JPH01175858A - Blood component separating bag - Google Patents

Abstract

PURPOSE:To sanitarily execute the action reducing its time by performing a series of actions of blood collecting, blood component separating and blood returning by two or more systems and the blood component separating and blood returning actions parallelly with a blood collecting bag. CONSTITUTION:A blood collecting needle 22 is pierced to a blood vessel, and collecting a predetermined quantity of blood to a blood collecting bag through blood collecting tubes 6, 7 thereafter closing a clamp 14 and centrifugally separating the blood in the blood collecting bag 2 to be processed, an upper blood component is partly taken into a blood plasma component separating bag 3 through a connecting tube 10. During this centrifugally separating process, blood is collected to another blood collecting bag 2a. A male member 20 of a connector 16 is connected to its female member 19, and the blood component, being left in the blood collecting bag 2, is returned to a donor from a blood guide needle 22 with physiological salt water from a physiological bag through blood returning tubes 8, 9, 17. During the action of blood returning, the blood collecting bag 2a performs a centrifugally separating process, after the blood returning of the blood collecting bag 2, the blood collecting bag 2a performs the action of blood returning. The separated blood component enables even air-tightness with the outside air to be maintained with no hazard of mixing.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a blood component separation bag for returning the remaining blood to the blood collector after separating and recovering necessary blood components from collected blood.

[Prior Art] Conventionally, blood used for plasma preparation, etc., is generally separated from necessary components such as plasma components from the collected blood, and then the remaining blood is discarded. Ta. In order to avoid such waste, recently, a system that separates and extracts only the necessary components from blood and then returns other remaining blood components to the blood collector has been attracting attention. As such devices, various devices have been developed in which blood is separated into plasma components and blood cell components using a membrane, and the blood cell components are returned to the person collecting the blood, but these devices are large-scale.

Because it is expensive, it can only be carried out in well-equipped hospitals, etc. For this reason, plasmapheresis bags, which are a combination of multiple conventional plastic blood bags, are also used.

Figure m12 is a schematic diagram of a conventional plasmapheresis bag. As shown in the figure, this plasmapheresis bag 600 includes a blood bag 601 and a plasma separation bag 60.
Two or three pairs of these are used in combination.

A blood collection tube 603 is connected to the upper end of the blood collection bag 601, and a branch blood collection tube 607 has a blood collection needle 606 attached to the blood collection tube 603 via a Y-tube.
and a blood cell return tube 605 to which a blood return port 604 is attached.

A blood transfusion port 60 is further provided at the upper end of the blood collection bag 601.
8,608, a connecting tube 61O is provided which is connected to the plasma separation bag 602 via the protector 609, 609 and the communication piece 610a.

These plasmapheresis bags 600 were used as follows when a pair of blood collection bag 601 and plasma separation bag 602 were provided.

First, the blood collection needle 606 is pierced into a blood vessel of the person collecting blood, and the blood is introduced into the blood collection bag 601 through the blood collection tubes 607 and 603. After collecting a predetermined amount of blood, the blood collection needle 606 is covered with a needle cap 611, and the plasmapheresis bag 600 is centrifuged to separate the blood in the blood collection bag 601 into blood cell components and plasma components.

Next, the communicating piece 610a is folded, only the plasma component of the supernatant is separated into the plasma separation bag 602 via the connecting tube 610, and the blood cell component remaining in the blood collection bag 601 is
A blood transfusion set 620 as shown in the figure was used and returned to the person collecting blood.

This blood transfusion set 620 includes a saline bottle 621 containing saline added with an anticoagulant, a saline introduction tube 622, an introduction needle 623, and a blood cell return tube 6.
29, a blood cell return tube 62 with a blood return needle 624 attached to the tip of the tube 629, a point WI tube 62s, and an adapter 628 formed to fit with the blood cell return port 604 of the plasmapheresis bag 600;
6, and a clamp 527 installed in the middle of the blood cell return tube 626.

In use, the blood cell return tube 626 of the blood transfusion set 620. After filling the inside of the saline introduction tube 622 and the drip tube 625 with saline in advance, and connecting the adapter 628 of the blood transfusion set 620 to the blood cell return port 604 of the plasmapheresis bag 600, the blood return needle 606 is used to collect blood. The blood return needle 624 is passed through the blood transfusion port 809 of the blood collection bag 601 to remove the blood from the blood collection bag 60.
The blood cell components in 1 were introduced into the drip tube 525 through the blood cell return tube 629, diluted with physiological saline inside the drip tube 625, and returned to the blood collector.

[Problems to be Solved by the Invention] However, in the plasmapheresis bag described above, when blood cell components are returned to the blood collector after plasma separation, the blood transfusion cell) 620 is transferred to the plasmapheresis bag 60.
0 blood cell return tube 605. or connect it to the blood return needle 6
24 into the blood transfusion port 608 of the blood collection bag 601,
Furthermore, the introduction needle 623 must be inserted into the physiological saline bottle 621, which is not only cumbersome to operate, but also causes the blood return needle 624, introduction needle 623, connector 628, etc. to come into contact with non-sterile objects or the atmosphere and become contaminated. There was a concern.

In addition, in such a bag system, each operation of blood collection, plasma separation processing, and blood return must be performed independently in sequence, especially in cases where multiple pairs of blood collection bags and plasma separation bags are provided. If the operation takes a long time.

There is a problem in that it places a psychological burden on the person collecting blood. Also, after separating these blood cell and plasma components, these components should not be mixed together again.

■For example, a slide clamp 67 as shown in FIG.
0 to block the liquid flow path.

■These tubes 610, 603.60 by high frequency welding
Weld 7.

(2) Tie these tubes 610, 603, and 607 as shown in FIG. 15 to completely block the liquid flow path.

The above methods have been tried.

In the method (2) using the slide clamp 670, the notch groove 6
71 clamps the tube 610 to block the fluid flow path, so when the slide clamp 670 is attached, if centrifugal force or some kind of impact is applied, the tube suppression of the slide clamp 670 will loosen. When the fluid flow path is opened, the blood components that have been separated will be mixed together again, so there is a risk that the work done up to that point will be completely wasted.

In the method (2) using high frequency welding, the high frequency welding device itself is heavy, inconvenient to carry, and difficult to handle during use. Moreover, since they are expensive, it is an economic burden to keep them on hand.

In the method (2), considerable skill is required to be able to quickly tie the fluid flow path to the extent that it is completely blocked, and the work is troublesome.

[Means for solving problems]

The present invention was proposed in order to solve these problems, and it enables the operations of blood collection, component separation, and blood return to be carried out simultaneously in parallel, and moreover, the operations are carried out in a sterile and hygienic manner. It is an object of the present invention to provide a blood component separation bag device that can be implemented in the following manner. These objectives are achieved by the means described below.

(1) That is, a blood collection bag 2 equipped with at least (a) blood collection tube 7, (b) blood return tube 8, 9, (e) connecting tube 10, (2) at least (d) connected tube 10 attached. Blood plasma component separation bag 3 (3) Blood introduction member 4 consisting of at least (e) blood introduction needle 22 (f) blood introduction tube 11 (4) At least (g) liquid introduction needle 23 or saline bag 38 (h) liquid introduction A connector member 16 consisting of a male member 20 and a female member 19 which are detachably formed to each other is provided in the middle of the blood return tube 8.9, which is composed of a liquid introduction member 5 consisting of a tube 12, and the blood collection tube 7. , (5) [1] (a) Convex clamping portion 505 (b) Fitting protrusion 506 (c) Fitting groove 507 is integrated into at least one location of the blood return tube 8.9 and the connecting tube IO. The formed sealing member 502 [2] (a) Convex holding part 508 (b) Fitting protrusion 510 (c) Fitting groove 509 (d) Fitting groove 511 of the liquid transfer tube (e) Fitting groove 511 of the liquid transfer tube Main body 513 integrally formed with holding member 512 ■ Sealing member 502 and main body 503 are connected to thin hinge portion 5
A blood component separation bag 1 is provided with a clamp 501 integrally formed via a 04.

[Effect]

The blood collection needle 22 is punctured into the blood vessel of the person collecting blood, and the blood collection tube 6.
After collecting a predetermined amount of blood into the blood collection bag 2 through the tube 7, the clamp 14 is closed, the blood collection tube 7 is cut, the blood in the blood collection bag z is centrifuged, and the blood component in the top light is passed through the connecting tube 10 into the plasma component separation bag. Aliquot 3. Note that while this centrifugation process is being performed, blood is being collected into the other blood collection bag 2a.

Next, the male member 20 and female member 19 of the connector 16 are connected, and the blood components remaining in the blood collection bag 2 are passed through the blood return tubes 8, 9, and 17, together with physiological saline from the saline bag, to the liquid introduction tube 13, and the drip Blood is returned to the person collecting blood from the blood guide needle 22 through the tube 24 and the blood guide tube 11.

While blood collection bag 2 is being returned blood, blood collection bag 2a
After the centrifugation process is performed and the blood return operation of the blood collection bag 2 is completed, the blood return operation of the blood collection bag 2a is performed.

The blood collection tube 7.7a and the connecting tube 1O110a have their flow paths completely blocked by the clamps 14.14a and 15.15a, so the separated blood components have no risk of mixing with each other and do not come into contact with the outside air. It is also possible to maintain airtightness.

(Example) FIG. 1 shows a schematic diagram of a blood component separation bag 1 of the present invention. The blood component separation bag 1 is basically a blood collection bag 2.
, plasma component separation bag 3, blood guide member 4, liquid introduction member 5, blood collection tube 6.7, blood return tube 8.9.17, and connection tube l connecting these components.
O1 blood guide tube 11, liquid introduction tube 12.1
Clamp 14.15 provided at at least one location of 3.
．． It further includes a connector 16 provided midway between the blood return tubes 8 and 9.

The connector 16 is composed of a male member 20 and a female member 19, which are attached to the ends of the blood return tubes 9 and 10, respectively, and are covered with protectors 36 and 37 to prevent contact with the outside air. At the upper end of the blood collection bag 2, a blood collection tube 7 with a clamp 14 attached to the middle, a blood return tube 8 with the female member 19 of the connector 16 attached to the tip, and a connecting tube 10 with a clamp 15 attached to the middle are attached. The fluid flow paths of these tubes 7.8, 1O are blocked by the communication piece 18.27.34.

The plasma component separation bag 3 has the connecting tube 1 at its upper end.
0 and the infusion port 21 are attached.

The blood guiding member 4 is composed of a blood guiding needle 22 and the blood guiding tube 11, while the liquid introducing member 5 is composed of a liquid introducing needle 23 and the aforementioned liquid introducing tube 12.13,
It consists of a drip tube 24, the liquid introduction needle 23 is covered with a protector 25 so as not to come into contact with the outside air, and a roll clamp 25, 26 for flow rate adjustment is attached to the middle of the liquid introduction tube 12, 13. .

Instead of the liquid introduction needle 23, the liquid introduction member 5 can also be integrally connected to a saline bag 38 filled with physiological saline via a communication piece 39.

The above components are connected by connecting pipes 28, 29, 30, and 31.

Blood collection tube 7a and blood return tube 9 are connected to the connecting tubes 29 and 30.
The aforementioned blood collection bag 2a, plasma component separation bag 3a connector 16a, etc. can be attached via a.

A clamp 14a, a roll clamp 32. A roll clamp 33 is placed in the middle of the blood return tube 9a, and a clamp 1 is placed in the middle of the connecting tube 10a.
5a is attached.

In FIG. 1, blood collection bag 2-plasma separation bag 3. Although two pairs of plasma bag 2a and plasma separation bag 3a are provided, only one pair may be used, such as blood collection bag 2 and plasma separation bag 3, or blood collection bag 2 and plasma separation bag 3 blood collection bag 2a and plasma separation bag. Two or more pairs may be provided, such as 3a blood collection bag, 2b-plasma separation bag 3b, blood collection bag 2n-plasma separation bag 3n.

Furthermore, a plurality of plasma component separation bags may be attached to the blood collection bag 2.

When each of the communication pieces 18.27, 34.39 is not in use,
The flow path is closed, and when in use, it is constructed so that it can be easily opened by folding it with your fingers.

For example, the head of the hard plastic cylinder is closed, and the thin part at the middle of the cylinder can be broken during use.

(Margins below) Furthermore, each of the above bags is formed by stacking two soft plastic sheets such as polyvinyl chloride and forming it into a bag shape, and each tube, connecting pipe, and drip tube are also made of plastic such as polyvinyl chloride.

The connector 16 of the present invention may be of a type in which both the male and female members 19 and 20 are simply fitted together, but in order to confirm the identity of both members when reconnecting after removal,
Preferably, a verification means is provided.

FIGS. 2 and 3 show an embodiment of the collation means.

In the figure, 70 is a male member, and 71 is a female member. Similarly, it is composed of a housing 75 and a large-diameter key ring 76 and a small-diameter key ring 77 that are inserted and fixed into the housing.

Further, a seal packing 78 is inserted into either one of the small diameter key rings 74, 76.

A tube connecting lower 9 is provided protruding from the rear end portion of the male member 70, and a male connecting tube 80 is provided protruding from the inner center portion. Further, a pair of upper and lower hook portions 81 and 82 are formed on the outside of the casing 72. This hook portion 81.
Both of the hook portions 82 have elastic force in the vertical direction, and are slightly wider than the width of one of the hook portions 81.

In this way, as will be described later, when connecting the male member 70 and the female member 71, they will not be connected upside down.

Further, a tube connection port 83 is protruded from the rear end of the housing 75 of the female member 71, and a female connecting tube 90 (see FIG. 3) is protruded from the center of the interior. Furthermore, engagement holes 84.85 are opened at the outer peripheral edge of the opening side of the housing 75, corresponding to the hook portions 81.82 of the male member. The width of one of the insertion holes 84.8.5 is wider than the width of the other insertion hole 85, corresponding to the hook portion. The large diameter key ring 73
．． Each of the cylinders 76 has a half circumference cut out at the tip thereof to form a concave portion 86 and a convex portion 86a. Further, the small diameter key rings 74, 77 are inserted and fixed into each housing with the positions of the projections and depressions being slightly shifted in the circumferential direction. When the concavo-convex portions of the large-diameter key rings on the male member side and the female member side match, the hook portions 81.82 of the male member engage with the engagement holes 84.85 of the female member. For this combination, for example, adjust the angle of the large diameter key ring and the small diameter key ring in steps of 5.

A total of 72X72X72=373248 combinations are obtained.

In the above-mentioned embodiment, the key ring is composed of a large diameter key ring and a small diameter key ring, but if a combination type is required, another key ring may be added.

Note that polycarbonate, polypropylene, vinyl chloride, etc. are used as the material for the housing and key ring. Further, the seal packing 78 is made of rubber, elastic synthetic resin, or the like.

FIG. 4 shows another embodiment of the collation means, in which 10
1 is a male member, and 102 is a female member.

The male member 101 consists of a housing 103 and a set of large and small key rings 104 and 105. The housing 103 has a connecting tube 106 formed in its center, and a seal ring 107 at the tip of the connecting tube 106.
is installed. Further, a hook portion 109 is formed on the outside of the housing 103 in an elastic manner in the vertical direction, and a tube 108 communicating with the connecting tube 106 is connected to the rear end portion. Further, in the key ring, a small diameter key ring 105 is inserted and fixed inside the large diameter key ring 104, and this small diameter key ring 105 is inserted and fixed on the outer periphery of the connecting cylinder 108 of the housing.

Further, the female member 102 also has the same characteristics as the male member 101.
Housing 101 and a set of large and small key rings 111,1
It consists of 12.

A connecting cylinder 113 into which the tip of the male connecting cylinder 116 can be inserted is formed in the center of the housing 110, and a connecting cylinder 113 that faces the hook part 109 of the male housing 101 is formed on the outside of the housing 110. An engaging portion 114 is formed at the tip of the hook at the position. Further, a tube 115 communicating with the connecting cylinder 113 is connected to the rear end of the housing 110. Furthermore, the key ring has a small diameter key ring 111 inside the large diameter key ring 112.
are inserted, and these are connected to the communication tube 113 of the housing 110.
The insertion is fixed.

The configurations of the large-diameter key ring 104.112 and the small-diameter key ring 105.111 are the same as those shown in FIGS. 2 and 3 above, and when the unevenness on the male member side and the female member side match,
Hook portion 109 of housing 103.194 and engaging portion 1
14 are adapted to engage with each other.

FIG. 5 shows a modification of the engaging portion of the housing in the embodiment shown in FIG. 4 above.

That is, in this engagement part, a hook part 120 is elastically movable up and down using a support part 121 outside the male housing 103 as a fulcrum, and the tip of the hook part 120 fits into the annular groove of the female housing 110. 112. The hook portion 120 may be provided at the upper and lower portions.

FIG. 6 shows yet another embodiment of the engaging portion of the housing, in which, in addition to the hook portion 109 and stopper portion 114 shown in FIG. 123 and an engaging portion 124 are provided.

The key rings shown in the above embodiments can be mass-produced at low cost because the male and female sides may have the same shape.

Next, the clamp attached to the blood component separation bag 1 of the present invention will be explained.

7 shows a schematic diagram of the clamp 501, and FIG. 8 shows a perspective view of the clamp 501 when it is opened.

The clamp 501 is made of polypropylene, polyacetal,
It is made of synthetic resin such as soft vinyl chloride, and basically consists of a sealing member 502, a main body 503, and a hinge part 504, which are integrally formed.

The sealing member 502 is formed into a rectangular shape, and includes a convex blood collection tube 8, a clamping portion 505 of a connecting tube IO (hereinafter referred to as a liquid transfer tube 513), and one end of the outer edge (
A fitting protrusion 506 and a fitting groove 507 are integrally formed at a position intersecting the length direction of the liquid transfer tube 513.

The main body 503 is formed into a rectangular shape, has a convex holding part 508 for the liquid transfer tube 513 inside, and has the sealing member 502 at one end of the outer edge (a position intersecting the length direction of the liquid transfer tube 513). A fitting groove 509 and a fitting protrusion 510 are formed in a negative body at positions facing the fitting protrusion 506 and the fitting groove 507 (FIG. 9 shows these fitting protrusions 506 and 510).
0 and a partially enlarged sectional view of the fitting groove 507 and 509),
Further, a mounting groove 511 for the liquid transfer tube 513 and a holding member 512 for the liquid transfer tube 513 are uniformly formed at one end of the outer edge (at the same position as the length direction of the liquid transfer tube).

As shown in FIG. 1θ, the holding member 512a may have a notch 5i4a formed therein so that the liquid transfer tube 513a can be easily attached to the tube attachment groove 511a.
The width W of the clamp 14a is preferably formed to be slightly smaller than the outer diameter of the liquid transfer tube 513a, thereby preventing the clamp 501a from coming off from the liquid transfer tube 513a.

Furthermore, a taper 515a may be formed at the tip of the notch 514a so that the liquid transfer tube 513a can be easily attached.

Next, how to attach the clamp 501 to the plasma component separation bag 1 and how to use it will be explained.

As shown in FIG. 8, the sealing member 502 and the main body 503 are
When assembling the medical device, the liquid transfer tube 513 is attached to the tube attachment groove 511 of the main body 503 with the liquid transfer tube 513 opened at an angle of 80 degrees, and then the liquid transfer tube 513 is inserted into the flexible bag 1, the drip tube, and the connecting tube. The blood component separation bag is assembled by connecting each member constituting the blood component separation bag.

Since the tube mounting groove 511 is formed to have a width W sufficient to allow sufficient play with the liquid transfer tube 513, the clamp 501 can be slid between the liquid transfer tubes 513 as necessary. The aforementioned notch 51
The relationship among the width W of 4a, the outer diameter of the liquid transfer tube 513, and the width W' of the tube mounting groove 511 is W>DEW.
It is.

In use, when the sealing member 502 is pushed toward the main body 503 to close it, the liquid transfer tube 513 is inserted into the clamping portion 505.
and 508 are gradually pressed.

Fitting protrusion between sealing member 502 and main body 503 - Fitting groove 50
9. When the fitting groove 507 and the fitting protrusion 51O are completely fitted, the liquid transfer tube 513 is inserted into the clamping part 505, 508.
is pressed to the bottom of the sealing member 502 and the main body 503,
The fluid path is completely blocked. (Figure 11).

Fitting protrusion 506.51 between sealing member 502 and main body 503
0 and fittings t4507 and 509 cross each other and are tightly fitted, so once they are fitted by -degree, they will never come off again.

In addition, in the clamp 501a in which a notch 514a is formed in the holding member 512a as shown in FIG. 1θ, the notch 51
4a, insert the liquid transfer tube 513a into the tube mounting groove 5.
11a (because the liquid transfer tube 513a is flexible, it will be crushed in the notch 514a, but will be restored to its original shape in the tube attachment groove 511a). It can be attached to the blood component separation bag as needed.

Next, an example of use of the blood component separation bag shown in FIG. 1 will be explained.

First, close the roll clamps 26, 32, 33, and open the blood collection bag 2 by folding the communication piece 34.
．． 3 is placed at a position lower than the arm of the person collecting blood, and when the blood guide needle 22 penetrates the blood vessel of the person collecting blood, the blood flows through the blood guide tube 11 and the blood collection tube 6, 7 due to the action of blood pressure and gravity. The blood is then introduced into the blood collection bag 2.

After introducing a predetermined amount of blood, the clamp 14 is closed to completely block the liquid flow path.The closing position of the clamp 14 is preferably as close to the upper end of the blood collection bag as possible.

This is to prevent the blood introduced into the blood collection bag 2 from flowing back into the blood collection tube.

Cut the blood collection tube 7 at position A with a cutter or the like to separate the blood collection bag 2 and plasma component separation bag 3. The liquid flow path of the blood collection tube 7 pressed by the clamp 14 is completely blocked and airtightness is maintained. can.

The blood collection bag 2 into which blood has been introduced is centrifuged together with the plasma separation bag 3 (empty bag). At this time, since the blood contained in the blood collection bag is completely blocked by the clamp 14 and the communication piece 18.27, it will not flow out from the blood collection bag during the centrifugation process.

After the blood collection bag 2 is opened and transferred to the plasma separation bag 3 through the connecting tube 10, the clamp 15.35 is closed and the connecting tube 1o is cut at positions B and C.

As a result, blood cell components remain in the blood collection bag 2. During the centrifugation process of the blood collection bag 2, the roll clamp 3
2, open the communication piece 14a, and remove the blood collection tube 7.
Blood is introduced into the blood collection bag 2a from a. After introducing a predetermined amount, the blood sampling tube 7a is cut at position a using a cutter or the like and centrifuged in the same manner as described above, and the plasma is separated into the plasma separation bag 2a.

When returning the plasma components remaining in the blood collection bag 2 to the blood collector, the male member 20 and female member 19 of the connector 16 are joined. In this case, the above-mentioned verification means confirms the identity of both the male and female members. For example, in the matching means shown in FIGS. 2 and 3, the unevenness of the large and small key rings 73, 76 and 74, 77 on both the male and female members are fixed in a manner shifted in the circumferential direction for each connector or for each product. Only when the concave and convex portions of the male and female key rings match can the two members 70 and 71 be connected, and the hook 81.
82 can be inserted into the insertion holes 84 and 85. Therefore, the identity of both male and female members can be confirmed, and mistakes such as returning someone else's blood can be prevented.

After connecting the connector 16 as described above, the liquid introduction needle 23 is connected to the saline bag 38 containing physiological saline used as a diluent, and the roll clamp 25 is opened.
The communication piece 18 is opened, the blood cell components in the blood collection bag 1 are passed through the blood return tube 8.9, and an electric current is applied to the liquid introduction tube 13.

An anticoagulant is added to the physiological saline, and when the blood cell components are returned, the flow rate is adjusted with the roll clamp 25 and the liquid is passed through the liquid introduction tube 12.13 into the drip tube 24.
flow down to. The blood return tube 8.
After the blood cell components from 9 and 17 and the dilution are thoroughly mixed,
While the flow rate is adjusted by the roll clamp 26, the blood is returned to the blood collector through the blood guide tube.

While the blood cell components in the blood collection bag z are being returned, the blood in the blood collection bag 2a is centrifuged as described above. After the blood return operation of the blood collection bag 2 is completed, the blood cell components remaining in the blood collection bag 2a are returned by the same method.

When blood is collected using the method described above, the blood is collected and returned in two steps, so there is less burden on the person collecting the blood. In the case of a confident blood collector, it is also possible to simultaneously collect blood into the blood collection bag 2.2a and perform centrifugal separation of blood components and return processing of blood cell components at the same time.

[Effects] According to the present invention described above, (1) The series of operations of blood collection, blood component separation, and blood return can be performed in a closed system composed of a plurality of bags, which is extremely hygienic. In addition, since the blood collection bag, blood component separation operation, and blood return operation can be performed simultaneously, the operation time per person can be shortened.
The burden on the person collecting blood will also be reduced. By providing a verification means on the male and female parts of the connector installed in the middle of the blood return tube, it is possible to confirm the identity of the person collecting blood and the blood components to be returned, and to prevent erroneously returning someone else's blood. It is safe because it prevents mistakes.

(2) Clamp, blood collection tube 7.7a communication tube 1
Since it is attached to the O110a, the liquid passage of the communication tube can be easily shut off with a single touch, and it has excellent airtightness to the extent that the separated blood components do not mix with each other and do not come into contact with the outside air. Therefore, blood fractionation work can be carried out with peace of mind.

This is an excellent invention.

[Brief explanation of the drawing]

FIG. 1 is an overall schematic diagram showing an embodiment of the present invention, FIG. 2 is an exploded view of the verification means in the present invention, and FIG.
The half-sectional view of the verification means in FIG. 2 and FIGS. 4 to 6 all show other embodiments of the verification means in the present invention, and FIG. 4 is an embodiment of the verification means in the present invention. FIG. 5 is a cross-sectional view showing the same, FIG. 6 is a perspective view, FIG. 7 is a perspective view of the clamp in a closed state, FIG. 8 is a perspective view of the clamp in an open state, and FIG. 9r! ! J is a schematic diagram showing an enlarged sectional view of the fitting protrusion and the fitting groove of the clamp, FIG. 11 is a central vertical sectional view of FIG. 7, and FIG. 12 is a schematic diagram of a conventional plasmapheresis bag. Fig. 13 is a schematic diagram of the infusion set connected to the plasmapheresis bag of Fig. 12, Fig. 14 is a schematic diagram of the plate clamp, and Fig. 15 is a schematic diagram showing the state where the tube is tied. It is. In the figure, l is a blood component separation bag, 2.2a is a blood collection bag, 3 and 3a are plasma component separation bags, 10.10a is a connection tube, 6.7 and 7a are blood collection tubes, and 8.9.17
is a blood return tube, 16 is a connector, 22 is a blood introduction needle, 20 is a male member, 19 is a female member, 73.76 is a large diameter key ring, 74.77 is a small diameter key ring, 81.82
is the hook part, 84.85 is the insertion hole, 501 is the clamp,
502 is a sealing member, 503 is a main body, 504 is a hinge part,
505.508 is a holding part, 506.510 is a fitting protrusion, 507.509 is a fitting groove, 511 is a mounting groove, 512 is a tube holding member, 513 is a liquid transfer tube 514a
515a indicates a notch, and 515a indicates a taper. Patent applicant: Kawasumi Chemical Industry Co., Ltd. Figure 2 Figure 7 Figure 8 Figure 11 Figure 13 Procedural amendment form) April 22, 1986

Claims (1)

[Scope of Claims] A bag device that fractionates blood collected from a blood donor, separates necessary blood components, and then returns the remaining blood components to the blood collector, comprising: (1) at least (a) blood collection; (b) a blood collection bag equipped with a blood return tube, (c) a connecting tube; (2) a plasma component separation bag equipped with at least (d) a connecting tube; and (3) a blood guide consisting of at least a blood guiding needle and a blood guiding tube. Member (4) is composed of a liquid introduction member consisting of at least a liquid introduction needle or a saline bag and a liquid introduction tube, and a connector member consisting of a male member and a female member that are detachably formed to each other is provided in the middle of the blood return tube, and the aforementioned blood collection tube, blood return tube,
A sealing member integrally formed with (5) [1] (a) a convex holding part (b) a fitting protrusion (c) a fitting groove in at least one part of the connecting tube [2] (a) a convex shape (b) Fitting protrusion (c) Fitting groove (d) Fitting groove for liquid transfer tube (e) Main body integrally formed with holding member for liquid transfer tube [3] The sealing member and main body are integrally formed. A blood component separation bag characterized by being equipped with a clamp formed integrally through a thin hinge part.