JPH01261325A - Emulsifier for suppressing formation of bacterial plaque - Google Patents
Emulsifier for suppressing formation of bacterial plaqueInfo
- Publication number
- JPH01261325A JPH01261325A JP8979188A JP8979188A JPH01261325A JP H01261325 A JPH01261325 A JP H01261325A JP 8979188 A JP8979188 A JP 8979188A JP 8979188 A JP8979188 A JP 8979188A JP H01261325 A JPH01261325 A JP H01261325A
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- polyglycerin
- emulsifier
- ester
- bacterial plaque
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003995 emulsifying agent Substances 0.000 title claims abstract description 12
- 230000001580 bacterial effect Effects 0.000 title abstract description 9
- 230000015572 biosynthetic process Effects 0.000 title abstract description 5
- 239000000194 fatty acid Substances 0.000 claims abstract description 27
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 24
- 229930195729 fatty acid Natural products 0.000 claims abstract description 24
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 17
- 150000002148 esters Chemical class 0.000 claims abstract description 13
- 230000002401 inhibitory effect Effects 0.000 claims description 17
- 230000007505 plaque formation Effects 0.000 claims description 16
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- 208000002064 Dental Plaque Diseases 0.000 claims description 9
- 208000002925 dental caries Diseases 0.000 abstract description 9
- 239000000203 mixture Substances 0.000 abstract description 5
- 238000006116 polymerization reaction Methods 0.000 abstract description 5
- 238000005886 esterification reaction Methods 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 4
- 210000000214 mouth Anatomy 0.000 abstract description 4
- 230000003405 preventing effect Effects 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 241000194019 Streptococcus mutans Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- -1 fatty acid ester Chemical class 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- 150000004676 glycans Chemical class 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 235000013353 coffee beverage Nutrition 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 244000299461 Theobroma cacao Species 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 229920000223 polyglycerol Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- WOKDXPHSIQRTJF-UHFFFAOYSA-N 3-[3-[3-[3-[3-[3-[3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)CO WOKDXPHSIQRTJF-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 235000013532 brandy Nutrition 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 235000021438 curry Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000000668 oral spray Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 125000005480 straight-chain fatty acid group Chemical group 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 235000012094 sugar confectionery Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【発明の詳細な説明】 本発明は新規な歯垢形成抑制乳化剤に関する。[Detailed description of the invention] The present invention relates to a novel plaque formation inhibiting emulsifier.
詳しくは、安全性の高い炭素数８〜１６を有する脂肪酸
のポリグリセリンエステルからなる歯垢形成抑制乳化剤
に関し歯面における歯垢の形成を抑制し虫歯を予防又は
その進行を阻止するために有効な歯垢形成抑制乳化剤を
提供するものである。Specifically, regarding a highly safe dental plaque formation-inhibiting emulsifier made of a polyglycerin ester of a fatty acid having 8 to 16 carbon atoms, it is effective for inhibiting the formation of dental plaque on tooth surfaces and preventing or inhibiting the progression of dental caries. The present invention provides an emulsifier that inhibits plaque formation.
虫歯は現代の食生活において重要な問題となっている。 Tooth decay has become an important problem in modern diets.
この虫歯という現象は、口腔連鎖球菌であるストレプト
コッカス・ミュータンスが食物に含有される砂糖を基質
として粘着性の多糖体を生成し、この多糖体によって菌
体が歯の平滑面に付着し歯の破壊が始まると言われてい
る。This phenomenon of tooth decay is caused by the oral streptococcus Streptococcus mutans producing sticky polysaccharides using sugars contained in food as a substrate, and these polysaccharides allow bacterial cells to adhere to the smooth surfaces of teeth, resulting in tooth decay. It is said that destruction will begin.
本発明の歯垢形成抑制乳化剤は皮膚、粘膜に対する刺激
性が極めて弱く、歯垢形成の抑制や虫歯を予防及びその
進行を阻止するのに特に有用である。The plaque formation-inhibiting emulsifier of the present invention has extremely weak irritation to the skin and mucous membranes, and is particularly useful for inhibiting dental plaque formation and preventing and inhibiting the progression of dental caries.
虫歯を肪止するためには、歯垢形成を抑制することが望
まれ、そのために種々の方法が行われている０例えば、
ストレプトコッカス・ミュータンスに対して殺菌又は静
菌作用を有する薬物を投与し、口腔内からストレプトコ
ッカス・ミュータンスを駆逐する方法がある。しかしこ
れらの薬物は口腔内及び腸内の細菌叢を乱すと共に、そ
の副作用に伴う危険があり、広く使用されるには至って
いない。In order to prevent tooth decay, it is desirable to suppress plaque formation, and various methods have been used for this purpose, such as:
There is a method for expelling Streptococcus mutans from the oral cavity by administering a drug that has a bactericidal or bacteriostatic effect on Streptococcus mutans. However, these drugs have not been widely used because they disturb the bacterial flora in the oral cavity and intestines, and there are risks associated with their side effects.
次に機械的方法で歯垢を取り除く方法がある。The next method is to remove plaque mechanically.
すなわちハブラシを用いる物理的清掃であり、各人の清
掃技術の良否の差が激しく完全に歯垢を除去することは
非常に困難である。That is, it is a physical cleaning using a toothbrush, and it is extremely difficult to completely remove dental plaque because the cleaning techniques of each person vary greatly.
［発明が解決しようとする問題点〕
このようなことから、ストレプトコッカス・ミニータン
スに対して殺菌又は静菌作用を有しており、口腔内及び
腸内の細菌叢を乱すことがなく、人体に対して副作用の
少ない歯垢形成抑制物質が望まれていた。[Problems to be solved by the invention] For these reasons, it has a bactericidal or bacteriostatic effect against Streptococcus minitans, does not disturb the bacterial flora in the oral cavity and intestines, and is not harmful to the human body. In contrast, there has been a desire for a substance that inhibits plaque formation with fewer side effects.
本発明者らは歯垢形成を抑制し、虫歯を予防又はその進
行を阻止する方法を開発する目的で鋭意研究を行った結
果、炭素数８〜１６を有する脂肪酸のポリグリセリンエ
ステルが歯垢の形成を抑制することを見い出し本発明を
完成した。The present inventors conducted extensive research with the aim of developing a method to inhibit dental plaque formation and prevent or halt the progression of dental caries. As a result, polyglycerin esters of fatty acids having 8 to 16 carbon atoms were found to inhibit dental plaque formation. The present invention was completed based on the discovery that the formation can be suppressed.
すなわち本発明は、安全性が高く、食品添加物に認可さ
れている炭素数８〜１６を有する脂肪酸のポリグリセリ
ンエステルからなる歯垢形成抑制乳化剤である。That is, the present invention is a plaque formation-inhibiting emulsifier made of a polyglycerin ester of a fatty acid having 8 to 16 carbon atoms, which is highly safe and approved as a food additive.
本発明に用いられる炭素数８〜１６を膚する脂肪酸ポリ
グリセリンエステルは、重合度が２以上のポリグリセリ
ンの脂肪酸エステルである。ポリグリセリン脂肪酸エス
テルに用いられる脂肪酸はカプリル酸、カプリン酸、ラ
ウリン酸、ミリスチン酸、パルミチン酸等の炭素数８〜
１６の飽和又は不飽和の直鎖脂肪酸であり、これらの脂
肪酸は単独又はその混合物でもよい。The fatty acid polyglycerin ester having 8 to 16 carbon atoms used in the present invention is a fatty acid ester of polyglycerin having a degree of polymerization of 2 or more. Fatty acids used in polyglycerin fatty acid esters have 8 or more carbon atoms, such as caprylic acid, capric acid, lauric acid, myristic acid, and palmitic acid.
16 saturated or unsaturated straight chain fatty acids, these fatty acids may be used alone or in mixtures thereof.
炭素数７以下の脂肪酸及び炭素数１７以上の脂肪酸のポ
リグリセリンエステルは、歯垢形成を抑制する効果がほ
とんどなく、実用的ではない。Polyglycerol esters of fatty acids having 7 or less carbon atoms and fatty acids having 17 or more carbon atoms have almost no effect on inhibiting dental plaque formation and are not practical.
本発明に用いられる炭素数８〜１６を有する脂肪酸のポ
リグリセリンエステルのポリグリセリンは重合度が２以
上である０重合度が２未満のポリグリセリン脂肪酸エス
テルは刺激味、苦味が強く又、加水分解が起こりやすく
実用的でない。The polyglycerin ester of a fatty acid having 8 to 16 carbon atoms used in the present invention has a degree of polymerization of 2 or more. Polyglycerin fatty acid esters with a degree of polymerization of less than 2 have a strong pungent taste and bitter taste, and can be hydrolyzed. is likely to occur and is not practical.
本発明の炭素数８〜１６を有する脂肪酸のポリグリセリ
ン脂肪酸エステルは重合度が２以上のポリグリセリンの
モノ、ジ、トリ、テトラ、ペンタの脂肪酸エステルであ
り中でも、モノ、ジの脂肪酸エステルが望ましく、これ
らは単独又はその混合物で用いられることができる。The polyglycerin fatty acid ester of a fatty acid having 8 to 16 carbon atoms of the present invention is a mono-, di-, tri-, tetra-, or penta-fatty acid ester of polyglycerin having a degree of polymerization of 2 or more, and among these, mono- and di-fatty acid esters are preferable. , these can be used alone or in mixtures thereof.
本発明の炭素数８〜１６を有する脂肪酸のポリグリセリ
ン脂肪酸エステルは、溶媒存在下、又は無溶媒の下で、
ポリグリセリンと脂肪酸のエステル化反応によって得ら
れる。このエステル化反応は一般のエステル化触媒の存
在下、又は無触媒下反応温度１５０°Ｃ〜２８０℃、窒
素等の不活性ガスを吹き込みながら生成する水を除去す
ることによって行われる。The polyglycerol fatty acid ester of a fatty acid having 8 to 16 carbon atoms of the present invention can be prepared in the presence of a solvent or in the absence of a solvent.
Obtained by the esterification reaction of polyglycerin and fatty acids. This esterification reaction is carried out in the presence of a general esterification catalyst or without a catalyst at a reaction temperature of 150 DEG C. to 280 DEG C. and by removing produced water while blowing inert gas such as nitrogen.
本発明に用いられる炭素数８〜１６を有する脂肪酸のポ
リグリセリンエステルは口腔用剤又は食品に対して０．
０１％〜１０％（重量部）添加する。０．０１％以下の
添加量では本発明の効果がなく、１０％以上の添加量で
、はポリグリセリン脂肪酸エステルが口腔用剤又は食品
において苦味が強く感じられ、更に経済的にも高価にな
り舅ましくない、 。The polyglycerin ester of a fatty acid having 8 to 16 carbon atoms used in the present invention is 0.0% for oral preparations or foods.
01% to 10% (parts by weight) is added. If the amount added is less than 0.01%, the effect of the present invention will not be achieved, and if the amount added is more than 10%, the polyglycerin fatty acid ester will taste strongly bitter in oral preparations or foods, and will also become economically expensive. Not my father-in-law.
本発明の歯垢形成抑制乳化剤は１１、水溶液形、態の口
腔内スプレー、うがい剤、水歯みがき１口腔用清掃剤等
に配合することができる。固体状形態としては、うがい
用錠剤、舌下錠、トローチ等の錠剤等があげられる。
。The plaque formation-inhibiting emulsifier of the present invention can be incorporated into oral sprays, gargles, water toothpastes, oral cleaning agents, etc. in the form of an aqueous solution. Examples of the solid form include tablets such as gargling tablets, sublingual tablets, and troches.
.
又、本発明の歯垢形成抑制乳化剤は、チューインガム、
キャンデイ−、ジュース、プリン、コーヒー飲料、ココ
ア飲料、紅茶飲料、しるこ、スーブ、カレー、チョコレ
ート、クツキー、ケーキ。Further, the plaque formation inhibiting emulsifier of the present invention can be used in chewing gum,
Candy, juice, pudding, coffee drinks, cocoa drinks, tea drinks, shiruko, soup, curry, chocolate, kutsky, cake.
パン、アイスクリーム、氷菓子、砂糖菓子、甘味料等に
配合すると２とができる。When added to bread, ice cream, frozen confectionery, sugar confectionery, sweeteners, etc., 2 can be obtained.
本発明の歯垢形成抑制乳化剤は、非常に親水性が強＜Ｈ
ＬＢ値が大きい界面活性剤であるためにストレプトコッ
カス・ミュータンスの増殖を抑制し、又殺菌する作用を
有するものと推定される。The plaque formation inhibiting emulsifier of the present invention has very strong hydrophilicity <H
Since it is a surfactant with a large LB value, it is presumed to have the effect of inhibiting the growth of Streptococcus mutans and also sterilizing it.
又、ストレブトコ・ンカス・ミュータンスによって生成
する多糖体の歯の平滑面への付着も肪止するものと推定
きれる。It can also be assumed that the adhesion of polysaccharides produced by Strebutococcus mutans to the smooth surfaces of teeth also causes fat retention.
次に本発明を試験例によって説明する。Next, the present invention will be explained using test examples.
試験例１
プレインハートインフュージョンブイヨン培地（Ｄｉ
ｆ’ｃｏ社）にデカグリセリンモノミリスチン酸エステ
ル（サンソフトＮｏ、Ｑ−１４８太陽化学（ロ）製）を
１００ｐｐｒｎ、３００ｐｐｍ、５００ｐｐｍ、７００
ｐｐｍになるように添加し試験管３本に５ｍ１分注し試
験用培地とした。Test Example 1 Plain Heart Infusion Broth Medium (Di
100 pprn, 300 ppm, 500 ppm, 700 ppm of decaglycerin monomyristic acid ester (Sunsoft No., Q-148 manufactured by Taiyo Kagaku (Ro))
It was added at a concentration of ppm and 5 ml was dispensed into three test tubes to prepare a test medium.
この試験培地にあらかじめプレインハートインフュージ
ョンブイヨン培地で調製したストレプトコッカス・ミュ
ータンスＭ７８１４Ｂ菌液を初発菌数１．２Ｘ１０”／
ｍｌとなるように加え３７°Ｃで培養し１日、２日、３
日ごとに菌数をプレインハートインフュージョンブイヨ
ン寒天培地で測定した。Into this test medium, a Streptococcus mutans M7814B bacterial solution prepared in advance with Plain Heart Infusion Broth Medium was added to the initial bacterial count of 1.2 x 10"/
ml and cultured at 37°C for 1, 2, and 3 days.
Bacterial counts were determined every day on plain heart infusion broth agar medium.
比較例１
試験例１において、デカグリセリンモノミリスチン酸エ
ステルを添加しない以外は、全く同じにして菌数を測定
した。その結果を表１に示した。Comparative Example 1 The number of bacteria was measured in exactly the same manner as in Test Example 1, except that decaglycerol monomyristate was not added. The results are shown in Table 1.
表１．ストレプトコッカス・ミュータンスに対する抗菌
作用（菌数／ｍｊ２）
試験例２
下記の処方に従ってうがい剤を調製した。Table 1. Antibacterial action against Streptococcus mutans (number of bacteria/mj2) Test Example 2 A gargle was prepared according to the following recipe.
デカグリセリンモノミリスチン ： １．５ 部酸エス
テル（サンソフトＮｏ、Ｑ−１４Ｓ太陽化学■製）
グリセリン ： ９．０ 部青色３号
０．４％溶液 ： ０．０１部ペパーミント
オイル ： ０．５ 部メントール
二′０．５ 部エタノール
： ３．０ 部蒸留水
：８５．４９部試験例３
下記の処方に従って、コーヒーゼリーを調製した。Decaglycerin monomyristin: 1.5 parts Acid ester (Sunsoft No., Q-14S Taiyo Kagaku ■) Glycerin: 9.0 parts Blue No. 3 0.4% solution: 0.01 parts Peppermint oil: 0.5 parts menthol
2'0.5 parts ethanol
: 3.0 parts distilled water
: 85.49 parts Test Example 3 Coffee jelly was prepared according to the following recipe.
グラニユー糖 １２．０ 部ブドウ
糖 ８．０ 部サンカラＮｏ、５
４０ ０．７５部（カラギナン製剤、太陽
化学■製）
コーヒー粉末 ２．０ 部ブラン
デイ−０，３部
デカグリセリンモノミリスチン酸 ０．０７部エステ
ル
（サンソフトＮｏ、Ｑ−１４３，太陽化学■製）水
７６．８８部［本
発明の効果〕
本発明の炭素数８〜１６を有する脂肪酸のポリグリセリ
ンエステルからなる歯垢形成抑制乳化剤は試験例の結果
から明らかなように、ストレプトフッカス・ミュータン
スの増殖を抑制し、又、死滅させてしまう、そのためス
トレプトコッカス・ミュータンスによる多糖体が生成さ
れに＜＜、歯垢の形成が抑制される。Granulated sugar 12.0 parts Glucose 8.0 parts Sankara No. 5
40 0.75 parts (Carrageenan formulation, manufactured by Taiyo Kagaku ■) Coffee powder 2.0 parts Brandy - 0.3 parts Decaglycerin Monomyristic acid 0.07 parts Ester (Sunsoft No., Q-143, manufactured by Taiyo Kagaku ■) water
76.88 parts [Effects of the present invention] As is clear from the results of the test examples, the plaque formation-inhibiting emulsifier comprising a polyglycerin ester of a fatty acid having 8 to 16 carbon atoms according to the present invention has an effect on Streptofuccus mutans. It inhibits the proliferation and also kills Streptococcus mutans, thereby inhibiting the production of polysaccharides by Streptococcus mutans and inhibiting the formation of dental plaque.
Claims (1)
ルからなる歯垢形成抑制乳化剤Dental plaque formation-inhibiting emulsifier consisting of polyglycerin ester of fatty acid having 8 to 16 carbon atoms
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63089791A JPH0672090B2 (en) | 1988-04-11 | 1988-04-11 | Streptococcus inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63089791A JPH0672090B2 (en) | 1988-04-11 | 1988-04-11 | Streptococcus inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01261325A true JPH01261325A (en) | 1989-10-18 |
| JPH0672090B2 JPH0672090B2 (en) | 1994-09-14 |
Family
ID=13980511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63089791A Expired - Lifetime JPH0672090B2 (en) | 1988-04-11 | 1988-04-11 | Streptococcus inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0672090B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6233694B1 (en) | 1997-12-24 | 2001-05-15 | Thomson Licensing S.A. | Synchronization device for synchronous dynamic random-access memory |
| JP2018030786A (en) * | 2016-08-22 | 2018-03-01 | ピジョン株式会社 | Personal care composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4067997A (en) * | 1975-05-21 | 1978-01-10 | Med-Chem Laboratories | Synergistic microbecidal composition and method |
| JPS6360917A (en) * | 1986-09-02 | 1988-03-17 | Lion Corp | Composition for oral cavity |
-
1988
- 1988-04-11 JP JP63089791A patent/JPH0672090B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4067997A (en) * | 1975-05-21 | 1978-01-10 | Med-Chem Laboratories | Synergistic microbecidal composition and method |
| JPS6360917A (en) * | 1986-09-02 | 1988-03-17 | Lion Corp | Composition for oral cavity |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6233694B1 (en) | 1997-12-24 | 2001-05-15 | Thomson Licensing S.A. | Synchronization device for synchronous dynamic random-access memory |
| JP2018030786A (en) * | 2016-08-22 | 2018-03-01 | ピジョン株式会社 | Personal care composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0672090B2 (en) | 1994-09-14 |
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