JPH02200626A - Aerosol-fed article - Google Patents

Abstract

PURPOSE: To obtain an aerosol-supplying device to supply a seasoning agent or a drug by a non-combustion low-temperature heat source generated by the exothermic reaction of chemical reagents. CONSTITUTION: This aerosol-supplying device is composed of (A) a seasoning agent or a drug and (B) a non-combustion heat source for the heating of the seasoning agent or the drug, physically separated from the seasoning agent or the drug and containing the 1st agent (e.g. Mg or Al) causing exothermic reaction with a 2nd agent (e.g. water), a 3rd agent (e.g. NaOH) causing exothermic reaction with the 1st agent and a dispersing agent (e.g. NaCl) for the 1st agent. At least a part of the seasoning agent or the drug is heated up to 70-350 deg.C by the heat source within 20sec after starting the exothermic reaction. The heat source preferably further contain a phase-changing agent or a heat- exchanging agent. The dispersing agent and the phase-changing agent are solid under normal condition.

Description

DETAILED DESCRIPTION OF THE INVENTION 1. Field of the Invention The present invention relates to an aerosol delivery article with a heat source of a subjectively low temperature for volatilization to deliver a flavor or drug (medicinal substance).

Juzu Xiafeng I Various types of smoking articles, flavor generators or medicinal inhalers that utilize various forms of energy as a means of volatilizing or heating volatile substances for delivery to the user's mouth. Conventional devices have been proposed.

For example, U.S. Patent No. 3,258,015 and Australian Patent No. 276.250 disclose the use of shredded or shredded tobacco and combustible materials such as ground aluminum hydride, hydrogen borohydride, calcium oxide or activated molecular sieves. Smoking articles mixed with When you inhale this,
One end is immersed in water, and the reaction between the water and the combustible substance generates heat. This heat heats the tobacco to 200 to 400 degrees Celsius.
It is said that volatile substances are released from the tobacco by heating it to a temperature of . Australian Patent No. 276.25
No. 0 also proposes an aerosol delivery article in which shredded or shredded tobacco is separated from an encapsulated combustible material such as fine metal particles. When this article is inhaled, it generates heat by breaking the seal on the metal particles and exposing them to the air. The heat is said to heat the tobacco to a temperature of 200-400°C, causing the tobacco to release aerosol-forming substances.

PCT Patent Application Publication No. WO36702528 also proposes a smoking article similar to that of the above-mentioned US Pat. No. 3,258,015. This smoking article has a shape similar to a cigarette holder, in which a cigarette without a mouthpiece made of tobacco material treated with an aqueous solution of sodium carbonate is inserted into the holder, and a heating coil in the holder is energized by a battery to heat the cigarette. is generated, thereby heating the tobacco material. The air drawn through the cigarette is heated to a temperature lower than the combustion temperature of the tobacco material, which is said to cause the tobacco material to release tobacco flavor. This patent also proposes another heat source that generates heat by mixing two liquids.

However, despite decades of interest and research, each of the non-combustible smoking articles mentioned above...
None of them achieved substantial commercial success and
It was never sold to the public. Additionally, the non-combustible smoking articles described above are unable to deliver sufficient aerosol to the inhaler.

The problem that Ming attempts to solve is therefore to utilize non-combustion energy and at least six to one
There is a need for an aerosol delivery article that can deliver a sufficient amount of a pleasant flavor or drug to a user in aerosol form over an o-puff. The present invention aims to satisfy such demands.

SUMMARY OF THE INVENTION To solve the above problems, the present invention provides an aerosol (flavor or drug) that uses a non-combustion heat source to heat the flavor or drug so that it can be delivered to the user. ) provide the goods to be sent; The aerosol delivery article of the present invention volatilizes a controlled amount of a flavorant or drug that is substantially volatile under ambient conditions, and the volatilized flavorant or drug does not need to be received during the useful life of the aerosol delivery article. It is possible to feed almost uniformly from 6 to 1 o puffs for each puff. A "puff" is a puff of tobacco.

More particularly, the present invention provides an aerosol delivery article having a non-combustion low temperature heat source that generates heat as a result of exothermic interactions or reactions between chemical agents. The flavoring agent or drug (which may be carried on the substrate) is physically separate from, and placed in a heat exchange relationship with, the heat source.

Here, "physically separate" means that the flavor or drug for delivery in aerosol form is not mixed with the heat source;
Alternatively, it means that it does not form part of the heat source.

The heat source includes at least one chemical agent capable of exothermically reacting when in contact with the second chemical agent (eg, water) and/or when suitably activated. Preferably, the heat source includes one or more chemical agents capable of reacting with the second chemical agent. Preferably, the chemicals also do not require ambient (ie, atmospheric) oxygen to generate heat.

These chemical agents (hereinafter simply referred to as "agents") can be incorporated or introduced into the heat source in a variety of ways. For example, the agents can be mixed together so that when a catalyst or initiator is introduced thereto, an exothermic reaction between the agents is initiated. Alternatively, different types of agents can be incorporated physically separately from each other within the heat source, such that exothermic reactions occur by initiating contact between the agents. . Alternatively, the agent within the heat source may include a second agent to initiate heat generation.

The heat source typically also includes (i) a dispersing agent to reduce the concentration of the chemical agent and control (i.e., limit) the reaction rate of the agent; Includes phase change agents that undergo a reversible phase change and return again to absorb heat emitted by a chemical reaction and then release that heat in the later stages of heat generation.Such dispersants and/or phase change agents (i) act to lower the maximum temperature of the heat source and flavor or drug; (ii) absorb heat in the case of dispersants, by limiting the reaction rate of chemical agents, and in the case of phase change agents; It works to extend the life of the heat source by emitting heat.

Preferred as the heat source are mixtures of solid components that generate the desired heat by interaction or reaction with a liquid such as water. For example, a solid mixture of calcium oxide, anhydrous magnesium sulfate, malic acid, glucose, and sodium chloride generates heat when in contact with water. Heat is generated by the hydration of anhydrous magnesium sulfate and the reaction of water and calcium oxide using malic acid as a catalyst to produce calcium hydroxide. When this exothermic chemical reaction occurs, the glucose undergoes a phase change from solid to liquid, thereby absorbing thermal energy. This absorbed thermal energy is then
The heat generated by the chemical reaction is reduced and released as the glucose solidifies again. Sodium chloride is used as a dispersant in an amount sufficient to disperse the components or chemicals of the heat source and control the reaction of those components over time.

Another preferred heat source is a mixture of ground aluminum metal and granulated sodium nitrite.

Heat is generated when this mixture is brought into contact with an aqueous solution of sodium hydroxide. In this case, heat is generated by the reaction of aluminum aluminum metal with sodium hydroxide and water to form sodium aluminate and hydrogen. Sodium nitrite reacts with hydrogen to regenerate water and sodium hydroxide. Thus, a controlled generation of heat over a period of time is obtained as the reactants for the exothermic reaction with the aluminum metal are regenerated.

Preferably, the heat source generates a relatively large amount of heat to rapidly heat at least a portion of the flavorant or drug to a temperature sufficient to volatilize the flavorant or drug. For example, a heat source that can heat at least a portion of the flavorant or drug to a temperature above about 70°C within 20 seconds of activation (initiation of an exothermic reaction) is preferred. It is also preferred to use a heat source that avoids excessive heating of the flavorant or drug and maintains the flavorant or drug within the desired temperature for about 4 to about 8 minutes. For example, the flavor or drug of the aerosol delivery article of the present invention preferably does not exceed 350°C, more preferably does not exceed 200°C during its useful life. It is highly preferred that during the useful life of the aerosol delivery article (ie, during inhalation) the heat source heats the flavorant or drug contained therein to a temperature range of about 70 to about 180<0>C.

Flavoring agents or drugs are usually supported on substrates that are porous or fibrous, or have a large surface area.

Typically, such substrates will readily carry the flavoring agent or drug prior to use of the aerosol delivery article, but will readily volatilize the flavoring agent or drug at the temperatures generated by the heat source in use. Use as base material.

To use the aerosol delivery article of the present invention, the inhaler initiates an interaction or reaction between the components (chemical agents) of the heat source, thereby generating heat. The reaction between the components of the heat source provides sufficient heat to heat the flavorant or drug, causing it to volatilize from the substrate. When an inhaler inhales the aerosol delivery article, the volatile components are drawn through the aerosol delivery article and into the inhaler's mouth.

Figure 1 shows an aerosol delivery article 10 according to one embodiment of the present invention. Aerosol delivery article 10 has the shape of an elongated cylindrical rod. Typically, the length of the aerosol delivery article is about 70 to about 120 mm, and its circumference is about 22 to about
It is approximately 30mm.

Aerosol delivery article 10 includes an outer member 13 that functions as a wrap and also has insulating properties.

As shown in FIG. 1, the outer member 13 is made of a sheet of polystyrene foam, foil-lined paperboard, etc.
It may be a layer of insulating material. Alternatively, the outer member 13 may be a paper wrap, or such a paper wrap may be further coated with a heat insulating member (not shown).

A flavor or drug carrying substrate 16 is inserted within the outer member 13 and extends along a portion of the longitudinal axis of the aerosol delivery article 10 . This flavor agent or drug-carrying base material 16 can be in various forms, but
It is preferred to have a large surface area to maximize contact with the passing suction air. As in the illustrated example, the carrier substrate 16 may be an air-permeable fabric, and such fabric may be provided with multiple air passageways.

The substrate 16 is inserted into a first cylindrical container 26, which can be made of a heat-resistant thermoplastic material, metal, or the like. Surrounding the first cylindrical container 26 and optionally an aerosol delivery article 1
A second cylindrical container 30 is provided that surrounds the entire length of the container. The second cylindrical container 30 may be formed of a heat resistant thermoplastic material, foil lined paperboard, or the like. A barrier or air seal 33 is provided within the annular space between the tubular containers 26 and 30 at the mouth end of the tubular container 26 . Barrier 3
3 is for sealing the annular space between the containers 26 and 30 to prevent air from flowing. The barrier 33 is
It can be made of thermoplastic material or the like and can be held between the containers by an interference fit, adhesive or other means.

A heat source 35, which will be described in detail later, is disposed within the annular space between the cylindrical containers 26 and 30. An air permeable plug 38 is fitted between the cylindrical containers 26 and 30 on the distal end opposite the mouth end of the aerosol delivery article. The plug 38 is
It serves to maintain the heat source 35 in a desired position around the substrate 16. Plug 38 may be formed from a fibrous material such as plasticized cellulose acetate or a resilient open cell foam material. The aerosol delivery article 10 has a mouth end portion 4
0, and the mouth end portion 40 may be provided with a filter element 43 or a suitable mouth end member constituting a means for delivering a flavor or drug flavor to the mouth of the inhaler. Filter element 43 can take a variety of forms and can be made from cellulose acetate tow, gathered polypropylene webs, molded polypropylene, and the like. This filter element 43 is provided for the purpose of improving the appearance, and usually has low filtration efficiency. For example, the filter element 43 can be shaped as shown in FIG. 1 with baffle walls to control fluid flow, and can be manufactured by molding. especially,
It is desirable to increase the amount of flavor or drug volatile components that pass into the inhaler's mouth and reduce the amount of flavor or drug volatile components that are captured by the filter element. Aerosol delivery article 10 has an air inlet portion 46 opposite mouth end portion 40 for introducing suction air.

FIG. 2 shows an aerosol delivery article 10 according to another embodiment of the invention. The aerosol delivery article 10 has a flavor or drug rod carrying substrate 16 surrounded by a cylindrical outer wrap 13, such as a cigarette wrapper. Within the flavor or drug carrying substrate 16 is a heat resistant cartridge 50 having an open end 52 on the air inlet portion 46 side of the aerosol delivery article and a sealed end 54 on the mouth end side of the aerosol delivery article. Insert. Cartridge 50 is preferably constructed from a thermally conductive material such as aluminum or other metal material.

A heat source 35, which will be described in detail later, is inserted into the cartridge 50. Heat source 35 is retained within cartridge 50 by an air permeable plug 38, such as cellulose acetate. Heat source 35 is embedded within substrate 16, but the flavor or drug component and the heat source components are physically separate from each other. heat source 3
The length of the rod (i.e., the length of the base material 16) in which 5 is embedded is about 50 to about 90 mm, and its circumference is about 22 mm.
~about 30 mm.

A filter element 43 is attached to the rod in axial alignment and abutting relationship. The filter element and rod are connected using tipping paper 58. For that purpose, the filter element and a portion of the rod adjacent to it are usually wrapped with tipping paper coated with adhesive on the inside surface.

In use, the inhaler initiates an exothermic reaction in the heat source to generate heat from the heat source. For example, injecting volumes of water into the heat source can cause an exothermic reaction between the water and certain components of the heat source.

The resulting heat heats a flavoring agent or drug that is physically separate from the heat source but is placed in close proximity to the heat source in a heat exchange relationship with the heat source, thereby heating the flavoring agent or drug, thereby creating a flavor profile. volatilizes the components of the agent or drug. The material thus volatilized is drawn into the mouth end of the aerosol delivery article and into the mouth of the inhaler. The heat source of the present invention provides sufficient heat to maintain the temperature of the flavorant or drug and its substrate within a desired temperature range and to volatilize the components of the flavorant or drug. Once the heat generation has ceased, the substrate carrying the flavorant or drug begins to cool and the amount of volatilization of that ingredient decreases. Once inhalation is complete, the aerosol delivery article may be thrown away or otherwise disposed of.

The heat source of the aerosol delivery article of the present invention generates heat not as a result of combustion of its components, but as a result of one or more chemical reactions between its components. "Combustion" here refers to a reaction in which a substance oxidizes and generates heat and carbon oxides. Additionally, the preferred non-combustion heat source of the aerosol delivery articles of the present invention provides a method for providing heat between its components without requiring the presence of gaseous oxygen or ambient oxygen (i.e., in the absence of ambient oxygen). heat is generated as a result of one or more chemical reactions.

Preferred heat sources of the present invention generate heat as soon as their components are activated. Thus, as soon as an inhaler begins inhaling an aerosol delivery article, the heat generated will disintegrate the flavor or drug and its carrier substrate to an extent sufficient to volatilize the appropriate amount of components of the flavor or drug. Heat.

This rapid heat generation allows a sufficient amount of volatile flavor or drug to be delivered even in the first few puffs of the aerosol delivery article. Typically, the heat source of the present invention will be used for 20 minutes from the time the inhaler begins using the aerosol delivery article.
The exothermically reactive component shall be included in an amount sufficient to heat at least a portion of the flavor or drug component to a temperature in excess of about 70°C, preferably 80°C, within seconds.

It is also preferred that the heat source of the present invention generates sufficient heat to maintain the flavor or drug within a desired temperature range during the useful life of the aerosol delivery article. For example, the heat source of the present invention desirably heats at least a portion of the flavor or drug to a temperature above about 70° C. quickly after the inhaler begins using the aerosol delivery article as described above; It is also desirable to limit the temperature of heat experienced by the flavor or drug to less than about 350<0>C, preferably less than about 200<0>C, during the 4-8 minute lifespan of the aerosol delivery article. That is, once the heat source has rapidly generated enough heat to heat the flavorant or drug to the desired minimum temperature, it can then heat the flavorant or drug to a relatively narrow, well-controlled It only needs to generate enough heat to maintain the temperature within the range.

For the aerosol delivery articles of the present invention, the temperature range of heat experienced by the flavorant or drug during its 4-8 minute lifetime is typically from about 70 to about 180°C, preferably from about 80 to about 140°C.
℃. Thus, it is desirable to control the maximum temperature of the heat generated by the heat source in order to avoid thermal degradation and/or excessive premature volatilization of the flavor or drug components.

The heat source includes components that react exothermically with each other when in contact with each other or when suitably activated. The components may be in physical contact (i.e., mixed) with each other;
The exothermic reaction can be initiated by heat or by contact with a catalyst or initiator or the like. Alternatively, the components may be physically separated from each other and the exothermic reaction initiated by contacting the components, often in the presence of a suitable catalyst or initiator. You can also do that.

Particularly preferred reactants (also referred to as "chemical agents", "reactive components" or simply "agents" or "component j") are agents that can react exothermically with water. Examples of such reactants constituting the heat source include:
There are metal oxides that react with water to generate heat and metal hydroxides.

Suitable metal oxides are calcium oxide, magnesium oxide, sodium oxide, and mixtures thereof. Other reactants include calcium hydride, calcium nitride, magnesium nitride, phosphorous pentoxide, and the like. These can be used in small amounts with metal oxides to promote rapid initial generation of heat, although metal oxides are not preferred.

Another highly preferred reactant is an exothermic agent that is easily hydrated by water. Examples of such reactants are anhydrous metal sulfates such as magnesium sulfate, aluminum sulfate, ferric chloride, magnesium chloride, and mixtures thereof. Other similar reagents will be apparent to those skilled in the art.

The water reacts with the components of the preferred heat source as described above to generate heat. Under certain circumstances, other liquids may also be used, such as lower alcohols (eg, ethanol) and polyhydroxy alcohols (eg, glycerin), and their mixtures with water. Contacting the water with the other reactants of the heat source can be done in a variety of ways.

For example, water may be injected into the heat source when it is desired to activate the heat source. Alternatively, the water may be contained in a separate container (e.g., a breakable capsule or microcapsule) from the other components of the heat source, and the container may be ruptured to release the water when the aerosol delivery article is used. . Alternatively, a porous wick member may be used to proportion water to the other components of the heat source. Alternatively, the water can be supplied by a normally solid fully hydrated salt (for example crystals of potassium aluminum sulfate dodecahydrate) mixed with a metal oxide.

In that case, if heat is applied to the heat source, for example using a lighter, the heat will initiate the dissociation of water from the hydrated salt, releasing water.

Catalysts or initiators can also be used in addition to or in addition to water to catalyze or initiate chemical reactions of exothermically reacting components. For example, an organic acid such as malic acid, palmitic acid, boric acid, etc. can be mixed with water and/or calcium oxide in an amount sufficient to catalyze an exothermic reaction in which the calcium oxide reacts to form calcium hydroxide. . The catalyst or initiator is preferably solid when mixed with the solid component of the heat source.

The heat source also includes a dispersant to physically separate each reactant, especially if at least one of the reactants is solid. Preferably, the dispersant is substantially inert to exothermically reacting components. The dispersant is normally used to (i) maintain the reaction components separated from each other, and (ii) facilitate the escape of gases such as water vapor from the heat source during the heat generation period of the heat source. It is preferable to use it in the form of solid granules. Examples of dispersants include inorganic salts such as sodium chloride, potassium chloride, anhydrous sodium sulfate,
Examples include inorganic materials such as finely ground alumina or silica, and carbonaceous materials such as finely ground graphite, activated carbon, and powdered charcoal. Generally, normally solid dispersants come in a variety of particle sizes ranging from fine powders to coarse particles, and the particle size of the dispersant influences the rate of reaction of the heat-generating component and thus the temperature and duration of the reaction. may be given. When using water as one of the chemical agents and a water-soluble inorganic salt such as sodium chloride as a dispersing agent, the amount of water and water-soluble inorganic salt should be such that the majority of the salt maintains its crystalline state. It is desirable that the amount is as follows.

Preferably, the heat source also includes a phase change agent or heat exchange agent. Examples of such substances include dextrose, which during inhalation changes from the same phase to the liquid phase and back again from the liquid phase to the solid phase within the temperature range set by the heat source;
There are sugars such as sucrose. Other phase change agents include certain waxes or mixtures of waxes, and inorganic materials such as magnesium chloride. Such materials absorb the heat of the exothermic reaction of the reactants and control the maximum temperature set by the heat source. Specifically, when heat is applied to sugars, the phase changes from a solid phase to a liquid phase and absorbs heat. However, as the exothermic reaction of the reactants nears completion and the resulting heat generation decreases, the heat absorbed by the phase change agent is released (i.e., the phase change agent changes from a liquid phase to a solid phase). , thereby extending the useful life of the aerosol delivery article. Phase change agents such as waxes, which become viscous liquids when heated, can also function as dispersants.

The relative amounts of each component of the heat source can vary and are often selected depending on factors such as the minimum and maximum amount of heat required and the desired period of time for heat generation. Ru. For example, if water is brought into contact with a mixture of metal oxide and anhydrous metal sulfide, the amount of water is sufficient to completely hydrate the anhydrous metal sulfide and react stoichiometrically with the metal oxide. It is desirable that the amount be sufficient to Additionally, the amount of metal oxide and anhydrous metal sulfide heats the flavor or drug carrying substrate sufficiently to volatilize the flavor or drug components during the life of the aerosol delivery article when reacted with water. Desirably, the amount is sufficient to generate sufficient heat.

Typically, the solid portion of such heat sources will weigh less than 2 grams, - for boat fishing from about 0.5 to about 1.5 grams.

Yet another preferred heat source is obtained by mixing particulate aluminum and/or magnesium metal with particulate sodium nitrite and/or sodium nitrate. The mixture or heat source thus obtained can generate heat by contacting it with an aqueous solution of sodium hydroxide. Typically, the solid portion of this heat source weighs approximately 50
~approximately 300 mg. The solid part of this heat source is approximately 5~
0.05-0.5 m 1 with a concentration of about 50% by weight
Contact with an aqueous solution of sodium hydroxide in Step 2.

Typically, relatively large aluminum or magnesium particles constitute a chemical agent that generates a low initial amount of heat, but a reasonably high amount of heat over a relatively long period of time. However, when this chemical agent is contacted with a relatively concentrated sodium hydroxide solution, a relatively high reaction occurs due to the initial heat generated. However, adding a buffer such as potassium to such chemicals (aluminum or magnesium), even if contact of the reacting components is made (e.g. adding an aqueous solution of sodium hydroxide to a mixture of aluminum and sodium nitrate) (even if it does) delays the initial fever. Alternatively, adding a base such as granular barium hydroxide or calcium hydroxide to the solid portion of the heat source does not readily generate heat when stored, but an aqueous solution of sodium hydroxide or other suitable starter A mixture of chemical agents is constructed that generates a significant amount of initial heat when brought into contact with an agent or initiating medium (eg, heat).

The flavoring agent used in the present invention is one that can be volatilized by the heat source of the present invention and can be delivered in the form of vapor (aerosol) to the user's breath. Flavoring agents with a pleasant flavor are particularly preferred. Such flavoring agents include menthol, spearmint, peppermint, cinnamon, vanilla, chocolate, licorice, ginger, coffee, spice, strawberry, cherry, citrus, raspberry, and the like. Breath freshening flavors are also particularly preferred. Concentrated flavor extracts and artificial flavors can also be used.

Flavoring agents are usually supported on the base material. For example, a sufficient amount of flavoring agent can be applied to the substrate to provide the desired amount of flavor per puff at the temperature set by the heat source of the present invention.

Drugs that can be used in the present invention are those that can be administered directly to the user's respiratory system in vapor form. "Drug" here refers to diagnosis, treatment,
Medical products or substances for use in pain relief, treatment or prevention of disease, and United States Law 21 USC 321 (
g) Refers to other specified substances. Examples of suitable drugs include propranolol and octyl nitrite.

Usually, the drug is carried by a substrate, especially a porous or fibrous or high surface area substrate. Typically, the substrate will be one that readily supports the drug prior to use of the aerosol delivery article, but readily volatilizes the drug at the temperatures generated by the heat source during use. For example, the substrate carries a sufficient amount of drug to deliver the desired dose at the temperature generated by the heat source of the present invention.

Examples of suitable substrates include cotton, cellulose acetate, carbon fiber, C from American Quinol Inc.
There are fibrous materials such as carbon filament yarn sold under the product number EF-0204-2. Also, charcoal, glass beads with a large number of depressions, alumina, etc. are suitable base materials. Microporous materials and microspheres can also be used. The configuration of the aerosol delivery article of the present invention can be modified to accommodate a variety of substrates having a variety of configurations.

Some specific examples will be described below to illustrate the configuration of the present invention, but these specific examples do not limit the scope of the present invention. Unless otherwise specified, all "parts" and "%" shown in the following specific examples are based on weight.

A flavored aerosol delivery article substantially similar to that shown in FIG. 1 was prepared as follows.

A. The heat source is 36.8 parts of granular calcium oxide and 10.3 parts of granular calcium oxide.
It was prepared by intimately mixing 1 part of granular anhydrous magnesium sulfate, 5.9 parts of malic acid, 22 parts of powdered dextrose, and 25 parts of granular sodium chloride.

B, Hou Eibe 11 CFY from American Kinol Incorporated
The flavor source was prepared by applying menthol to a flavor-bearing substrate consisting of a length of carbon fiber yarn sold under the product number -0204-Z.

C. Aerosol delivery The thread stand of 1. The above flavoring agent-carrying base material has a length of 65 mm and an outer diameter of 4°35 mm.
was inserted into a polypropylene cylindrical container (hereinafter referred to as "first polypropylene tube"). The inner diameter of the first polypropylene tube was determined so that the flavoring agent-carrying base material could be held by frictional engagement.

A short annular member with a length of 3 mm made of Delrin manufactured by DuPont was fitted onto the outer peripheral surface of one end of the first polypropylene tube. The outer diameter of this annular member is 7.7 mm, and the inner diameter is slightly larger than the inner diameter of the first polypropylene tube, and the annular member is tightly fitted to the outer peripheral surface of the first polypropylene tube to establish an airtight seal. I did it like that.

The first polypropylene tube and annular member have a length of 85 mm.
mm, and inserted into a second polypropylene tube with an outer diameter of 8 mm. One end of the second polypropylene tube is aligned with the end of the first polypropylene tube having a length of 65 mm on the side opposite to the side where the annular member is located, and the other end is 20 mm from the first polypropylene tube and the annular member.
Made it stand out. The inner diameter of the second polypropylene tube is
It was determined that the annular member should be tightly fitted to the outer circumferential surface of the annular member to form an airtight seal.

1.5 g of the heat source component described above is inserted into the annular space between the first polypropylene tube and the second polypropylene tube, and the heat source extends over a length of about 40 mm along the length of the smoking article (aerosol delivery article). I made it extend.

A cellulose acetate annular body (plug) having a length of 7 mm was inserted into the tip space between the first polypropylene tube and the second polypropylene tube. This cellulose acetate is an air permeable material sold by American Filtrona under the product number SO3-1.

As the mouthpiece end, an elastic mouthpiece end with a deflecting wall having a diameter of 7.75 mm and a length of 5 mm was manufactured from polypropylene by molding. The mouth end member was a tight fit within the second polypropylene tube at the end of the aerosol delivery article.

Approximately 0.8 mm thick, sold under the trade name Roll Stock by Palkawa Incorporated.
The second polypropylene tube was wrapped with a polystyrene foam sheet over its entire length.

This aerosol delivery article has a total length of 85 mm.

The outer diameter was 9.42 mm.

D. For aerosol opening: Insert a small diameter tube from the air inlet of this aerosol delivery article through the cellulose acetate ring to the solid part of the heat source, and insert the tube into the heat source approximately 2 mm from the cellulose acetate ring. Water at about 0.4 m°C was injected.

When water was injected, the heat source began to generate heat.

No combustion phenomenon was observed. Within 7 seconds, the temperature of the heat source is 7
The temperature reached 0°C. For aerosol delivery items, for more than 5 minutes85~
A temperature range of 120°C was maintained, with an average temperature of 103°C.

This aerosol delivery article produced flavor in every puff of 10 puffs, and the heat source continued to produce heat even when no visible aerosol was seen.

Dan 1 Gai λ A heat source was prepared as described below.

Wax sold under the trade name Paraflint by Parafilm Corporation is crushed to a particle size of approximately 40 to 60 mesh, and 10 g of wax particles are
g of calcium oxide and 40 g of anhydrous magnesium sulfate. The resulting solid mixture was weighed at 6,750 kg (15,000 kg) using a press manufactured by Carver Laboratory.
Compressed with the pressure of 1b), diameter 2.54cm, length 14c
It was made into a cylindrical body of m. This cylinder was ground to a coarse powder.

Approximately 1 g of the coarse powder was contacted with approximately 0.5 mβ of water, generating heat.

Three Dan' I soup branch A heat source was prepared as described below.

Approximately t 0 with a particle size of -325 mesh (US standard)
0 mg of aluminum metal powder was mixed with approximately 200 mg of ground sodium nitrate having a particle size of 1200 mesh (US standards). When a 20% aqueous solution of sodium hydroxide at 0.1 m°C was added to about 75 mg of this aluminum/sodium nitrate mixture (heat source), this heat source
It rapidly reaches a temperature of about 140°C in less than 0 seconds and remains at 1 for about 7 minutes.
The temperature was maintained above 00°C and below about 140°C.

Common use A heat source was prepared as described below.

Approximately 50m with a particle size of -200 mesh (US standard)
g of aluminum metal powder was mixed with 150 mg of granular sodium nitrate. When approximately 0.3 m I2 of a 5% aqueous solution of sodium hydroxide was added to this aluminum/sodium nitrate mixture (mixture), the heat source
It rapidly reaches a temperature of about 120°C in less than a second, and 1 minute for about 11 minutes.
The temperature was maintained at 00'C and above 80'C for a total of about 12 minutes.

Just a small gift A heat source was prepared as described below.

Approximately 5 grams of granular calcium oxide was mixed with approximately 3.48 grams of granular aluminum potassium sulfate dodecahydrate. 0.5 g of the resulting mixture was mixed with 0.5 g of calcium oxide and 0.5 g of the mixture.
Mixed with 5g of boric acid. The resulting mixture (heat source) was placed in a small test tube and kept at room temperature overnight. The next day, when the test tube was heated for about 2 seconds with the flame of an aerosol delivery product lighter, the heat source rapidly reached a temperature of about 100°C and maintained a temperature range of about 100°C to about 135°C for about 4 minutes. was maintained.

Dan” I skin mutual A heat source was prepared as described below.

Approximately 28m with a particle size of 1200 mesh (US standard)
g of aluminum metal powder was mixed with 86 mg of granular sodium nitrate and 86 mg of potassium dicarbonate in a glass tube. Upon addition of 0.3 m I2 of a 5% aqueous solution of sodium hydroxide to the resulting mixture (heat source), the reactive mixture rose to a temperature of approximately 50 °C in less than 1 minute and remained at that temperature for approximately 15 minutes. was maintained. This reactive mixture (aluminum/sodium nitrate/potassium dicarbonate mixture) then begins to generate heat and rises to a temperature above 90° C. for about 20 to about 30 minutes from the time the aqueous sodium hydroxide solution is added. showed that. This example shows that it is possible to control the temperature of the initial heat produced by the heat source and then allow each component of the heat source to react with each other to produce the required heat. There is.

Ingredients A heat source was prepared as described below.

Approximately 28 mg with a particle size of 200 mesh (US standard)
of aluminum metal powder was mixed with approximately 86 mg of granular sodium nitrate and 86 mg of granulated sodium nitrate in a glass tube. When this reactive mixture (heat source) was heated with the flame of an aerosol delivery article lighter for about 3 seconds, the heat source rapidly generated heat, reaching a temperature of about 320 °C in less than 20 seconds and lOOC for about 4 minutes. The temperature was maintained above ℃.

40・Suction end part 43: Filter element 46: Air inlet part 50: Heat resistant cartridge

[Brief explanation of the drawing]

1 and 2 are longitudinal cross-sectional views of aerosol delivery articles according to different embodiments of the invention. FIG. 1A is a cross-sectional view taken along line 1--1 of FIG. 10: Aerosol delivery article 13: Outer member (wrap) 16: Flavor or drug carrying base material 26: First cylindrical container 30: Second cylindrical container 35: Heat source 38: Air permeable plug

Claims (1)

[Scope of Claims] 1. a) a flavoring agent or drug; and b) the flavoring agent or drug are physically separate and for heating the flavoring agent or drug, ) a first drug capable of exothermically reacting with a second drug; a third drug capable of exothermically reacting with the first drug; and (ii) a non-combustion heat source comprising a dispersant for the first drug. , an aerosol delivery article consisting of. 2. a) a flavoring agent or drug, and b) the flavoring agent or drug are physically separate entities and are for heating the flavoring agent or drug, and (i) a second agent and a heat generating agent. a first drug capable of reacting; (ii) a dispersant for the first drug;
and iii) a phase change agent. 3. The aerosol delivery article according to claim 2, wherein the heat source includes a third drug capable of exothermically reacting with the first drug. 4. The aerosol delivery article according to claim 1 or 2, wherein the dispersant is normally solid. 5. Claims 1 or 2, characterized by having a mouthpiece member for delivering the flavor agent or drug volatilized by the heat source to the mouth of the person inhaling the aerosol delivery article. aerosol delivery articles. 6. The aerosol delivery article according to claim 2, wherein the phase change agent is solid before use of the aerosol delivery article. 7. The aerosol delivery article according to claim 1 or 2, wherein the first drug and the dispersant are both solid. 8. The heat source is capable of heating at least a portion of the flavorant or drug to a temperature above about 70°C within 20 seconds from the time the exothermic reaction of the drug is initiated. Aerosol delivery article according to scope 1 or 2. 9. The aerosol delivery article of claim 1 or 2, wherein the heat source is configured not to heat the flavoring agent to a temperature exceeding about 350° C. during its lifetime. . 10. a) a flavoring agent or drug; and b) the flavoring agent or drug are physically separate and for heating the flavoring agent or drug, and (i) a second agent and a heat generating agent. An aerosol delivery article comprising: a non-combustion heat source comprising at least one drug capable of reacting and (ii) a normally solid dispersant for the drug. 11. The aerosol delivery article of claim 10, wherein the heat source further includes a phase change agent. 12. The smoking article of claim 10, wherein the heat source includes at least two agents capable of exothermically reacting with water. 13. The heat source is capable of heating a portion of the flavor or drug to a temperature exceeding about 70° C. within 20 seconds from the start of the exothermic reaction between the drug and water. An aerosol delivery article according to claim 10. 14. The aerosol delivery device according to claim 10, further comprising a suction member for delivering the flavor agent or drug volatilized by the heat source to the mouth of the person inhaling the aerosol delivery article. supplies. 15. a) a flavoring agent or drug, and b) the flavoring agent or drug are physically separate and for heating the flavoring agent or drug, and (i) a second agent and a heat generating agent. An aerosol delivery article comprising: a first agent capable of reacting; and (ii) a non-combustion heat source comprising a phase change agent. 16. Claim 1, wherein the heat source includes a third agent capable of reacting with the first agent.
The aerosol delivery article according to item 5. 17. The aerosol delivery article according to claim 15 or 16, wherein the phase change agent is solid before use of the aerosol delivery article. 18. The heat source is capable of heating at least a portion of the flavoring agent or drug to a temperature above about 70° C. within 20 seconds from the time the exothermic reaction of the drug is initiated. The aerosol delivery article of scope 15. 19. The aerosol delivery device according to claim 15, further comprising a suction member for delivering the flavor agent or drug volatilized by the heat source to the mouth of the person inhaling the aerosol delivery article. supplies. 20. a) a flavoring agent or drug; and b) the flavoring agent or drug are physically separate and for heating the flavoring agent or drug, and (i) react exothermically with water. and (ii) a non-combustion heat source comprising a phase change agent. 21. The aerosol delivery article of claim 20, wherein the agent capable of exothermically reacting with water comprises a metal oxide. 22. The aerosol delivery article of claim 20, wherein the agent capable of exothermically reacting with water comprises anhydrous magnesium sulfate. 23. The aerosol delivery article of claim 20, wherein the heat source includes at least two agents capable of exothermically reacting with water. 24. The aerosol delivery device according to claim 20, further comprising a suction member for delivering the flavor agent or drug volatilized by the heat source to the mouth of the person inhaling the aerosol delivery article. supplies. 25. a) a flavoring agent or drug, and b) the flavoring agent or drug are physically separate entities for heating the flavoring agent or drug, and (i) have an exothermic reaction with each other; (ii) after the exothermic reaction, reacting with the products of the exothermic reaction to further cause the second and third agents to react with the remaining first agent; an aerosol delivery article comprising: a non-combustion heat source comprising a fourth agent capable of regenerating the second and third agents. 26. The first drug is magnesium and/or aluminum, the second drug is water, the third drug is sodium hydroxide, and the fourth drug is sodium nitrite and/or sodium nitrate. An aerosol delivery article according to claim 25. 27. The aerosol delivery article of claim 25, wherein the amount of the first drug and the fourth drug per aerosol delivery article is about 50 to about 300 mg. 28. The aerosol delivery device according to claim 25, further comprising a suction member for delivering the flavor agent or drug volatilized by the heat source to the mouth of an inhaler of the aerosol delivery article. supplies.