JPH02191128A - Method for sterile packaging - Google Patents

Abstract

PURPOSE:To perform sterile packaging with minimum equipment with sterilization process of a vessel itself omitted by a method wherein under sterile conditions a film with its inner face sterilized is spread inside a vessel which is not sterilized, a sterile object to be wrapped is placed on the film, and its upper face is covered with the film with its inner face sterilized. CONSTITUTION:A vessel 3 is formed with a recess inside and used without special sterilization. The vessel 3 is mounted on a transfer device 4 and sent to a sterilization chamber 1. A sterilized film 5 is put over the vessel 3. At this time, the vessel is covered with the film 6 with at least its sterilized surface facing upward. A sterile object 6 is put in from over the sterilized surface of the sterilized film 5. Even if the vessel has not been subject to sterilization, since the sterilized film 5 exists between the sterile object 6 and the vessel 3, the sterile object 6 may not be contaminated. After placement is completed, the sterilized film 5 is again put over the vessel 3 to seal its periphery. To seal the upper and lower films 5, a means for welding and pressure-welding with an O-ring interposed for example can be used.

Description

[Detailed Description of the Invention] <Industrial Application Field> The present invention enables
This relates to a method for packaging cultured seedlings, foods, and other objects in a sterile state.

<Prior Art> When sterile cultured seedlings, foods, medicines, etc. are sealed in a container in a sterile state, the container itself must be sterilized.

However, when a large number of containers are used, not only the container sterilization equipment, but also the container storage equipment after sterilization and the container transportation equipment must all be maintained in a sterile state, and the equipment is large-scale. becomes.

<Objective of the present invention> The present invention has been made to improve these conventional problems, and provides a method that allows sterile packaging to be performed with a minimum amount of equipment by omitting the sterilization process of the container itself. The purpose is to provide

<Configuration of the present invention> Next, one embodiment of the present invention will be described.

<B> Overall configuration In Fig. 1, numeral 1 is a sterile room, which is installed inside the general environment.

Sterile air 2 is constantly supplied to the inside of the sterile room 1, and this sterile air 2 is blown out to the outside of the sterile room 1, so that air does not enter the sterile room 1 from the outside. .

The sterile room 1 is provided with a transfer device 4 for transferring containers 3 from the outside.

In other words, this transfer device 4 is configured, for example, by a belt conveyor or the like, and is configured so that the container 3 passes through the sterile chamber 1 and is sent outside after completing the work inside the chamber.

<mouth> Film supply means Inside the sterile room 1, a means 6 for feeding the film 5 is provided.

The film 5 used here has been sterilized on both or one side, and can be stored, for example, in a roll or folded form, and then rolled out one after another.

Even if the inner circumferential surface of the film 5 is sterilized, the outermost film surface of the roll or the like may be contaminated by the time it is brought into the evacuating chamber 1.

However, as described above, the sterile room 1 always discharges the sterile air 2 to the outside.

Therefore, it does not contaminate other items, and after only discarding the first part, such as the roll, it can be used normally thereafter.

(c) Container The container 3 can be made of any material or structure as long as it has four parts inside and an open top surface.

In particular, this invention is characterized in that the container 3 is used without being sterilized.

Since it is not necessary to sterilize the containers 3, a large number of containers 3 can be stored anywhere.

<2> Place the container 3 on the packaging process transfer device 4 and send it into the sterilization chamber l.

A sterilized film 5 is placed over the container 3 in the sterilization chamber 1.

At this time, at least the sterilized side of the film 5 is placed facing upward.

A sterilized material 6 is introduced onto the sterilized surface of the sterilized film 5.

Even if the container 3 is not sterilized, the sterile film 5 is placed between the sterile object 6 and the container 3, so the sterile object 6 will not be contaminated.

Once the placement is complete, place the sterile film 5 over the container 3 again.
Cover and seal the surrounding area.

For sealing the upper and lower films 5, known means such as welding or pressure bonding using an O-ring or the like can be used.

As described above, a large number of continuous containers 3 or individual containers 3 can be continuously transferred, and operations such as covering with the film 5, installing the sterile material 6, and covering with the upper film 5 can be performed continuously.

When the container 3 and the film 5 are continuous, they are cut at the end to form an independent container.

<E> When installing the nozzle, if the sterile material 6 is, for example, a bed material containing a culture solution and cultured bacteria, it is necessary to supply the culture solution and ventilate after packaging.

A method of installing such a nozzle with a valve for communication with the outside will be explained with reference to FIG.

In that case, make a hole for the nozzle in advance in the container 3 (.

On the other hand, a nozzle 8 equipped with a valve 7 that can be opened and closed is prepared in a sterilized state (.

After placing the sterile film 5 inside the container 3, the robot gently inserts the nozzle 8 into the container 3 from the sterile side toward the opening.

Then, the nozzle 8 pushes out the film 5 from the opening, and the outer surface of the nozzle 8 and the inner surface of the film 5 are bonded inside the nozzle 8.

This adhesion can be easily achieved by external heating or welding.

A container 3 equipped with such a nozzle 8 can be connected to an external pipe.

That is, before use, the film 5 at the tip of the nozzle 8 is removed, and the inside of the nozzle 8 (up to the position of the valve 7) is sterilized by heating or other known methods.

Since it is connected to a sterilized external culture solution pipe, the inside will not be contaminated.

<Effects of the present invention> The present invention can achieve the following effects.

<B> There is no need for the step of sterilizing the container itself.

The container can therefore be handled and stored under normal circumstances and by normal operations without the need for extensive equipment.

<Exposure> Therefore, aseptic packaging can be performed as long as there is space to spread the sterilized film.

<C> Since it is sufficient to lay the film on the container, it is sufficient to supply a continuous film to the continuous container and cut the film at the end.

Therefore, a series of high-volume processing operations are possible.

(2) By pushing out a sterilized connection valve from inside the sterilized container, gas and liquid can be supplied from the outside in a sterile state.

[Brief explanation of the drawing]

Fig. 1 2 An explanatory diagram of the entire process of the present invention Figure 2: Illustration of the packaging state of the container Figure 3: Explanatory diagram of another embodiment Procedural amendment May 8, 1989 Day

Claims (2)

[Claims] (1) In a sterile environment, a container that has not been specially sterilized is placed, a film with at least the inside surface sterilized is placed inside the container, and the sterile packaging object is placed on top of this film. , an aseptic packaging method in which the upper surface is covered with a film whose at least the inner surface is sterilized. (2) In a sterile environment, place a container that has not been specially sterilized, make an opening in this container to insert a pipe, and lay a sterilized film on at least the inside surface inside this container. Then, from inside this film, extrude the sterilized pipe along with the film toward the opening of the container, then place the sterile packaged object on top of the film, and cover the top surface with at least the inside surface of the sterilized film. Aseptic packaging method