JPH01246205A - Effect enhancer for pyrethroid compounds - Google Patents

Abstract

PURPOSE:To obtain a pyrethroid enhancer by selecting, as active ingredients, one or more selected from ethylene oxide adducts onto higher alcohols, ethylene oxide adducts onto polyhydric alcohols and imidazoline derivatives. CONSTITUTION:In order to compensate the defect of pyrethroid acaricides, namely slow-acting properties, and enhance the effect, one or more selected from ethylene oxide adducts onto higher alcohols, ethylene oxide adducts onto polyhydric alcohols, ethylene oxide adducts onto polyhydric alcohol higher fatty acid esters, phosphate ester salts of higher alcohol ethylene oxide adducts, imidazoline derivatives, alkyldiaminoalkylglycines and their salts, higher fatty acid amides and their ethylene oxide adducts, higher alkylamines and their ethylene oxide adducts are added to pyrethroids.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a potency enhancer for pyrethroid compounds.

[Conventional technology]

Dust mites are almost always present in the indoor dust of ordinary households, but in recent years, as housing and lifestyles have changed, more and more mites have been observed.

Conventionally, known acaricides against indoor mites include, for example, organic phosphorus compounds such as fenitrothion, fenthion, and diazinon, and pyrethroid compounds such as pyrethrin and allethrin.

[Problem that the invention seeks to solve]

These known acaricides are used by keeping them on insect repellent paper for tatami mats and carpets, or by spraying or spraying them as they are, but poisoning by organophosphorus acaricides has recently become a problem, and It has become difficult to use highly toxic acaricides at home. In addition, although pyrethroid acaricides are highly safe, they are slow-acting against mites, so if there are a large number of mites, their effectiveness may be insufficient.
Even if you add a general synergist for pyrethroid acaricides,
No significant synergistic effect was observed against mites.

[Means and effects for solving the problem] Therefore, the present inventor has conducted intensive research to compensate for the slow-acting drawback of pyrethroid acaricides and to enhance their efficacy. Ethylene adducts, ethylene oxide adducts of polyhydric alcohols, ethylene oxide adducts of polyhydric alcohol higher fatty acid esters, phosphate ester salts of ethylene oxide adducts of higher alcohols, imidazoline derivatives, alkyldiaminoalkylglycines and their salts, higher Fatty acid amides and their ethylene oxide adducts,
The present invention has been completed based on the discovery that when one or more selected from higher alkylamines and their ethylene oxide adducts are added to a pyrethroid compound, the acaricidal effect is significantly enhanced.

Although the efficacy enhancer of the present invention has a strong acaricidal effect by itself, it showed an extremely high synergistic effect especially when mixed with a pyrethroid compound.

In addition, the efficacy enhancer of the present invention is a highly safe surfactant used in cosmetics, etc., and is used in bedding, sofas, and other utensils that people frequently and directly come into contact with in their daily lives. can also be processed.

Examples of pyrethroid compounds whose acaricidal effect is enhanced by the efficacy enhancer of the present invention include permethrin, resmethrin, phenothrin, d-resmethrin, enventrin, and those containing isomers thereof, but are particularly limited to these. It is not something that will be done.

A miticidal composition prepared by adding 0.5 to 20 times the amount of one or more of the efficacy enhancers of the present invention to one or more of the above pyrethroid compounds can It is effective against mites such as Dermatophagoides nigricans such as Dermatophagoides nigricans and Dermatophagoides nigricans, Dermatophagoides mites such as Dermatophagoides nigricans and Dermatophagoides nigricans, Dermatophagoides mites such as Dermatophagoides nigricans and Dermatophagoides nigricans.

In addition, an appropriate amount of the above pyrethroid compound and the potency enhancer of the present invention are mixed, the composition is usually held in a liquid carrier or a solid carrier, and if necessary, emulsifiers, dispersants, wetting agents, stabilizers, etc. It can be used in the form of oils, emulsions, wettable powders, sprays, aerosols, liniments, powders, granules, etc. by adding a propellant or the like.

Examples of liquid carriers include water, alcohols such as methyl alcohol, ethyl alcohol, and isopropyl alcohol, ketones such as acetone, methyl ethyl ketone, and cyclohexanone, ethers such as tetrahydrofuran, dioxane, and dimethyl ether, hexane, kerosene,
Examples include aliphatic hydrocarbons such as normal paraffin and solvent naphtha, aromatic hydrocarbons such as benzene and toluene, halogenated hydrocarbons such as dichloromethane and dichloroethane, and esters such as ethyl acetate and butyl acetate. .

Examples of solid carriers include mineral powders such as silicic acid, kaolin, activated carbon, bentonite, diatomaceous earth, talc, clay, calcium carbonate, and ceramic powder; vegetable powders such as wood flour, soybean flour, wheat flour, and starch; Examples include clathrate compounds such as dextrin.

In addition, as the emulsifier and dispersant, the efficacy enhancer of the present invention can be substituted, but if necessary, sorbitan fatty acid ester, glycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkylphenyl ether, higher alcohol sulfate ester,
Examples of surfactants such as alkylaryl sulfonates and propellants include liquefied petroleum gas, dimethyl ether, fluorocarbons, fluorocarbons, carbon dioxide, nitrogen gas, and laughing gas.

Note that other acaricides, fungicides, fungicides, insecticides, repellents, synergists, fragrances, and the like can be added to the efficacy enhancer of the present invention, if necessary.

[Examples and effects of the invention]

EXAMPLES Hereinafter, the effects of the present invention will be explained in detail with reference to Examples.

Example 1. Non-woven fabric (polypropylene, thickness 230
μ), an acetone-water (1:1) mixed solution of the test compound such that the potency enhancer and synergist of the present invention is 0.5 g/m/m of the pyrethroid compound (0.1 g/r+). After removing the solvent, this impregnated cloth is
A polyethylene bag (6X 5 cra
) and make sure the four sides are stuck together. After 24 hours, the animals were judged to be alive or dead under a stereomicroscope. The results were determined by the mortality rate (%) according to Abbott's correction using the following formula, and are shown in Table 1.

-y Corrected mortality rate (%) --X 100 As shown in Table 1 above, the potency enhancer of the present invention exhibited a remarkable potency enhancing effect compared to conventional synergists of pyrethroid compounds.

Example 2 Sample 1 shown in Table 2 below was used for the purpose of insect repellent for car vents.
A mite control material in the form of a carpet was produced with specifications of 1 mA-F.

(The following is a blank space) Table 2 (The following is a blank space) The following tests were conducted on the mite-control carpet samples NaA to F obtained above.

(Test method) A mite medium containing about 1,000 Dermatophagoides mites was placed in the center of the carpet sample NnA-F and the chemical-free carpet (each 20 x 20 C11), and this was placed in a container (
41X31X22cm1) 25°C after putting it in the bottom
After storage for 7 days under conditions of 164% RH, dust mites on the surface or back of the carpet were sucked off using a vacuum cleaner with two sheets of 200 mesh nylon cloth sandwiched between the connection part of the suction cylinder. next,
Remove the nylon goose from the vacuum cleaner and add Darling liquid 10
Dust mites were shaken off into a 300 jd beaker containing 01d, stirred, transferred to a centrifuge tube, centrifuged at 1000 rpm+s, and the supernatant was transferred to a Buchner funnel with a spout and passed through the suction port. The living mites on this paper were counted, and the result was determined as a mortality rate (%) using the following formula.

-y Corrected mortality rate (%) = -X 100 show.

Table 3 As shown in Table 3 above, each sample showed sufficient mite control properties.

Example 3 0.6 g of phenothrin, a small amount of fragrance, and 50 d of ethyl alcohol were added to 3 g of each of the following test compound samples NaA-D.
and further normal paraffin to reduce the total to 15%.
Fill an aerosol pressure can (content: 400d) with Freon 12 and dimethyl ether mixture (volume ratio 2:1) 150-, attach it to an injection device, and seal it to prevent mites in the form of an aerosol. I got the material.

Using each aerosol thus obtained, the mite control effect was tested in the same manner as in Example 1.

(Test method) Apply each aerosol to a nonwoven fabric (30X30CII) for 3 seconds.
Spray it as evenly as possible, store it at room temperature for 24 hours, then cut it out into a 5x5C11 size sheet.
The mite control effect was tested according to the test method of Example 1 below.

The above test was repeated three times, and the results are shown in Table 4 as the average value.

Table 4 As shown in Table 4 above, each sample showed sufficient mite control properties.

Example 4 A sample of NaA-E mixed with the test compound shown in Table 5 below was sprayed on futon cotton so that the test compound was Ig/kg cotton, and then dried.

Table 5 (blank below) The following tests were conducted on the mite-proofed futon cotton samples NaA-E obtained above.

(Test method) Place 1 g of each of the futon cotton samples kA-E into sample tubes (30d).
Tori, put about 500 Kona hypodermis mites in it,
Cover and place at 25°C.

After 48 hours, the cotton was taken out from the sample tube, the living mites were collected by the heat expulsion method, and the mortality rate (%) was determined using the following formula.

χ -y Mortality rate (%) = -X 100 x; Percentage of recovered mites in untreated area y; Percentage of recovered mites in treated area As a result, almost 100% mortality rate could be obtained for all samples. Example 5 showing sufficient mite control properties: To 5 parts of the efficacy enhancer of the present invention used in Example 3, 1 part of resmethrin and 25 parts of silicon oxide were added, thoroughly stirred and mixed to form a powder. A powdered mite control material was obtained.

The dust mite control effect of the thus obtained powder was tested using the following test method.

(Test method) Straw cut into approximately 2 CI length was heated to kill insects, and then 5 g was
0d Erlenmeyer flask, then add 0.05g of each powder, mix, and heat at 25°C and 185-90% RH.
Store for 4 hours. Approximately 400 woolly mites were placed in this Erlenmeyer flask, and after storage under the same conditions for 48 hours, the surviving mites were expelled by the heat expulsion method, the number was counted, and the mortality rate was calculated according to the test method in Example 3. did.

As a result, all powders had a mortality rate of almost 100% and exhibited sufficient mite control properties.

Example 6゜Acetone-ethanol (1:l) of the test compound of the potency enhancer of the present invention shown in Table 6 below was placed in a vacuum cleaner paper bag.
The mixed solution was impregnated and dried to obtain a mite control material.

Table 6 The following tests were conducted on the mite control paper bag samples N [LA~已] obtained above.

(Test method) After attaching the dust mite prevention paper bag sample NIIA-E and the untreated paper puncture to a commercially available vacuum cleaner (suction power 160W), 20g of cotton-like short polyester fibers were thoroughly loosened as a substitute for indoor dust. After suctioning, the bag was taken out and 3 ml of water was sprayed on it. In addition, about 200 mite breeding medium containing about 1000 Kona hypodermis mites.
After placing the paper pack into the paper pack, the paper pack was placed inside the vacuum cleaner again and placed at 25° C. and 175% RH for two weeks. Thereafter, the mites in the Gion bag were collected by the saturated saline suspension method, and the survival rate (%) was determined by determining whether they were alive or dead. The above test was repeated three times and the results are shown in Table 7 as an average value.

Table 7 As shown in Table 7 above, each sample showed sufficient mite control properties.

Claims (1)

[Claims] 1. Ethylene oxide adducts of higher alcohols, ethylene oxide adducts of polyhydric alcohols, ethylene oxide adducts of polyhydric alcohol higher fatty acid esters, phosphate ester salts of ethylene oxide adducts of higher alcohols, imidazoline derivatives, alkyldiaminoalkyl glycine and its salts,
1. An efficacy enhancer for pyrethroid compounds, comprising as an active ingredient at least one selected from higher fatty acid amides and their ethylene oxide adducts, higher alkyl amines, and their ethylene oxide adducts.