JPH02168971A - Ceramics heating element for thermaltherapy and its production - Google Patents
Ceramics heating element for thermaltherapy and its productionInfo
- Publication number
- JPH02168971A JPH02168971A JP63325250A JP32525088A JPH02168971A JP H02168971 A JPH02168971 A JP H02168971A JP 63325250 A JP63325250 A JP 63325250A JP 32525088 A JP32525088 A JP 32525088A JP H02168971 A JPH02168971 A JP H02168971A
- Authority
- JP
- Japan
- Prior art keywords
- heating element
- ferrite
- bioactive
- ferrite particles
- long period
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000010438 heat treatment Methods 0.000 title claims abstract description 36
- 239000000919 ceramic Substances 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 239000002245 particle Substances 0.000 claims abstract description 28
- 229910000859 α-Fe Inorganic materials 0.000 claims abstract description 24
- 230000000975 bioactive effect Effects 0.000 claims abstract description 14
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 13
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 13
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000004202 carbamide Substances 0.000 claims abstract description 6
- 230000005307 ferromagnetism Effects 0.000 claims abstract description 6
- 239000000725 suspension Substances 0.000 claims abstract description 6
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 4
- 239000010452 phosphate Substances 0.000 claims abstract description 4
- 238000000015 thermotherapy Methods 0.000 claims description 11
- 239000011575 calcium Substances 0.000 claims description 7
- 230000001747 exhibiting effect Effects 0.000 claims description 6
- 239000007900 aqueous suspension Substances 0.000 claims description 2
- 230000005294 ferromagnetic effect Effects 0.000 abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 238000002513 implantation Methods 0.000 abstract description 4
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 4
- 239000011248 coating agent Substances 0.000 abstract description 3
- 238000000576 coating method Methods 0.000 abstract description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract description 2
- JXGGISJJMPYXGJ-UHFFFAOYSA-N lithium;oxido(oxo)iron Chemical compound [Li+].[O-][Fe]=O JXGGISJJMPYXGJ-UHFFFAOYSA-N 0.000 abstract description 2
- 239000011777 magnesium Substances 0.000 abstract description 2
- 229910052749 magnesium Inorganic materials 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 description 15
- 201000011510 cancer Diseases 0.000 description 13
- 230000005291 magnetic effect Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 210000000988 bone and bone Anatomy 0.000 description 6
- 229910052586 apatite Inorganic materials 0.000 description 5
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 5
- 239000011521 glass Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 239000004254 Ammonium phosphate Substances 0.000 description 2
- 208000018084 Bone neoplasm Diseases 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 229910000148 ammonium phosphate Inorganic materials 0.000 description 2
- 235000019289 ammonium phosphates Nutrition 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 description 2
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000011866 long-term treatment Methods 0.000 description 2
- 230000005415 magnetization Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000007669 thermal treatment Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 229910001006 Constantan Inorganic materials 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000009217 hyperthermia therapy Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- -1 metals Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000007777 multifunctional material Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000010456 wollastonite Substances 0.000 description 1
- 229910052882 wollastonite Inorganic materials 0.000 description 1
Landscapes
- Radiation-Therapy Devices (AREA)
- Magnetic Treatment Devices (AREA)
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、癌などの温熱療法に使用する発熱体およびそ
の製法、特に、体内に埋入したとききわめて優れた生体
親和性を示し、しかも交流磁場のもとて患部だけを局部
的に効率よく加熱するのに適したセラミック発熱体およ
びその製法に関する。Detailed Description of the Invention (Field of Industrial Application) The present invention relates to a heating element used in thermotherapy for cancer, etc., and a method for producing the same, in particular, it exhibits extremely excellent biocompatibility when implanted in the body, and The present invention relates to a ceramic heating element suitable for locally and efficiently heating only the affected area under an alternating magnetic field, and a method for manufacturing the same.
（従来の技術）
−ａに癌細胞は熱に弱＜、４３℃付近まで加熱されると
死滅すると言われている。しかも癌の患部は血流が少な
いので周囲に比べて加熱されやすい。(Prior Art) Cancer cells are said to be sensitive to heat and die when heated to around 43°C. Moreover, the area affected by cancer has less blood flow, so it is more likely to be heated than the surrounding area.
したがって、癌の患部を局部的に加熱する温熱療法はき
わめて有力な癌の治療方法である。Therefore, thermotherapy, which locally heats the affected area of cancer, is an extremely effective cancer treatment method.
従来、癌の患部を局部的に加熱する方法としては、温水
、赤外線、超音波、マイクロ波、高周波などが試みられ
ている。特開昭５８−２０９３５０号および同６１−１
５８９３１号公報参照。Conventionally, hot water, infrared rays, ultrasonic waves, microwaves, high frequency waves, and the like have been tried as methods for locally heating the affected area of cancer. JP-A-58-209350 and JP-A No. 61-1
See Publication No. 58931.
しかしながら、これらいずれも骨腫瘍のような深部癌に
は有効ではない。However, none of these are effective against deep cancers such as bone tumors.
例えば、癌の発生部位近傍の人体表面（「体表」という
）を、塩水と電極板の入った袋がら成る一対の電極袋で
侠圧し、該電極袋を介して８ＭＨｚ（メガヘルツ）程度
の高周波電流を直接人体に流して癌細胞を加熱するよう
に構成した温熱治療装置が提案されているが、この種の
温熱治療装置では体表近傍の癌細胞だけしか加熱するこ
とができず、体表から１５ ｃｍ程度の深部が限界であ
る。しかも、癌細胞だけでなく正常細胞をも加熱するこ
とになるから、特に連続治療、長期治療に際しては、正
常細胞への影響が問題となる。For example, the surface of the human body near the site of cancer (referred to as the "body surface") is compressed with a pair of electrode bags containing salt water and an electrode plate, and a high frequency of about 8 MHz (megahertz) is transmitted through the electrode bags. A thermotherapy device configured to heat cancer cells by passing an electric current directly through the human body has been proposed, but this type of thermotherapy device can only heat cancer cells near the body surface; The limit is about 15 cm deep. Furthermore, since not only cancer cells but also normal cells are heated, the effect on normal cells becomes a problem, especially in continuous or long-term treatments.
そこで、従来から、癌細胞だけを加熱するため、生体内
の患部に、金属棒や金属張り、金属粉などの強磁性体を
投与埋入して交流磁場下で発熱させる方法が試みられて
いる。しかし、金属材料は電気伝導度が高いので発熱効
率が低く、しかも有害なイオンを溶出しやすく、体内に
埋入するのに適していない。Therefore, in order to heat only the cancer cells, attempts have been made to implant ferromagnetic materials such as metal rods, metal cladding, or metal powder into the affected area of the body and generate heat under an alternating magnetic field. . However, metal materials have high electrical conductivity, have low heat generation efficiency, and also easily elute harmful ions, making them unsuitable for implantation into the body.
なお、特開昭５７−１７６４７号公報には、強磁性フェ
ライト含有のガラス、結晶化ガラスおよび焼結セラミッ
クを温熱治療用の材料として使用した例が開示されてい
る。しかし、かかる材料は、特に優れた生体親和性を有
するとは言えない。Incidentally, Japanese Patent Application Laid-Open No. 57-17647 discloses an example in which ferromagnetic ferrite-containing glass, crystallized glass, and sintered ceramic are used as materials for thermal treatment. However, such materials cannot be said to have particularly good biocompatibility.
（発明が解決しようとする課題）
ここに、本発明の一般的目的は、深部癌の温熱治療に適
した生体親和性にすぐれたセラミック発熱体およびその
製法を提供することである。(Problems to be Solved by the Invention) A general object of the present invention is to provide a ceramic heating element with excellent biocompatibility and suitable for thermal treatment of deep cancer, and a method for manufacturing the same.
本発明のより具体的な目的は、長期間体内に埋入しても
安全で周囲の生体＆ＩＩ織ときわめて優れた親和性を示
し、長期にわたって安定に維持され、しかも人体の深部
も含め患部を選択的に効率よく加熱し得る生体内発熱体
およびその製法を提供することである。A more specific object of the present invention is to be safe even when implanted in the body for a long period of time, to exhibit extremely good affinity with the surrounding living tissue, to be stably maintained over a long period of time, and to be able to protect affected areas including deep parts of the human body. An object of the present invention is to provide an in-vivo heating element that can selectively and efficiently heat the body and a method for producing the same.
（課題を解決するための手段）
本発明者らは、これまで詳細な実験により、水溶液中で
作られたままの水酸化物の形態のアパタイト （以下、
「水酸アパタイト」という）は生体内で周囲の骨と自然
に結合するほど優れた生体親和性を示すことを明らかに
してきた。この生体活性な無機質層であるアパタイトの
膜は生体内の骨＆Ｉｌ織と直接に化学結合し得るほど、
生体と馴染みが良く、しかも筋肉、皮膚などの柔らかい
組織とも優れた親和性を示す。(Means for Solving the Problems) Through detailed experiments, the present inventors have discovered that apatite in the form of hydroxide (hereinafter referred to as
It has been revealed that ``hydroxyapatite'' (called ``hydroxyapatite'') exhibits such excellent biocompatibility that it naturally bonds with surrounding bones in vivo. The apatite film, which is a bioactive mineral layer, is so strong that it can chemically bond directly to bone and tissue in the living body.
It is compatible with living organisms and also shows excellent affinity with soft tissues such as muscles and skin.
この点、従来の発熱体は、毒性を有する金属イオンの溶
出がない場合でも生体内で異物と見られ、繊維性被膜で
覆われている。この繊維性被膜は、材料の生体適合性が
悪くなる程厚くなる。In this regard, conventional heating elements are seen as foreign substances in living bodies even when no toxic metal ions are eluted, and are covered with a fibrous film. This fibrous coating becomes thicker as the material becomes less biocompatible.
そこで、上述のような知見をもとに前記目的を達成すべ
く種々検討を重ねた結果、強磁性フェライト粒子と前記
生体活性な無機質膜、特に水酸アパタイト膜との組合せ
がすぐれていることを知り、本発明を完成した。Therefore, as a result of various studies to achieve the above objective based on the above knowledge, we found that the combination of ferromagnetic ferrite particles and the bioactive inorganic film, especially the hydroxyapatite film, is excellent. I learned this and completed the present invention.
ここに、本発明は、生体活性な無機質層で被覆された強
磁性を示すフェライト粒子から成ることを特徴とする温
熱療法のためのセラミック発熱体である。The present invention is a ceramic heating element for hyperthermia therapy characterized by comprising ferrite particles exhibiting ferromagnetism coated with a bioactive inorganic layer.
また、別な面からは、本発明は、強磁性を示すフェライ
ト粒子の水性懸濁液に、水溶性カルシウム塩および水溶
性リン酸塩をＣａ／Ｐ比が１．４〜１．８の範囲になる
ように加え、更にカルシウム塩の２倍モル量以上の尿素
を加え、得られた懸濁液を６０℃以上に加熱して前記フ
ェライト粒子表面に水酸アパタイトを被覆することを特
徴とする温熱療法のためのセラミックス発熱体の製法で
ある。In addition, from another aspect, the present invention provides a method for adding a water-soluble calcium salt and a water-soluble phosphate to an aqueous suspension of ferrite particles exhibiting ferromagnetism, with a Ca/P ratio in the range of 1.4 to 1.8. The method is characterized by adding urea in an amount equal to or more than twice the molar amount of the calcium salt, and heating the resulting suspension to 60° C. or higher to coat the surfaces of the ferrite particles with hydroxyapatite. This is a method for manufacturing ceramic heating elements for thermotherapy.
なお、［生体活性な無機質層」とは強磁性フェライトと
組合わせて本発明の目的が達成されるものであれば、特
に制限ない０例えばＣａＯ・Ｓｉｎ！系ガラス、ウオラ
ストナイト （β−ＣａＯ・Ｓｉｎｇ）なども挙げられ
るが、アパタイト系ガラス特に好ましくは水酸アパタイ
トである。無機質ということでフェライト粒子との接着
もよく、さらに生体活性ということで体内に埋入したと
きの親和性にもすぐれている。Note that the term "bioactive inorganic layer" is not particularly limited, as long as the object of the present invention can be achieved in combination with ferromagnetic ferrite. For example, CaO/Sin! Examples include apatite-based glass, wollastonite (β-CaO·Sing), and apatite-based glass, particularly hydroxyapatite. Because it is inorganic, it adheres well to ferrite particles, and because it is bioactive, it has excellent compatibility when implanted in the body.
このように、本発明にかかる発熱体は、強磁性フェライ
ト粒子を生体活性な無機質層で包んだ構造を有すること
を特徴とするのであって、その発熱体は体内に埋入され
たとき、周囲の組成ときわめて優れた生体親和性を示し
、長期にわたって安定に維持され、特に骨内部もしくは
その周辺に埋入されたときには、周囲の骨と自然に結合
し、長期にわたってそこに安定にとどまる。さらに、交
流磁場下におかれたとき磁気誘導現象により体内深部に
おいてもその埋入された周辺部のみを局部的にきわめて
効果的に加熱しうる。As described above, the heating element according to the present invention is characterized by having a structure in which ferromagnetic ferrite particles are wrapped in a bioactive inorganic layer, and when the heating element is implanted in the body, the heating element It exhibits excellent biocompatibility with its composition, and remains stable over long periods of time. In particular, when implanted in or around bone, it naturally integrates with the surrounding bone and remains stable there for a long period of time. Furthermore, when placed under an alternating magnetic field, only the surrounding area where it is implanted can be heated locally and extremely effectively even deep within the body due to the magnetic induction phenomenon.
このように、本発明にかかる発熱体は、生体活性を示す
無Ｎ質層で包んだ強磁性フェライト粒子を生体が異物と
して認識し得ないという特徴を有するのであって、さら
にそれに加えて磁気ヒステリシス損のみの発熱能も有し
、温熱療法には理想的な多機能材料である。As described above, the heating element according to the present invention has the feature that the ferromagnetic ferrite particles wrapped in the bioactive N-free layer cannot be recognized by living organisms as foreign matter, and in addition, the heating element has magnetic hysteresis. It also has the ability to heat up heat, making it an ideal multifunctional material for thermotherapy.
（作用）
次に、本発明にかかるセラミック発熱体の製法およびそ
の効果についてさらに具体的に説明する。(Function) Next, the manufacturing method of the ceramic heating element according to the present invention and its effects will be explained in more detail.
以下の説明にあって生体活性の無機質層として水酸アパ
タイトを例にとり説明するが、本発明は特にそれにのみ
制限されないことはその趣旨からも明らかである。In the following description, hydroxyapatite will be used as an example of the bioactive inorganic layer, but it is clear from the gist that the present invention is not limited thereto.
まず、本発明の温熱療法のためのセラミック発熱体は、
マグネタイト（ＦｅｘＯ４）、リチウムフェライト（Ｌ
ｉＦｅ５０Ｊ ％マグネシウムフェライト（ＭｇＦｅｌ
Ｏｓ）などの＋１磁性を示すフェライト粒子の懸濁液に
水溶性カルシウム塩、水溶性リン酸塩、および尿素を加
えて、得られた水溶液を６０℃以上に加熱して強磁性フ
ェライト粒子表面に水酸アパタイトを被覆することによ
って製造し得る。First, the ceramic heating element for thermotherapy of the present invention is
Magnetite (FexO4), lithium ferrite (L
iFe50J% Magnesium ferrite (MgFel
A water-soluble calcium salt, a water-soluble phosphate, and urea are added to a suspension of ferrite particles exhibiting +1 magnetism such as Os), and the resulting aqueous solution is heated to 60°C or higher to coat the surface of the ferromagnetic ferrite particles. It can be produced by coating hydroxyapatite.
フェライト粒子はこれまでも温熱療法用の発熱体として
その利用が提案され、本発明にあってもそれをそのま＼
利用すればよい、一般には平均粒径１００人〜１０ＪＪ
ＩＡの粒子であればよい。Ferrite particles have been proposed to be used as a heating element for thermotherapy, and the present invention does not use them as they are.
Generally, the average particle size is 100 to 10 JJ.
Any IA particles may be used.
水溶性カルシウム塩としては、塩化カルシウム、硝酸カ
ルシウム等、水溶性リン酸塩としてはリン酸ナトリウム
、リン酸アンモニウム等を用いることができ、これらの
添加比（重量）はアパタイトのＣａ”／Ｐｏｔ”−比で
ある１、６７に近（、Ｃａ／Ｐ比で１．４〜１，８とす
る。また、尿素は添加するカルシウム塩に対してモル比
で２倍以上必要であり、これ以下であると水酸アパタイ
トが生成しない、この水溶液の加熱温度が６０℃より低
温では水酸アパタイトが十分に生成しない。As water-soluble calcium salts, calcium chloride, calcium nitrate, etc. can be used, and as water-soluble phosphates, sodium phosphate, ammonium phosphate, etc. can be used, and the addition ratio (weight) of these is Ca"/Pot" of apatite. - The Ca/P ratio is close to 1.67 (the Ca/P ratio is 1.4 to 1.8. Also, urea is required in a molar ratio of at least twice that of the calcium salt to be added, and less than this is required. If this happens, hydroxyapatite will not be produced, and if the heating temperature of this aqueous solution is lower than 60°C, hydroxyapatite will not be sufficiently produced.
フェライト粒子を被覆する生体活性な無機質層、例えば
水酸アパタイトの量は、好ましくは１０〜８０重量％で
あり、１０重量％未満では強磁性フェライト粒子表面を
十分に被覆できない、また、８０重量％超では磁気ヒス
テリシス損失により発熱能が十分なものとならない。The amount of the bioactive inorganic layer, such as hydroxyapatite, which coats the ferrite particles is preferably 10 to 80% by weight, and if it is less than 10% by weight, the surface of the ferromagnetic ferrite particles cannot be sufficiently covered, and if it is less than 80% by weight, At higher than
このように、本発明の発熱体の主な特徴は、強磁性の粒
子を生体活性な無ＲＭで包んだ構造を有する点にあり、
生体内で周囲の組織ときわめて優れた親和性を示し長期
にわたってそこに安定してとどまる利点を有する。As described above, the main feature of the heating element of the present invention is that it has a structure in which ferromagnetic particles are wrapped in bioactive RM-free,
It has the advantage of exhibiting extremely good affinity with surrounding tissues in vivo and remaining stably there for long periods of time.
本発明にかかる被誘導加熱体は、微粉末の他種々の方法
で成形体あるいは繊維状の形態に加工して利用すること
が可能であり、そしてそれに応じて静脈注射、皮下注射
、あるいは口からの注入、あるいは埋入手術などによっ
て、被加療体の癌細胞からなる患部に移送し、その後、
該患部と共に交流磁場に置くことによって、＃！磁性体
フェライト粒子力＜ｆＨ気ヒステリシス川用により発熱
して、患部を加熱治療することができる。The induction heated body according to the present invention can be used by processing it into a molded body or fibrous form by various methods other than fine powder, and can be used by intravenous injection, subcutaneous injection, or orally. is transferred to the affected area of the patient's cancer cells by injection or implantation surgery, and then
By placing it in an alternating magnetic field with the affected area, #! The magnetic ferrite particle force < fH hysteresis generates heat, allowing heat treatment of the affected area.
なお、被加療体への埋入はこれまで一般に行われている
手段で十分に行うことができるのであって、これ以上の
具体的説明は省略する。It should be noted that the implantation into the subject can be sufficiently carried out by conventional means, and further detailed explanation will be omitted.
以下に、本発明の実施例を示す、なお、本実施例におい
て磁気特性は振動試料型磁力計ＣＴＯＥＴ社製ＶＳＦＩ
−３型）を用いて最大印加磁場１０ ＫＯｅにて測定し
た値である。Examples of the present invention are shown below. In this example, the magnetic characteristics are those of a vibrating sample magnetometer manufactured by CTOET, VSFI.
-3 type) at a maximum applied magnetic field of 10 KOe.
実施例
平均粒径０．５ ％のマグネタイトＦｅｘＯａ （飽和
磁化値＝８８ ｅｍｕ／ｇ、保磁力−１０００ｅ） １
０ ｇを３００ｍ１の蒸留水に分散させて懸濁液とする
。塩化カルシウム（Ｃａ Ｃ１ｚ −２１１ｚＯ） １
１．１０ｇ、リン酸アンモニウム（（Ｎｌｌａ） ｘＰ
Ｏｅ） １２．１９ｇ、および尿素６０．０６ｇを別に
２００ｍ１１の蒸留水に溶解させた後マグネタイトの懸
濁液に加える。ゆるやかに撹拌しながら該水溶液を４℃
／ｗｉｎの昇温速度で８０℃まで加熱し、その温度で４
時間保持した後、室温まで冷却した。沈殿物は、十分に
’１Ｊｆｌ水で洗浄したのち、アセトンで置換して約４
０℃にて乾燥させた。粉末Ｘ′ｆＬｆＡ回折によるとＦ
ｅ５０．と微粒子の水酸アパタイト （Ｃａ、。Example Magnetite FexOa with average particle size of 0.5% (saturation magnetization value = 88 emu/g, coercive force -1000e) 1
Disperse 0 g in 300 ml of distilled water to form a suspension. Calcium chloride (Ca C1z-211zO) 1
1.10g, ammonium phosphate ((Nlla) xP
Oe) 12.19 g and 60.06 g of urea are separately dissolved in 200 ml of distilled water and then added to the magnetite suspension. The aqueous solution was heated to 4°C with gentle stirring.
/win heating rate to 80℃, and at that temperature 4
After holding for an hour, it was cooled to room temperature. After thoroughly washing the precipitate with 1 Jfl water, the precipitate was replaced with acetone and
It was dried at 0°C. According to powder X'fLfA diffraction, F
e50. and fine particles of hydroxyapatite (Ca.
（ＰＯｓ）ｂ （ＯＨ） ｚの混合物であることが認め
られ、走査型電子ｇＪｉ微鏡観察の結果、この水酸アパ
タイトはＰｅ１０４粒子表面を十分に被覆しており、こ
の複合体の磁気特性は飽和磁化値６２ｅｓｕ／ｇ、保磁
力＋１００ｅであった。It was confirmed that it is a mixture of (POs) b (OH) z, and as a result of scanning electron gJi microscopic observation, this hydroxyapatite sufficiently covers the surface of Pe104 particles, and the magnetic properties of this composite are The saturation magnetization value was 62 esu/g and the coercive force was +100 e.
このセラミックス発熱体の３５０メツシユ（４４ＩＩｊ
ａ）以下の粒度の粒子２ｇを直径４０（１ｇ＋＋ ｘｌ
ｌＯ１１１１の大きさの寒天の中央部に埋入し、これを
内径５０■−１長さ２４０ ｍ＋＊の空芯コイルの中心
に置き、コイルに１００ｋｌｌｚ、最大５ｋｗの電流を
流し、発熱体の温度変化をその中心部に挿入した銅−コ
ンスタンタン熱電対により測定した。寒天は比熱、密度
などにおいて人体の組織に近似している。この実験によ
って、１７００ｅの磁場下において発熱体中心部の温度
が約５分以内に４３℃に達することが明らかになった。350 mesh (44IIj) of this ceramic heating element
a) 2 g of particles with a particle size of 40 (1 g++ xl
Embed it in the center of agar with a size of 1111 lO, place it at the center of an air-core coil with an inner diameter of 50cm-1 and a length of 240m+*, and apply a current of 100kllz and a maximum of 5kw to the coil to reduce the temperature of the heating element. Changes were measured by a copper-constantan thermocouple inserted into its center. Agar approximates human tissue in terms of specific heat, density, etc. This experiment revealed that the temperature at the center of the heating element reaches 43° C. within about 5 minutes under a magnetic field of 1700 e.
本例のセラミックス発熱体はその組成からも、いわゆる
重金属イオンの溶出がみられないのは明らかである。ま
た生体親和性については、骨と直接結合し得るほど良好
であった。It is clear from the composition of the ceramic heating element of this example that so-called heavy metal ions are not eluted. Furthermore, the biocompatibility was so good that it could be directly bonded to bones.
（発明の効果）
以上説明したように、本発明にかかるセラミック発熱体
である温熱治療用被誘導加熱体は、加温特性、骨との生
体親和性に優れ、骨腫瘍のような深部癌に特に有効であ
り、金属のような有害イオンを溶出することもなく、長
期治療や連続治療には特に効果的であることが分かる。(Effects of the Invention) As explained above, the induced heating element for thermotherapy, which is a ceramic heating element according to the present invention, has excellent heating properties and biocompatibility with bones, and is effective against deep cancers such as bone tumors. It is found that it is particularly effective, does not elute harmful ions such as metals, and is particularly effective for long-term treatment or continuous treatment.
Claims (2)
ェライト粒子から成ることを特徴とする温熱療法のため
のセラミック発熱体。(1) A ceramic heating element for thermotherapy, characterized in that it consists of ferrite particles exhibiting ferromagnetism coated with a bioactive inorganic layer.
溶性カルシウム塩および水溶性リン酸塩をＣａ／Ｐ比が
１．４〜１．８の範囲になるように加え、更にカルシウ
ム塩の２倍モル量以上の尿素を加え、得られた懸濁液を
６０℃以上に加熱して前記フェライト粒子表面に水酸ア
パタイトを被覆することを特徴とする温熱療法のための
セラミックス発熱体の製法。(2) Add a water-soluble calcium salt and a water-soluble phosphate to an aqueous suspension of ferrite particles exhibiting ferromagnetism so that the Ca/P ratio is in the range of 1.4 to 1.8, and then add the calcium salt A ceramic heating element for thermotherapy, characterized in that urea is added in an amount twice or more in molar amount, and the resulting suspension is heated to 60°C or higher to coat the surfaces of the ferrite particles with hydroxyapatite. Manufacturing method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63325250A JP2829997B2 (en) | 1988-12-23 | 1988-12-23 | Preparation of ceramic heating elements for hyperthermia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63325250A JP2829997B2 (en) | 1988-12-23 | 1988-12-23 | Preparation of ceramic heating elements for hyperthermia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02168971A true JPH02168971A (en) | 1990-06-29 |
| JP2829997B2 JP2829997B2 (en) | 1998-12-02 |
Family
ID=18174713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63325250A Expired - Fee Related JP2829997B2 (en) | 1988-12-23 | 1988-12-23 | Preparation of ceramic heating elements for hyperthermia |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2829997B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008162884A (en) * | 2007-01-04 | 2008-07-17 | Korea Univ Foundation | Magnetic core-ceramic shell nano-crystal and method for producing the same |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065306A1 (en) * | 2003-01-17 | 2004-08-05 | Hitachi Maxell, Ltd. | Composite particle and process for producing the same |
| JP5154785B2 (en) * | 2006-11-30 | 2013-02-27 | 国立大学法人東京工業大学 | Apatite-coated magnetic nanoparticles with high biocompatibility |
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1988
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008162884A (en) * | 2007-01-04 | 2008-07-17 | Korea Univ Foundation | Magnetic core-ceramic shell nano-crystal and method for producing the same |
| US8557337B2 (en) | 2007-01-04 | 2013-10-15 | Korea University Foundation | Magnetic core—ceramic shell nanocrystals and manufacturing method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2829997B2 (en) | 1998-12-02 |
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