JPH0211265B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a jetting hypodermic syringe with an adapter attached to the neck of the injection vial to enable transfer of the injection into the jetting hypodermic syringe.

(Prior Art) US Pat. No. 3,330,276, US Pat. No. 3,521,633, and US Pat. No. 3,908,651 disclose the structure and operating method of typical well-known injection hypodermic syringes. Each publication discloses that a nozzle member is fixed to the end of the syringe body, the nozzle member having a relatively small diameter orifice formed at the end thereof, and the orifice passing the injection liquid through a two-way valve member. A device is disclosed that is in communication with a hole leading to a chamber. A piston is disposed within the chamber, and when actuated by a power spring, the piston causes injection liquid within the chamber to be discharged through the hole and out of the orifice of the nozzle member. Each of these patent publications also discloses a valve device by which injection fluid can be withdrawn from the vial and directed through a series of holes and a two-way valve into the injection fluid chamber of the syringe. When the valve is then in the "fill" position and the piston is withdrawn, the resulting vacuum causes injection liquid to be drawn out of the vial and through the series of holes and the valve into the injection liquid chamber. Let it flow so that it is filled with water. At the same time the spring is compressed. The valve is then rotated to create a direct passage to the orifice of the injection chamber nozzle member. When the syringe trigger is pulled, the spring rapidly drives the piston or plunger forward, forcing the injection fluid out of the injection chamber and through the orifice.

SUMMARY OF THE INVENTION In these known syringes, due to the residual amount of injection solution remaining in the various passages leading from the vial to the injection chamber, it is difficult to remove the first vial and remove another injection solution. It is not possible to easily interchange different injection solutions by substituting a second vial containing a second vial.

An object of the present invention is to provide an injection-type hypodermic syringe equipped with an injection-type hypodermic syringe that allows injection vials containing different injection solutions to be easily replaced with an injection-type hypodermic syringe.

(Means for solving the problem) In order to achieve the above object, the present invention includes:
An adapter for an injection vial includes a base member that firmly grips the neck of an injection vial, a connecting ring member that connects the adapter to the injection hypodermic syringe, and a connection between the two by the base member and the connecting ring member. It has a rigidly clamped disc member and a needle member centrally located on the base member. The disk member has a cylindrical cavity in its center and a diaphragm membrane that seals the cavity, and a through hole in the center of the diaphragm membrane that is closed when the diaphragm membrane is in a relaxed state. is formed. The needle member has a pointed end that pierces the rubber plug of the injection vial, and a first opening in the side wall of the needle member.
and a second opening, each of which has first and second holes extending longitudinally within the needle member and communicating with each other. A first hole communicates with the atmosphere and a second hole communicates with the cavity. In addition, injection type hypodermic syringe,
The nozzle member has a protrusion that expands the diaphragm membrane from a relaxed state when connected to the adapter to open the through hole and align it with the injection nozzle.

(Function) The rubber plug of the injection vial is pierced with the needle member of the adapter, and the adapter is firmly gripped by the neck of the injection vial by the base member of the adapter. At this time, since the diaphragm membrane of the disk member is in a relaxed state, the through hole formed in the diaphragm membrane is kept in a closed state. Therefore, the injection solution in the injection solution vial is prevented from leaking to the outside.

The nozzle portion of the injection hypodermic syringe is connected to the adapter by a connecting ring member. At this time, the protruding part of the nozzle part of the injection hypodermic syringe pushes the diaphragm membrane toward the cavity, expands it, and pushes open the through hole formed in the diaphragm membrane. The through-hole is aligned with the injection liquid injection port of the injection hypodermic syringe.

The connected hypodermic syringe and injection vial are inverted, and the piston of the hypodermic syringe is retracted. At this time, the injection liquid in the injection liquid vial passes through the second hole, is drawn into the cavity, and is further drawn into the injection liquid chamber of the injection hypodermic syringe. The first hole is in communication with the atmosphere, thereby compensating for the pressure drop within the injection vial due to injection liquid aspiration and allowing injection liquid to be drawn off.

After the predetermined amount of injection solution has been drawn, the spray hypodermic syringe is removed from the injection vial. This causes the adapter's diaphragm membrane to relax,
The through hole is closed to prevent the injection solution from leaking outside the vial.

This prevents the injection liquid from remaining in the passageway leading from the injection liquid vial to the injection liquid chamber of the injection hypodermic syringe, allowing a predetermined amount of a different injection liquid to be aspirated from another injection liquid vial. .

(Embodiment) First of all, referring to FIG.
The internal structure of the adapter for an injection vial, which is a part of the adapter, is shown as a cross-sectional view. The adapter is indicated generally at 10. As can be seen from this drawing, the adapter 10 basically consists of three members: a base member 12, a disk member 14, and a connecting ring member 16. Base member 12 is preferably injection molded from a sterilizable, non-toxic plastic material such as polysulfone. The base member 12 has an annular groove 2
0 has a substantially flat surface 18 formed therein. A needle member 22 is centrally located on base member 12 and extends outwardly from a surface opposite surface 18 . It is adapted to pierce the well-known rubber plug of injection vials used when drugs are to be administered by subcutaneous injection. As shown, a first hole 24 and a second hole 26 are provided longitudinally through the needle member 22. First hole 24
extends from an opening adjacent the needle tip 28 to a proximal outlet 30 proximate the needle base. The second hole 26 has a lateral opening 32 in the side wall of the needle member.
and an outlet opening 34 located approximately in the center of said circular surface 18.

Reference numerals 36 and 38 designate two of the fingers of the collet adapted to fit around the neck of a known injection vial. An axially slidable ring 40 surrounds the collector of the adapter 10 and is used to press the fingers 36 and 38 to firmly grip the neck of the injection vial.

The disc-shaped disc member 14 is preferably made of natural rubber and has an annular bead 4 cooperating with an annular groove 20 provided in the surface 18 of the base member 12.
It has 2. Similarly, disk member 14 has an annular bead 44 on its opposite surface adapted to mate with a corresponding annular groove in coupling ring member 16. When the connecting ring member 16 is then adhered to the base member 12, the disk member 14 is firmly gripped with a liquid-tight seal formed therebetween.

A cylindrical recess or cavity 46 is formed in the center of the disk member 14. As shown, the needle member 2
The second hole 26 opened in 2 is in communication with the cavity 46. A diaphragm membrane 48 integrally formed with the disk member 14 and located at the center thereof.
The outer surface is flat, but the inner surface has a void 4
The disk member 14 has an inclined surface extending from the side wall of the disk member 6 toward the geometric center of the disk member 14.

When manufacturing the disk member 14, the disk member 14 is stretched using a suitable jig, and in the stretched state, a hole of a predetermined size is punched in the center of the diaphragm membrane 48. When the stretching force is then released, the hole shrinks to approximately a "zero diameter hole" and the diaphragm membrane 4
Located approximately in the center of 8.

Although it should not be interpreted as a limitation, the disk member 1
The dimensions of the diaphragm membrane in step 4 are as follows:
0.05808mm to 0.381mm (approximately 0.002 to 0.015 inch)
, and the intersection with the cylindrical side wall of the cavity 46 is tapered to a thickness in the range of approximately 0.006 to 0.40 inches. It was found to be appropriate. However, different dimensions may be used for natural rubbers with different durometer values.

The connecting ring member 16 has a substantially cylindrical shape,
Preferably, the base member 12 is made of the same type of plastic used in forming the base member 12, and polysulfone is a non-toxic and Food and Drug Administration (FDA) approved material with satisfactory performance. Demonstrate. The inner diameter of the connecting ring member 16 is sized to fit around the nozzle member of a jet hypodermic syringe, and is further provided with two L-shaped slots as shown at 50 at diametrically opposed locations. ing. L-shaped slot 5
0,50 is a cylindrical shape extending radially from the side of the nozzle member of the syringe in order to fix the adapter 10 and the injection vial attached thereto to the injection hypodermic syringe, as will be explained later. It is designed to match the insertion pin.

Referring to FIG. 2, the adapter 10 shown in FIG. 1 is fixed to the neck of the injection vial 52 with the metal cap portion 54 of the injection vial 52 firmly gripped by the collector. A cross-sectional view is shown. The needle member 22 of the adapter 10 pierces the rubber plug 56 of the injection vial 52 and the injection solution enters the lateral opening 32 of the needle member 22 and passes through the second longitudinal hole 26 into the cavity. It is in a position that fills 46. Base outlet 3 of said first hole 24
Note that 0 is located below the metal cap portion of the injection vial 52 and is therefore exposed to the atmosphere. There, when the injection solution is allowed to flow from the injection solution vial 52 into the cavity 46,
A volume of air is allowed to pass through the first hole 24, resulting in the pressure within the injection vial 52 being balanced, ie maintained at a pressure equal to atmospheric pressure. Since the diaphragm membrane 48 is in a relaxed, unstretched state, the "zero diameter hole" therethrough is closed and no injection fluid can escape through the diaphragm membrane 48.

In FIG. 2, the adapter 10 and its associated injection vial 52 are suspended above the nozzle of a hypodermic syringe, but are not yet mechanically coupled thereto. Only a portion of the jetting hypodermic syringe is shown, which is designated as a whole at 58. The body portion 60 of the syringe 58 has a piston 6 placed within an injection fluid chamber 64.
It incorporates a spring (not shown) arranged to drive 2. A nozzle member 66 is screwed onto the head of the syringe 58 . Nozzle member 66 is provided with a slotted hole 68 which terminates in a smaller orifice 70 drilled in a hemispherical projection 72 of nozzle member 66 .

In FIG. 3, adapter 10 connects its insertion pins 74, 74 (FIG. 2) to nozzle member 66 of injection hypodermic syringe 58 through L-shaped slots provided in the side wall of connecting ring member 16 of adapter 10. 50 (FIG. 1). Hemispherical projection 72 of nozzle member 66
expands the diaphragm membrane 48 into the cavity 46 of the disk member 14, and it can be seen that this expansion causes the diaphragm membrane 48 to elongate and thereby open a zero diameter hole through the membrane at its center. Probably. This now open hole is aligned with the orifice 70, and when the piston 62 is moved rearward within the injection chamber 64, a vacuum is created within the injection chamber 64; The injection solution is withdrawn from the injection solution vial 52 through the lateral opening 32 and the second longitudinal hole 26 . Because of the first hole 24 or pressure equalization hole, air is replaced by the volume of injection solution withdrawn from the injection vial 52.

Once a pre-measured dose has been drawn into the cylinder bore 64 of the jet syringe 58, the adapter 1
0 is again removed from the nozzle member 66 of the syringe 58 and, in doing so, the diaphragm membrane 48 returns to its self-sealing condition to prevent spillage or leakage from the injection vial 52. syringe 5
8 is now ready for injection.

In order to obtain the necessary accuracy of the dose drawn and injected by the jet injector, it is important that atmospheric pressure is maintained within the injection vial. The present invention requires the techniques described below.

In FIG. 4, an injection vial 52 and an adapter 10 secured thereto are connected to a jetting hypodermic syringe 58 in the manner previously described;
The injection liquid vial is located below the syringe so that the injection liquid does not cover the needle member 22. When in this position, the pressure due to the initial deflection of the diaphragm membrane 48 during coupling will be compensated by air escaping from the base outlet 30. The assembly is then inverted as shown in FIG.
is allowed to submerge into the injection solution. If the assembly is held in the position of FIG. 5 for a short period of time, such as for 5 seconds, the trapped air will be located above the level of the injection solution in the injection vial 52. The prescribed injection dose is then withdrawn from the injection liquid vial 52 into the injection liquid chamber of the injection hypodermic syringe. When the injection solution is withdrawn, air will be replaced by the volume of injection solution withdrawn from the injection solution vial 52. That is, air flows through the base outlet 3
It will be seen that it is inhaled through the first hole 24 and rises through the injection as a bubble. While holding the assembly in the position shown in FIG. 5, the adapter 10 is twisted and removed from the injection hypodermic syringe. Upon removal, the injection solution will remain in the cavity 46 and air will be excluded therefrom. Once removed, the injection vial and adapter assembly can be stored in any position without injection liquid spilling or seeping.

(Effects of the Invention) There is practically no injection solution remaining in the injection hypodermic syringe after the injection is performed. Therefore, another injection vial containing a different injection solution can be immediately attached to the injection hypodermic syringe, and the injection solution chamber can be filled with a different injection solution. At this time, the remaining injection solution does not mix with the newly filled injection solution, as in the well-known injection type hypodermic syringe.

Additionally, when it is intended to inject a mixture of two or more different injection solutions in a single dose, the first injection vial with the adapter attached is connected to the injection hypodermic syringe and placed in the injection chamber. 1st
A predetermined amount of injection solution is aspirated, and then a second injection vial with another adapter attached is connected to the injection hypodermic syringe to aspirate a predetermined amount of the second injection solution into the injection solution chamber. can be mixed and injected as a single dose.

[Brief explanation of drawings]

FIG. 1 shows a cross-sectional view of an embodiment of an adapter forming part of the invention, and FIG. 2 shows the adapter of FIG. FIG. 3 is a cross-sectional view showing a state in which the adapter and an injection vial connected thereto are connected to a nozzle member of a hypodermic syringe. FIG. 4 is an elevational side view showing the assembly shown in FIG. 3 in the first stage of the filling operation, and FIG. 5 is the second stage of the filling operation.
FIG. 3 is an elevational side view showing the orientation of the staged assembly; DESCRIPTION OF SYMBOLS 10... Adapter, 12... Base member, 14... Disc member, 22... Needle member, 24... First hole, 2
6... Second hole, 28... Needle member tip, 32... Lateral opening, 36, 38... Collet finger-like member, 46...
Blank space, 48... Diaphragm membrane, 52... Injection vial, 56... Rubber plug, 58... Injection type hypodermic syringe, 60... Main body portion, 62... Piston, 64...
Injection liquid chamber, 66... Nozzle member, 68... Pore, 70
...Orifice, 72...Protrusion, 74...Insertion pin.

Claims (1)

[Scope of Claims] 1. An injection type hypodermic syringe equipped with an injection liquid vial adapter, wherein the injection liquid vial adapter comprises: a base member that firmly grips the neck of the injection liquid vial; a connecting ring member connected to a hypodermic syringe; a disk member firmly sandwiched between the base member and the connecting ring member, the disk member having a cylindrical cavity in the center thereof; a diaphragm membrane having a through hole in the center thereof that is closed when the diaphragm membrane is in a relaxed state; The needle member has a pointed end that pierces the rubber plug of the injection vial, and first and second openings in the side wall of the needle member.
first and second holes extending longitudinally within the needle member, the first hole communicating with the atmosphere and the second hole communicating with the cavity; a needle member having first and second holes, and when the injection hypodermic syringe is connected to the adapter, the diaphragm membrane is expanded from a relaxed state to open the through hole. A jet-type hypodermic syringe equipped with an adapter for an injection vial, characterized in that the nozzle member has a protrusion that is aligned with an injection nozzle.