JPH02111703A - Suspension preparation of agricultural chemicals - Google Patents
Suspension preparation of agricultural chemicalsInfo
- Publication number
- JPH02111703A JPH02111703A JP26448988A JP26448988A JPH02111703A JP H02111703 A JPH02111703 A JP H02111703A JP 26448988 A JP26448988 A JP 26448988A JP 26448988 A JP26448988 A JP 26448988A JP H02111703 A JPH02111703 A JP H02111703A
- Authority
- JP
- Japan
- Prior art keywords
- water
- soluble
- suspension
- agricultural chemicals
- self
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000725 suspension Substances 0.000 title claims abstract description 26
- 239000003905 agrochemical Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title abstract description 14
- 229920001222 biopolymer Polymers 0.000 claims abstract description 12
- 239000004094 surface-active agent Substances 0.000 claims abstract description 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 21
- 238000009472 formulation Methods 0.000 claims description 13
- 229920003169 water-soluble polymer Polymers 0.000 claims description 12
- -1 polyoxyethylene Polymers 0.000 abstract description 17
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract description 10
- 239000006185 dispersion Substances 0.000 abstract description 7
- 229920000642 polymer Polymers 0.000 abstract description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract description 3
- 229920001732 Lignosulfonate Polymers 0.000 abstract description 2
- 150000001346 alkyl aryl ethers Chemical class 0.000 abstract 1
- 229920006158 high molecular weight polymer Polymers 0.000 abstract 1
- 150000002605 large molecules Chemical class 0.000 abstract 1
- 239000000575 pesticide Substances 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
- 239000000843 powder Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 235000001727 glucose Nutrition 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000011324 bead Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000013583 drug formulation Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 150000002304 glucoses Chemical class 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920001206 natural gum Polymers 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 150000008379 phenol ethers Chemical class 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- WCVOGSZTONGSQY-UHFFFAOYSA-N 2,4,6-trichloroanisole Chemical compound COC1=C(Cl)C=C(Cl)C=C1Cl WCVOGSZTONGSQY-UHFFFAOYSA-N 0.000 description 1
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical compound C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 241000589634 Xanthomonas Species 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 231100000045 chemical toxicity Toxicity 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000003090 pesticide formulation Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は懸濁安定性・流動性及び自己分散性の優れた懸
濁状農薬製剤に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a suspended agricultural chemical formulation with excellent suspension stability, fluidity and self-dispersibility.
従来の技術
従来、ａ薬は粉剤、乳剤、水和剤等の剤型に製剤され、
使用されている。しかし、これらは次のような欠点を有
している。例えば、粉剤は散布時に飛散するため、公害
の原因となる。また、乳剤は多量に有機溶剤を使用する
ため、大気汚染に繋がるだけでなく、省資源化にも反し
ている。更に、水和剤は、水希釈時に粉が飛散するため
、作業者の安全性に問題がある。Conventional technology Traditionally, a drug has been formulated into powders, emulsions, wettable powders, etc.
It is used. However, these have the following drawbacks. For example, powder agents scatter when sprayed and cause pollution. Furthermore, since emulsions use large amounts of organic solvents, they not only lead to air pollution but also go against resource conservation. Furthermore, since powders of wettable powders scatter when diluted with water, there is a safety problem for workers.
そこで、これらの欠点を改善するため、懸濁状製剤（フ
ロアブル製剤）が開発されている。懸濁状製剤は、微細
に粉砕した農薬原体を界面活性剤及び水溶性高分子等を
配合し、懸濁状に安定化した製剤であり、使用に際して
は、乳剤と同様に水に希釈して散布でき、乳剤と同様の
薬効が期待できる。また、懸濁状製剤は有機溶剤を殆ど
含まないため、乳剤に比べ溶媒に起因する薬害の問題も
なく、更に製造、貯蔵、輸送上においても安全である等
の利点を備えている。Therefore, in order to improve these drawbacks, suspension preparations (flowable preparations) have been developed. Suspension preparations are stabilized suspension preparations by blending finely ground agricultural chemical ingredients with surfactants, water-soluble polymers, etc., and when used, they must be diluted with water in the same way as emulsions. It can be sprayed by hand and can be expected to have the same medicinal efficacy as emulsion. In addition, since suspension preparations contain almost no organic solvent, they have the advantage that, compared to emulsion preparations, there is no problem of chemical toxicity caused by solvents, and they are also safer in production, storage, and transportation.
この種の製剤では、懸濁液中の原体等の安定化のために
、種々の方法が試みられている。その一つに分散効果の
ある界面活性剤と保護コロイド剤として水溶性高分子化
合物を併用し、系の粘度を適当に高め、分散粒子の分離
、沈降を防ぐ方法がある。In this type of formulation, various methods have been tried to stabilize the drug substance in suspension. One method is to use a surfactant with a dispersing effect and a water-soluble polymer compound as a protective colloid in combination to appropriately increase the viscosity of the system and prevent separation and sedimentation of dispersed particles.
保護コロイド剤としての水溶性高分子化合物として、ア
ラビアゴム、アルギン酸ソーダ、トラガン（・ガム、デ
キストリン、ゼラチン、カゼイン、ニカワ、カルボキシ
メチルセルロース、メチルセルロース、ヒドロキシエチ
ルセルロース、ポリビニルアルコール、ポリビニルピロ
リドン、可溶性澱粉、ポリアクリル酸ソーダ、無水マレ
イン酸スチレン共重合体、無水マレイン酸−イソブチレ
ン共重合体等が挙げられる。また、水溶性バイオポリマ
ーであるキサンタンガムも懸濁状農薬製剤に使用される
ことは公知である。Water-soluble polymer compounds used as protective colloid agents include gum arabic, sodium alginate, tragan, dextrin, gelatin, casein, glue, carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, soluble starch, and polyacrylic. Examples include acid soda, maleic anhydride styrene copolymer, maleic anhydride-isobutylene copolymer, etc. It is also known that xanthan gum, which is a water-soluble biopolymer, is also used in suspended agricultural chemical formulations.
このような農薬懸濁状製剤において、長期間の安定性を
得るためには、前述の如き高分子化合物を多量に使用し
、系の粘度を高めてやらなければならず、更に、粘度を
高めた農薬懸濁状製剤を水に希釈するには、自己分散性
が悪いため撹拌装置を必要とする。In order to obtain long-term stability in such pesticide suspension formulations, it is necessary to use a large amount of the above-mentioned polymer compounds to increase the viscosity of the system. In order to dilute a pesticide suspension preparation in water, a stirring device is required due to its poor self-dispersibility.
発明が解決しようとする課題
本発明は、このように、安定した製品を得るためには、
高分子化合物の添加量を多（しなければならず、扱い難
いとされていた農薬懸濁状製剤を改良し、懸濁安定性、
流動性及び自己分散性いずれにも優れた扱い易い農薬懸
濁状製剤を提供することを課題とする。Problems to be Solved by the Invention The present invention solves the following problems in order to obtain a stable product.
We improved the suspension stability of pesticide suspension formulations, which were considered difficult to handle due to the large amount of polymer compounds added.
It is an object of the present invention to provide an easy-to-handle pesticide suspension formulation that has excellent fluidity and self-dispersibility.
問題点を解決するための手段
本発明者らは、鋭意研究の結果、懸濁安定化ならしめる
ための界面活性剤と、水溶性バイオポリマーを含む懸濁
状農薬製剤に、カル７にキシル基を有する水溶性高分子
を配合することにより、自己分散性が著しく向上するこ
とを見い出し本発明を達成した。Means for Solving the Problems As a result of intensive research, the present inventors added a xyl group to Cal7 in a suspended agricultural chemical formulation containing a surfactant for stabilizing the suspension and a water-soluble biopolymer. The present invention has been achieved by discovering that self-dispersibility is significantly improved by incorporating a water-soluble polymer having the following.
本発明における水溶性バイオポリマーとは、キサンクン
ガム、ラムザンガム等の醗酵多［１’ｆｌである。キサ
ンタンガムは微生物キサントモナス（ＸＡＮＴＩＩＩＯ
ＩＩＡＳ） 、キャンヘストリス（ＣＡＭＰＩｉＳＴｌ
？ＩＳ）が、ブドウ糖を醗酵させて、その菌体外に７！
ｓ ４ｎ した多糖類を精製し、粉末にした天然のガム
質である。The water-soluble biopolymer in the present invention is a fermented polymer such as xanthogum or ramsan gum. Xanthan gum is derived from the microorganism Xanthomonas (XANTIIIO
IIAS), CAMPIiSTl
? IS) ferments glucose and releases 7!
It is a natural gum made by refining s 4n polysaccharides and turning them into powder.
キサンタンガムの構造は下記に示す通り、直鎖は２個の
グルコースからなり、側鎖は２個のマンノースと１個の
グルコン酸からなるものである。The structure of xanthan gum is shown below, with the straight chain consisting of two glucose units, and the side chain consisting of two mannose units and one gluconic acid unit.
また、ラムザンガＪ、は倣生物へＬＣＡＬＩＧＩ！ＮＩ
！Ｓ ５ＰＩＥＣ１１！Ｓ、 ＾ＴＣＣ３１９６１（
八ＩＩＥＲＩｃＡＮ ＴＹＰＩ！ ＣｔｌＬＴｔｌ
ＲＵ Ｃ０ＬＬ［ＣＴｌ０Ｎにおける登録Ｎｏ、）が
グルコースを醗酵さ・Ｕて、その菌体外に蓄積した多ｔ
Ｊ！類を精製し、粉末にした天然ガム質である。その化
学構造は下記に示すように、主鎖は２個のグルコースと
、グルクロン酸とラムノースが各１個、側鎖は２個のグ
ルコースより構成されている。Also, Ramzanga J, LCALIGI to imitators! N.I.
! S5PIEC11! S, ^TCC31961(
8IIERIcAN TYPI! CtlLTtl
RU C0LL [registration number in CTl0N, )] ferments glucose and accumulates it outside the bacterial body.
J! It is a natural gum substance that has been refined and powdered. Its chemical structure is shown below, with the main chain consisting of two glucoses, one each of glucuronic acid and rhamnose, and the side chain consisting of two glucoses.
ｉｏ はＮ ａ ＊ ”又はｚ（：１を示す。io indicates Na*” or z(:1.
上記バイオポリマーは、農薬懸濁状製剤中に掻少量添加
することにより、著しいチキソトロピー性を示し、懸濁
安定化に効果を発揮する。その添加量は０．０２〜０．
５重量％、特に０．０２〜０．１重量％であるのが好ま
しい。 ′″′次に本発明に用いられる界面
活性剤としては、リグニンスルホン酸塩、アルキルアリ
ルスルホン酸塩、ジアルキルスルホサクシネート、ポリ
オキシエチレンアルキル了りルフォスフェート、ポリオ
４−ジエチレンアルキルアリルエーテルサルフェート、
アルキルナフタレンスルホン酸塩、ポリオキシエチレン
スヂリルフェニルエーテサルフエト等のアニオン性界面
活性剤、ポリオキシエチレンアルキルアリルエーテル、
ポリオキシエヂレンスチリルフヱニルエーテル、ポリオ
キシエチレンアルキルエーテル、ポリオキシエチレンア
ルキルエステル、ポリオキシエチレンソルビタンアルキ
レート、ポリオキシアルキレングリコール、ポリオキシ
エチレンスチリルフェノールエーテルボリマー等のノニ
オン性界面活性剤が挙げられるが、これらに限定される
ものではない。これらは単独で使用しても、２種以上混
合使用してもよい。When the above-mentioned biopolymer is added in a small amount to a pesticide suspension preparation, it exhibits remarkable thixotropy and is effective in stabilizing the suspension. The amount added is 0.02 to 0.
Preferably it is 5% by weight, especially 0.02-0.1% by weight. ''''Next, the surfactants used in the present invention include lignin sulfonate, alkylaryl sulfonate, dialkyl sulfosuccinate, polyoxyethylene alkyl phosphate, and poly(4-diethylene alkyl allyl ether sulfate). ,
Alkylnaphthalene sulfonate, anionic surfactant such as polyoxyethylene dilylphenyl ether sulfate, polyoxyethylene alkyl allyl ether,
Nonionic surfactants such as polyoxyethylene styryl phenol ether, polyoxyethylene alkyl ether, polyoxyethylene alkyl ester, polyoxyethylene sorbitan alkylate, polyoxyalkylene glycol, polyoxyethylene styryl phenol ether polymer, etc. These include, but are not limited to. These may be used alone or in combination of two or more.
また、本発明の自己分散性向上剤として働くカルボキシ
ル基を有する水溶性高分子とは、カルボキシメチルセル
ロース、カルボキシメチル化デンプン、ポリアクリル酸
、無水マレイン酸−スチレン共重合体、無水マレイン酸
−イソブチレン共重合体及びその塩等である。In addition, water-soluble polymers having carboxyl groups that act as self-dispersion improvers in the present invention include carboxymethyl cellulose, carboxymethylated starch, polyacrylic acid, maleic anhydride-styrene copolymer, maleic anhydride-isobutylene copolymer, and so on. These include polymers and their salts.
上記カルボキシル基を有する水溶性高分子は、農薬懸濁
製剤の自己分散性に効果を発揮するものであり、その添
加量は０．０５〜５重量％、特に０．１〜２重量％であ
るのが好ましい。The above-mentioned water-soluble polymer having a carboxyl group exhibits an effect on the self-dispersibility of the pesticide suspension preparation, and the amount added is 0.05 to 5% by weight, particularly 0.1 to 2% by weight. is preferable.
なお、本発明の製品には、防腐剤、香料、染料等を添加
されてもよい。Note that preservatives, fragrances, dyes, etc. may be added to the product of the present invention.
次に、本発明を実施例により具体的に説明するが、本発
明はこれら実施例に限定されるものではない、なお、実
施例において部及び％とあるのは、特に断りがない限り
重量部及び重量％を示す。Next, the present invention will be specifically explained with reference to Examples, but the present invention is not limited to these Examples. In the Examples, parts and % refer to parts by weight unless otherwise specified. and weight %.
縣 の ゛ ＡＸＪｌ成 （
り 硫 黄 ５０％Ｉチレ
ングリコール ８％界面活性剤
３％
水 ３９％−（ＩＩＹ）％
バイオポリ７− Ｘ％％
１００％
５００Ｉｌ＋ ｊ！ビーカーに、組成（りの硫黄、エチ
レングリコール、界面活性剤及び水と、〜■成（１）１
００部に対して２００部の０．８＋ｎｍのガラスピーズ
を入れ、ホモデイスパー（日本特殊機化ｆ！壜製）で２
０００ｒｐｍ ｘ １時間撹拌し、その後、組成（＋）
のバイオポリマーと自己分散性改良剤（カルボキシル基
を有する水溶性高分子）を加え、２０００ｒｐｍ ｘ
１分撹拌混合した後、濾過してガラスピーズを除去し、
懸濁状農薬製剤を得る。Prefecture's ゛ AXJl formation (
Ri Sulfur 50%I tyrene glycol 8% Surfactant
3% Water 39%-(IIY)%
Biopoly7- X%% 100% 500Il+ j! In a beaker, add the composition (sulfur, ethylene glycol, surfactant, and water, ~■ Composition (1) 1
Add 200 parts of 0.8+nm glass beads to 00 parts, and add 200 parts of 0.8+nm glass beads to 00 parts, and mix with Homo Disper (made by Nippon Tokushu Kikaku f! Bottle).
000 rpm x 1 hour, then composition (+)
Add biopolymer and self-dispersion improver (water-soluble polymer with carboxyl group) and mix at 2000 rpm x
After stirring and mixing for 1 minute, filter to remove glass beads.
A suspended pesticide formulation is obtained.
実施例１〜１６及び比較例１〜１０
組成−（りの、バイオポリマーと自己分散性改良剤（カ
ルボキシル基を有する水溶性高分子）の種類及び添加量
を表−１に示すように変化させ、界面活性剤としてポリ
オキジエチレンジスチレン化フェノールエーテル（ＥＯ
１３モル）を使用して、前記製法式に従って懸濁状ａ薬
製剤を１３た。Examples 1 to 16 and Comparative Examples 1 to 10 Composition - The types and amounts of biopolymer and self-dispersion improver (water-soluble polymer having a carboxyl group) were changed as shown in Table 1. , polyoxydiethylene distyrenated phenol ether (EO) as a surfactant.
13 mol) was used to prepare a suspension a-drug formulation according to the above manufacturing formula.
各懸濁状ａ薬製剤の懸濁安定性及び自己分散性を下記の
方法で試験した結果を表−１に示す。Table 1 shows the results of testing the suspension stability and self-dispersibility of each suspended drug formulation using the following methods.
−盟９亘ｒＦＪｆＬ査
２５ｍ ｌの栓付き試験管に′Ｍ、濁状層状農薬製剤Ｏ
ｎ＋ｌ加え、そのまま放置し、１０℃×ｌケ月及び４０
’Ｃ×１ケ月の経時安定性を次の式により算出し、数字
が大きいほど安定性が悪いことを示す。- In a 25 ml test tube with a stopper, add the cloudy layered pesticide preparation O.
Add n+l, leave as is, and incubate at 10°C for 1 month and 40
The stability over time of 'C x 1 month was calculated using the following formula, and the larger the number, the worse the stability.
１００Ｉ１１７！ツメスジリンダ−に５°硬水をｌｏｏ
ｍ ｊｌ加え、懸濁状農薬製剤を１滴落とし、その自己
分散性を肉眼判定する。表示は以下により行った。100I117! Add 5° hard water to Tsumesji Linda.
m jl, one drop of the suspended agricultural chemical formulation is dropped, and its self-dispersibility is visually judged. The display was performed as follows.
実施例１７〜３０及び比較例１１−１５組成（１）の、
バイオポリマーと自己分散性改良剤（カルボキシル基を
有する水溶性高分子）の種類及び添加量を表−２に示す
ように変化させ、界面活性剤としてポリオキシエチレン
（１３，０モル）ジスチレン化フェノールエーテル 号
ルフエート アンモニウムを使用して、前記製法へに
従って懸濁状ａ薬製剤を得た。Examples 17-30 and Comparative Examples 11-15 Composition (1),
The types and amounts of the biopolymer and self-dispersion improver (water-soluble polymer with carboxyl groups) were changed as shown in Table 2, and polyoxyethylene (13.0 mol) and distyrenated phenol were used as the surfactant. A suspended a drug formulation was obtained using ether No. sulfate ammonium according to the above manufacturing method.
各懸濁状農薬製剤の懸濁安定性及び自己分散性の試験結
果を表−２に示す。Table 2 shows the suspension stability and self-dispersibility test results for each suspended agricultural chemical formulation.
実施例３１〜４０及び比較例１６〜２０組成＜１＞の、
バイオポリマーと自己分散性改良剤（カルボキシル基を
有する水溶性高分子）の種類及び添加量を表−３に示す
ように変化させ、界面活性剤としてポリオキシエ・ｙ−
レン（１３，０モル）ジスチレン化フェノールエーテル
フォスフェートを使用して、前記製法Ａに従って懸濁
状農薬製剤を得た。Examples 31 to 40 and Comparative Examples 16 to 20 composition <1>,
The types and amounts of the biopolymer and self-dispersion improver (water-soluble polymer having carboxyl groups) were varied as shown in Table 3, and polyoxyethylene y-
A pesticide suspension formulation was obtained according to Process A above using Ren (13.0 mol) distyrenated phenol ether phosphate.
各懸濁状農薬製剤の懸濁安定性及び自己分散性の試験結
果を表−３に示す。Table 3 shows the suspension stability and self-dispersibility test results for each suspended agricultural chemical formulation.
発明の効果
本発明の懸濁状農薬製剤は、少量の高分子化合物の添加
で製造でき、流動性、自己分散性及び安定性いずれにも
葬常に優れた扱い易い製品となる。Effects of the Invention The suspension agricultural chemical formulation of the present invention can be manufactured by adding a small amount of a polymer compound, and becomes an easy-to-handle product with excellent fluidity, self-dispersibility, and stability.
Claims (1)
ための界面活性剤、水溶性バイオポリマー及びカルボキ
シル基を有する水溶性高分子を配合して、該農薬原体を
水中に懸濁してなるものであり、上記水溶性バイオポリ
マーを０．０２〜０．５重量％、上記水溶性高分子を０
．０５〜５重量％含有することを特徴とする懸濁状農薬
製剤。A surfactant, a water-soluble biopolymer, and a water-soluble polymer having a carboxyl group are blended into a water-insoluble or poorly soluble agricultural chemical to stabilize the suspension, and the agricultural chemical is suspended in water. The water-soluble biopolymer is 0.02 to 0.5% by weight, and the water-soluble polymer is 0.02 to 0.5% by weight.
．． A suspension agricultural chemical formulation characterized by containing 0.05 to 5% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26448988A JPH02111703A (en) | 1988-10-19 | 1988-10-19 | Suspension preparation of agricultural chemicals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26448988A JPH02111703A (en) | 1988-10-19 | 1988-10-19 | Suspension preparation of agricultural chemicals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02111703A true JPH02111703A (en) | 1990-04-24 |
| JPH0364481B2 JPH0364481B2 (en) | 1991-10-07 |
Family
ID=17403949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP26448988A Granted JPH02111703A (en) | 1988-10-19 | 1988-10-19 | Suspension preparation of agricultural chemicals |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH02111703A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010913A1 (en) * | 1994-10-11 | 1996-04-18 | Basf Aktiengesellschaft | Stable mixture of water and methazachlorine |
| WO1998034484A1 (en) * | 1997-02-10 | 1998-08-13 | Takeda Chemical Industries, Ltd. | Aqueous suspension of agrochemical |
| US5889088A (en) * | 1996-02-09 | 1999-03-30 | Hodogaya Chemical Co., Ltd. | Composite particle aqueous suspension and process for producing same |
| US6153657A (en) * | 1997-06-02 | 2000-11-28 | Hodogaya Chemical Co., Ltd. | Process for producing a solvent-less O/W type emulsion |
| EP1024692A4 (en) * | 1997-10-14 | 2001-01-03 | Huntsman Surfactants Technology Corp | A method of dispersing an insoluble material in an aqueous solution and an agricultural formulation |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3894879A (en) * | 1974-11-04 | 1975-07-15 | Kelco Co | Process of suspending soluble xanthan gum and pumpable compositions so produced |
| JPS5758601A (en) * | 1980-09-25 | 1982-04-08 | Toho Chem Ind Co Ltd | Suspension of agricultural chemical |
| JPS5878597A (en) * | 1981-10-21 | 1983-05-12 | メルク エンド カムパニー インコーポレーテッド | Heteropolysaccharide s-194 |
| JPS60197230A (en) * | 1984-01-31 | 1985-10-05 | ロ−ヌ−プ−ラン・スペシアリテ・シミ−ク | Aqueous dispersion of solid particle |
| JPS60214701A (en) * | 1984-04-05 | 1985-10-28 | Mitsubishi Petrochem Co Ltd | Suspended agricultural chemical composition |
| JPS6163601A (en) * | 1984-09-05 | 1986-04-01 | Kao Corp | Finely granulated destroying substance, its production, and suspended agricultural chemical preparation containing same |
| JPS6197202A (en) * | 1984-10-17 | 1986-05-15 | Kao Corp | Aqueous suspension composition of biocide |
| JPS6236302A (en) * | 1985-08-09 | 1987-02-17 | Kumiai Chem Ind Co Ltd | Wettable granular agricultural chemical composition |
-
1988
- 1988-10-19 JP JP26448988A patent/JPH02111703A/en active Granted
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3894879A (en) * | 1974-11-04 | 1975-07-15 | Kelco Co | Process of suspending soluble xanthan gum and pumpable compositions so produced |
| JPS5758601A (en) * | 1980-09-25 | 1982-04-08 | Toho Chem Ind Co Ltd | Suspension of agricultural chemical |
| JPS5878597A (en) * | 1981-10-21 | 1983-05-12 | メルク エンド カムパニー インコーポレーテッド | Heteropolysaccharide s-194 |
| JPS60197230A (en) * | 1984-01-31 | 1985-10-05 | ロ−ヌ−プ−ラン・スペシアリテ・シミ−ク | Aqueous dispersion of solid particle |
| JPS60214701A (en) * | 1984-04-05 | 1985-10-28 | Mitsubishi Petrochem Co Ltd | Suspended agricultural chemical composition |
| JPS6163601A (en) * | 1984-09-05 | 1986-04-01 | Kao Corp | Finely granulated destroying substance, its production, and suspended agricultural chemical preparation containing same |
| JPS6197202A (en) * | 1984-10-17 | 1986-05-15 | Kao Corp | Aqueous suspension composition of biocide |
| JPS6236302A (en) * | 1985-08-09 | 1987-02-17 | Kumiai Chem Ind Co Ltd | Wettable granular agricultural chemical composition |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010913A1 (en) * | 1994-10-11 | 1996-04-18 | Basf Aktiengesellschaft | Stable mixture of water and methazachlorine |
| US5889088A (en) * | 1996-02-09 | 1999-03-30 | Hodogaya Chemical Co., Ltd. | Composite particle aqueous suspension and process for producing same |
| WO1998034484A1 (en) * | 1997-02-10 | 1998-08-13 | Takeda Chemical Industries, Ltd. | Aqueous suspension of agrochemical |
| US6306414B1 (en) | 1997-02-10 | 2001-10-23 | Takeda Chemical Industries, Ltd. | Aqueous suspension of agrochemical |
| US6153657A (en) * | 1997-06-02 | 2000-11-28 | Hodogaya Chemical Co., Ltd. | Process for producing a solvent-less O/W type emulsion |
| EP1024692A4 (en) * | 1997-10-14 | 2001-01-03 | Huntsman Surfactants Technology Corp | A method of dispersing an insoluble material in an aqueous solution and an agricultural formulation |
| US6844293B1 (en) * | 1997-10-14 | 2005-01-18 | Huntsman Surfactants Technology Corporation | Method of dispersing an insoluble material in aqueous solution and agricultural formulation |
| US6855763B1 (en) | 1997-10-14 | 2005-02-15 | Huntsman Surfactants Technology Corporation | Method of dispersing an insoluble material in an aqueous solution and an agricultural formulation |
| US7109267B2 (en) | 1997-10-14 | 2006-09-19 | Huntsman Surfactants Technology Corporation | Method of dispersing an insoluble material in an aqueous solution and an agricultural formulation |
| US7179859B2 (en) | 1997-10-14 | 2007-02-20 | Huntsman Surfactants Technology Corporation | Method of dispersing an insoluble material in aqueous solution and agricultural formulation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0364481B2 (en) | 1991-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0322736B1 (en) | Water-soluble polymer dispersion | |
| RU2132344C1 (en) | Use of methyl-beat-cyclodextrin, method of reversible reduction of viscosity of aqueous solution, and thickened aqueous system | |
| US20020193256A1 (en) | Suspensions of particles in non-aqueous solvents | |
| JPS6335502A (en) | Aqueous microemulsion base plant protector | |
| JPH08511555A (en) | Stable aqueous formulations and uses | |
| EP0630871A1 (en) | Thickener combinations for building products | |
| CA1058050A (en) | Process of suspending soluble alignates and compositions so produced | |
| JP2011057614A (en) | Aqueous suspended agrochemical composition | |
| KR0154894B1 (en) | Aqueous suspension of hydroxyethylcellulose | |
| JPH02111703A (en) | Suspension preparation of agricultural chemicals | |
| HU228945B1 (en) | Agrochemical formulation | |
| JPH06256122A (en) | Agrichemical composition suspended in water | |
| JPS61180701A (en) | Aqueous suspensionlike biocidal composition and production thereof | |
| JPS5824401B2 (en) | Antennarukendakujiyounoyaku | |
| JPH09278602A (en) | Aqueous suspension of agrochemical preparation | |
| CN112205398A (en) | Azocyclotin water suspending agent and preparation method thereof | |
| JPS61136534A (en) | Readily soluble paste-like thickener | |
| EP0839888B1 (en) | Liquid adhesive concentrate | |
| US6410632B1 (en) | Method for suspending borate particles in aqueous dispersions | |
| JPH0334904A (en) | Microbicidal suspension composition | |
| JP2660269B2 (en) | Suspending agent for aqueous starch slurry and highly concentrated aqueous starch slurry composition | |
| CN113508808B (en) | Dispersible oil suspending agent and preparation method thereof | |
| JPS623122B2 (en) | ||
| JPH0563481B2 (en) | ||
| CN114190374B (en) | Microcapsule suspension preparation, microcapsule suspension seed coating agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |