JPH0197865A - Automatic pipette - Google Patents
Automatic pipetteInfo
- Publication number
- JPH0197865A JPH0197865A JP25490187A JP25490187A JPH0197865A JP H0197865 A JPH0197865 A JP H0197865A JP 25490187 A JP25490187 A JP 25490187A JP 25490187 A JP25490187 A JP 25490187A JP H0197865 A JPH0197865 A JP H0197865A
- Authority
- JP
- Japan
- Prior art keywords
- tip
- pipette
- motor
- test tube
- moving body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001514 detection method Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 7
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 7
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000012840 feeding operation Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
Abstract
Description
【発明の詳細な説明】 〔産業上の利用分野〕 自動分析装置等に使用される自動ピペッタに関する。[Detailed description of the invention] [Industrial application field] This invention relates to an automatic pipettor used in automatic analyzers, etc.
（発明の概要〕
本発明は自動ピペッタにおいてチップ先端が試験管に接
触したことを検知する機構を設けることにより、試験管
形状によらず微量の液体の吸引、吐出を精度良く行うこ
とを可能としたものである。(Summary of the invention) By providing an automatic pipetter with a mechanism that detects when the tip of the tip contacts a test tube, it is possible to aspirate and dispense a small amount of liquid with high precision regardless of the shape of the test tube. This is what I did.
従来、自動ピペッタがピペット動作を行う場合、コント
ローラが常にチップ先端と試験管との相対距離を把握し
ながらビベフタ移動用モータを制御していた。Conventionally, when an automatic pipettor performs a pipetting operation, a controller controls the motor for moving the pipette lid while always grasping the relative distance between the tip end and the test tube.
従来法により、複数の試験管に対しピペット動作を行う
場合、試験管の形状のばらつきがあるため、コントロー
ラは全ての試験管に対して各々相対距離を把握しなけれ
ばならず、ピペット動作の制御が複雑であった。またピ
ペッタ装置の組み込み誤差等を吸収することができなか
った。そこで本発明では、チップの先端が試験管に接触
したことを検知する機構を設けることにより、試験管の
形状の影響を受けず、また装置の組み込み誤差を吸収し
ながら精度の良いピペット動作を行えるようにする。When performing pipetting operations on multiple test tubes using conventional methods, due to variations in the shape of the test tubes, the controller must know the relative distances for all test tubes, making it difficult to control pipetting operations. was complicated. Furthermore, it was not possible to absorb installation errors of the pipettor device. Therefore, in the present invention, by providing a mechanism that detects when the tip of the tip comes into contact with a test tube, it is possible to perform pipetting operations with high precision while being unaffected by the shape of the test tube and absorbing device installation errors. do it like this.
上記問題点を解決するため、本発明においては、自動ピ
ペッタを、移動体と、該移動体を往復駆動するための駆
動手段と、前記移動体に前記駆動の方向と同方向に摺動
自在に取り付けられた摺動体と、前記摺動体に少なくと
も吐出、吸引端を取り付けられた液体吸引、吐出手段と
、前記摺動体が摺動したことを検知し、信号を出力する
検知手段から構成した。In order to solve the above problems, the present invention includes an automatic pipettor that includes a movable body, a drive means for reciprocating the movable body, and a movable body that is slidable in the same direction as the driving direction. The present invention is comprised of an attached sliding body, a liquid suction/discharge means having at least a discharge/suction end attached to the sliding body, and a detection means for detecting sliding of the sliding body and outputting a signal.
上記構成による作用を説明すると、移動体が駆動手段に
より所定方向に移動されると液体吸引吐出手段の吸引、
吐出端が試験管等の内部に挿入される。更に同方向に駆
動されると、吸引、吐出端の先端が試験管の底にあたる
、更に駆動すると、前記摺動体が相対的に駆動方向とは
逆方向に摺動される。検知手段はこれを検知し、駆動体
に信号を出力する。駆動体はこの信号を受は駆動を停止
する。To explain the effect of the above configuration, when the movable body is moved in a predetermined direction by the drive means, the liquid suction and discharge means suction,
The discharge end is inserted into a test tube or the like. When further driven in the same direction, the tips of the suction and discharge ends hit the bottom of the test tube, and when further driven, the sliding body is relatively slid in the opposite direction to the driving direction. The detection means detects this and outputs a signal to the driving body. When the driver receives this signal, it stops driving.
以下に本発明の実施例を図面に基づいて説明する。 Embodiments of the present invention will be described below based on the drawings.
第１図、第２図は本発明の装置の左側断面図であり、１
はピペッタ部、２はＺ軸駆動部、３はベース部である。1 and 2 are left sectional views of the device of the present invention, and 1
2 is a pipettor section, 2 is a Z-axis drive section, and 3 is a base section.
ピペッタ部１は、ピペッタ部ｌを構成する各部材を固着
するピペッタフレームｌ−１、先端部の空間Ｋに液体の
試薬を吸引及び吐出するチップ１−２、前記チップを固
着するニードルガイド１−３、前記チップの先端の空間
Ａの体積を変位させるニードル１−４、前記チップの先
端の空間をシールする０リング１−５、前記０リングを
押さえるナレート１−６、前記ニードルをチップ軸方向
に移動させる移動台１−７、前記移動台の摺動をガイド
するガイドレール１−８、前記移動台を送るための送り
ネジ１−９、前記送りネジを回転させるピペッタモータ
１−１０、前記ピペッタモータの回転力を前記送りネジ
に伝えるカップリング１−１１、前記ピペッタ部のチッ
プ１−２の先端が他の物に接触したのを検出するために
あるセンサープレー）１−１２からなる。The pipetter part 1 includes a pipetter frame l-1 to which each member constituting the pipetter part l is fixed, a tip 1-2 which aspirates and discharges a liquid reagent into a space K at the tip, and a needle guide 1 to which the tip is fixed. -3, a needle 1-4 that displaces the volume of the space A at the tip of the tip, an O-ring 1-5 that seals the space at the tip of the tip, a navigator 1-6 that presses the O-ring, and a needle that displaces the volume of the space A at the tip of the tip; a moving table 1-7 for moving the moving table in a direction, a guide rail 1-8 for guiding the sliding of the moving table, a feed screw 1-9 for feeding the moving table, a pipettor motor 1-10 for rotating the feed screw, and a pipette motor 1-10 for rotating the feed screw. It consists of a coupling 1-11 that transmits the rotational force of the pipettor motor to the feed screw, and a sensor plate 1-12 for detecting when the tip of the tip 1-2 of the pipetter section comes into contact with another object.
Ｚ軸駆動部２は、前記ピペッタ部のとペフタフレームを
チップ軸方向に摺動可能に取り付けるガ −イドレール
２−１．前記ガイドレールを固着し、ピペッタ部１をチ
ップ軸（２軸）方向に移動させる往復台２−２、透過形
フォトセンサであるチップ加圧センサー２−３、前記往
復台の摺動をガイドするガイドレール２−４、前記往復
台を送るための送りネジ２−５、前記送りネジのスラス
トを規制するリング２−６、前記送りネジを回転させる
Ｚ軸モータ２−７、前記Ｚ軸モータの回転力を前記送り
ネジに伝えるカップリング２−８、前記２軸駆動部を支
える支柱２−９からなる。The Z-axis drive unit 2 includes a guide rail 2-1 to which the pipetter frame and the pipetter frame are slidably attached in the tip axis direction. A reciprocating table 2-2 that fixes the guide rail and moves the pipetter section 1 in the direction of the tip axis (two axes), a tip pressure sensor 2-3 that is a transmission type photosensor, and guides the sliding movement of the reciprocating table. A guide rail 2-4, a feed screw 2-5 for feeding the carriage, a ring 2-6 for regulating the thrust of the feed screw, a Z-axis motor 2-7 for rotating the feed screw, and a Z-axis motor for rotating the feed screw. It consists of a coupling 2-8 that transmits rotational force to the feed screw, and a column 2-9 that supports the two-axis drive section.
ベース部３は、液体の試薬３−１が入った試験管３−２
、前記試験管を立てるラック３−３、前記ラック及び前
記２軸駆動部を固着するベース３−４からなる。The base part 3 includes a test tube 3-2 containing a liquid reagent 3-1.
, a rack 3-3 for standing the test tubes, and a base 3-4 for fixing the rack and the two-axis drive unit.
次に動作について以下に説明する。Next, the operation will be explained below.
本装置で試薬を吸引する場合、第１図の状態でＺ軸駆動
部２のＺ軸モータ２−７が上部から見て反時計方向に回
転するとピペッタ部１は下方に送られて第２図の状態に
なり、ピペッタ部１のチップ１−２の先端が試験管３−
２の底に接触したのをチップ加圧センサー２−３が検出
する。この検出により２軸モータ２−７が停止すると同
時にピペッタ部１のピペッタモータ１−１０が上部から
見て時計方向に所定量、回転するとニードル１−４も所
定量上昇するため、チップ１−２の先端の空間Ａの圧力
が大気圧に対して負圧になり、試薬３−１を所定量吸引
する。吸引が終了するとＺ軸駆動部２の２軸モータ２−
７が上部から見て時計方向に回転するとピペッタ部１は
上昇して元の定位置に戻って停止し、吸引の動作が終了
する。When aspirating a reagent with this device, when the Z-axis motor 2-7 of the Z-axis drive section 2 rotates counterclockwise when viewed from the top in the state shown in FIG. 1, the pipetter section 1 is sent downward and the position shown in FIG. The tip of the pipettor part 1's tip 1-2 is now in the state of the test tube 3-.
The chip pressure sensor 2-3 detects contact with the bottom of the chip. Upon this detection, the two-axis motor 2-7 stops, and at the same time, when the pipettor motor 1-10 of the pipetter section 1 rotates a predetermined amount clockwise when viewed from the top, the needle 1-4 also rises a predetermined amount, so that the tip 1-2 The pressure in the space A at the tip becomes negative with respect to atmospheric pressure, and a predetermined amount of reagent 3-1 is sucked. When the suction is finished, the two-axis motor 2- of the Z-axis drive unit 2
When the pipette 7 rotates clockwise when viewed from the top, the pipetter part 1 rises, returns to its original position, and stops, thus completing the suction operation.
なお、吐出する場合の動作は上記で説明した吸引の場合
の動作とピペッタ部の送り動作が逆になるだけなので説
明を省きます。Note that the operation for dispensing is omitted because the operation for suction and the feeding operation of the pipetter part are just the opposite of the operation for suction explained above.
次にチップ先端が試験管に接触したことを検知する機構
を以下に説明する。第２図はピペッタ部１が試験管３−
２に向かって下に移動しており、チップ１−２の先端が
試験管３−２に接触して停止した状態を表している。ピ
ペッタフレーム１−１とガイドレール２−１とは接触し
ているが上下方向にスライド可能である。第２図の状態
においては前記ピペッタフレーム１−１は重力により往
復台２−２の突起と接触している。往復台２−２に固定
されたチップ加圧センサ２−３は例えばフォトセンサの
ごときもので、発光部と受光部との間に物体が存在する
かしないかを識別できる。今、ピペッタフレーム１−１
に固定されたセンサープレート１−１２は前記チップ加
圧センサ２−７の発光部と受光部との間隙を遮っている
。さてこのままピペッタが試験管３−２にチップ１−２
先端に接触するとピペッタフレーム１−１に付随する部
分を物理的に下へ移動できなくなる。しかしピペッタフ
レーム１−１は往復台２−２に対しスライド可能なので
往復台２−２はこの往復台を移動させているＺ軸モータ
２−７が停止しない限り下方への移動を続ける。すると
今度はピペッタフレーム１−１と往復台２−２との相対
位置が第２図の符号Ｂの寸法だけ変位する。即ちそれら
に固定されているセンサブレート１−１２とチップ加圧
センサ２−３との位置関係に変位が生じる。そしてこの
センサブレートがチップ加圧センサ２−３の発光部と受
光部との間隙からすりぬける時が（る。Next, a mechanism for detecting that the tip end has contacted the test tube will be described below. In Figure 2, the pipettor section 1 is connected to the test tube 3-
2, and the tip of the tip 1-2 comes into contact with the test tube 3-2 and stops. Although the pipetter frame 1-1 and the guide rail 2-1 are in contact with each other, they are slidable in the vertical direction. In the state shown in FIG. 2, the pipettor frame 1-1 is in contact with the protrusion of the carriage 2-2 due to gravity. A chip pressure sensor 2-3 fixed to the carriage 2-2 is, for example, a photosensor, and can identify whether an object exists between the light emitting part and the light receiving part. Now pipettor frame 1-1
The sensor plate 1-12 fixed to the chip pressure sensor 2-7 blocks the gap between the light emitting part and the light receiving part of the chip pressure sensor 2-7. Now, just like this, the pipettor will insert the tip 1-2 into the test tube 3-2.
If it comes into contact with the tip, it becomes impossible to physically move the part attached to the pipetter frame 1-1 downward. However, since the pipetter frame 1-1 is slidable relative to the carriage 2-2, the carriage 2-2 continues to move downward unless the Z-axis motor 2-7, which is moving the carriage, stops. Then, the relative positions of the pipettor frame 1-1 and the carriage 2-2 are displaced by the dimension B in FIG. 2. That is, a displacement occurs in the positional relationship between the sensor plate 1-12 and the chip pressure sensor 2-3, which are fixed thereto. There are times when this sensor plate slips through the gap between the light emitting part and the light receiving part of the chip pressure sensor 2-3.
この時にチップ加圧センサがその旨をコントローラ（図
示せず）に伝え、コントローラは２軸モータ２−７に対
し、回転停止指令を与えればモータは停止し、チップ１
−２の先端が試験管３−２の底部にピペッタフレーム１
−１やそれに付随する部品の重量で決まる圧力をもって
接している状態ができる。第３図はセンサブレート１−
１２とチップ加圧センサ２−３との２種類の位置関係に
より異なる２種類の電気的処理を示している。At this time, the chip pressure sensor notifies the controller (not shown) of this fact, and the controller issues a rotation stop command to the two-axis motor 2-7, causing the motor to stop.
The tip of pipettor frame 1 is attached to the bottom of test tube 3-2.
A state of contact is created with a pressure determined by the weight of -1 and its accompanying parts. Figure 3 shows sensor plate 1-
12 and the chip pressure sensor 2-3, two different types of electrical processing are shown depending on the two types of positional relationships.
第３図のＬＥＤ３−１とホトトランジスタ３−２の対は
第１図のチップ加圧センサ２−３に当たる、このＬＥＤ
３−１とホトトランジスタ３−２の間隙を第１図のセン
サープレー）１−１２に当たる遮蔽板３−３で遮蔽して
いるときホトトランジスタ３−２のコレクタ、エミッタ
間には電流は流れないので２人カアンド素子３−４の一
方の入力電圧はＶｃｃであり、もう一方の出力であるモ
ータドライブパルス信号がそのまま出力に現れ、この信
号がモータドライバ３−５を通してモータ３−６を駆動
する。一方、ＬＥＤ３−１とホトトランジスタ３−２の
間に何もない時にはホトトランジスタ３−２のコレクタ
、エミッタ間には電流が流れ、アンド素子の一方のΔカ
ミ圧がグラウンドレベルとなるので、もう一方の入力い
かんによらずその出力は直流となり従ってモータには駆
動信号が入力されない０以上のようにＬＢＤ３−１とホ
トトランジスタ３−２の間隙の物体の有無によりモータ
の動作は制御される。The pair of LED 3-1 and phototransistor 3-2 in FIG. 3 corresponds to the chip pressure sensor 2-3 in FIG.
When the gap between phototransistor 3-1 and phototransistor 3-2 is shielded by shielding plate 3-3, which corresponds to sensor plate 1-12 in Figure 1, no current flows between the collector and emitter of phototransistor 3-2. Therefore, the input voltage of one side of the two-man AND element 3-4 is Vcc, and the motor drive pulse signal that is the output of the other side appears as it is, and this signal drives the motor 3-6 through the motor driver 3-5. . On the other hand, when there is nothing between the LED 3-1 and the phototransistor 3-2, a current flows between the collector and emitter of the phototransistor 3-2, and the Δ voltage on one side of the AND element becomes the ground level. Irrespective of the input to one side, the output becomes a direct current, so no drive signal is input to the motor.As shown in the figure above 0, the operation of the motor is controlled depending on the presence or absence of an object between the LBD 3-1 and the phototransistor 3-2.
本発明によれば試験管の形状や装置の組み込み誤差に係
わらず、チップ先端と試験管との位置関係を一定に保つ
ことが可能である。またチップ先端が試験管に接するこ
とにより、液の混入を防ぎ精度の良い吐出、吸入を可能
にするという効果がある。According to the present invention, it is possible to maintain a constant positional relationship between the tip end and the test tube regardless of the shape of the test tube or the installation error of the device. Furthermore, since the tip of the tip is in contact with the test tube, it has the effect of preventing liquid from entering the test tube and enabling highly accurate dispensing and suction.
第１図は本発明実施例の左側断面図、第２図は本実施例
の自動ピペッタ装置が動作中の状態を表す左側断面図、
第３図は本実施例における電気的処理を説明図である。
ｌ・・・・・ピペンタ部
１−１・・・ピペッタフレーム
１−２・・・チップ
１−４・・・ニードル
１−７・・・移動台
１−１０・・・ピペッタモータ
１−１２・・・センサープレート
２・・・・・２軸駆動部
２−１・・・ガイドレール
２−２・・・往復台
２−３・・・チップ加圧センサー
２−７・・・２軸モータ
３・・・・・ベース部
３−１・・・試薬
３−２・・・試験管
以上
出願人 セイコー電子工業株式会社
不禿萌１＝よう自動ご公ツタ装置の断面図第 １ 図
動作中の状ａ表表す断面図
第 ２ 図
電気的な槙床図
第３図FIG. 1 is a left sectional view of the embodiment of the present invention, and FIG. 2 is a left sectional view showing the automatic pipettor device of the embodiment in operation.
FIG. 3 is an explanatory diagram of electrical processing in this embodiment. l... Pipenter section 1-1... Pipettor frame 1-2... Tip 1-4... Needle 1-7... Moving table 1-10... Pipettor motor 1-12... ...Sensor plate 2...Two-axis drive unit 2-1...Guide rail 2-2...Reciprocating carriage 2-3...Chip pressure sensor 2-7...Two-axis motor 3 ...Base part 3-1...Reagent 3-2...Test tube and above Applicant: Seiko Electronics Co., Ltd. Fumoe 1 = Cross-sectional view of automatic vine device Fig. 1 During operation Figure 2: Cross-sectional diagram representing the state of the table Figure 3: Electrical floor diagram
Claims (1)
前記移動体に前記駆動の方向と同方向に摺動自在に取り
付けられた摺動体と、前記摺動体に少なくとも吐出、吸
引端を取り付けられた液体吸引、吐出手段と、前記摺動
体が摺動したことを検知し信号を出力する検知手段とか
らなり、前記駆動手段は、前記検知手段からの信号に基
づき移動体の駆動を停止することを特徴とする自動ピペ
ッタ。a moving body; a driving means for reciprocating the moving body;
A sliding body slidably attached to the movable body in the same direction as the driving direction, a liquid suction/discharge means having at least a discharge/suction end attached to the sliding body, and the sliding body slid. an automatic pipettor comprising: a detection means for detecting this and outputting a signal; and wherein the drive means stops driving the movable body based on the signal from the detection means.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25490187A JPH0197865A (en) | 1987-10-09 | 1987-10-09 | Automatic pipette |
| DE8888309401T DE3872341T2 (en) | 1987-10-09 | 1988-10-07 | DEVICE FOR CARRYING OUT A LIQUID REACTION. |
| EP88309401A EP0311440B1 (en) | 1987-10-09 | 1988-10-07 | Apparatus for carrying out a liquid reaction |
| US07/255,474 US5102623A (en) | 1987-10-09 | 1988-10-11 | Infinitesimal liquid reactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25490187A JPH0197865A (en) | 1987-10-09 | 1987-10-09 | Automatic pipette |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0197865A true JPH0197865A (en) | 1989-04-17 |
Family
ID=17271415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP25490187A Pending JPH0197865A (en) | 1987-10-09 | 1987-10-09 | Automatic pipette |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0197865A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04161856A (en) * | 1990-10-26 | 1992-06-05 | Hitachi Ltd | Sampling device |
| US5507193A (en) * | 1993-11-04 | 1996-04-16 | Tosoh Corporation | Pipette device |
| JP2002283239A (en) * | 2001-03-27 | 2002-10-03 | Miyagi Prefecture | Base board for superabrasive grain cutter and method of manufacture and superabrasive grain cutter using this base board |
| US7051133B2 (en) | 2002-11-25 | 2006-05-23 | Renesas Technology Corp. | Arbitration circuit and data processing system |
| WO2007011534A3 (en) * | 2005-07-15 | 2007-03-08 | Beckman Coulter Inc | Method and apparatus for maximizing liquid aspiration from small vessels |
| JP2010096640A (en) * | 2008-10-17 | 2010-04-30 | Hitachi High-Technologies Corp | Dispenser |
| WO2011030616A1 (en) * | 2009-09-11 | 2011-03-17 | 株式会社日立ハイテクノロジーズ | Dispensing device and analysis device |
| JP2018028523A (en) * | 2016-08-19 | 2018-02-22 | 東ソー株式会社 | Method for positioning operator to target object, and nozzle device |
| WO2019198493A1 (en) * | 2018-04-12 | 2019-10-17 | 株式会社日立ハイテクノロジーズ | Electrolyte analyzing device |
| EP4184176A1 (en) | 2021-11-17 | 2023-05-24 | Roche Diagnostics GmbH | Method for detection of a bottom of at least one well |
| US11982681B2 (en) | 2018-04-12 | 2024-05-14 | Hitachi High-Tech Corporation | Electrolyte analyzing device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6021455A (en) * | 1983-07-15 | 1985-02-02 | Hitachi Ltd | Sampling apparatus for automatic chemical analyzer |
| JPS61275660A (en) * | 1985-05-31 | 1986-12-05 | Hitachi Ltd | Sampling instrument |
-
1987
- 1987-10-09 JP JP25490187A patent/JPH0197865A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6021455A (en) * | 1983-07-15 | 1985-02-02 | Hitachi Ltd | Sampling apparatus for automatic chemical analyzer |
| JPS61275660A (en) * | 1985-05-31 | 1986-12-05 | Hitachi Ltd | Sampling instrument |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04161856A (en) * | 1990-10-26 | 1992-06-05 | Hitachi Ltd | Sampling device |
| US5507193A (en) * | 1993-11-04 | 1996-04-16 | Tosoh Corporation | Pipette device |
| JP2002283239A (en) * | 2001-03-27 | 2002-10-03 | Miyagi Prefecture | Base board for superabrasive grain cutter and method of manufacture and superabrasive grain cutter using this base board |
| US7051133B2 (en) | 2002-11-25 | 2006-05-23 | Renesas Technology Corp. | Arbitration circuit and data processing system |
| WO2007011534A3 (en) * | 2005-07-15 | 2007-03-08 | Beckman Coulter Inc | Method and apparatus for maximizing liquid aspiration from small vessels |
| US7284453B2 (en) | 2005-07-15 | 2007-10-23 | Beckman Coulter, Inc. | Method and apparatus for maximizing liquid aspiration from small vessels |
| JP2009501339A (en) * | 2005-07-15 | 2009-01-15 | ベックマン コールター， インコーポレイテッド | Method and apparatus for maximizing liquid aspiration from small containers |
| JP2010096640A (en) * | 2008-10-17 | 2010-04-30 | Hitachi High-Technologies Corp | Dispenser |
| WO2011030616A1 (en) * | 2009-09-11 | 2011-03-17 | 株式会社日立ハイテクノロジーズ | Dispensing device and analysis device |
| JP2011059008A (en) * | 2009-09-11 | 2011-03-24 | Hitachi High-Technologies Corp | Dispensing device and analysis device |
| US8679421B2 (en) | 2009-09-11 | 2014-03-25 | Hitachi High-Technologies Corporation | Dispensing device and analyzer |
| JP2018028523A (en) * | 2016-08-19 | 2018-02-22 | 東ソー株式会社 | Method for positioning operator to target object, and nozzle device |
| WO2019198493A1 (en) * | 2018-04-12 | 2019-10-17 | 株式会社日立ハイテクノロジーズ | Electrolyte analyzing device |
| JPWO2019198493A1 (en) * | 2018-04-12 | 2021-04-08 | 株式会社日立ハイテク | Electrolyte analyzer |
| US11982681B2 (en) | 2018-04-12 | 2024-05-14 | Hitachi High-Tech Corporation | Electrolyte analyzing device |
| EP4184176A1 (en) | 2021-11-17 | 2023-05-24 | Roche Diagnostics GmbH | Method for detection of a bottom of at least one well |
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