquindocus showed better growth effects than the single treatment.
Claims (1)
示す。） で表わされる化合物の一種又は二種以上とオラキ
ンドツクス又はコリスチンを有効成分とする動物
用発育促進組成物。[Claims] 1. General formula (In the formula, R 1 , R 2 , R 3 and R 4 represent a lower alkyl group.) An animal growth promoting composition containing one or more compounds represented by the following and Oraquindox or colistin as active ingredients.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58067104A JPS59193823A (en) | 1983-04-18 | 1983-04-18 | Growth promoting composition for animal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58067104A JPS59193823A (en) | 1983-04-18 | 1983-04-18 | Growth promoting composition for animal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59193823A JPS59193823A (en) | 1984-11-02 |
| JPH0220607B2 true JPH0220607B2 (en) | 1990-05-10 |
Family
ID=13335247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58067104A Granted JPS59193823A (en) | 1983-04-18 | 1983-04-18 | Growth promoting composition for animal |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59193823A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2652486B1 (en) * | 1989-10-04 | 1993-05-14 | Dievet Sa | PROCESS FOR THE PREPARATION OF FEED FOR CATTLE AVOIDING THE DEGRADATION OF AMINO ACIDS IN THE RUMEN. |
| CN102960558A (en) * | 2012-11-21 | 2013-03-13 | 江苏华威农牧发展有限公司 | Suhuai pig piglet feed and preparation method thereof |
| CN103494007B (en) * | 2013-08-27 | 2015-12-23 | 安徽省瑞森生物科技有限责任公司 | A kind of anti diar rhea pig starter feed and preparation method thereof |
-
1983
- 1983-04-18 JP JP58067104A patent/JPS59193823A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59193823A (en) | 1984-11-02 |
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