JPH0197468A - Wound covering material - Google Patents

Abstract

PURPOSE:To safely and continuously perform the treatment of a wound by far infrared rays for a necessary period, by bonding an alumina-silica ceramic powder containing a heavy metal emitting far infrared rays having a specific wavelength to a base material using a resin binder and specifying the pH of the whole. CONSTITUTION:An alumina-silica ceramic layer 2 is formed to the surface of a base material 1. In use, alumina-silica ceramic layer 2 is provided so as to become the surface side of a wound. The alumina-silica ceramic powder contains substantially no heavy metal and one generating far infrared rays having a peak wavelength of 4-12mum when heated to the bodily temp. of a human being or a temp. range of about room temp. is used. A wound covering material prepared by bonding this ceramic powder to the base material 1 by a resin binder is adjusted to 6-8 in its pH as a whole. As the wound covering material, polydimethylsiloxane as the binder and a material using a high pressure steam sterilizable nylon or cotton fibers as the base material 1 are desirably combined.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to wound dressings. More specifically, the present invention relates to a wound dressing that can protect a wound surface and promote healing by emitted far infrared rays.

[Prior Art] It is generally known that far infrared rays with a peak wavelength of about 4 to 12 - are effective in keeping food fresh and promoting metabolism in the human body ("The Age of Far Infrared Rays", written by Kazuyoshi Konno, 1986, ■Published by Human and History Publishing, see pages 131-250). In addition, in recent years, in hopes of promoting health through far infrared rays, cloth,
Far-infrared irradiation cloth for the human body (Utility Model Application Publication No. 55-27533, (Refer to Publications No. 55-27549 and No. 55-17L145) and far-infrared saunas have been reported to treat diseases and improve health using equipment (``New Far-Infrared Therapy'', Yamazaki Written by Toshiko, 1982, published by Human and History Company, 107-172
(see page).

[Problems to be solved by the invention] When the far-infrared irradiated cloth for the human body is applied to uninjured skin that is not injured or damaged, there is no need to sterilize the dressing material, and there are also problems regarding biocompatibility. However, there are problems with safety, sterility, and biocompatibility when trying to cover the wound directly or with gauze placed after drug treatment.

In addition, treatment using the above-mentioned equipment has the advantage of being able to change the far-infrared wavelength, radiation amount, emissivity, etc. depending on the symptom, but it has the limitation that treatment cannot be performed unless the equipment is available. .

Therefore, in view of the problems of the prior art described above, the present inventors have conducted extensive research in order to find a means to safely and continuously treat wounds with far infrared rays for a necessary period of time without using large-scale equipment. As a result, they have found for the first time a wound dressing material that not only solves these problems but also can scientifically heal wounds, and have completed the present invention.

[Means for Solving the Problems] The present invention uses alumina-silica ceramic powder that does not contain heavy metals and emits far infrared rays with a peak wavelength of 4 to 12 mm in the temperature range of human body temperature or room temperature. It is attached to the base material using a resin binder, and the overall I)H is 6.
-8.

[Operations and Examples] The alumina-silica ceramic powder used in the present invention has high purity kQ 20 s and 5i02 as main components, and contains JV 203 and 5i02 in an amount of 75% by weight or more, preferably 95% by weight or more.

Ag2 contained in the alumina-silica ceramic powder
The composition ratio (weight ratio) of Os and 5i02 is 30/-3 = 70-70/30, Nakazu<40/80-80/
Preferably, it is 40. In addition, for example, Zrs T1% Co5C is contained in the alumina-silica ceramic powder.
If heavy metals such as r are contained, they may have an adverse effect on the wound surface, so it is desirable that such heavy metals be substantially free of the wound dressing material. The detection limit of heavy metals per 1 ci of sample surface area when eluted with a solution at 60°C for 30 minutes is 1 μg/ml using the sodium sulfide colorimetric method.
It is desirable that it not be detected.

The alumina-silica ceramic powder emits far-infrared rays having a peak wavelength of 4 to 12 μm when heated to a temperature range of, for example, human body temperature or room temperature.

The particle size of the alumina-silica ceramic powder is usually adjusted by grinding to a particle size of 1 to 50, but is not particularly limited in the present invention.

As the resin binder used in the present invention, one with excellent heat resistance and biocompatibility is selected. As such a resin binder, polydimethylsiloxane is particularly preferred.

However, when the obtained wound dressing is packaged in a sterilized bag and subjected to ethylene oxide gas sterilization, gamma ray sterilization, etc. to produce a product, polyurethane, polyacrylate, or the like may be used as the resin binder.

The amount of the alumina-silica ceramic powder used is 1 part by weight (parts by weight, same hereinafter) of the resin binder.
Preferably, the amount is 0 to 70 parts, and <30 to 50 parts. If the amount used is less than 10 parts, the amount of far-infrared rays emitted will be too small and the effect of the radiation will be too small, and if it exceeds 70 parts, it will be difficult to adhere to the substrate. The amount of the ceramic powder to be used is appropriately adjusted within the above range depending on the amount of far-infrared radiation.

Examples of the base used in the present invention include woven fabrics, nonwoven fabrics, and films made of raw materials such as polyester, nylon, and cotton, which can be subjected to high-pressure steam sterilization and have low toxicity. Such a base material is effective for applications where sterility is important and must be sterilized, such as for surgical applications.

The wound dressing in which the ceramic powder is attached to the base material with a resin binder preferably has a pT of 6 to 8 as a whole. This means that if the pl of the wound dressing is 5 or less or 9 or more, When a sheet made of the ceramic powder is used to directly cover a wound surface, it causes strong irritating pain and at the same time causes chemical burns.
This is because it may worsen the wound. This pH adjustment can be done either on the resin binder side, or after the ceramic powder is attached to the base material with a resin binder, as the pH when ceramic powder is dispersed in water tends to fluctuate depending on the ceramic raw material composition and firing method. Preferably, the adjustment is carried out by treatment with a polyhydric or weakly basic solution. In the latter case, for example, if the wound dressing is alkaline, it can be soaked in a weakly acidic solution such as acetic acid or formic acid, then washed with water and dried; if it is acidic, it can be soaked in a weakly basic solution such as ammonia water. After soaking, wash with water and dry.

The wound dressing must be sterilized before use. Such sterilization methods include ethylene oxide gas sterilization, γ-ray irradiation sterilization, and high-pressure steam sterilization, but high-pressure steam sterilization, which is widely used in hospitals on a daily basis, is the most reliable. The wound dressing material that can be used in this method is preferably a material in which the binder is polydimethylsiloxane and the base material is a fiber that can be sterilized by high-pressure steam, such as polyester, nylon, or cotton.

There are no particular limitations on the method of attaching the alumina-silica ceramic powder to the base material using a resin binder, and such methods include, for example, mixing ceramic powder with a resin binder and coating, printing, impregnating, etc. An example of this is a method of attaching it by a known method. The amount of alumina-silica ceramic powder attached to the base material is adjusted depending on the amount of far infrared rays emitted.

A cross-section of one embodiment of the dressing thus obtained is shown in FIG. In FIG. 1, an alumina-silica ceramic layer (2) is formed on the surface of a base material (1). When used, the alumina-silica ceramic layer (2)
It is used with the side facing the wound side. The dressing of the present invention may be used as it is, or it may be used as a bandage by attaching the dressing to the center of an adhesive sheet base material as a wound dressing pad and covering the adhesive surface with a release sheet. good.

Next, the wound dressing of the present invention will be explained in more detail based on Examples, but the present invention is not limited to these Examples.

Examples 1 to 4 Polyester fiber (fineness: 3 denier, fiber length: 64 m
A binder-free nonwoven fabric (fabric weight: 80 g/rr?) was made by the hydroentanglement method using the material M), and this was used as a base material. The composition of a far-infrared ceramic powder having a particle size in the range of 2 to 4 lJm was adjusted as shown in Table 1, and a base material was impregnated into a suspension of the ceramic powder and a binder, and then dried. Wound dressings were obtained having the amounts of ceramic powder and binder deposited as shown in the table.

[Margins below] The thus obtained dressing material was cut to a predetermined size, and after sterilization using high-pressure steam, a clinical trial was conducted. Target diseases were evaluated using a half-side test on the naked skin surface. The results are shown below.

Case 1 The skin of the thigh of a 36-year-old woman was cut into a length of about 10 mm (711 cm) using a dermatome, which is normally used for skin grafting.
% Width approx. 5 cm 5 Thickness 18/1000 inch (approx. 0.46
The bare skin part after harvesting only 2 mm) was treated with ointment, the upper half was treated with the wound dressing obtained in Example 1, and then a gauze dressing was applied over the entire bare skin part.

After 3 months, when the gauze dressing was removed, the bare skin that had not been covered with the wound dressing showed
The skin had thick, inelastic skin that was raised higher than the surrounding skin, which had reddish-black spots in some areas, and an overall reddish-purple color similar to that of a keloid. On the other hand, unthickened skin of the same color as normal new skin was formed on the bare skin that had been covered with the wound dressing.

Case 2 The thigh skin of a 43-year-old woman was harvested in the same manner as in Case 1. After the skin was harvested, the naked skin was treated with two types of antibacterial ointment, and the upper half was treated with Example 3. The skin was covered with the resulting dressing material, and then a gauze dressing was applied over the entire bare skin area. After 4 months had passed, when the gauze dressing was removed, the bare skin that had not been covered by the wound dressing had reddish-dark spots in some areas, and the overall appearance was darker than the surrounding skin, which had a brownish color similar to that of a keloid. Thick, raised skin with no elasticity had formed.

On the other hand, unthickened skin of the same color as normal new skin was formed in the bare skin area that had been covered with the wound dressing.

The above results demonstrate that the wound dressing of the present invention can promote wound healing.

[Effects of the Invention] The wound dressing material of the present invention can protect and heal the wound surface by far infrared rays emitted by body temperature, and can be suitably used as a dressing pad, bandage, etc. .

[Brief explanation of the drawing]

FIG. 1 is a sectional view showing one embodiment of the covering material of the present invention. (Main symbols in the drawing) (1): Base material

Claims (1)

[Claims] 1. An alumina-silica ceramic powder containing no heavy metals that emits far infrared rays with a peak wavelength of 4 to 12 μm in the temperature range of human body temperature or room temperature is used as a base material using a resin binder. A wound dressing that is made by adhering to the skin and has an overall pH of 6 to 8. 2. The wound dressing according to claim 1, wherein the resin binder is polydimethylsiloxane, and the base material is a fiber or film that can be autoclaved. 3. The wound dressing according to claim 2, wherein the autoclave sterilizable fiber is made of polyester, nylon, or cotton. 4. The wound dressing according to claim 2, wherein the autoclave sterilizable film is made of polyester or nylon.