JPH01305031A - Constitution-strengthening agent for prevention of cancer - Google Patents

Abstract

PURPOSE:To obtain a constitution-strengthening agent effective in preventing cancer by using concentrated minor components of sea water including magnesium hydroxide as a main component. CONSTITUTION:Concentrated minor components of sea water including magnesium hydroxide are used as active components for the objective agent. The concentrated minor components of sea water can be produced by removing NaCl and CaSO4 from sea water or brine and adding lime milk or a caustic alkali solution to the concentrated mother liquor to form magnesium hydroxide. Natural radioactive boron compound, mineral substances, etc., of sea water have been included in the component of the present agent based on the finding that there is no patient of cancer in the workers of salt farm.

Description

DETAILED DESCRIPTION OF THE INVENTION The present inventor has lived in various salt production areas for more than 60 years, and during that time he discovered Irihama Salt Fields (Osaka Salt Fields), a salt field where sand is sprinkled on the ground and seawater permeates into the ground. While replenishing the sand with seawater through capillary action, the water is evaporated using solar heat and wind power, salt is crystallized in the sand, and the sand is put into a filtration device called a numai, which dissolves the salt adhering to the seawater. A worker (known as Hamao, Hamako, Saiko, etc.) who worked on a method to obtain concentrated water in the salt pans (the sand was repeatedly scattered over the salt pans) was diagnosed with cancer, so research was conducted on this topic. started.

First, in order to confirm this, we conducted a follow-up survey on the health status of the employees of the Osake Salt Farm (269 hectares) at the Ako Nishihama Salt Industry Association, which had been operating the Osake Salt Farm for many years in the Ako area of Hyogo Prefecture. The results shown in the table were obtained.

As a result, the research subjects were a total of 2,015 employees who could be traced over the 74-year period from 1885 to 1959, when the Taizake Salt Farm was abolished. In addition, those who could not be traced did not live in the area and their whereabouts were unknown.)
Of these, 15 actors were sick or had accidents during their tenure up to the time of their retirement, but there were no deaths or illnesses due to cancer. Details are as described in Tables A2 and A3.

In addition, a post-retirement health follow-up survey was conducted on 1,432 people who were able to do so. No one contracted cancer within a year after retiring, but from 1961 to March 1976, 3.
There were 18 deaths, of which 42 people died from cancer as listed in Table A.

Based on the above, it was found that none of the sake salt field workers had contracted cancer while on active duty, and none had contracted cancer within one year after retiring.

After that, cancer patients appeared, and it was confirmed that the cancer mortality rate was roughly the same as the cancer mortality rate in the Japanese society.

When working in salt fields, most of the work is done barefoot, so there is a possibility that some substances may be absorbed into the human body through the skin from the legs and feet, or inhaled as fine powder dispersed in the air. I can't help but think that it helped prevent cancer. Therefore, the present inventor conducted research on substances that may have affected the human body.

Salt farm soil, sand, concentrated mother liquor of seawater, suspended solids, etc.
Although we conducted various investigations on all materials in cooperation with specialized organizations, no organic antibiotics for cancer were detected. Therefore, is it possible that the concentration 1 is contained in the salt field ground and scattered sand through the skin of the legs and feet? ! It has been determined that the only reason for this is that the components in the mother liquor are absorbed into the body.

This mother liquor is a concentrated seawater solution used as a raw material in the examples of the present invention.
It is almost the same as mother liquor. In other words, in the Taizake Salt Field, most of the NaCl and CaSO3 in the seawater are crystallized in the scattered sand, and the mother liquor, which contains seawater components other than NaCl, Ca5O, is attached to the ground and sand in the form of a concentrated solution. . Therefore, the mother liquor contains concentrated concentrations of boric acid, natural radionuclides and other trace components, and magnesium contained in seawater. The mother liquor contains, for example, Na, Mg, Ca, Si, A
l, K, Fe, Mn.

Sr, U, Se, Ra, Th, Rh, C1C4! , S, etc., and it was concluded that several of them are useful for cancer prevention.

These details will be explained in detail below.

Most of the elements present on land are dissolved in seawater, numbering about 80 types, and an example of the analysis values of the main components is shown in Table B. Among these are natural radionuclides, for example 2.
U + 22' U + "2'Ra,"
'S e, 2ko 2Th.

It is known that substances such as 1γRl, , SOS, , l4C, and 4° are contained.

Naturally, the concentrated mother liquor from Taizake salt fields contains this naturally radioactive material. Radioactive substances are said to induce cancer, but in extremely small amounts, the appropriate amounts present in the aforementioned mother liquor in nature can actually prevent the development of cancer, and in conjunction with this, they can also cause small amounts of Magneto 9911, boron, and other substances. The ingredients are also thought to comprehensively prevent the development of cancer. The theory that seawater components are absorbed into the human body when working in the Taizake salt fields, and that the workers had other illnesses but not cancer, has been held not only by the inventor but also in the salty region for a long time. Some spoke out. Because Shioda's work was extremely hard work, he was prone to gluttony, and there were relatively many patients with gastric dilatation, but not many of them contracted cancer.

Therefore, the present inventor thought that if we could bring in the same trust effect as we had done in the salt fields, we might be able to prevent cancer. He became convinced that the same effects could be introduced into the human body by taking a substance adsorbed in magnesium hydroxide produced using magnesium hydroxide.

Then, natural radionuclide materials such as boron compounds, mineral substances, etc. are taken in the form that exists in seawater, and the magnesium content in seawater is taken into the body as magnesium hydroxide, which is more effective than magnesium salt. succeeded in.

That is, according to the present invention, the following constitution-strengthening agent is provided: (1) A constitution-strengthening agent for cancer prevention consisting of a seawater trace component concentrate containing magnesium hydroxide as a main component.

(2) Seawater trace component concentrates are salt (NaC1) and calcium sulfate (CaSOl) from seawater or canned water.
1. The constitution strengthening agent according to item 1, which is obtained by adding milk of lime or a caustic alkaline solution to a concentrated mother liquor obtained by removing .

(3) The constitution-strengthening agent according to item 2, in which boric acid is added and dissolved in the mother liquor.

(4) The above-mentioned magnesium hydroxide has adsorbed trace components of seawater into the magnesium hydroxide, which is further added to a mother liquor containing concentrated trace components of seawater, and stirred to further absorb the trace components into the magnesium hydroxide. Physical Strengthening Agent 6 of Item 1 Made by Adsorption The Kansui used in the present invention can be obtained by the above-mentioned Tashu-style salt pan or by the ion exchange method. Kansui produced by the ion-exchange method is a concentrated liquid with a high salt content obtained by treating seawater with an ion-exchange resin membrane.

When this concentrated liquid is passed through an evaporator and further concentrated, NaC
f, Ca5O, are crystallized, and the remaining liquid after removing these crystals is called seawater tj & quantity component concentrated mother liquor or simply concentrated mother liquor. ).

With the present invention, it is possible to bring into the human body exactly the same effects as those obtained by working in Taizake salt fields, but the investigation into the effectiveness of this substance against cancer has not been made because it contains many types of trace ingredients. This is extremely difficult, including the interaction between them.

However, as mentioned above, many years of experience in drinking salt fields has proven that it is effective against cancer.

In other words, regarding the effects of the substances of the present invention, as shown in Table A, large-scale clinical experimental data has been produced using large-scale sake salt fields and with large numbers of participants over many years. Therefore, it is considered that there is ample basis for using this as clinical experiment data for this substance as an essential cancer-fighting agent.

Attempts to prevent cancer by incorporating an appropriate amount of trace components in seawater into magnesium hydroxide are unknown and are a feature of the present invention. It is well known that magnesium hydroxide serves as an antacid laxative for the human body and has no side effects.

The present invention is the result of many years of large-scale research to find something that can strengthen the body against cancer based on seawater, and this substance is completely unknown as an agent for strengthening the body against cancer.

The substance of the present invention is a strengthening agent against cancer, but in order to easily prove its effectiveness, we will take an example of a part that is likely to cause cancer.A boron substance with a weak natural radionuclide adsorbed on magnesium hydroxide is concentrated in the above-mentioned areas and prevents the development of cancer, while magwincinium hydroxide has an antacid-laxative effect and absorbs and renders harmful gases generated in the body harmless, and mineral substances have synergistic effects such as contributing to normal biological activities. Combined with its effectiveness, it is thought to suppress the occurrence of cancer. This effect is exactly the same as the above-mentioned mechanism of cancer prevention when people are constantly engaged in drinking salt fields. One basis for inferring the above-mentioned effects is that it has already been determined that boron absorbs radioactivity from radioactive substances and that boron is concentrated in areas of the body that have tumors such as cancer. It is.

Also, in 1976, at the 60th Annual Meeting of the American Society for Experimental Biology, a joint study by Ms. Christine Wilson and Mr. Nicholas Betrakis reported that eating foods relatively high in Se (selenium) reduces the chance of developing breast cancer. Ya197
At the 2006 Japanese Society of Nutrition and Food Science, it was reported that I (iodine) contained in seaweed suppresses carcinogenicity.

Below are the constitution strengthening agents of the present invention! # List examples for legacy. However, the present invention is not limited to the following examples.

Example - Clear seawater from which harmful substances such as mercury heavy metals, PCBs, pesticides, and oils have been removed was used as raw material seawater.

Generally known filtration is performed to obtain clear seawater, which is then treated with an ion exchange resin membrane to obtain kansui with a concentration of 1 NaC.

Next, by passing this through an evaporator, the MgCl2 concentration is concentrated to 30 to 50 times that of seawater, resulting in NaCl and CaSO3.
crystallizes.

The mother liquor after removing these (NaCl, Ca5O<) (hereinafter referred to as concentrated mother liquor) was used.

As mentioned above, this mother liquor has almost the same concentration and composition as the mother liquor from Taizake Salt Farm.

Depending on the properties of the ion exchange resin membrane, the ratio of magnesium to boron in seawater after treatment may be significantly lower than the ratio of seawater. In this case, boron such as boric acid is added to maintain the natural state in substantially the same proportion as in seawater.

Concentrated mother liquor 4801 (11 and a half M
g, 52g, B, 0.078g, K, 35. , Ca
, 21f) and quicklime 59.5Ag (98% purity)
and lime milk to which water 2651 has been added.

1404 of the suspension of magnesium hydroxide and calcium chloride obtained here! (Mg(OH)215.
2Ay, CaCL29A9) remained in the reaction tank, and while stirring, concentrated mother 14801 (11 and a half Mg, 52y, B, 0.078g, K, 35g
, Cm, 21y) and quicklime 59.5Ag (purity 9
8%) and lime milk with water 2651 added to it. Gradually stir the mixture.

By operating in this manner, trace and minor components are efficiently adsorbed to the magnesium hydroxide produced.

Injection f1 After stirring for 15 minutes, apply to a filter press,
After 40 minutes, the solution is separated into a calcium chloride solution as a mother liquor and magnesium hydroxide.

Next, water was sent to the filter press, and after 2 hours, water washing of magnesium hydroxide was completed, and magnesium hydroxide 123Ag (M g (OH) z 49%, H2O4
7%, other 4%).

This magnesium hydroxide precipitate is washed with water and dried with hot air at about 80°C. (Drying at too high a temperature will cause changes in the magnesium hydroxide containing the V&acid components, so dry at as low a temperature as possible to maintain its natural form.) In this way, active magnesium hydroxide containing an appropriate amount of trace components found in seawater is obtained. The wood reinforcing agent in the present invention is this substance.

However, magnesium oxide obtained by dry processing this substance is also naturally included in the present invention.

The product thus obtained contains M g (OH) 2 in 1 gram.
980 2, B2032m1F, coz5mg, K2O
2&1F, Sr0.3HS Rb0.018mg, Th
O,0OO03zy, Ra I X 1O-1ozy,
Natural radionuclides of UO, OOlmy, Ca, Al, S
i, Na.

A wide variety of oxide hydroxides, salts, and trace amounts of heavy metal oxides such as S and Fe are adsorbed and contained.

However, although it is difficult to analyze, if a detailed table including even trace amounts of substances that are estimated to be adsorbed, it would be as shown in Table 0.

Picture 1 Magnesium hydroxide was produced in the same manner as in Example 1, except that the calcium chloride solution in which magnesium hydroxide was suspended, which was produced in the previous operation, was not left in the reaction tank. 1g contains Mg(OH)2
It contained 980 grams.

1k of clear seawater (containing 0.14% Mg) obtained in λ Example 1
30 kg of 10% lime milk directly without going through the concentration process
(Used lime purity 98%) was added, stirred for about 1 hour after the addition, and then left to stand for about 20 hours.

Magnesium hydroxide was produced in the same manner as in Production Example 1, except for the method of obtaining a magnesium hydroxide cake by filtration and washing with water. 1 g of obtained magnesium hydroxide
It contained 29,601 g of Ma+ (○H).

l1 Kansui obtained in Example 1 (containing 0.69% Mg) 1.1
10% lime milk directly without going through the concentration process to 140 to 9
(Quicklime purity used: 98%) was added, stirred for about 1 hour, and then left to stand for about 20 hours.

Magnesium hydroxide was produced in the same manner as in Production Example 1 except for obtaining a magnesium hydroxide cake by filtering and washing with water. 1 g of obtained magnesium hydroxide
It contained Me(OH)z9701y.

Magnesium hydroxide containing trace components produced by the above method is mixed with various pharmaceutical additives in the following composition, mixed, pressed, and molded to form a tablet, which can then be taken as a tablet.

Magnesium hydroxide tablet formulation (per tablet) Magnesium hydroxide 320. OB calcium hydrogen phosphate 333 dextrin
13.7 Crystalline cellulose
45.0 Hydroxypropyl cellulose 22
．． 5-force carboxymethylcellulose calcilla=<CMC-Ca) 10.5!
- Menthol 0.5 Magnesium stearate 4.5 Total 45019 几i Height before drying of magnesium hydroxide produced in Example 1 10
0Ay was placed in the concentrated mother liquor LAN and gently stirred for 1 hour to adsorb trace components again.

Thereafter, magnesium hydroxide was produced in the same manner as in Example 1 except for obtaining magnesium hydroxide cake by filtration and washing with water. 1 g of obtained magnesium hydroxide
It contained 2980 ty of Mg(OH).

If you take the substance according to the present invention with an appropriate amount of water, adjusting the amount according to your constitution, you can achieve the purpose of strengthening your constitution suitable for cancer prevention.After taking the substance, it will be excreted from the body. The fact that it is not okay to not take the drug after that is also judged from Tables A to A3, which show the results of the AT health follow-up survey of employees at Taizake Shioda during their employment and after their retirement. Therefore, it is necessary to take it appropriately on a daily basis.

8 about the 2015 people in this survey! Health follow-up surveys have confirmed that none of the soldiers contracted cancer while on active duty.

◎ In this study, the cancer incidence rate after quitting WA was 5 per 100,000 people.
There will be 0 people.

In this survey, the average age for boys in 1945 was 32.9 years old, the average for girls was 41.0 years old, the total average was 33.6 years old, and the average age for boys in 1954 was 3.
The average age for girls is 6.2 years old, 41.0 years old, and the overall average age is 38.1 years old.

The number of people surveyed in this study was 2,015.

(Individuals who have not been confirmed in this survey are those whose location is unknown, etc.) ◎ () indicates deaths due to cancer (neoplasm).

O This survey does not include those killed in battle.

◎ The subjects of this survey are those born between the years M6 and 316.

◎ Among the 15 people who died due to illness during work in this survey, there were no deaths due to cancer.

Table A2 Table A3 Pharmacological experiments were conducted using rats as follows to correlate the analysis of the survey results shown in Table A above with the effectiveness (carcinogenicity inhibiting effect) of the constitution-enhancing agent of the present invention.

A total of 155 male F344 rats, 6 weeks old, were used and divided into 6 groups. The first group (32 animals) was treated with 25% g/kg body weight of methylazoxymethanol (MAM) acetate [Sigma Chemical Co., St. Louis, USA (SigsaC
He so.

Co, Ltd,, St, Louis, U, S, A,)
] was administered intraperitoneally once a week for a total of three times. Basal food C for animals
E-2 [CLEA Japan,
Co, LLd,.

(manufactured by Tokyo)] was administered during the experimental period. MAM acetate was administered to the second group (31 animals) in the same manner as in the first group, and from 2 weeks after the end of administration of the carcinogenic agent, feed containing 0.05% of the constitution strengthening agent of the present invention obtained in Example 1 was given. was administered until the end of the experiment. In the third group (32 animals), after administering MAM acetate, the feed containing 0.1% of the constitution strengthening agent was administered in the same manner as in the second group.

The 4th group (20 animals) received only feed containing 0.05% of the above constitution strengthener, and the 5th group (20 animals) received 0.1% of the above constitution strengthener.
Only the included feed was administered.

Group 6 (20 animals) received basal diet 〇E as an untreated control group.
-2 only was administered. The experimental protocol is shown in FIG. Tap water was administered as drinking water during the experiment.

The experiment was completed after 255 days, and the animals were sacrificed and autopsied. At the time of autopsy, body weight, liver weight, and % liver weight (total weight ÷ body weight x 100) were measured. In addition, all organs, especially the large intestine, small intestine, stomach, liver, and kidney, were carefully observed macroscopically, and after fixation with 10% formalin, tissue sections were prepared using a conventional method and stained with H-E. Histological diagnosis of intestinal tumors is performed by Ward (Lab, Invest) 30.
:505-513. <974) and Maskens (Mas
Kens) and D Bardin,
Loies, Cancer 4
7+81-89.1981, and renal II tumors were treated according to the method of Hard and 13utler, CancerRes 30:
The diagnosis was made according to the diagnostic criteria of 2796-2805, 1970.

Statistically significant differences were tested using Student's Shiichi test (S
(student's t-test), ×2 test, and Fisher's exact probability calculation method, and P=0.05 or less was considered a significant difference.

l Large intestines of rats that died 126 days after the start of the experiment in the second group;
Because tumors were found in the kidneys, animals that survived for 126 days or more were considered effective animals. Effective number of animals in each group at the end of the experiment, average survival days, body weight, liver weight, % liver weight, second and third
No significant difference was observed between the groups, except that the average body weight of each group was significantly lower than that of the first group.

The frequency of tumor occurrence in each group is shown in Table 1.
．． Tumors, which were observed to occur only in Group 3, mainly occurred in the large intestine, and were also found in the small intestine and kidneys, although less frequently.

Regarding the frequency of tumor occurrence, the frequency of colon tumor occurrence was lower in both groups 2 and 3 than in group 1, and a statistically significant difference was observed between group 2 and group 1 (adenoma + adenocarcinoma: P <0. 0002;1111
11: P <0.003; Adenocarcinoma: P < 0.003)
. There was no significant difference in the incidence of small intestine tumors between groups 1, 2, and 38 yen.In terms of the incidence of tumors in the entire intestinal tract (large intestine and small intestine combined), both groups 2 and 3 were higher than group 1. It showed a low value, and there was a statistically significant difference between the second group and the first group (
Adenoma+adenocarcinoma: P<0.001; Gland 11: P<0.003
; adenocarcinoma: P<0.008).

Kidney tumors are histologically treated as tumors in private practice, and the incidence of all tumors, including large intestine and small intestine tumors, is lower in both Groups 2 and 3 than in Group 1; A statistically significant difference was observed (P<0.005).

There were no differences in the histological type of tumors between the groups, nor were there any differences in the location of colon tumors.

The frequency of occurrence of MAM acetate-induced colon tumors was significantly reduced by administration of the diet containing the constitution strengthening agent.

In particular, the suppressive effect of the feed with a concentration of 0.005% was remarkable.

[Brief explanation of the drawing]

Figure 1 is a schematic diagram showing the protocol of a pharmacological experiment to explain the effectiveness of the constitution-strengthening agent of the present invention, and the marks in the figure have the following meanings: ↓: MAM acetate 25xg/kg body weight Internal administration: Constitution strengthening agent obtained in Example 1 0.1% ×: Slaughter knee 4

Claims (4)

[Claims] (1) A constitution strengthening agent for cancer prevention consisting of a seawater trace ingredient concentrate containing magnesium hydroxide as the main ingredient. (2) Seawater trace component concentrates are salt (NaCl) and calcium sulfate (CaSO_4) from seawater or canned water.
The constitution strengthening agent according to claim 1, wherein magnesium hydroxide is produced by adding milk of lime or a caustic alkaline solution to a concentrated mother liquor obtained by removing the hydroxide. (3) The constitution strengthening agent according to claim 2, wherein boric acid is added and dissolved in the mother liquor. (4) The above-mentioned magnesium hydroxide has adsorbed trace components of seawater into the magnesium hydroxide, which is further added to a mother liquor containing concentrated trace components of seawater, and stirred to further absorb the trace components into the magnesium hydroxide. The constitution strengthening agent according to claim 1, which is obtained by adsorption.