JPH01226898A - Novel peptide and hypotensive agent containing said peptide - Google Patents

Novel peptide and hypotensive agent containing said peptide

Info

Publication number
JPH01226898A
JPH01226898A JP5403788A JP5403788A JPH01226898A JP H01226898 A JPH01226898 A JP H01226898A JP 5403788 A JP5403788 A JP 5403788A JP 5403788 A JP5403788 A JP 5403788A JP H01226898 A JPH01226898 A JP H01226898A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
peptide
group
amino
resin
presence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5403788A
Inventor
Yasuo Ariyoshi
Masanori Komura
Noriki Nio
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
    • Y02P20/55Synthetic design, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A peptide (salt) expressed by formulas I-XIII. USE:A hypotensive agent. PREPARATION:For example, proline having the amino group protected with 9-fluorenylmethoxycarbonyl group is bound to a p-alkoxybenzyl alcohol resin in the presence of a condensing agent to remove the protecting group. Amino acids having protected alpha-amino group and functional group in the side chain are linked in the presence of a condensing agent according to the amino acid sequence of a peptide and the alpha-amino protecting group is removed. The above- mentioned operation is repeated to synthesize a peptide chain. The resin having the two peptide chains linked thereto is subsequently suspended in a solvent and treated with trifluoroacetic acid to eliminate the peptide from the resin. After removing all the protecting groups, the peptide is purified by ion exchange chromatography, reversed phase liquid chromatography, etc., to afford the aimed peptide expressed by the formula.
JP5403788A 1988-03-08 1988-03-08 Novel peptide and hypotensive agent containing said peptide Pending JPH01226898A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5403788A JPH01226898A (en) 1988-03-08 1988-03-08 Novel peptide and hypotensive agent containing said peptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5403788A JPH01226898A (en) 1988-03-08 1988-03-08 Novel peptide and hypotensive agent containing said peptide

Publications (1)

Publication Number Publication Date
JPH01226898A true true JPH01226898A (en) 1989-09-11

Family

ID=12959393

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5403788A Pending JPH01226898A (en) 1988-03-08 1988-03-08 Novel peptide and hypotensive agent containing said peptide

Country Status (1)

Country Link
JP (1) JPH01226898A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063233A2 (en) * 1999-04-21 2000-10-26 University Of Florida Research Foundation, Inc. Peptides and the use thereof to control pests
WO2000062620A3 (en) * 1999-04-21 2001-07-05 Univ Florida Transformed cells useful for the control of pests
US6593299B1 (en) 1999-04-21 2003-07-15 University Of Florida Research Foundation, Inc. Compositions and methods for controlling pests
US6635265B1 (en) 1999-04-21 2003-10-21 University Of Florida Research Foundation, Inc. Materials and methods useful for the control of insect larvae
US6884878B2 (en) 1999-04-21 2005-04-26 University Of Florida Research Foundation, Inc. Neuropeptides and their use for pest control

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063233A2 (en) * 1999-04-21 2000-10-26 University Of Florida Research Foundation, Inc. Peptides and the use thereof to control pests
WO2000063233A3 (en) * 1999-04-21 2001-01-11 Univ Florida Peptides and the use thereof to control pests
WO2000062620A3 (en) * 1999-04-21 2001-07-05 Univ Florida Transformed cells useful for the control of pests
US6413530B1 (en) 1999-04-21 2002-07-02 University Of Florida Research Foundation, Inc. Pesticidal peptides
US6562590B1 (en) 1999-04-21 2003-05-13 University Of Florida Research Foundation, Inc. Transformed cells useful for the control of pests
US6566129B1 (en) 1999-04-21 2003-05-20 University Of Florida Research Foundation, Inc. Transformed cells useful for the control of pests
US6593299B1 (en) 1999-04-21 2003-07-15 University Of Florida Research Foundation, Inc. Compositions and methods for controlling pests
US6635265B1 (en) 1999-04-21 2003-10-21 University Of Florida Research Foundation, Inc. Materials and methods useful for the control of insect larvae
US6884878B2 (en) 1999-04-21 2005-04-26 University Of Florida Research Foundation, Inc. Neuropeptides and their use for pest control
US7491795B2 (en) 1999-04-21 2009-02-17 University Of Florida Research Foundation, Inc. Neuropeptides and their use for pest control
US7714106B2 (en) 1999-04-21 2010-05-11 University Of Florida Research Foundation, Inc. Neuropeptides and their use for pest control

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