JPH01275767A - Production of implant material - Google Patents

Abstract

PURPOSE:To produce an implant material having a great affinity for a living body and high strength by adding P and Ca compds. to a soln. prepd. by hydrolyzing alkyl silicate to obtain sol, introducing hydroxyl groups into a metal chloride layer formed on the surface of a metal, dipping this metal in the sol, drying and calcining a formed sol film. CONSTITUTION:Ethyl silicate is hydrolyzed by mixing with a soln. of ethanol in hydrochloric acid and the resulting soln. is mixed with calcium ethoxide and phosphoric acid to obtain sol. A metal bar such as a stainless steel bar is heated in gaseous HCl or Cl2 to form a metal chloride layer on the surface of the bar and this bar is put in water, heated, taken out and dried to introduce hydroxyl groups into the metal chloride layer. The bar is then dipped in the sol and a formed sol film is dried at about 60 deg.C and heated at about 350 deg.C. An implant material having a great affinity for a living body and high strength and useful as an artificial tooth or bone is produced.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a method for manufacturing a temple implant material used as an artificial tooth or bone.

(Prior art) Conventional implant materials include ceramics 20, (198
5) As described in No. 12, P4O10, bioacceptability (polyethylene, stainless steel), bioinertness (alumina, carbon), bioactivity (apatite, T
There were three types of materials: CP and Ca 40 (P04)2).

(Problem to be Solved by the Invention) However, each of the above-mentioned prior art techniques has the following problems, and therefore has not been widely used.

In the case of bioacceptable and bioinert materials, they are not directly bonded to the bone and are only fixed by mechanical fitting, so there is a risk of loosening or falling off after long-term use.

On the other hand, in the case of bioactive materials, especially apatite, the compressive strength is sufficient or the tensile, bending, and torsional strengths are insufficient. Therefore, it cannot be used in areas subject to excessive tensile stress.

For this reason, attempts have been made to improve material strength without impairing biocompatibility. There are no reports of this attempt reaching a practical level yet, and it is still under development.

One way to try this is to coat the surface of stainless steel or titanium alloy with bioglass to create a material that has both strength and biocompatibility. The problem is that the adhesive strength between the coating film and the metal is weak, and conventionally coating was done by melting bioglass, but this has problems such as poor workability and not being suitable for mass production. Was.

SUMMARY OF THE INVENTION The present invention aims to solve these problems, and its purpose is to provide a method for easily forming a bioglass film with strong adhesive strength on a metal surface.

[Means to solve the problem]

The method for manufacturing an implant material of the present invention is characterized in that a metal surface is coated with bioglass in the following steps.

a) Adding a phosphorus compound and a calcium compound to a hydrolyzed solution of alkyl silicate to form a sol; b) Applying HCI or Cl to the metal surface to form a layer of metal chloride; A process of generating hydroxyl groups on the metal surface by the above method, i) A method of reacting a chloride layer with water to generate a hydroxyl group, ii) A process of reacting an alcohol with a chloride layer to form an alkoxide, and then reacting it with acid or water. iii) A method in which sodium alkoxide is applied to a chloride layer to form a metal alkoxide layer on the surface of the metal, and acid or water is applied to the metal to generate hydroxyl groups. A step of forming a sol film by dipping in the sol.

d) Drying the coating and baking it at an appropriate temperature.

(Function) According to the above configuration of the present invention, a chloride layer is formed on the metal surface, and a large amount of hydroxyl groups can be introduced into the metal surface layer directly or via an alkoxide.

When a metal having a large amount of hydroxyl groups on its surface is immersed in a sol of bioglass composition, the hydroxyl groups and the sol bond, resulting in a coating film with strong adhesion.

(Example) To 1 mole of ethyl silicate, 100 m of ethyl alcohol
32 mM of 0.1N hydrochloric acid aqueous solution was added and stirred well. After completion of hydrolysis, 1 mol of calcium chloride and 0.6 mol of phosphoric acid were added and stirred well. If necessary, appropriate amounts of water, alcohol, thickener (ethylene glycol, etc.), silica particles, etc. were added to control the film thickness and film properties. This is called sol.

On the other hand, a metal rod made of stainless steel, titanium, titanium-chromium alloy, or the like was heated in chlorine or chlorine gas to chlorinate the surface of the metal rod. Next, hydroxyl groups were introduced using the following three methods.

■ A chlorinated metal rod was placed in water, heated, and then taken out and dried.

■ A chlorinated metal rod was placed in ethanol to form an alkoxide, taken out, reacted with water, and dried.

■ A chlorinated metal rod was immersed in a solution of sodium ethoxide to form an alkoxide, which was taken out, reacted with water, and dried.

The metal rod with hydroxyl groups introduced onto its surface in this way was immersed in the above sol and coated by dipping. Subsequently, it was dried at 60°C and then heated to 350°C to form a bioglass coating film.

The obtained implant material had sufficient biocompatibility and strength, and was suitable for practical use.

(Effects of the Invention) As described above, according to the present invention, the sol of the sol-gel process is added with a composition of hydroxyapatite, and furthermore, hydroxyl groups are introduced onto the metal surface, and then the sol is coated. By doing so, it is possible to form a strong thin film, resulting in a strong implant material with excellent biocompatibility.

Claims (1)

[Claims] A method for producing an implant material, characterized in that a metal surface is coated with bioglass in the following steps. a) Adding a phosphorus compound and a calcium compound to a hydrolyzed solution of alkyl silicate to form a sol; b) Applying HCl or Cl_2 to the metal surface;
A step of forming a chloride layer of the metal and generating hydroxyl groups on the metal surface by one of the following methods: i) A method of reacting water with the chloride layer to generate hydroxyl groups ii) A method of forming a hydroxyl group on the chloride layer A method in which alcohol is reacted to form an alkoxide, and then acid or water is applied to produce a hydroxyl group. iii) A layer of metal alkoxide is formed on the surface of the metal by applying sodium alkoxide to a chloride layer, and then acid or water is applied. Method for producing hydroxyl groups c) A step of immersing the metal with hydroxyl groups in the sol and forming a sol film by dipping; d) Drying the coated material and baking it at an appropriate temperature.